Castor1 (cytosolic arginine sensor for mTORC1 subunit 1) - Rat Genome Database

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Gene: Castor1 (cytosolic arginine sensor for mTORC1 subunit 1) Rattus norvegicus
Analyze
Symbol: Castor1
Name: cytosolic arginine sensor for mTORC1 subunit 1
RGD ID: 1304774
Description: Predicted to enable several functions, including arginine binding activity; identical protein binding activity; and protein sequestering activity. Predicted to be involved in cellular response to L-arginine; cellular response to amino acid starvation; and regulation of TORC1 signaling. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol. Orthologous to human CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Gats protein; GATS protein-like 3; GATS-like protein 3; Gatsl3; LOC360969; MGC109140; RGD1304774; similar to opposite strand transcription unit to Stag3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,309,710 - 83,314,123 (+)NCBIGRCr8
mRatBN7.21479,086,136 - 79,090,549 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,086,136 - 79,090,548 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,526,728 - 83,531,138 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,766,807 - 84,771,217 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,212,732 - 81,217,144 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,447,552 - 84,457,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,447,885 - 84,452,367 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,129,496 - 85,139,061 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,840,815 - 84,845,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,859,946 - 84,863,912 (+)NCBI
Celera1477,997,130 - 78,001,543 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,ISO,ISS)
GATOR2 complex  (ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. CASTORing New Light on Amino Acid Sensing. Hallett JE and Manning BD, Cell. 2016 Mar 24;165(1):15-7. doi: 10.1016/j.cell.2016.03.002.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:25416956   PMID:26972053  


