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Gene: Rubcnl (rubicon like autophagy enhancer) Rattus norvegicus

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Symbol:

Rubcnl

Name:

rubicon like autophagy enhancer

RGD ID:

1304929

Description:

Predicted to enable phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Predicted to be involved in macroautophagy and regulation of primary metabolic process. Predicted to be active in autophagosome membrane. Orthologous to human RUBCNL (rubicon like autophagy enhancer); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; atrazine.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC290403; RGD1304929; rubicon like autophagy regulator; RUN and cysteine rich domain containing beclin 1 interacting protein like; similar to chromosome 13 open reading frame 18; uncharacterized protein KIAA0226-like homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RUBCNL (rubicon like autophagy enhancer)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Rubcnl (RUN and cysteine rich domain containing beclin 1 interacting protein like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rubcnl (rubicon like autophagy enhancer)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RUBCNL (rubicon like autophagy enhancer)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RUBCNL (rubicon like autophagy enhancer)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rubcnl (rubicon like autophagy enhancer)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RUBCNL (rubicon like autophagy enhancer)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RUBCNL (rubicon like autophagy enhancer)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rubcnl (rubicon like autophagy enhancer)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rubcnl (rubicon like autophagy enhancer)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FIP1L1 (factor interacting with PAPOLA and CPSF1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RUBCNL (rubicon like autophagy enhancer)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rubcnl (RUN and cysteine rich domain containing beclin 1 interacting protein like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12772	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG12772	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	rubcnl	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rubcnl	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rubcnl	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	56,741,897 - 56,807,086 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	56,741,869 - 56,779,649 (+)	Ensembl				GRCr8
mRatBN7.2	15	50,332,458 - 50,377,494 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	50,332,418 - 50,400,849 (+)	Ensembl				mRatBN7.2
Rnor_6.0	15	57,065,512 - 57,109,197 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	57,065,428 - 57,102,599 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	60,777,541 - 60,821,362 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	55,894,968 - 55,913,448 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	49,964,999 - 50,008,655 (+)	NCBI		Celera
RGSC_v3.1	15	55,815,486 - 55,929,226 (+)	NCBI
Cytogenetic Map	15	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

Cuprizon (EXP)

D-glucose (ISO)

Dibutyl phosphate (ISO)

dimethylarsinic acid (ISO)

dioxygen (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

fructose (ISO)

gentamycin (EXP)

glucose (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methylarsonic acid (ISO)

nickel atom (ISO)

nitrates (ISO)

ozone (ISO)

paracetamol (EXP)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome maturation (IBA,IEA,ISO)

autophagosome-endosome fusion (IBA,IEA,ISO)

autophagosome-lysosome fusion (IBA,IEA,ISO)

autophagy (IEA)

regulation of glycogen metabolic process (ISO)

regulation of lipid metabolic process (ISO)

Cellular Component

autophagosome membrane (IBA,IEA,ISO)

Molecular Function

phosphatidylinositol phosphate binding (IBA)

phosphatidylinositol-3-phosphate binding (IEA,ISO)

phosphatidylinositol-4-phosphate binding (IEA,ISO)

phosphatidylinositol-5-phosphate binding (IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:28306502	PMID:30704899

Genomics

Comparative Map Data

Rubcnl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	56,741,897 - 56,807,086 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	56,741,869 - 56,779,649 (+)	Ensembl				GRCr8
mRatBN7.2	15	50,332,458 - 50,377,494 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	50,332,418 - 50,400,849 (+)	Ensembl				mRatBN7.2
Rnor_6.0	15	57,065,512 - 57,109,197 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	57,065,428 - 57,102,599 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	60,777,541 - 60,821,362 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	55,894,968 - 55,913,448 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	49,964,999 - 50,008,655 (+)	NCBI		Celera
RGSC_v3.1	15	55,815,486 - 55,929,226 (+)	NCBI
Cytogenetic Map	15	q11	NCBI

RUBCNL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	46,334,681 - 46,390,042 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	46,334,681 - 46,438,190 (-)	Ensembl			hg38	GRCh38
GRCh37	13	46,908,816 - 46,964,177 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	45,814,137 - 45,859,636 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	13	45,815,100 - 45,859,385	NCBI
Celera	13	27,971,122 - 28,016,591 (-)	NCBI		Celera
Cytogenetic Map	13	q14.13	NCBI
HuRef	13	27,713,683 - 27,759,154 (-)	NCBI		HuRef
CHM1_1	13	46,884,932 - 46,930,398 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	45,555,685 - 45,611,047 (-)	NCBI		T2T-CHM13v2.0

Rubcnl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	75,253,467 - 75,289,977 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	75,253,467 - 75,289,972 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	75,015,987 - 75,052,537 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	75,016,027 - 75,052,532 (+)	Ensembl			mm10	GRCm38
MGSCv37	14	75,415,834 - 75,452,339 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	73,736,988 - 73,786,572 (+)	NCBI		MGSCv36	mm8
Celera	14	72,515,864 - 72,552,426 (+)	NCBI		Celera
Cytogenetic Map	14	D3	NCBI
cM Map	14	39.53	NCBI

Rubcnl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	140,922 - 206,951 (-)	Ensembl
ChiLan1.0	NW_004955431	140,999 - 206,570 (-)	NCBI	ChiLan1.0	ChiLan1.0

RUBCNL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	44,953,710 - 45,049,079 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	36,007,854 - 36,111,800 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	26,594,545 - 26,600,412 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

RUBCNL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	4,874,384 - 4,903,044 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	4,874,575 - 4,903,033 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	4,916,030 - 4,953,319 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	4,980,314 - 5,017,734 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	4,976,624 - 5,016,959 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	4,762,415 - 4,800,374 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	4,825,919 - 4,863,052 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	4,830,727 - 4,868,748 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rubcnl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	156,428,120 - 156,521,426 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936857	839,418 - 870,961 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RUBCNL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	20,995,688 - 21,036,014 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	11	20,995,439 - 21,036,429 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	21,427,767 - 21,445,259 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RUBCNL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	24,400,507 - 24,445,514 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	24,399,500 - 24,430,601 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666057	19,554,526 - 19,600,019 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rubcnl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624748	8,605,272 - 8,652,785 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rubcnl
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	12	49,339,581 - 49,358,897 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rubcnl
351 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	22
Count of miRNA genes:	21
Interacting mature miRNAs:	22
Transcripts:	ENSRNOT00000039518
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300144	Rf23	Renal function QTL 23	3.61		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	15	44806773	104695021	Rat
152025253	Hrtrt24	Heart rate QTL 24	3.82		heart pumping trait (VT:2000009)		15	31855803	92671517	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	43677244	88677244	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	28527732	73527732	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	43677244	88677244	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	25285835	104695021	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	25285835	104695021	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	19155762	87086765	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	40463152	85463152	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	14926594	71614418	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	22336351	67336351	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	43677244	88677244	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	43677244	88677244	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	25285835	104695021	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	43677244	88677244	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	157	91	90	59	92	59	6	348	192	11	131	73	92	31	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008769991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001841377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001846321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC110315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000039518 ⟹ ENSRNOP00000035595

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	56,741,869 - 56,779,649 (+)	Ensembl
mRatBN7.2 Ensembl	15	50,332,418 - 50,400,849 (+)	Ensembl
Rnor_6.0 Ensembl	15	57,065,428 - 57,102,599 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000139385 ⟹ ENSRNOP00000112320

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	56,741,869 - 56,779,649 (+)	Ensembl

RefSeq Acc Id:

XM_008770905 ⟹ XP_008769127

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	56,741,897 - 56,781,917 (+)	NCBI
mRatBN7.2	15	50,332,458 - 50,370,226 (+)	NCBI
Rnor_6.0	15	57,065,512 - 57,103,301 (+)	NCBI

Sequence:

show sequence

GTGAAAACTTTCTGTATTCGTTGGCAGCTCCTCTCGGCACCATCAGAAGTTCAGAGTTGGCACA
CCGAAGAAGTGATCCGGACCTGTCACTACCACGAGGCAAGGTGGCTATTAGGTGGATAAAACGG
CCAGGAGACGTAGATAAACTTATCAGACCTCTAGCTGGCCATGTGATGAATTCAAGGATCACAC
CCAGTGGTACAACGGCCATTGGAGAACTGAGTTTTGAGCACGTTCACTCCACACCTGGAAAGAT
GGTGTCCCAATCCACAGGCCAGCAAGACTATCCTATGGACTCCTGTGAAAGGACCAGCCATGCC
TTTCAGGACGCTGATGGCTTGCCCAGTGTCCTGGACACTGACCAACCTGCTTGCCAGTTAGATG
TGAGACTCGTAAGACACAAAGCTTCCTGGATCAACCCACTGTGTGTGCAGCAGCCACTTCGAGA
ATCAGGCCTCCAAAGACCAACGGCGCAGAACAGTGAGAACCACGTGGTCGTGGACACTCCCTCT
CCCTCGGACCTTTCGATATTGCCCCAGAGGGACTCCCTGGCTGAGATGTCATTGTCTGAGAATA
CTGCTGATGTCATCTGCAACAGCTCTGCTTATTGCTCCTGGGGAGAGAAGGGTGACTTCTTCCT
GGCTACAGAAGAGCAAGAGGCTCATCCTCAGCAGAAGTCTCTGCTCAAAAACCCCAAGGCTGTG
GCCACTTCCCCATTCTCTAAGGCCAGTGTCCATTCTGAGTCTCCTCATTTGACAGCTTCTACGG
ATGATGGTGATGCTCAGAGCAGCAGGAGCCATTCTTGGAATTTCTTCCCACTGGAGACATTCAT
TCTGCCTGCTGACATGGAAAAGGAAAACGTCCACTTTTATGCTGCAGACTTGATCATCTCAGTA
ATAGAGAATTTGAAGTGCAGTCTTCTGAGTCAACAGCAGCCAGGGAGTTCGGGCACAGAAGAGG
CCAGCAGGTCATGTGGGACTGGAGCAGAAGTGACCTTTCATACCCATGCAAAGCAGGAGCCAGA
CCCCTCCGCTTCTTCACACACTGGCTGTGAAGGTTGCGCTGCACTCCAGGTCAGCCCAGTGGCT
GAGGCACTTTCTTACTGTCCTGTGGCGATAGAGGCCTGCACACTTGACTTGAACAAATTGGTCA
TATTAGAACTTGGGAAATCCAATGACCTCACGGAAGGCTGCAGAGGCTCCTATAGCTCTTCAGA
GAGTGCAACTTGCAAGTCGAATCTCAGTCTTGCTGGGCTCTTAGCCAGAGAGTTGTTCCGAGGG
TTCTATAAGTACTGGATGCTGTCAGAAGAAGTCACTCGTCAGCCTCCAGGCTCCCTGATCCCCG
CTAGCTCAGGAGTTGGGGAAGAAGAACAAGCTGAGGAAGAGCTTGACTCCAGTGTGGATACAGC
ACGGGAAGTCATGCTTAAGTCCAGGGTCCCAGGGACTGAAGACTGGGTGCCCCCTCCATGCCAA
ATCATACTTACTGTTCACCCGCCAGTCAAGAGGGACATAGCAGTCGTGGCCCAGAATTTCTTCT
GTGCTGGATGTGGGACTCCCATACAACCCAAGTTTGTGAAGCGGCTCCGATACTGTGAGTACCT
CGGGAAGTACTTCTGTGACAGATGCCACTCATCTGCAGAGTCCTGTATCCCTGCTCGGATCCTG
CTGATGTGGGACTTCAGGAAGTACCAAGTCAGCGATTTCTCTAAATGGCTACTGGACAGCATAT
GGCATCAGCCCATCTTCAACCTGTTAAGTGGGCATCACAGCCTCTATGCAAAAGTCAAGGAACT
GGATAGGGTGAAGGACATCCAGGAGCAACTTTTTCATATCAAGAAGCTGTTGAAGACTTGCAGG
TTTGCTGACAGTGTGCTGAAGGAGTTTGAACAGGTTCCCAGTCATTTGACTGATGAATGCCACA
TGTTCTCCATGGACGACTTCCTCAGGACCAAGAAAGGACTGTTGGCACCTTTGCTCAAGGACAT
CCTGAGAGCTTCTCTTGCCCACGTGGACAGCTGTGAGCTGTGCCAGGGAAAGGGCTTCATTTGT
GAGTTTTGCCAGAGCACGACTGTCATCTTCCCATTTCAGACCATGACTTGTAGAAGATGTGCAG
GGTGCAGGGCCTGCTTCCACAAACAGTGCTTCCAGTCTTCCAGATGCCCTCGCTGTGCCAGGAT
CATAGCCCGGAGACAACATTCGGAGAGCTTAACAGGAACATGACAGCCCAAAGTTGTTCCAAAC
ACCTCATGGTGATGCCAAATTGTGTCTGCTCCTGGTAACATTGTTTCAGATGCTAAGTATTTTA
TAGTAAGAAAAGGACAACCAAAATTCCCCTCTTGTATGTATTTAATGCTTTCAAGGAGTATGGA
AGCTTTGTTACTAGGTAAAGGGTTGTTGAGAAAGGTTTGTTTACAAATGTTTGACATTGTTTTG
CTGCTGTTGGCTGGTTTTTTTTAAGAAGTCTTTTTTTCATTTACATTGCACTGGGATAGTTTTT
TTTAAGTTAAATACAGAACCTATTTTTTTATGAACTGTAACTGACAAGGTGGCTGTTTAACTCT
TCCTCCTCCAGAGTTGTTTGGAATGTGAAATGGATTGGTGCCACAAGGGAGCGAAATGCCACCA
GAATTCTGTTTGGCCAAGTTTGTGTTAAAGACTACATTGAATGTTGTTTTGCAACTGTGTCAGT
TTCCTGTTTTATTCATTCCTCTCTAGATGACAGTTTCAGCCGCCACCCACCAAGGTCCCGGTGA
ACTGTCATTTGGAGCAGCTGCCTCTAGATGGCACTGTTTGATGAGCGAACGTTCAACCACTTTG
TCATCTCTGCCTGTGCTAAAAACCTTGGGAGCCAGAGGGGACAACACCAATCTAGCCCTTCATG
ATCTAGCTTCCTGGATATAAACAAACAAACAAACAAACAAACAGACAGACAAAATCAGAACATA
GAGACTCTGAAAGCTGAGCATGGTGGTGTGCACCTGTAATCCCTGCCTTTAGGAAATAGAGGCA
GAAATTAAGACTTTCTGTATGAACATAGAAAACCACACACAACCTGTACTTTTTTTTTTTAAAT
TTTAAAATAACGGAATTTTAAAAACAAGTAAATTTGGGTAAAATAA

hide sequence

RefSeq Acc Id:

XM_039093952 ⟹ XP_038949880

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	56,742,289 - 56,781,917 (+)	NCBI
mRatBN7.2	15	50,332,858 - 50,370,226 (+)	NCBI

RefSeq Acc Id:

XM_039093953 ⟹ XP_038949881

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	56,742,289 - 56,807,086 (+)	NCBI
mRatBN7.2	15	50,332,858 - 50,377,494 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008769127	(Get FASTA)	NCBI Sequence Viewer
	XP_038949880	(Get FASTA)	NCBI Sequence Viewer
	XP_038949881	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM02285	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000035595
	ENSRNOP00000035595.6
	ENSRNOP00000112320.1

RefSeq Acc Id:	XP_008769127 ⟸ XM_008770905
- Peptide Label:	isoform X1
- UniProtKB:	D4A680 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNSRITPSGTTAIGELSFEHVHSTPGKMVSQSTGQQDYPMDSCERTSHAFQDADGLPSVLDTDQ PACQLDVRLVRHKASWINPLCVQQPLRESGLQRPTAQNSENHVVVDTPSPSDLSILPQRDSLAE MSLSENTADVICNSSAYCSWGEKGDFFLATEEQEAHPQQKSLLKNPKAVATSPFSKASVHSESP HLTASTDDGDAQSSRSHSWNFFPLETFILPADMEKENVHFYAADLIISVIENLKCSLLSQQQPG SSGTEEASRSCGTGAEVTFHTHAKQEPDPSASSHTGCEGCAALQVSPVAEALSYCPVAIEACTL DLNKLVILELGKSNDLTEGCRGSYSSSESATCKSNLSLAGLLARELFRGFYKYWMLSEEVTRQP PGSLIPASSGVGEEEQAEEELDSSVDTAREVMLKSRVPGTEDWVPPPCQIILTVHPPVKRDIAV VAQNFFCAGCGTPIQPKFVKRLRYCEYLGKYFCDRCHSSAESCIPARILLMWDFRKYQVSDFSK WLLDSIWHQPIFNLLSGHHSLYAKVKELDRVKDIQEQLFHIKKLLKTCRFADSVLKEFEQVPSH LTDECHMFSMDDFLRTKKGLLAPLLKDILRASLAHVDSCELCQGKGFICEFCQSTTVIFPFQTM TCRRCAGCRACFHKQCFQSSRCPRCARIIARRQHSESLTGT hide sequence

Ensembl Acc Id:

ENSRNOP00000035595 ⟸ ENSRNOT00000039518

RefSeq Acc Id:	XP_038949881 ⟸ XM_039093953
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038949880 ⟸ XM_039093952
- Peptide Label:	isoform X1
- UniProtKB:	D4A680 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000112320 ⟸ ENSRNOT00000139385

Protein Domains

Rubicon Homology

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A680-F1-model_v2	AlphaFold	D4A680	1-681	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304929	AgrOrtholog
BioCyc Gene	G2FUF-13139	BioCyc
Ensembl Genes	ENSRNOG00000022760	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000039518	ENTREZGENE
	ENSRNOT00000039518.8	UniProtKB/TrEMBL
	ENSRNOT00000139385.1	UniProtKB/TrEMBL
InterPro	Autophagy_HostDef_Reg	UniProtKB/TrEMBL
	DUF4206	UniProtKB/TrEMBL
	RUBC_PIKBD	UniProtKB/TrEMBL
KEGG Report	rno:290403	UniProtKB/TrEMBL
NCBI Gene	290403	ENTREZGENE
PANTHER	PHOX (PX) DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	PROTEIN ASSOCIATED WITH UVRAG AS AUTOPHAGY ENHANCER	UniProtKB/TrEMBL
Pfam	DUF4206	UniProtKB/TrEMBL
	RUBC_PIKBD	UniProtKB/TrEMBL
PhenoGen	Rubcnl	PhenoGen
RatGTEx	ENSRNOG00000022760	RatGTEx
SMART	DUF4206	UniProtKB/TrEMBL
UniProt	A0ABK0M510_RAT	UniProtKB/TrEMBL
	D4A680	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-02	Rubcnl	rubicon like autophagy enhancer	Rubcnl	rubicon like autophagy regulator	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2018-12-10	Rubcnl	rubicon like autophagy regulator	Rubcnl	RUN and cysteine rich domain containing beclin 1 interacting protein like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-08-24	Rubcnl	RUN and cysteine rich domain containing beclin 1 interacting protein like	RGD1304929	similar to chromosome 13 open reading frame 18	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1304929	similar to chromosome 13 open reading frame 18	RGD1304929_predicted	similar to chromosome 13 open reading frame 18 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1304929_predicted	similar to chromosome 13 open reading frame 18 (predicted)	LOC290403_predicted	similar to chromosome 13 open reading frame 18 (predicted)	Symbol and Name status set to approved	1331353	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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