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Gene: Lars1 (leucyl-tRNA synthetase 1) Rattus norvegicus

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Symbol:

Lars1

Name:

leucyl-tRNA synthetase 1

RGD ID:

1304962

Description:

Predicted to enable GTPase activator activity and catalytic activity, acting on a tRNA. Predicted to be involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and tRNA aminoacylation for protein translation. Predicted to be located in cytosol; endoplasmic reticulum; and lysosome. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; valine, leucine and isoleucine biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Lars; leucine--tRNA ligase, cytoplasmic; leucyl-tRNA synthetase; leucyl-tRNA synthetase, cytoplasmic; LOC291624; MGC105585

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LARS1 (leucyl-tRNA synthetase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Lars1 (leucyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lars1 (leucyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LARS1 (leucyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LARS1 (leucyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lars1 (leucyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LARS1 (leucyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LARS1 (leucyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lars1 (leucyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Lars1 (leucyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	LARS1 (leucyl-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lars1 (leucyl-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	larsb (leucyl-tRNA synthetase b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	larsb (leucyl-tRNA synthetase b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CDC60	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	LeuRS	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lars-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lars1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	34,452,567 - 34,507,030 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	34,452,561 - 34,506,938 (-)	Ensembl				GRCr8
mRatBN7.2	18	34,201,555 - 34,256,003 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	34,201,549 - 34,255,931 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	34,305,753 - 34,360,085 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	35,024,076 - 35,078,405 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	34,400,977 - 34,455,312 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	36,524,013 - 36,579,471 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	36,524,007 - 36,579,403 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	36,191,058 - 36,244,388 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	35,399,197 - 35,455,759 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	33,798,541 - 33,852,822 (-)	NCBI		Celera
RGSC_v3.1	18	35,434,464 - 35,491,025 (-)	NCBI
Cytogenetic Map	18	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

infantile liver failure syndrome 1 (ISO)

microcephaly (ISO)

sensorineural hearing loss (ISO)

transient infantile liver failure (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

2,6-dinitrotoluene (EXP)

2-bromohexadecanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

chloroacetaldehyde (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cidofovir anhydrous (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (EXP,ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

dibutyl phthalate (EXP)

diuron (ISO)

dorsomorphin (ISO)

enzyme inhibitor (ISO)

fenofibrate (EXP,ISO)

fenthion (ISO)

flutamide (EXP)

furfural (ISO)

geldanamycin (ISO)

gentamycin (EXP)

glycine betaine (EXP)

hydrogen peroxide (ISO)

ibuprofen (ISO)

ivermectin (ISO)

metformin (EXP)

methapyrilene (EXP)

methidathion (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP)

Nutlin-3 (ISO)

ochratoxin A (ISO)

paracetamol (ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenethyl isothiocyanate (EXP)

pirinixic acid (EXP,ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium chloride (ISO)

sunitinib (ISO)

T-2 toxin (EXP)

temozolomide (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

thimerosal (ISO)

torcetrapib (ISO)

trichostatin A (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aminoacyl-tRNA metabolism involved in translational fidelity (IEA)

cellular response to amino acid starvation (IEA,ISO)

cellular response to amino acid stimulus (IEA,ISO)

cellular response to L-leucine (IEA,ISO)

cellular response to leucine starvation (IEA,ISO)

glutaminyl-tRNA aminoacylation (IEA,ISO)

leucyl-tRNA aminoacylation (IBA,IEA,ISO)

positive regulation of TORC1 signaling (IEA,ISO)

translation (IEA)

tRNA aminoacylation for protein translation (IEA)

Cellular Component

aminoacyl-tRNA synthetase multienzyme complex (IEA,ISO)

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

endomembrane system (IEA,ISO)

endoplasmic reticulum (IEA,ISO)

lysosome (IEA,ISO)

Molecular Function

aminoacyl-tRNA deacylase activity (IEA,ISO)

aminoacyl-tRNA ligase activity (IEA)

ATP binding (IEA)

glutamine-tRNA ligase activity (IEA,ISO)

GTPase activator activity (IEA,ISO)

leucine-tRNA ligase activity (IBA,IEA,ISO)

ligase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

aminoacyl-tRNA biosynthetic pathway (IEA)

valine, leucine and isoleucine biosynthetic pathway (IEA)

External Pathway Database Links

KEGG Pathway

Valine, leucine and isoleucine biosynthesis

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles.	Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.

Additional References at PubMed

PMID:12060739	PMID:12477932	PMID:19131329	PMID:19289464	PMID:22424946	PMID:26869582

Genomics

Comparative Map Data

Lars1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	34,452,567 - 34,507,030 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	34,452,561 - 34,506,938 (-)	Ensembl				GRCr8
mRatBN7.2	18	34,201,555 - 34,256,003 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	34,201,549 - 34,255,931 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	34,305,753 - 34,360,085 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	35,024,076 - 35,078,405 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	34,400,977 - 34,455,312 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	36,524,013 - 36,579,471 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	36,524,007 - 36,579,403 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	36,191,058 - 36,244,388 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	35,399,197 - 35,455,759 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	33,798,541 - 33,852,822 (-)	NCBI		Celera
RGSC_v3.1	18	35,434,464 - 35,491,025 (-)	NCBI
Cytogenetic Map	18	p11	NCBI

LARS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	146,113,034 - 146,182,650 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	146,110,566 - 146,182,696 (-)	Ensembl			hg38	GRCh38
GRCh37	5	145,492,597 - 145,562,213 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	145,472,782 - 145,542,487 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	145,473,220 - 145,542,321	NCBI
Celera	5	141,572,531 - 141,642,218 (-)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI
HuRef	5	140,639,339 - 140,709,091 (-)	NCBI		HuRef
CHM1_1	5	144,925,472 - 144,995,023 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	146,647,338 - 146,718,197 (-)	NCBI		T2T-CHM13v2.0

Lars1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	42,335,363 - 42,395,302 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	42,335,363 - 42,395,259 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	42,202,298 - 42,262,237 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	42,202,298 - 42,262,194 (-)	Ensembl			mm10	GRCm38
MGSCv37	18	42,362,003 - 42,421,725 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	42,328,271 - 42,388,167 (-)	NCBI		MGSCv36	mm8
Celera	18	43,563,719 - 43,623,468 (-)	NCBI		Celera
Cytogenetic Map	18	B3	NCBI
cM Map	18	22.37	NCBI

Lars1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	7,923,059 - 7,983,757 (+)	Ensembl
ChiLan1.0	NW_004955415	7,923,292 - 7,983,757 (+)	NCBI	ChiLan1.0	ChiLan1.0

LARS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	141,366,769 - 141,435,479 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	139,506,319 - 139,575,029 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	141,562,798 - 141,631,388 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	147,577,848 - 147,646,298 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	147,578,042 - 147,646,834 (-)	Ensembl			panPan2	panpan1.1

LARS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	40,544,031 - 40,619,268 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	40,544,210 - 40,635,281 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	37,588,723 - 37,663,534 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	41,007,758 - 41,082,885 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	41,005,058 - 41,082,832 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	38,074,367 - 38,149,607 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	38,890,902 - 38,966,001 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	39,716,067 - 39,791,315 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	146,926,031 - 146,994,504 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936504	8,499,978 - 8,570,715 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936504	8,500,024 - 8,568,477 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LARS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	147,477,370 - 147,554,047 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	147,480,132 - 147,554,197 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	153,830,763 - 153,892,032 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LARS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	48,691,361 - 48,761,664 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	48,677,622 - 48,761,596 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666034	29,029,415 - 29,099,213 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lars1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	5,609,623 - 5,673,791 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624774	5,609,623 - 5,673,815 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lars1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	15	3,382,335 - 3,430,686 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lars1
160 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	101
Count of miRNA genes:	85
Interacting mature miRNAs:	90
Transcripts:	ENSRNOT00000025284
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	22015562	61600538	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26822186	71822186	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26822186	71822186	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26822186	71822186	Rat
1331727	Bp237	Blood pressure QTL 237	3.053		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	63968306	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26822186	71822186	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26822186	71822186	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26822186	71822186	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	31990891	76990891	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31610505	85493247	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	33379158	78379158	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34566578	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4482648	49482648	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	31990891	76990891	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	54490981	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
11565454	Kidm59	Kidney mass QTL 59		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	7065728	52065728	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34566578	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	4307354	49307354	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	33379158	78379158	Rat
2301409	Cm70	Cardiac mass QTL 70		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	18	7065728	52065728	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	33379158	78379158	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	33379158	78379158	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26822186	71822186	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31522783	76522783	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	33379158	78379158	Rat
12904716	Am21	Aortic mass QTL 21		0.005	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	7065728	52065728	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	33379158	78379158	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	33379158	78379158	Rat
12904714	Cm131	Cardiac mass QTL 131		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	7065728	52065728	Rat
12904715	Cm132	Cardiac mass QTL 132		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	7065728	52065728	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31610505	77371277	Rat
6903345	Bp349	Blood pressure QTL 349	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	15226101	42690662	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	31990891	76990891	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5460455	42690191	Rat
6903349	Bp351	Blood pressure QTL 351	3.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	26415821	71415821	Rat
6903351	Bp352	Blood pressure QTL 352	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31644508	79484311	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	44930869	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	12066482	57066482	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	31990891	76990891	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31610505	72538878	Rat

Markers in Region

D18Mco2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	18	34,461,743 - 34,461,900 (+)	Marker Load Pipeline
mRatBN7.2	18	34,210,731 - 34,210,888 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	36,533,190 - 36,533,346	NCBI	Rnor6.0
Rnor_5.0	18	36,200,235 - 36,200,391	UniSTS	Rnor5.0
RGSC_v3.4	18	35,408,373 - 35,408,530	RGD	RGSC3.4
RGSC_v3.4	18	35,408,374 - 35,408,530	UniSTS	RGSC3.4
Celera	18	33,807,718 - 33,807,874	UniSTS
RGSC_v3.1	18	35,443,639 - 35,443,796	RGD
Cytogenetic Map	18	p11	UniSTS

RH130080

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	34,201,657 - 34,201,848 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	36,524,116 - 36,524,306	NCBI	Rnor6.0
Rnor_5.0	18	36,191,161 - 36,191,351	UniSTS	Rnor5.0
RGSC_v3.4	18	35,399,300 - 35,399,490	UniSTS	RGSC3.4
Celera	18	33,798,644 - 33,798,834	UniSTS
Cytogenetic Map	18	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254672	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025284 ⟹ ENSRNOP00000025284

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	34,452,561 - 34,506,938 (-)	Ensembl
mRatBN7.2 Ensembl	18	34,201,549 - 34,255,931 (-)	Ensembl
Rnor_6.0 Ensembl	18	36,524,007 - 36,579,403 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113094 ⟹ ENSRNOP00000081927

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	34,452,561 - 34,506,938 (-)	Ensembl
mRatBN7.2 Ensembl	18	34,201,549 - 34,252,272 (-)	Ensembl

RefSeq Acc Id:

NM_001009637 ⟹ NP_001009637

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	34,452,567 - 34,506,898 (-)	NCBI
mRatBN7.2	18	34,201,555 - 34,255,891 (-)	NCBI
Rnor_6.0	18	36,524,013 - 36,579,363 (-)	NCBI
Rnor_5.0	18	36,191,058 - 36,244,388 (-)	NCBI
RGSC_v3.4	18	35,399,197 - 35,455,759 (-)	RGD
Celera	18	33,798,541 - 33,852,822 (-)	RGD

Sequence:

show sequence

CTTTGGTGTCCTGAGAGACTAGGCTTCTACGAGTAGGAGGGAAAAGTTGGACCCACATCTCTGA
GGGATTCATTGGGGCCATCGTACTGGATCTTGAGTCGTTTGGGCGGCGCCATGGCGGAAAGAAA
AGGAACAGCCAAAGTAGACTTCTTGAAGAAGATTGAGAAAGAAGTCCAGCAGAAATGGGAAGCG
GAGAAAGTGTTTGAAGTCAGCGCGTCTTCACTGGAGAAGCAGAAGCAGAGCAGCAAGGGCAAAT
ACTTTGTCACCTTTCCATATCCATACATGAATGGACGCCTTCATTTGGGACACACGTTTTCCTT
ATCCAAGTGTGAGTTTGCAGTAGGATACCAGAGATTAAAAGGAAAAAGCTGTCTGTTCCCCTTC
GGGTTACACTGTACCGGTATGCCTATTAAGGCATGTGCTGACAAGCTGAAAAGGGAGATAGAGC
TGTATGGCTGCCCTCCTGATTTTCCAGAGGAGGAGGAGGAAGAGGAAGAAAGCAGTGCTAAACC
TGGAGATATAGTAATGAAGGATAAAGCCAAAGGGAAAAAGAGTAAAGCCGCTGCTAAAGCAGGA
TCTTCTAAGTACCAGTGGAACATTATGAAATCCCTTGGGCTCTCTGATGAAGACATCGCGAAGT
TTTCTGAAGCAGAACATTGGCTTGATTATTTCCCACCACTGGCTGTTCAGGATCTGAAGAAAAT
AGGTTTGAAGGTAGACTGGCGGCGTTCCTTCATCACCACGGATGTGAATCCTTACTATGATTCT
TTTGTCAGGTGGCAATTTTTAACTTTAAGAGAAAGAAATAAAATTAAATTCGGGAAGCGGTACA
CTATTTATTCCCCAAAAGATGGACAGCCTTGCATGGATCATGACAGACAAACCGGAGAGGGTGT
TGGACCTCAGGAATATACCCTAGTCAAACTGAAGGTGCTTGATCCATACCCATCAAAATTAAGT
GGCCTGAAAGGGAAAAATATCTTCCTAGTAGCTGCCACACTCAGACCTGAGACTATGTTTGGAC
AGACAAATTGTTGGGTTCGGCCTGATATGAAATACATTGGGTTTGAGACAGCAAATGGAGACAT
ATTCATCTGTACCCAGAGAGCAGCCAGGAATATGTCATACCAAGGCTTCACCAAGCACAATGGC
GTGGTGCCGGTTGTGAAGGAGTTAATGGGAGAGGAAATCCTTGGGGCTTCACTTTCTGCACCCC
TGACATGCTATAAGGTGATCTATGTTCTCCCTATGCTGACCATTAAGGAGGATAAAGGCACTGG
GGTGGTCACAAGCGTTCCTTCTGATTCCCCGGATGATTTTGCGGCACTCAGAGACTTGAAGAAA
AAGCAAGCCTTACGAGCAAAGTATGCAGTCAGAGATGACATGGTCCTGCCCTTTGAACCGGTGC
CAGTCCTTGAAATCCCAGGGATTGGAAATCTTCCTGCTGTGACCGTTTGTGACGAACTGAAAAT
TCAGAGCCAGAATGACCGTGAAAAACTTGCAGAGGCAAAGGAGAAATTGTATCTAAGAGGATTT
TATGATGGTGTAATGCTAGTGGATGGATTTAAAGGGCAGAAGATCCAACATGTAAAGAAGACTA
TTCAGAAAAACATGATTGATGCTGGAGATGCGCTTATCTACATGGAGCCAGAAAAACAAGTGGT
GTCGAGGTCTGCAGATGAGTGTGTTGTGGCCCTGTGTGACCAATGGTACTTGGATTATGGAGAT
GAGAACTGGAAGAAACAGACATTTCAGTGCCTGAAGAACATGGAAACATTCTGCGAGGAGAGCA
GGAAGAATTTTGAAGCTTCCTTAGACTGGCTGCAAGAACATGCCTGCTCAAGAACTTACGGTTT
AGGCACGCGTCTGCCTTGGGATGAGCAGTGGTTGATTGAATCCCTCTCAGACTCCACTATTTAC
ATGGCGTTTTACACAGTTGCACACCTGTTGCAGGGGGGTGACCTGCAGGGTCAGGCGGAGTCTC
CACTGGGCATCAGACCCCAGCAGATGACGAGGGATGTTTGGGATTATGTGTTCTTCAAGGATGC
TCCATTTCCCAAGACTCAGATCCCAAAGGAAAAGCTGGATCAGCTGAAGCAGGAATTTGAGTTT
TGGTATCCAGTGGACCTTCGAGCCTCTGGCAAGGATCTGATTCCAAATCATCTTTCATATTACA
TTTACAATCATGTGGCCATGTGGCCAGAACAAAGCGACAAGTGGCCTGTATCCGTTCGAGCAAA
TGGACACCTGCTGCTCAACTCCGAGAAGATGTCAAAATCTACGGGAAACTTCCTCACTTTGAGC
CAAGCTGTTGACAAGTTTTCCGCTGATGGAATGCGCCTGGCTCTGGCTGATGCTGGCGACACTG
TTGAAGATGCTAACTTTGTGGAAGCTATGGCAGACGCAGGCATTCTCCGTCTGTACACATGGGT
AGAGTGGGTCAAAGAAATGCTTGCCAACTGCAGCAGCCTGAGAAGTGGACCTGCCAACTCATTC
AATGATCGTGTGTTTGCCAGTGAAATGAATGCAGGAATTATAAAAACAGATCAAAACTATGAAA
AGATGATGTTTAAAGAAGCGTTGAAAACAGGTTTTTTTGAGTTTCAGGCTGCGAAAGACAAGTA
CCGTGAACTGGCCACAGAGGGGATGCACAGAGAGCTTGTGTTCCGGTTTATTGAAGTTCAAACA
ATCCTTCTGACTCCATTCTGTCCACATTTGTGTGAGCACATCTGGACACTGCTGGGAAAGCCTG
ATTCAATTATGCATGCCTCATGGCCTGTGGCAGGTCCCGTGGATGAATCCCTGATTCGTTCCTC
ACAGTACCTCATGGAAGTAGCACACGACCTTAGATTACGGCTCAAGAATTACATGACGCCAGCT
AAAGGGAAGAAGACGGACAAGCAACCAGTTCAGAGGCCCTCACACTGCACCATCTATGTGGCAA
AGAACTACCCTGTCTGGCAGCACATTACCCTGACAACCCTACGGAGCCACTTTGAGGCTAACAA
TGGAAAATTGCCTGATAACAAAGTCATCGCTTGTGAACTAGGCAGTTTGCCAGAACTGAAGAAA
TATATGAAGAAAGTTATGCCATTTGTTGCCATGATTAAGGAAAACATGGAGAAGAAAGGGCCGC
GAGTCTTGGATTTAGAGTTGGAATTTGATGAGCAGGCAGTCCTTATGGAGAATATAGTCTACCT
AACCAATTCTCTTGAGCTGGAACATATAGACGTCAAGTTTGCCTCTGAAGCTGAAGATAAAGTC
AGGGAAGAGTGCTGTCCTGGGAAGCCACTTAATGTTTTCAGAACAGAACCTGGTGTGCCAGTTT
CCCTAGTAAATCCTCAGCCATCCAGCGGGCACTTCTCTACCAAAATCGACATCAGACAAGGAGA
TAGCTGTGAGTCCATAATCAGACGCCTGACGAAAATGGACCGAGGAATCAAAGATCTCTCCAAA
GTGAAACTCATGCGCTTTGATGATCCTCTGTTGGGGCCTCGACGAGTTCCAGTCCTGGGGAGAG
AGCAGAACGAGAAGACACTCATTTCTGAGAATGCCATTTTCCACGTGGACCTAGTGAGCAAGAA
AGTTCACCTTACTGAGAACGGGCTGCGCGCAGACATCGGTGACACAATAGTCTATCTGGTTCAC
TGAGACCATGCAAACGGAAAAGTCAGGATGGTTATAGGATGCTTCTGCTCTGAGACTCTCAAGC
TAGATCTAAACAAACTTCATTTCTAACTGCTGGGTTCTGTATGTAATCATAATTACCCCAATTC
TTTCATTTCTAATCTAATAAACTAGCAGTTTTCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006254672 ⟹ XP_006254734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	34,453,502 - 34,507,030 (-)	NCBI
mRatBN7.2	18	34,202,490 - 34,256,003 (-)	NCBI
Rnor_6.0	18	36,524,963 - 36,579,471 (-)	NCBI
Rnor_5.0	18	36,191,058 - 36,244,388 (-)	NCBI

Sequence:

show sequence

GGCCTCTAGTACTCATAGTCTGGGAACTACAACTCCCTGCTGCCGGCAAGATGCACTCGGGTGT
AGTCAGTGAGCTTTGCGATTGCCTCAGCAAGTGTGTAGTGTGTGCTTTGGTGTCCTGAGAGACT
AGGCTTCTACGAGTAGGAGGGAAAAGTTGGACCCACATCTCTGAGGGATTCATTGGGGCCATCG
TACTGGATCTTGAGTCGTTTGGGCGGCGCCATGGCGGAAAGAAAAGGAACAGCCAAAGTAGACT
TCTTGAAGAAGATTGAGAAAGAAGTCCAGCAGAAATGGGAAGCGGAGAAAGTGTTTGAAGTCAG
CGCGTCTTCACTGGAGAAGCAGAAGCAGAGCAGCAAGGGCAAATACTTTGTCACCTTTCCATAT
CCATACATGAATGGACGCCTTCATTTGGGACACACGTTTTCCTTATCCAAGTGTGAGTTTGCAG
TAGGATACCAGAGATTAAAAGGAAAAAGCTGTCTGTTTCCCTTCGGGTTACACTGTACCGGTAT
GCCTATTAAGGCATGTGCTGACAAGCTGAAAAGGGAGATAGAGCTGTATGGCTGCCCTCCTGAT
TTTCCAGAGGAGGAGGAGGAAGAGGAAGAAAGCAGTGCTAAACCTGGAGATATAGTAATGAAGG
ATAAAGCCAAAGGGAAAAAGAGTAAAGCCGCTGCTAAAGCAGGATCTTCTAAGTACCAGTGGAA
CATTATGAAATCCCTTGGGCTCTCTGATGAAGACATCGCGAAGTTTTCTGAAGCAGAACATTGG
CTTGATTATTTCCCACCACTGGCTGTTCAGGATCTGAAGAAAATAGGTTTGAAGGTAGACTGGC
GGCGTTCCTTCATCACCACGGATGTGAATCCTTACTATGATTCTTTTGTCAGGTGGCAATTTTT
AACTTTAAGAGAAAGAAATAAAATTAAATTCGGGAAGCGGTACACTATTTATTCCCCAAAAGAT
GGACAGCCTTGCATGGATCATGACAGACAAACCGGAGAGGGTGTTGGACCTCAGGAATATACCC
TAGTCAAACTGAAGGTGCTTGATCCATACCCATCAAAATTAAGTGGCCTGAAAGGGAAAAATAT
CTTCCTAGTAGCTGCCACACTCAGACCTGAGACTATGTTTGGACAGACAAATTGTTGGGTTCGG
CCTGATATGAAATACATTGGGTTTGAGACAGCAAATGGAGACATATTCATCTGTACCCAGAGAG
CAGCCAGGAATATGTCATACCAAGGCTTCACCAAGCACAATGGCGTGGTGCCGGTTGTGAAGGA
GTTAATGGGAGAGGAAATCCTTGGGGCTTCACTTTCTGCACCCCTGACATGCTATAAGGTGATC
TATGTTCTCCCTATGCTGACCATTAAGGAGGATAAAGGCACTGGGGTGGTCACAAGCGTTCCTT
CTGATTCCCCGGATGATTTTGCGGCACTCAGAGACTTGAAGAAAAAGCAAGCCTTACGAGCAAA
GTATGCAGTCAGAGATGACATGGTCCTGCCCTTTGAACCGGTGCCAGTCCTTGAAATCCCAGGG
ATTGGAAATCTTCCTGCTGTGACCGTTTGTGACGAACTGAAAATTCAGAGCCAGAATGACCGTG
AAAAACTTGCAGAGGCAAAGGAGAAATTGTATCTAAGAGGATTTTATGATGGTGTAATGCTAGT
GGATGGATTTAAAGGGCAGAAGATCCAACATGTAAAGAAGACTATTCAGAAAAACATGATTGAT
GCTGGAGATGCGCTTATCTACATGGAGCCAGAAAAACAAGTGGTGTCGAGGTCTGCAGATGAGT
GTGTTGTGGCCCTGTGTGACCAATGGTACTTGGATTATGGAGATGAGAACTGGAAGAAACAGAC
ATTTCAGTGCCTGAAGAACATGGAAACATTCTGCGAGGAGAGCAGGAAGAATTTTGAAGCTTCC
TTAGACTGGCTGCAAGAACATGCCTGCTCAAGAACTTACGGTTTAGGCACGCGTCTGCCTTGGG
ATGAGCAGTGGTTGATTGAATCCCTCTCAGACTCCACTATTTACATGGCGTTTTACACAGTTGC
ACACCTGTTGCAGGGGGGTGACCTGCAGGGTCAGGCGGAGTCTCCACTGGGCATCAGACCCCAG
CAGATGACGAGGGATGTTTGGGATTATGTGTTCTTCAAGGATGCTCCATTTCCCAAGACTCAGA
TCCCAAAGGAAAAGCTGGATCAGCTGAAGCAGGAATTTGAGTTTTGGTATCCAGTGGACCTTCG
AGCCTCTGGCAAGGATCTGATTCCAAATCATCTTTCATATTACATTTACAATCATGTGGCCATG
TGGCCAGAACAAAGCGACAAGTGGCCTGTATCCGTTCGAGCAAATGGACACCTGCTGCTCAACT
CCGAGAAGATGTCAAAATCTACGGGAAACTTCCTCACTTTGAGCCAAGCTGTTGACAAGTTTTC
CGCTGATGGAATGCGCCTGGCTCTGGCTGATGCTGGCGACACTGTTGAAGATGCTAACTTTGTG
GAAGCTATGGCAGACGCAGGCATTCTCCGTCTGTACACATGGGTAGAGTGGGTCAAAGAAATGC
TTGCCAACTGCAGCAGCCTGAGAAGTGGACCTGCCAACTCATTCAATGATCGTGTGTTTGCCAG
TGAAATGAATGCAGGAATTATAAAAACAGATCAAAACTATGAAAAGATGATGTTTAAAGAAGCG
TTGAAAACAGGTTTTTTTGAGTTTCAGGCTGCGAAAGACAAGTACCGTGAACTGGCCACAGAGG
GGATGCACAGAGAGCTTGTGTTCCGGTTTATTGAAGTTCAAACAATCCTTCTGACTCCATTCTG
TCCACATTTGTGTGAGCACATCTGGACACTGCTGGGAAAGCCTGATTCAATTATGCATGCCTCA
TGGCCTGTGGCAGGTCCCGTGGATGAATCCCTGATTCGTTCCTCACAGTACCTCATGGAAGTAG
CACACGACCTTAGATTACGGCTCAAGAATTACATGACGCCAGCTAAAGGGAAGAAGACGGACAA
GCAACCAGTTCAGAGGCCCTCACACTGCACCATCTATGTGGCAAAGAACTACCCTGTCTGGCAG
CACATTACCCTGACAACCCTACGGAGCCACTTTGAGGCTAACAATGGAAAATTGCCTGATAACA
AAGTCATCGCTTGTGAACTAGGCAGTTTGCCAGAACTGAAGAAATATATGAAGAAAGTTATGCC
ATTTGTTGCCATGATTAAGGAAAACATGGAGAAGAAAGGGCCGCGAGTCTTGGATTTAGAGTTG
GAATTTGATGAGCAGGCAGTCCTTATGGAGAATATAGTCTACCTAACCAATTCTCTTGAGCTGG
AACATATAGACGTCAAGTTTGCCTCTGAAGCTGAAGATAAAGTCAGGGAAGAGTGCTGTCCTGG
GAAGCCACTTAATGTTTTCAGAACAGAACCTGGTGTGCCAGTTTCCCTAGTAAATCCTCAGCCA
TCCAGCGGGCACTTCTCTACCAAAATCGACATCAGACAAGGAGATAGCTGTGAGTCCATAATCA
GACGCCTGACGAAAATGGACCGAGGAATCAAAGAGAGAACAAAATGCCTGGAAGACTTCAACTC
TGGATATGGCTGCCAGCTGCATTAATGTCTTCTTTTATCTCTAATCCCTTACAAAGCCAAGCTT
TGTCCTCTTGAGACACCAGGAGGGAATGCAGCTCACAGACCACCCAGTGATCTGCTTTAGAAAA
GCTTAGAAGTAATGTAGGAAATGTGTTTGGGGAGGGATAGGTGAAGCACAACTGGCCACACTGC
TTAGAATGACACAGACCTAGAACGAGCTTTTGTGGTTTGCATAAGTGTTTTCCCATCAGATGAA
AACGGAATTCTTTGATGTTGAAGTCTCAAAATGGCTTAAATAAAAAGTTTTTGACCTGA

hide sequence

RefSeq Acc Id:

XM_039096707 ⟹ XP_038952635

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	34,453,908 - 34,507,030 (-)	NCBI
mRatBN7.2	18	34,202,922 - 34,256,003 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001009637	(Get FASTA)	NCBI Sequence Viewer
	XP_006254734	(Get FASTA)	NCBI Sequence Viewer
	XP_038952635	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87655	(Get FASTA)	NCBI Sequence Viewer
	EDL76478	(Get FASTA)	NCBI Sequence Viewer
	EDL76479	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025284
	ENSRNOP00000025284.6
	ENSRNOP00000081927.2

RefSeq Acc Id:

NP_001009637 ⟸ NM_001009637

- UniProtKB:

Q5PPJ6 (UniProtKB/TrEMBL), F1LQC0 (UniProtKB/TrEMBL), A0A8I5ZW22 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAERKGTAKVDFLKKIEKEVQQKWEAEKVFEVSASSLEKQKQSSKGKYFVTFPYPYMNGRLHLG
HTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPEEEEEEEE
SSAKPGDIVMKDKAKGKKSKAAAKAGSSKYQWNIMKSLGLSDEDIAKFSEAEHWLDYFPPLAVQ
DLKKIGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQ
TGEGVGPQEYTLVKLKVLDPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFET
ANGDIFICTQRAARNMSYQGFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVIYVLPMLTIKE
DKGTGVVTSVPSDSPDDFAALRDLKKKQALRAKYAVRDDMVLPFEPVPVLEIPGIGNLPAVTVC
DELKIQSQNDREKLAEAKEKLYLRGFYDGVMLVDGFKGQKIQHVKKTIQKNMIDAGDALIYMEP
EKQVVSRSADECVVALCDQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEASLDWLQEHACS
RTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLQGQAESPLGIRPQQMTRDVWDYV
FFKDAPFPKTQIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEQSDKWPV
SVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILR
LYTWVEWVKEMLANCSSLRSGPANSFNDRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQA
AKDKYRELATEGMHRELVFRFIEVQTILLTPFCPHLCEHIWTLLGKPDSIMHASWPVAGPVDES
LIRSSQYLMEVAHDLRLRLKNYMTPAKGKKTDKQPVQRPSHCTIYVAKNYPVWQHITLTTLRSH
FEANNGKLPDNKVIACELGSLPELKKYMKKVMPFVAMIKENMEKKGPRVLDLELEFDEQAVLME
NIVYLTNSLELEHIDVKFASEAEDKVREECCPGKPLNVFRTEPGVPVSLVNPQPSSGHFSTKID
IRQGDSCESIIRRLTKMDRGIKDLSKVKLMRFDDPLLGPRRVPVLGREQNEKTLISENAIFHVD
LVSKKVHLTENGLRADIGDTIVYLVH

hide sequence

RefSeq Acc Id:	XP_006254734 ⟸ XM_006254672
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZW22 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAERKGTAKVDFLKKIEKEVQQKWEAEKVFEVSASSLEKQKQSSKGKYFVTFPYPYMNGRLHLG HTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPEEEEEEEE SSAKPGDIVMKDKAKGKKSKAAAKAGSSKYQWNIMKSLGLSDEDIAKFSEAEHWLDYFPPLAVQ DLKKIGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQ TGEGVGPQEYTLVKLKVLDPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFET ANGDIFICTQRAARNMSYQGFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVIYVLPMLTIKE DKGTGVVTSVPSDSPDDFAALRDLKKKQALRAKYAVRDDMVLPFEPVPVLEIPGIGNLPAVTVC DELKIQSQNDREKLAEAKEKLYLRGFYDGVMLVDGFKGQKIQHVKKTIQKNMIDAGDALIYMEP EKQVVSRSADECVVALCDQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEASLDWLQEHACS RTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLQGQAESPLGIRPQQMTRDVWDYV FFKDAPFPKTQIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEQSDKWPV SVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILR LYTWVEWVKEMLANCSSLRSGPANSFNDRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQA AKDKYRELATEGMHRELVFRFIEVQTILLTPFCPHLCEHIWTLLGKPDSIMHASWPVAGPVDES LIRSSQYLMEVAHDLRLRLKNYMTPAKGKKTDKQPVQRPSHCTIYVAKNYPVWQHITLTTLRSH FEANNGKLPDNKVIACELGSLPELKKYMKKVMPFVAMIKENMEKKGPRVLDLELEFDEQAVLME NIVYLTNSLELEHIDVKFASEAEDKVREECCPGKPLNVFRTEPGVPVSLVNPQPSSGHFSTKID IRQGDSCESIIRRLTKMDRGIKERTKCLEDFNSGYGCQLH hide sequence

Ensembl Acc Id:

ENSRNOP00000025284 ⟸ ENSRNOT00000025284

RefSeq Acc Id:	XP_038952635 ⟸ XM_039096707
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZW22 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000081927 ⟸ ENSRNOT00000113094

Protein Domains

Aminoacyl-tRNA synthetase class Ia Leucine--tRNA ligase RagD-binding Leucine--tRNA ligase ubiquitin-like Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5PPJ6-F1-model_v2	AlphaFold	Q5PPJ6	1-1178	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700749

Promoter ID:

EPDNEW_R11273

Type:

initiation region

Name:

Lars_1

Description:

leucyl-tRNA synthetase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	36,579,379 - 36,579,439	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304962	AgrOrtholog
BioCyc Gene	G2FUF-7702	BioCyc
BioCyc Pathway	TRNA-CHARGING-PWY [tRNA charging]	BioCyc
BioCyc Pathway Image	TRNA-CHARGING-PWY	BioCyc
Ensembl Genes	ENSRNOG00000018304	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025284	ENTREZGENE
	ENSRNOT00000025284.9	UniProtKB/TrEMBL
	ENSRNOT00000113094.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.620	UniProtKB/TrEMBL
	3.90.740.10	UniProtKB/TrEMBL
	Isoleucyl-tRNA Synthetase, Domain 1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7312531	IMAGE-MGC_LOAD
InterPro	aa-tRNA-synth_I_CS	UniProtKB/TrEMBL
	Aminoacyl-tRNA-synth_Ia	UniProtKB/TrEMBL
	LARS1_ULD	UniProtKB/TrEMBL
	Leu-tRNA-synth_Ia_arc/euk	UniProtKB/TrEMBL
	RBD_LARS1	UniProtKB/TrEMBL
	Rossmann-like_a/b/a_fold	UniProtKB/TrEMBL
	tRNAsynth_1a_anticodon-bd	UniProtKB/TrEMBL
	V/L/I-tRNA-synth_anticodon-bd	UniProtKB/TrEMBL
	Val/Leu/Ile-tRNA-synth_edit	UniProtKB/TrEMBL
KEGG Report	rno:291624	UniProtKB/TrEMBL
MGC_CLONE	MGC:105585	IMAGE-MGC_LOAD
NCBI Gene	291624	ENTREZGENE
PANTHER	LEUCINE--TRNA LIGASE, CYTOPLASMIC	UniProtKB/TrEMBL
	PTHR45794	UniProtKB/TrEMBL
Pfam	Anticodon_1	UniProtKB/TrEMBL
	RBD_LARS1	UniProtKB/TrEMBL
	tRNA-synt_1	UniProtKB/TrEMBL
	ULD_3	UniProtKB/TrEMBL
PhenoGen	Lars1	PhenoGen
PROSITE	AA_TRNA_LIGASE_I	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018304	RatGTEx
Superfamily-SCOP	Nucleotidylyl transferase	UniProtKB/TrEMBL
	tRNAsyn_1a_bind	UniProtKB/TrEMBL
	ValRS_IleRS_edit	UniProtKB/TrEMBL
UniProt	A0A8I5ZW22	ENTREZGENE, UniProtKB/TrEMBL
	F1LQC0	ENTREZGENE
	Q5PPJ6	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1LQC0	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-08	Lars1	leucyl-tRNA synthetase 1	Lars	leucyl-tRNA synthetase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Lars	leucyl-tRNA synthetase	Lars_predicted	leucyl-tRNA synthetase (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Lars_predicted	leucyl-tRNA synthetase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

External Pathway Database Links

BioCyc Pathways

External Pathway Database Links

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

External Pathway Database Links

BioCyc Pathways

External Pathway Database Links