Genomics

Comparative Map Data
Castor1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,309,710 - 83,314,123 (+)NCBIGRCr8
mRatBN7.21479,086,136 - 79,090,549 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,086,136 - 79,090,548 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,526,728 - 83,531,138 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,766,807 - 84,771,217 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,212,732 - 81,217,144 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,447,552 - 84,457,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,447,885 - 84,452,367 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,129,496 - 85,139,061 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,840,815 - 84,845,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,859,946 - 84,863,912 (+)NCBI
Celera1477,997,130 - 78,001,543 (+)NCBICelera
Cytogenetic Map14q21NCBI
CASTOR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,285,117 - 30,289,505 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,285,117 - 30,289,622 (-)EnsemblGRCh38hg38GRCh38
GRCh372230,681,106 - 30,685,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,011,107 - 29,015,502 (-)NCBINCBI36Build 36hg18NCBI36
Celera2214,480,787 - 14,485,320 (-)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2213,642,884 - 13,647,417 (-)NCBIHuRef
CHM1_12230,640,242 - 30,644,751 (-)NCBICHM1_1
T2T-CHM13v2.02230,748,432 - 30,752,844 (-)NCBIT2T-CHM13v2.0
Castor1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,167,401 - 4,172,409 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,168,225 - 4,172,409 (+)EnsemblGRCm39 Ensembl
GRCm38114,218,166 - 4,222,409 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,218,225 - 4,222,409 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,118,254 - 4,122,412 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,118,254 - 4,122,412 (+)NCBIMGSCv36mm8
Celera114,715,195 - 4,719,353 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.94NCBI
Castor1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,531,325 - 4,535,217 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,530,842 - 4,535,358 (-)NCBIChiLan1.0ChiLan1.0
CASTOR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22340,252,281 - 40,256,971 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12242,950,890 - 42,955,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02211,321,259 - 11,325,787 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,123,198 - 29,127,736 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,123,198 - 29,127,736 (-)Ensemblpanpan1.1panPan2
CASTOR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,439,472 - 23,443,950 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,439,475 - 23,443,955 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,310,655 - 23,315,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,823,438 - 23,827,916 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,823,438 - 23,827,802 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,525,122 - 23,529,600 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,787,956 - 23,792,434 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,848,310 - 23,852,788 (-)NCBIUU_Cfam_GSD_1.0
Castor1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,357,353 - 116,361,622 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936904373,198 - 376,370 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936904372,609 - 376,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASTOR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,261,911 - 47,266,996 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,261,905 - 47,266,729 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,300,851 - 50,305,678 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASTOR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,165,945 - 13,172,734 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,165,873 - 13,170,465 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,975,807 - 112,980,488 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Castor1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247476,600,335 - 6,604,890 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247476,592,962 - 6,604,811 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Castor1
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:51
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000009150
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009150   ⟹   ENSRNOP00000009150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1479,086,136 - 79,090,548 (+)Ensembl
Rnor_6.0 Ensembl1484,447,885 - 84,452,367 (+)Ensembl
RefSeq Acc Id: NM_001025128   ⟹   NP_001020299
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,309,710 - 83,314,123 (+)NCBI
mRatBN7.21479,086,136 - 79,090,549 (+)NCBI
Rnor_6.01484,447,921 - 84,452,334 (+)NCBI
Rnor_5.01485,129,496 - 85,139,061 (+)NCBI
RGSC_v3.41484,840,815 - 84,845,228 (+)RGD
Celera1477,997,130 - 78,001,543 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020299 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91274 (Get FASTA)   NCBI Sequence Viewer  
  EDM00218 (Get FASTA)   NCBI Sequence Viewer  
  EDM00219 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009150.4
  ENSRNOP00055042650
  ENSRNOP00060035578
  ENSRNOP00065042325
GenBank Protein Q5BJZ0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020299   ⟸   NM_001025128
- UniProtKB: Q5BJZ0 (UniProtKB/Swiss-Prot),   A6IKF4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009150   ⟸   ENSRNOT00000009150
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BJZ0-F1-model_v2 AlphaFold Q5BJZ0 1-331 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699444
Promoter ID:EPDNEW_R9967
Type:initiation region
Name:Castor1_1
Description:cytosolic arginine sensor for mTORC1 subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01484,447,933 - 84,447,993EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304774 AgrOrtholog
BioCyc Gene G2FUF-15181 BioCyc
Ensembl Genes ENSRNOG00000006740 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055029847 UniProtKB/Swiss-Prot
  ENSRNOG00060024842 UniProtKB/Swiss-Prot
  ENSRNOG00065029749 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009150.7 UniProtKB/Swiss-Prot
  ENSRNOT00055051712 UniProtKB/Swiss-Prot
  ENSRNOT00060042972 UniProtKB/Swiss-Prot
  ENSRNOT00065051390 UniProtKB/Swiss-Prot
Gene3D-CATH VC0802-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7383249 IMAGE-MGC_LOAD
InterPro ACT-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASTOR1_ACT-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASTOR1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASTOR_ACT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASTOR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASTOR_mTORC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360969 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109140 IMAGE-MGC_LOAD
NCBI Gene 360969 ENTREZGENE
PANTHER CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOSOLIC ARGININE SENSOR FOR MTORC1 SUBUNIT 1 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam ACT_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASTOR1_ACT-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Castor1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Castor1 PhenoGen
PRINTS GATSLIKEFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006740 RatGTEx
  ENSRNOG00055029847 RatGTEx
  ENSRNOG00060024842 RatGTEx
  ENSRNOG00065029749 RatGTEx
Superfamily-SCOP ACT-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IKF4 ENTREZGENE, UniProtKB/TrEMBL
  CAST1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Castor1  cytosolic arginine sensor for mTORC1 subunit 1  Gatsl3  GATS protein-like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-12 Gatsl3  GATS protein-like 3  RGD1304774  similar to opposite strand transcription unit to Stag3; Gats protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1304774  similar to opposite strand transcription unit to Stag3; Gats protein  RGD1304774_predicted  similar to opposite strand transcription unit to Stag3; Gats protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1304774_predicted  similar to opposite strand transcription unit to Stag3; Gats protein (predicted)  LOC360969_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360969_predicted  similar to opposite strand transcription unit to Stag3; Gats protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL