Il21r (interleukin 21 receptor) - Rat Genome Database

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Gene: Il21r (interleukin 21 receptor) Rattus norvegicus
Analyze
Symbol: Il21r
Name: interleukin 21 receptor
RGD ID: 1304950
Description: Predicted to enable cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including B-cell lymphoma (multiple); human immunodeficiency virus infectious disease; immunodeficiency 56; systemic lupus erythematosus; and vasculitis (multiple). Orthologous to human IL21R (interleukin 21 receptor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interleukin-21 receptor; LOC308977; MGC108921
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eae31 Pia41
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81189,598,682 - 189,626,340 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1189,598,558 - 189,626,342 (+)EnsemblGRCr8
mRatBN7.21180,168,028 - 180,195,690 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,168,097 - 180,195,522 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1188,504,931 - 188,532,715 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01195,690,963 - 195,718,760 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01188,374,105 - 188,401,804 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01196,996,405 - 197,024,185 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1196,996,581 - 197,024,166 (+)Ensemblrn6Rnor6.0
Rnor_5.01203,980,627 - 204,008,648 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41184,665,737 - 184,693,583 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1177,837,561 - 177,865,054 (+)NCBICelera
RGSC_v3.11184,815,617 - 184,843,462 (+)NCBI
Cytogenetic Map1q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Bubier JA, etal., Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1518-23. Epub 2009 Jan 21.
2. IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Frohlich A, etal., Science. 2009 Jun 19;324(5934):1576-80. Epub 2009 May 28.
3. Regulatory dendritic cells protect against allergic airway inflammation in a murine asthmatic model. Fujita S, etal., J Allergy Clin Immunol. 2008 Jan;121(1):95-104.e7. Epub 2007 Oct 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Critical role of IL-21 in modulating TH17 and regulatory T cells in Behcet disease. Geri G, etal., J Allergy Clin Immunol. 2011 Sep;128(3):655-64. Epub 2011 Jul 2.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Hanash AM, etal., Blood. 2011 Jul 14;118(2):446-55. Epub 2011 May 19.
8. A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice. Jang E, etal., J Immunol. 2009 Apr 15;182(8):4649-56.
9. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. Jin H, etal., J Clin Invest. 2009 Jan;119(1):47-60. doi: 10.1172/JCI32310. Epub 2008 Dec 15.
10. Upregulated IL-21 and IL-21 receptor expression is involved in experimental autoimmune uveitis (EAU). Liu L, etal., Mol Vis. 2009 Dec 31;15:2938-44.
11. IL-21 receptor expression determines the temporal phases of experimental autoimmune encephalomyelitis. Liu R, etal., Exp Neurol. 2008 May;211(1):14-24. Epub 2007 Nov 22.
12. Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease. Liu Z, etal., Inflamm Bowel Dis. 2009 Aug;15(8):1133-44.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. Nimmo ER, etal., Inflamm Bowel Dis. 2012 May;18(5):889-99. doi: 10.1002/ibd.21912. Epub 2011 Oct 21.
15. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Nohra R, etal., Genes Immun. 2010 Jun;11(4):279-93. Epub 2010 Jan 14.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Immune activation and increased IL-21R expression are associated with the loss of memory B cells during HIV-1 infection. Ruffin N, etal., J Intern Med. 2012 Apr 24. doi: 10.1111/j.1365-2796.2012.02550.x.
23. Screening of functional and positional candidate genes in families with common variable immunodeficiency. Salzer U, etal., BMC Immunol. 2008 Feb 7;9:3.
24. IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. Sonderegger I, etal., Eur J Immunol. 2008 Jul;38(7):1833-8.
25. IL-21 promotes the pathologic immune response to pneumovirus infection. Spolski R, etal., J Immunol. 2012 Feb 15;188(4):1924-32. Epub 2012 Jan 11.
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. Interleukin-21 is required for the development of type 1 diabetes in NOD mice. Sutherland AP, etal., Diabetes. 2009 May;58(5):1144-55. Epub 2009 Feb 10.
28. Interleukin-21 modulates Th1 and Th17 responses in giant cell arteritis. Terrier B, etal., Arthritis Rheum. 2012 Jun;64(6):2001-11. doi: 10.1002/art.34327. Epub 2011 Dec 6.
29. IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. Tzartos JS, etal., Am J Pathol. 2011 Feb;178(2):794-802.
30. The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. Ueda C, etal., Oncogene. 2002 Jan 17;21(3):368-76.
31. In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus. Vugmeyster Y, etal., MAbs. 2010 May-Jun;2(3):335-46. Epub 2010 May 23.
32. Key role for IL-21 in experimental autoimmune uveitis. Wang L, etal., Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9542-7. Epub 2011 May 18.
33. A polymorphism within IL21R confers risk for systemic lupus erythematosus. Webb R, etal., Arthritis Rheum. 2009 Aug;60(8):2402-7.
Additional References at PubMed
PMID:11016959   PMID:11081504   PMID:19159826  


Genomics

Comparative Map Data
Il21r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81189,598,682 - 189,626,340 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1189,598,558 - 189,626,342 (+)EnsemblGRCr8
mRatBN7.21180,168,028 - 180,195,690 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,168,097 - 180,195,522 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1188,504,931 - 188,532,715 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01195,690,963 - 195,718,760 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01188,374,105 - 188,401,804 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01196,996,405 - 197,024,185 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1196,996,581 - 197,024,166 (+)Ensemblrn6Rnor6.0
Rnor_5.01203,980,627 - 204,008,648 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41184,665,737 - 184,693,583 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1177,837,561 - 177,865,054 (+)NCBICelera
RGSC_v3.11184,815,617 - 184,843,462 (+)NCBI
Cytogenetic Map1q36NCBI
IL21R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381627,402,174 - 27,452,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1627,402,174 - 27,452,050 (+)Ensemblhg38GRCh38
GRCh371627,413,495 - 27,463,363 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361627,321,224 - 27,369,616 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341627,321,923 - 27,369,616NCBI
Celera1626,190,799 - 26,240,689 (+)NCBICelera
Cytogenetic Map16p12.1NCBI
HuRef1625,501,903 - 25,551,799 (+)NCBIHuRef
CHM1_11628,425,032 - 28,475,081 (+)NCBICHM1_1
T2T-CHM13v2.01627,680,921 - 27,730,794 (+)NCBIT2T-CHM13v2.0
Il21r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397125,202,424 - 125,232,742 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7125,202,601 - 125,232,742 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387125,603,252 - 125,634,397 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7125,603,429 - 125,633,570 (+)Ensemblmm10GRCm38
MGSCv377132,746,943 - 132,777,084 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367125,394,625 - 125,424,718 (+)NCBIMGSCv36mm8
Celera7125,462,065 - 125,492,498 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map768.98NCBI
Il21r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554935,613,564 - 5,650,583 (+)Ensembl
ChiLan1.0NW_0049554935,613,704 - 5,646,692 (+)NCBIChiLan1.0ChiLan1.0
IL21R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21828,799,773 - 28,846,635 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11633,339,801 - 33,387,335 (+)NCBINHGRI_mPanPan1
PanPan1.11627,774,864 - 27,821,769 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1627,774,864 - 27,821,769 (+)EnsemblpanPan2panpan1.1
IL21R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1619,181,846 - 19,217,915 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl619,182,071 - 19,217,931 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha620,760,615 - 20,796,374 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0619,321,734 - 19,357,467 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl619,321,718 - 19,357,757 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1619,119,564 - 19,155,747 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0619,033,216 - 19,068,970 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0619,379,434 - 19,415,204 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il21r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344122,984,094 - 123,014,575 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,100,170 - 11,110,744 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,100,170 - 11,112,112 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL21R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl319,443,359 - 19,489,152 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1319,447,488 - 19,489,201 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2319,681,475 - 19,697,842 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL21R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1525,105,947 - 25,153,914 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl525,106,519 - 25,153,703 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660684,543,066 - 4,590,469 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il21r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478212,057,651 - 12,068,650 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478212,037,338 - 12,070,479 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Il21r
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1276,297,579 - 76,308,125 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il21r
136 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:155
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000021690
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1182383862191260518Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
D1Got393  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,184,027 - 180,184,119 (+)MAPPERmRatBN7.2
Rnor_6.01197,012,509 - 197,012,600NCBIRnor6.0
Rnor_5.01203,996,972 - 203,997,063UniSTSRnor5.0
RGSC_v3.41184,681,924 - 184,682,015UniSTSRGSC3.4
Celera1177,853,388 - 177,853,485UniSTS
Cytogenetic Map1q36UniSTS
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 63 146 91 90 59 92 59 6 350 188 11 119 79 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000021690   ⟹   ENSRNOP00000021690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1189,598,558 - 189,626,342 (+)Ensembl
mRatBN7.2 Ensembl1180,168,097 - 180,195,522 (+)Ensembl
Rnor_6.0 Ensembl1196,996,581 - 197,024,166 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096587   ⟹   ENSRNOP00000079649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,176,286 - 180,195,522 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098669   ⟹   ENSRNOP00000092888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1189,598,558 - 189,626,342 (+)Ensembl
mRatBN7.2 Ensembl1180,168,097 - 180,195,522 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113765   ⟹   ENSRNOP00000097444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1189,598,747 - 189,626,338 (+)Ensembl
mRatBN7.2 Ensembl1180,187,703 - 180,195,522 (+)Ensembl
RefSeq Acc Id: NM_001012469   ⟹   NP_001012487
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81189,598,753 - 189,626,340 (+)NCBI
mRatBN7.21180,168,097 - 180,195,689 (+)NCBI
Rnor_6.01196,996,581 - 197,024,168 (+)NCBI
Rnor_5.01203,980,627 - 204,008,648 (+)NCBI
RGSC_v3.41184,665,737 - 184,693,583 (+)RGD
Celera1177,837,561 - 177,865,054 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230261   ⟹   XP_006230323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81189,598,682 - 189,626,340 (+)NCBI
mRatBN7.21180,168,028 - 180,195,690 (+)NCBI
Rnor_6.01196,996,406 - 197,024,168 (+)NCBI
Rnor_5.01203,980,627 - 204,008,648 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001012487   ⟸   NM_001012469
- Peptide Label: precursor
- UniProtKB: Q5EBB1 (UniProtKB/TrEMBL),   A6I919 (UniProtKB/TrEMBL),   A0A8I6ASZ0 (UniProtKB/TrEMBL),   F7FPE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230323   ⟸   XM_006230261
- Peptide Label: isoform X1
- UniProtKB: Q5EBB1 (UniProtKB/TrEMBL),   A6I919 (UniProtKB/TrEMBL),   A0A8I6ASZ0 (UniProtKB/TrEMBL),   F7FPE1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021690   ⟸   ENSRNOT00000021690
Ensembl Acc Id: ENSRNOP00000092888   ⟸   ENSRNOT00000098669
Ensembl Acc Id: ENSRNOP00000079649   ⟸   ENSRNOT00000096587
Ensembl Acc Id: ENSRNOP00000097444   ⟸   ENSRNOT00000113765
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5EBB1-F1-model_v2 AlphaFold Q5EBB1 1-521 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690392
Promoter ID:EPDNEW_R915
Type:initiation region
Name:Il21r_1
Description:interleukin 21 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01196,996,522 - 196,996,582EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304950 AgrOrtholog
BioCyc Gene G2FUF-57480 BioCyc
Ensembl Genes ENSRNOG00000015773 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021690 ENTREZGENE
  ENSRNOT00000021690.6 UniProtKB/TrEMBL
  ENSRNOT00000098669.2 UniProtKB/TrEMBL
  ENSRNOT00000113765 ENTREZGENE
  ENSRNOT00000113765.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381492 IMAGE-MGC_LOAD
InterPro FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
KEGG Report rno:308977 UniProtKB/TrEMBL
MGC_CLONE MGC:108921 IMAGE-MGC_LOAD
NCBI Gene 308977 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  INTERLEUKIN-21 RECEPTOR UniProtKB/TrEMBL
PhenoGen Il21r PhenoGen
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015773 RatGTEx
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt A0A8I6AER5_RAT UniProtKB/TrEMBL
  A0A8I6ASZ0 ENTREZGENE, UniProtKB/TrEMBL
  A6I919 ENTREZGENE, UniProtKB/TrEMBL
  A6I920_RAT UniProtKB/TrEMBL
  F7FPE1 ENTREZGENE, UniProtKB/TrEMBL
  Q5EBB1 ENTREZGENE
UniProt Secondary Q5EBB1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Il21r  interleukin 21 receptor  Il21r_predicted  interleukin 21 receptor (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Il21r_predicted  interleukin 21 receptor (predicted)      Symbol and Name status set to approved 70820 APPROVED