Ube4b (ubiquitination factor E4B) - Rat Genome Database

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Gene: Ube4b (ubiquitination factor E4B) Rattus norvegicus
Analyze
Symbol: Ube4b
Name: ubiquitination factor E4B
RGD ID: 1304738
Description: Enables ATPase binding activity. Predicted to be involved in several processes, including ERAD pathway; granzyme-mediated apoptotic signaling pathway; and protein polyubiquitination. Predicted to act upstream of or within several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; and ventricular trabecula myocardium morphogenesis. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBE4B (ubiquitination factor E4B); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC298652; ubiquitin conjugation factor E4 B; ubiquitination factor E4B (UFD2 homolog, yeast); ubiquitination factor E4B, UFD2 homolog; ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) ; ufd2a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,049,897 - 165,153,572 (-)NCBIGRCr8
mRatBN7.25159,766,829 - 159,870,509 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,766,829 - 159,870,509 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5162,483,476 - 162,587,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,303,204 - 164,407,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,259,574 - 164,363,516 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05166,156,033 - 166,259,069 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5166,156,033 - 166,259,069 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05169,803,423 - 169,906,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45166,406,498 - 166,508,716 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15166,416,018 - 166,519,419 (-)NCBI
Celera5158,037,224 - 158,140,311 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
nefazodone  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
pirinixic acid  (ISO)
pyrogallol  (ISO)
selenium atom  (ISO)
sertraline  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
toxaphene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
nucleus  (IBA,ISO)
ubiquitin ligase complex  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. Meyer HH, etal., EMBO J 2000 May 15;19(10):2181-92.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11435423   PMID:11802788   PMID:12504083   PMID:15466860   PMID:16314518   PMID:18783366   PMID:20017557   PMID:23509263   PMID:31505169   PMID:32841720  


Genomics

Comparative Map Data
Ube4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,049,897 - 165,153,572 (-)NCBIGRCr8
mRatBN7.25159,766,829 - 159,870,509 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,766,829 - 159,870,509 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5162,483,476 - 162,587,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,303,204 - 164,407,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,259,574 - 164,363,516 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05166,156,033 - 166,259,069 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5166,156,033 - 166,259,069 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05169,803,423 - 169,906,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45166,406,498 - 166,508,716 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15166,416,018 - 166,519,419 (-)NCBI
Celera5158,037,224 - 158,140,311 (-)NCBICelera
Cytogenetic Map5q36NCBI
UBE4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38110,032,958 - 10,181,239 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl110,032,832 - 10,181,239 (+)EnsemblGRCh38hg38GRCh38
GRCh37110,093,016 - 10,241,297 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36110,015,603 - 10,163,884 (+)NCBINCBI36Build 36hg18NCBI36
Build 34110,027,308 - 10,175,560NCBI
Celera19,204,450 - 9,352,734 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef19,248,003 - 9,396,147 (+)NCBIHuRef
CHM1_1110,082,336 - 10,230,685 (+)NCBICHM1_1
T2T-CHM13v2.019,576,012 - 9,724,288 (+)NCBIT2T-CHM13v2.0
Ube4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394149,412,873 - 149,512,618 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4149,412,873 - 149,511,206 (-)EnsemblGRCm39 Ensembl
GRCm384149,328,416 - 149,428,161 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,328,416 - 149,426,749 (-)EnsemblGRCm38mm10GRCm38
MGSCv374148,702,525 - 148,800,740 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364148,172,216 - 148,270,549 (-)NCBIMGSCv36mm8
Celera4151,595,282 - 151,693,721 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map479.08NCBI
Ube4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554863,518,740 - 3,626,121 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554863,518,873 - 3,626,036 (-)NCBIChiLan1.0ChiLan1.0
UBE4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21218,037,934 - 218,185,819 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11216,684,027 - 216,831,909 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v018,801,707 - 8,949,465 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1110,033,084 - 10,178,765 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl110,033,084 - 10,178,759 (+)Ensemblpanpan1.1panPan2
UBE4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1563,214,846 - 63,339,218 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl563,215,470 - 63,338,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha563,229,535 - 63,353,896 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0563,443,094 - 63,568,097 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl563,443,104 - 63,568,238 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1563,464,036 - 63,588,520 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0563,301,738 - 63,426,261 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0563,707,401 - 63,831,989 (+)NCBIUU_Cfam_GSD_1.0
Ube4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505833,449,211 - 33,565,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366233,934,310 - 4,051,146 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366233,934,439 - 4,051,083 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBE4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl670,345,813 - 70,462,434 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1670,345,789 - 70,462,434 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2664,377,223 - 64,395,789 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBE4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120121,597,775 - 121,744,986 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605425,517,934 - 25,665,341 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ube4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248182,447,368 - 2,562,128 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248182,448,809 - 2,561,947 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ube4b
470 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:115
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000021197, ENSRNOT00000055572
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat

Markers in Region
D5Rat48  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85165,132,197 - 165,132,329 (+)Marker Load Pipeline
mRatBN7.25159,849,133 - 159,849,265 (+)MAPPERmRatBN7.2
Rnor_6.05166,237,695 - 166,237,826NCBIRnor6.0
Rnor_5.05169,885,052 - 169,885,183UniSTSRnor5.0
RGSC_v3.45166,487,856 - 166,487,988RGDRGSC3.4
RGSC_v3.45166,487,857 - 166,487,988UniSTSRGSC3.4
RGSC_v3.15166,498,044 - 166,498,176RGD
Celera5158,118,937 - 158,119,068UniSTS
RH 3.4 Map51115.3UniSTS
RH 3.4 Map51115.3RGD
RH 2.0 Map51103.2RGD
SHRSP x BN Map596.6599RGD
Cytogenetic Map5q36UniSTS
R75060  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25159,767,597 - 159,767,747 (+)MAPPERmRatBN7.2
mRatBN7.2X68,446,692 - 68,446,970 (+)MAPPERmRatBN7.2
Rnor_6.0X74,296,417 - 74,296,694NCBIRnor6.0
Rnor_6.05166,156,802 - 166,156,951NCBIRnor6.0
Rnor_5.05169,804,192 - 169,804,341UniSTSRnor5.0
Rnor_5.0X75,101,633 - 75,101,910UniSTSRnor5.0
RGSC_v3.4X91,417,726 - 91,418,003UniSTSRGSC3.4
RGSC_v3.45166,406,600 - 166,406,749UniSTSRGSC3.4
Celera5158,037,993 - 158,038,142UniSTS
CeleraX69,814,233 - 69,814,510UniSTS
Cytogenetic Map5q36UniSTS
AU014668  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25159,766,857 - 159,766,988 (+)MAPPERmRatBN7.2
mRatBN7.2X68,447,550 - 68,447,679 (+)MAPPERmRatBN7.2
Rnor_6.0X74,297,275 - 74,297,403NCBIRnor6.0
Rnor_6.05166,156,062 - 166,156,192NCBIRnor6.0
Rnor_5.05169,803,452 - 169,803,582UniSTSRnor5.0
Rnor_5.0X75,102,491 - 75,102,619UniSTSRnor5.0
RGSC_v3.4X91,418,584 - 91,418,712UniSTSRGSC3.4
RGSC_v3.45166,405,860 - 166,405,990UniSTSRGSC3.4
Celera5158,037,253 - 158,037,383UniSTS
CeleraX69,815,091 - 69,815,219UniSTS
Cytogenetic Map5q36UniSTS
BF399470  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25159,860,681 - 159,860,780 (+)MAPPERmRatBN7.2
Rnor_6.05166,249,243 - 166,249,341NCBIRnor6.0
Rnor_5.05169,896,600 - 169,896,698UniSTSRnor5.0
RGSC_v3.45166,499,405 - 166,499,503UniSTSRGSC3.4
Celera5158,130,485 - 158,130,583UniSTS
RH 3.4 Map51116.1UniSTS
Cytogenetic Map5q36UniSTS
AW916095  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25159,767,650 - 159,767,819 (+)MAPPERmRatBN7.2
mRatBN7.2X68,446,616 - 68,446,917 (+)MAPPERmRatBN7.2
Rnor_6.0X74,296,341 - 74,296,641NCBIRnor6.0
Rnor_6.05166,156,855 - 166,157,023NCBIRnor6.0
Rnor_5.05169,804,245 - 169,804,413UniSTSRnor5.0
Rnor_5.0X75,101,557 - 75,101,857UniSTSRnor5.0
RGSC_v3.4X91,417,650 - 91,417,950UniSTSRGSC3.4
RGSC_v3.45166,406,653 - 166,406,821UniSTSRGSC3.4
Celera5158,038,046 - 158,038,214UniSTS
CeleraX69,814,157 - 69,814,457UniSTS
RH 3.4 Map51114.4UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000055572   ⟹   ENSRNOP00000052435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5159,766,829 - 159,870,509 (-)Ensembl
Rnor_6.0 Ensembl5166,156,033 - 166,259,069 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105982   ⟹   ENSRNOP00000080439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5159,766,829 - 159,842,136 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116191   ⟹   ENSRNOP00000084700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5159,766,829 - 159,870,509 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118861   ⟹   ENSRNOP00000093656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5159,766,829 - 159,870,509 (-)Ensembl
RefSeq Acc Id: NM_001271198   ⟹   NP_001258127
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,049,897 - 165,153,572 (-)NCBI
mRatBN7.25159,766,829 - 159,870,509 (-)NCBI
Rnor_6.05166,156,033 - 166,259,069 (-)NCBI
Rnor_5.05169,803,423 - 169,906,426 (-)NCBI
Celera5158,037,224 - 158,140,311 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239387   ⟹   XP_006239449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,049,897 - 165,153,450 (-)NCBI
mRatBN7.25159,766,829 - 159,870,396 (-)NCBI
Rnor_6.05166,156,033 - 166,258,957 (-)NCBI
Rnor_5.05169,803,423 - 169,906,426 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593310   ⟹   XP_017448799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,049,897 - 165,153,449 (-)NCBI
mRatBN7.25159,767,822 - 159,870,396 (-)NCBI
Rnor_6.05166,156,033 - 166,258,956 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258127 (Get FASTA)   NCBI Sequence Viewer  
  XP_006239449 (Get FASTA)   NCBI Sequence Viewer  
  XP_017448799 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052435.4
  ENSRNOP00000080439.1
  ENSRNOP00000084700.1
  ENSRNOP00000093656.1
RefSeq Acc Id: NP_001258127   ⟸   NM_001271198
- UniProtKB: A0A8I6G4J1 (UniProtKB/TrEMBL),   F1M8V2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239449   ⟸   XM_006239387
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GAW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448799   ⟸   XM_017593310
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GKR7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052435   ⟸   ENSRNOT00000055572
Ensembl Acc Id: ENSRNOP00000080439   ⟸   ENSRNOT00000105982
Ensembl Acc Id: ENSRNOP00000084700   ⟸   ENSRNOT00000116191
Ensembl Acc Id: ENSRNOP00000093656   ⟸   ENSRNOT00000118861
Protein Domains
U-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8V2-F1-model_v2 AlphaFold F1M8V2 1-1173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694270
Promoter ID:EPDNEW_R4795
Type:multiple initiation site
Name:Ube4b_1
Description:ubiquitination factor E4B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05166,258,731 - 166,258,791EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304738 AgrOrtholog
BioCyc Gene G2FUF-39134 BioCyc
Ensembl Genes ENSRNOG00000014986 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055572.6 UniProtKB/TrEMBL
  ENSRNOT00000105982.1 UniProtKB/TrEMBL
  ENSRNOT00000116191.1 UniProtKB/TrEMBL
  ENSRNOT00000118861.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro Ub_conjug_fac_E4_core UniProtKB/TrEMBL
  UBE4 UniProtKB/TrEMBL
  Ubox_domain UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:298652 UniProtKB/TrEMBL
NCBI Gene 298652 ENTREZGENE
PANTHER PTHR13931 UniProtKB/TrEMBL
  UBIQUITIN CONJUGATION FACTOR E4 B UniProtKB/TrEMBL
Pfam U-box UniProtKB/TrEMBL
  Ufd2P_core UniProtKB/TrEMBL
PhenoGen Ube4b PhenoGen
PROSITE U_BOX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014986 RatGTEx
SMART Ubox UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8I6G4J1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GAW9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKR7 ENTREZGENE, UniProtKB/TrEMBL
  F1M8V2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Ube4b  ubiquitination factor E4B  Ube4b  ubiquitination factor E4B (UFD2 homolog, yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-25 Ube4b  ubiquitination factor E4B (UFD2 homolog, yeast)  Ube4b  ubiquitination factor E4B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Ube4b  ubiquitination factor E4B  Ube4b  ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ube4b  ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)   Ube4b_predicted  ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ube4b_predicted  ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED