Tp53rkb (tumor protein p53 regulating kinase B) - Rat Genome Database

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Gene: Tp53rkb (tumor protein p53 regulating kinase B) Rattus norvegicus
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Symbol: Tp53rkb
Name: tumor protein p53 regulating kinase B
RGD ID: 1304911
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in tRNA threonylcarbamoyladenosine metabolic process. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase); INTERACTS WITH 1,2-dimethylhydrazine (ortholog); 4,4'-sulfonyldiphenol (ortholog); bisphenol A (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362272; TP53 regulating kinase; TP53 regulating kinase B; TP53-regulating kinase; Tp53rk; transformation related protein 53 regulating kinase B; Trp53rk; Trp53rkb
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,948,060 - 175,951,732 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3175,948,368 - 175,951,732 (+)EnsemblGRCr8
mRatBN7.23155,529,298 - 155,532,662 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,529,298 - 155,532,728 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3159,330,153 - 159,333,722 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,829,113 - 167,832,682 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,570,818 - 165,574,387 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3174,027,185 - 174,030,753 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3180,888,049 - 180,891,617 (+)NCBILyon_Normotensive
Lyon_Hypertensive3172,854,946 - 172,858,514 (+)NCBILyon_Hypertensive
F344_StmMcwi3153,751,752 - 153,755,116 (+)NCBIF344_StmMcwi
Rnor_6.03163,552,166 - 163,555,925 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,552,166 - 163,555,596 (+)Ensemblrn6Rnor6.0
Rnor_5.03169,715,189 - 169,718,948 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43157,949,564 - 157,953,323 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3154,111,274 - 154,115,346 (+)NCBICelera
RGSC_v3.13157,856,207 - 157,858,815 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)
EKC/KEOPS complex  (IBA,IEA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11546806   PMID:27903914   PMID:28805828  


Genomics

Comparative Map Data
Tp53rkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,948,060 - 175,951,732 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3175,948,368 - 175,951,732 (+)EnsemblGRCr8
mRatBN7.23155,529,298 - 155,532,662 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,529,298 - 155,532,728 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3159,330,153 - 159,333,722 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,829,113 - 167,832,682 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,570,818 - 165,574,387 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3174,027,185 - 174,030,753 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3180,888,049 - 180,891,617 (+)NCBILyon_Normotensive
Lyon_Hypertensive3172,854,946 - 172,858,514 (+)NCBILyon_Hypertensive
F344_StmMcwi3153,751,752 - 153,755,116 (+)NCBIF344_StmMcwi
Rnor_6.03163,552,166 - 163,555,925 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,552,166 - 163,555,596 (+)Ensemblrn6Rnor6.0
Rnor_5.03169,715,189 - 169,718,948 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43157,949,564 - 157,953,323 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3154,111,274 - 154,115,346 (+)NCBICelera
RGSC_v3.13157,856,207 - 157,858,815 (+)NCBI
Cytogenetic Map3q42NCBI
Trp53rkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392166,634,379 - 166,641,412 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2166,634,451 - 166,641,425 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382166,792,459 - 166,799,492 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2166,792,531 - 166,799,505 (+)Ensemblmm10GRCm38
MGSCv372166,619,267 - 166,624,992 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362166,484,972 - 166,490,697 (+)NCBIMGSCv36mm8
Celera2172,733,223 - 172,738,948 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.22NCBI

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:94
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000049082
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
RH131345  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,532,236 - 155,532,456 (+)MAPPERmRatBN7.2
Rnor_6.03163,555,105 - 163,555,324NCBIRnor6.0
Rnor_5.03169,718,128 - 169,718,347UniSTSRnor5.0
RGSC_v3.43157,952,503 - 157,952,722UniSTSRGSC3.4
Celera3154,114,415 - 154,114,634UniSTS
RH 3.4 Map31441.6UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000049082   ⟹   ENSRNOP00000050360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3175,948,368 - 175,951,732 (+)Ensembl
mRatBN7.2 Ensembl3155,529,298 - 155,532,728 (+)Ensembl
Rnor_6.0 Ensembl3163,552,166 - 163,555,596 (+)Ensembl
RefSeq Acc Id: NM_001108606   ⟹   NP_001102076
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,948,368 - 175,951,732 (+)NCBI
mRatBN7.23155,529,298 - 155,532,662 (+)NCBI
Dahl_SR_JrHsd3174,027,185 - 174,030,753 (+)NCBI
Lyon_Normotensive3180,888,049 - 180,891,617 (+)NCBI
Lyon_Hypertensive3172,854,946 - 172,858,514 (+)NCBI
F344_StmMcwi3153,751,752 - 153,755,116 (+)NCBI
Rnor_6.03163,552,166 - 163,555,925 (+)NCBI
Rnor_5.03169,715,189 - 169,718,948 (+)NCBI
RGSC_v3.43157,949,564 - 157,953,323 (+)RGD
Celera3154,111,274 - 154,115,346 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105544   ⟹   XP_038961472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,949,120 - 175,951,732 (+)NCBI
mRatBN7.23155,530,050 - 155,532,662 (+)NCBI
RefSeq Acc Id: XM_039105545   ⟹   XP_038961473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,948,642 - 175,951,732 (+)NCBI
mRatBN7.23155,529,330 - 155,532,662 (+)NCBI
RefSeq Acc Id: XM_039105546   ⟹   XP_038961474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,948,642 - 175,951,732 (+)NCBI
mRatBN7.23155,529,323 - 155,532,662 (+)NCBI
RefSeq Acc Id: XM_063284222   ⟹   XP_063140292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,948,060 - 175,951,732 (+)NCBI
RefSeq Acc Id: XM_063284223   ⟹   XP_063140293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,948,060 - 175,950,427 (+)NCBI
RefSeq Acc Id: XM_063284224   ⟹   XP_063140294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,948,613 - 175,951,732 (+)NCBI
RefSeq Acc Id: NP_001102076   ⟸   NM_001108606
- UniProtKB: D3ZCD7 (UniProtKB/TrEMBL),   A6JXH6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050360   ⟸   ENSRNOT00000049082
RefSeq Acc Id: XP_038961474   ⟸   XM_039105546
- Peptide Label: isoform X3
- UniProtKB: A6JXH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961473   ⟸   XM_039105545
- Peptide Label: isoform X3
- UniProtKB: A6JXH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961472   ⟸   XM_039105544
- Peptide Label: isoform X3
- UniProtKB: A6JXH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140292   ⟸   XM_063284222
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140293   ⟸   XM_063284223
- Peptide Label: isoform X2
- UniProtKB: A6JXH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140294   ⟸   XM_063284224
- Peptide Label: isoform X3
- UniProtKB: A6JXH8 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCD7-F1-model_v2 AlphaFold D3ZCD7 1-244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304911 AgrOrtholog
BioCyc Gene G2FUF-46763 BioCyc
Ensembl Genes ENSRNOG00000007285 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049082 ENTREZGENE
  ENSRNOT00000049082.5 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kae1-assoc_kinase_Bud32 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:362272 UniProtKB/TrEMBL
NCBI Gene 362272 ENTREZGENE
PANTHER EKC/KEOPS COMPLEX SUBUNIT TP53RK UniProtKB/TrEMBL
  PTHR12209 UniProtKB/TrEMBL
Pfam Kdo UniProtKB/TrEMBL
PhenoGen Tp53rkb PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007285 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A6JXH6 ENTREZGENE, UniProtKB/TrEMBL
  A6JXH7 ENTREZGENE, UniProtKB/TrEMBL
  A6JXH8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCD7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-03-09 Tp53rkb  tumor protein p53 regulating kinase B  Trp53rkb  transformation related protein 53 regulating kinase B  Name and Symbol changed 629549 APPROVED
2022-03-03 Trp53rkb  transformation related protein 53 regulating kinase B  Tp53rkb  transformation related protein 53 regulating kinase B  Symbol changed 629549 APPROVED
2022-03-03 Tp53rkb  transformation related protein 53 regulating kinase B  Tp53rkb  TP53 regulating kinase B  Name changed 629549 APPROVED
2022-03-03 Tp53rkb  TP53 regulating kinase B  Tp53rk  TP53 regulating kinase  Name and Symbol changed 629549 APPROVED
2010-05-25 Tp53rk  TP53 regulating kinase  Trp53rk  TP53 regulating kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Trp53rk  TP53 regulating kinase   Trp53rk_predicted  TP53 regulating kinase (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 Trp53rk_predicted  TP53 regulating kinase (predicted)  LOC686212  similar to TP53-regulating kinase (p53-related protein kinase) (Nori-2)  Data merged from RGD:1584351 1643240 APPROVED
2006-11-19 LOC686212  similar to TP53-regulating kinase (p53-related protein kinase) (Nori-2)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Trp53rk_predicted  TP53 regulating kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED