Serpina9 (serpin family A member 9) - Rat Genome Database

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Gene: Serpina9 (serpin family A member 9) Rattus norvegicus
Analyze
Symbol: Serpina9
Name: serpin family A member 9
RGD ID: 1304789
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human SERPINA9 (serpin family A member 9); INTERACTS WITH ammonium chloride; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299274; serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9; serpin A9; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9; serpin peptidase inhibitor, clade A, member 9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,683,650 - 128,700,784 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,683,664 - 128,700,784 (-)EnsemblGRCr8
mRatBN7.26122,918,819 - 122,936,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,918,880 - 122,936,000 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6123,059,784 - 123,076,902 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,355,064 - 123,372,182 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,691,927 - 122,709,053 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,662,348 - 127,680,232 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,662,813 - 127,679,951 (-)Ensemblrn6Rnor6.0
Rnor_5.06136,881,410 - 136,898,530 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46128,052,256 - 128,069,518 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6120,398,966 - 120,416,084 (-)NCBICelera
RGSC_v3.16128,056,362 - 128,072,771 (-)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15489334  


Genomics

Comparative Map Data
Serpina9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,683,650 - 128,700,784 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,683,664 - 128,700,784 (-)EnsemblGRCr8
mRatBN7.26122,918,819 - 122,936,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,918,880 - 122,936,000 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6123,059,784 - 123,076,902 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,355,064 - 123,372,182 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,691,927 - 122,709,053 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,662,348 - 127,680,232 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,662,813 - 127,679,951 (-)Ensemblrn6Rnor6.0
Rnor_5.06136,881,410 - 136,898,530 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46128,052,256 - 128,069,518 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6120,398,966 - 120,416,084 (-)NCBICelera
RGSC_v3.16128,056,362 - 128,072,771 (-)NCBI
Cytogenetic Map6q32NCBI
SERPINA9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,462,721 - 94,476,197 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,462,717 - 94,481,125 (-)Ensemblhg38GRCh38
GRCh371494,929,058 - 94,942,534 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361493,998,811 - 94,012,423 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341494,000,715 - 94,012,423NCBI
Celera1474,984,948 - 74,998,549 (-)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,109,316 - 75,122,913 (-)NCBIHuRef
CHM1_11494,866,855 - 94,880,458 (-)NCBICHM1_1
T2T-CHM13v2.01488,692,234 - 88,705,726 (-)NCBIT2T-CHM13v2.0
Serpina9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912103,962,877 - 103,979,911 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12103,961,002 - 103,980,014 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3812103,996,615 - 104,013,652 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12103,994,743 - 104,013,755 (-)Ensemblmm10GRCm38
MGSCv3712105,234,830 - 105,251,862 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612104,397,670 - 104,414,702 (-)NCBIMGSCv36mm8
Celera12105,214,012 - 105,231,660 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.98NCBI
Serpina9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543817,866,796 - 17,875,104 (+)Ensembl
ChiLan1.0NW_00495543817,862,064 - 17,875,490 (+)NCBIChiLan1.0ChiLan1.0
SERPINA9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,610,914 - 95,624,365 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,827,419 - 94,840,870 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01475,085,874 - 75,099,381 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,418,728 - 94,431,999 (-)NCBIPanPan1.1PanPan1.1panPan2
SERPINA9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,473,622 - 63,487,720 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,473,687 - 63,488,556 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha863,050,176 - 63,064,142 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0863,740,521 - 63,754,568 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,740,505 - 63,754,602 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,415,783 - 63,429,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,468,110 - 63,482,144 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,798,760 - 63,812,804 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SERPINA9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,247,517 - 72,255,199 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,248,001 - 72,254,999 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605359,473,350 - 59,485,363 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpina9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247347,162,235 - 7,173,654 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247347,165,467 - 7,181,908 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpina9
108 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:123
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000012861
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
renal system
reproductive system
respiratory system
1 13 11 31 40 15 8 15 6 49 26 7 68 25

Sequence


Ensembl Acc Id: ENSRNOT00000012861   ⟹   ENSRNOP00000012861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6128,683,664 - 128,700,784 (-)Ensembl
mRatBN7.2 Ensembl6122,918,880 - 122,936,000 (-)Ensembl
Rnor_6.0 Ensembl6127,662,813 - 127,679,951 (-)Ensembl
RefSeq Acc Id: NM_001106754   ⟹   NP_001100224
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,683,664 - 128,700,784 (-)NCBI
mRatBN7.26122,918,880 - 122,936,000 (-)NCBI
Rnor_6.06127,662,813 - 127,679,951 (-)NCBI
Rnor_5.06136,881,410 - 136,898,530 (-)NCBI
RGSC_v3.46128,052,256 - 128,069,518 (-)RGD
Celera6120,398,966 - 120,416,084 (-)RGD
Sequence:
RefSeq Acc Id: XM_039112074   ⟹   XP_038968002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,683,650 - 128,695,888 (-)NCBI
mRatBN7.26122,918,819 - 122,931,104 (-)NCBI
RefSeq Acc Id: XM_063261768   ⟹   XP_063117838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,683,650 - 128,698,798 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100224 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968002 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117838 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81793 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012861
  ENSRNOP00000012861.3
RefSeq Acc Id: NP_001100224   ⟸   NM_001106754
- Peptide Label: precursor
- UniProtKB: D3ZAT4 (UniProtKB/TrEMBL),   A6JEP9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012861   ⟸   ENSRNOT00000012861
RefSeq Acc Id: XP_038968002   ⟸   XM_039112074
- Peptide Label: isoform X1
- UniProtKB: D3ZAT4 (UniProtKB/TrEMBL),   A6JEP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117838   ⟸   XM_063261768
- Peptide Label: isoform X1
- UniProtKB: A6JEP9 (UniProtKB/TrEMBL),   D3ZAT4 (UniProtKB/TrEMBL)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAT4-F1-model_v2 AlphaFold D3ZAT4 1-417 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304789 AgrOrtholog
BioCyc Gene G2FUF-36399 BioCyc
Ensembl Genes ENSRNOG00000042391 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012861 ENTREZGENE
  ENSRNOT00000012861.6 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
  Serpins superfamily UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:299274 UniProtKB/TrEMBL
NCBI Gene 299274 ENTREZGENE
PANTHER Prot_inh_serpin UniProtKB/TrEMBL
  SERPIN A9 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpina9 PhenoGen
RatGTEx ENSRNOG00000042391 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A6JEP9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAT4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpina9  serpin family A member 9  Serpina9  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Serpina9  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9  Serpina9  serpin peptidase inhibitor, clade A, member 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-03-05 Serpina9  serpin peptidase inhibitor, clade A, member 9  Serpina9  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Serpina9  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9   Serpina9_predicted  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Serpina9_predicted  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 (predicted)    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Serpina9_predicted  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 (predicted)      Symbol and Name status set to approved 70820 APPROVED