Ttc34 (tetratricopeptide repeat domain 34) - Rat Genome Database

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Gene: Ttc34 (tetratricopeptide repeat domain 34) Rattus norvegicus
Analyze
Symbol: Ttc34
Name: tetratricopeptide repeat domain 34
RGD ID: 1304840
Description: Orthologous to human TTC34 (tetratricopeptide repeat domain 34); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC102550274; LOC366517; RGD1304840; similar to RIKEN cDNA B230396O12; tetratricopeptide repeat protein 34; uncharacterized LOC102550274
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,693,410 - 170,711,215 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5170,693,402 - 170,710,368 (+)EnsemblGRCr8
mRatBN7.25165,411,063 - 165,428,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,411,058 - 165,428,857 (+)EnsemblmRatBN7.2
Rnor_6.05172,253,257 - 172,271,056 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,259,520 - 172,269,213 (+)Ensemblrn6Rnor6.0
Rnor_5.05175,714,925 - 175,724,963 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45171,658,968 - 171,668,759 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5163,617,537 - 163,635,393 (+)NCBICelera
RGSC_v3.15171,643,843 - 171,679,156 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ttc34
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,693,410 - 170,711,215 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5170,693,402 - 170,710,368 (+)EnsemblGRCr8
mRatBN7.25165,411,063 - 165,428,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,411,058 - 165,428,857 (+)EnsemblmRatBN7.2
Rnor_6.05172,253,257 - 172,271,056 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,259,520 - 172,269,213 (+)Ensemblrn6Rnor6.0
Rnor_5.05175,714,925 - 175,724,963 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45171,658,968 - 171,668,759 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5163,617,537 - 163,635,393 (+)NCBICelera
RGSC_v3.15171,643,843 - 171,679,156 (+)NCBI
Cytogenetic Map5q36NCBI
TTC34
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,636,986 - 2,801,693 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12,636,986 - 2,801,693 (-)Ensemblhg38GRCh38
GRCh3712,568,425 - 2,718,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,689,996 - 2,707,252 (-)NCBIBuild 36Build 36hg18NCBI36
Celera11,898,499 - 1,923,916 (-)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef11,852,084 - 1,875,285 (-)NCBIHuRef
HuRef11,993,249 - 1,999,306 (-)NCBIHuRef
CHM1_112,559,861 - 2,649,648 (-)NCBICHM1_1
T2T-CHM13v2.012,078,230 - 2,301,463 (-)NCBIT2T-CHM13v2.0
Ttc34
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,921,871 - 154,951,582 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,921,916 - 154,951,584 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384154,837,308 - 154,867,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,837,459 - 154,867,127 (+)Ensemblmm10GRCm38
MGSCv374154,230,309 - 154,241,236 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364153,700,148 - 153,710,924 (+)NCBIMGSCv36mm8
Celera4157,122,995 - 157,139,547 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map485.47NCBI
Ttc34
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,620,516 - 8,631,399 (+)Ensembl
ChiLan1.0NW_0049554868,620,609 - 8,633,069 (+)NCBIChiLan1.0ChiLan1.0
TTC34
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,525,787 - 225,611,699 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11224,171,630 - 224,271,207 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011,374,206 - 1,454,684 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112,512,513 - 2,584,564 (-)NCBIPanPan1.1PanPan1.1panPan2
TTC34
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,470,807 - 57,481,874 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,473,001 - 57,490,971 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha557,483,646 - 57,503,595 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0557,673,967 - 57,693,869 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,674,238 - 57,694,631 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,665,271 - 57,685,129 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,557,583 - 57,577,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,947,361 - 57,967,296 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ttc34
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,502,832 - 28,531,358 (-)NCBIHiC_Itri_2
TTC34
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,478,408 - 64,499,986 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1664,478,117 - 64,499,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2659,035,533 - 59,050,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTC34
(Chlorocebus sabaeus - green monkey)		 No map positions available.
Ttc34
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,427,787 - 7,447,303 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248187,435,250 - 7,447,905 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ttc34
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v115,853,730 - 5,868,384 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000037211
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat

Markers in Region
BF386934  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,426,890 - 165,427,063 (+)MAPPERmRatBN7.2
Rnor_6.05172,269,083 - 172,269,255NCBIRnor6.0
Rnor_5.05175,724,736 - 175,724,908UniSTSRnor5.0
RGSC_v3.45171,668,531 - 171,668,703UniSTSRGSC3.4
Celera5163,633,420 - 163,633,592UniSTS
RH 3.4 Map51157.3UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 5 116 18 28 7 6 7 4 38 17 1 108 13 61 21 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000037211   ⟹   ENSRNOP00000029146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5170,693,402 - 170,710,368 (+)Ensembl
mRatBN7.2 Ensembl5165,411,058 - 165,428,857 (+)Ensembl
Rnor_6.0 Ensembl5172,259,520 - 172,269,213 (+)Ensembl
RefSeq Acc Id: XM_039111371   ⟹   XP_038967299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,693,410 - 170,711,215 (+)NCBI
mRatBN7.25165,411,063 - 165,428,864 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038967299 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81275 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029146
  ENSRNOP00000029146.5
Ensembl Acc Id: ENSRNOP00000029146   ⟸   ENSRNOT00000037211
RefSeq Acc Id: XP_038967299   ⟸   XM_039111371
- UniProtKB: D3ZC99 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZC99-F1-model_v2 AlphaFold D3ZC99 1-554 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304840 AgrOrtholog
BioCyc Gene G2FUF-38947 BioCyc
Ensembl Genes ENSRNOG00000024526 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037211 ENTREZGENE
  ENSRNOT00000037211.6 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
  TTC34 UniProtKB/TrEMBL
NCBI Gene 366517 ENTREZGENE
PANTHER PTHR44874 UniProtKB/TrEMBL
  TETRATRICOPEPTIDE REPEAT PROTEIN 34 UniProtKB/TrEMBL
PhenoGen Ttc34 PhenoGen
PROSITE TPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024526 RatGTEx
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt D3ZC99 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Ttc34  tetratricopeptide repeat domain 34  LOC102550274  uncharacterized LOC102550274  Data merged from RGD:7732915 737654 PROVISIONAL
2013-12-18 LOC102550274  uncharacterized LOC102550274      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-02-12 Ttc34  tetratricopeptide repeat domain 34  RGD1304840  similar to RIKEN cDNA B230396O12   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1304840  similar to RIKEN cDNA B230396O12   RGD1304840_predicted  similar to RIKEN cDNA B230396O12 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1304840_predicted  similar to RIKEN cDNA B230396O12 (predicted)  LOC366517_predicted  similar to RIKEN cDNA B230396O12 (predicted)  Symbol and Name status set to approved 1331353 APPROVED
2005-01-20 RGD1304840_predicted  similar to RIKEN cDNA B230396O12 (predicted)  LOC366517_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC366517_predicted  similar to RIKEN cDNA B230396O12 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL