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Gene: Txndc15 (thioredoxin domain containing 15) Rattus norvegicus

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Symbol:

Txndc15

Name:

thioredoxin domain containing 15

RGD ID:

1304696

Description:

Predicted to be involved in cilium assembly and positive regulation of smoothened signaling pathway. Predicted to be located in ciliary membrane. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in Meckel syndrome. Orthologous to human TXNDC15 (thioredoxin domain containing 15); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC103690142; LOC307180; MGC109343; RGD1304696; similar to hypothetical protein FLJ22625; thioredoxin domain-containing protein 15; uncharacterized LOC103690142

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TXNDC15 (thioredoxin domain containing 15)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Txndc15 (thioredoxin domain containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Txndc15 (thioredoxin domain containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TXNDC15 (thioredoxin domain containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TXNDC15 (thioredoxin domain containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Txndc15 (thioredoxin domain containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TXNDC15 (thioredoxin domain containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TXNDC15 (thioredoxin domain containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Txndc15 (thioredoxin domain containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Txndc15 (thioredoxin domain containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	XPO1 (exportin 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TXNDC15 (thioredoxin domain containing 15)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Txndc15 (thioredoxin domain containing 15)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	txndc15 (thioredoxin domain containing 15)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C53D6.4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	C53D6.4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	bug	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	bug	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	txndc15	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	8,903,248 - 8,915,714 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	8,903,252 - 8,916,079 (-)	Ensembl				GRCr8
mRatBN7.2	17	8,898,074 - 8,910,538 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	52,241,219 - 52,242,524 (-)	Ensembl				mRatBN7.2
mRatBN7.2 Ensembl	17	8,845,084 - 8,910,539 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	8,913,869 - 8,925,925 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	10,443,457 - 10,455,502 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	8,910,250 - 8,922,309 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	9,429,171 - 9,441,628 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	9,429,175 - 9,441,526 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	11,147,137 - 11,170,340 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	17	11,542,064 - 11,548,898 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	14,938,295 - 14,950,842 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	8,979,947 - 8,992,303 (-)	NCBI		Celera
RGSC_v3.1	17	14,938,294 - 14,950,842 (-)	NCBI
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Meckel syndrome (ISO)

Meckel Syndrome 14 (ISO)

severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

arsane (ISO)

arsenic atom (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

butanal (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

ethanol (ISO)

folic acid (ISO)

glafenine (EXP)

ivermectin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

nitrogen dioxide (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

quercetin (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell projection organization (IEA)

cilium assembly (IBA,IEA,ISO,ISS)

L-tyrosine biosynthetic process, by oxidation of phenylalanine (IEA)

positive regulation of smoothened signaling pathway (IEA,ISO,ISS)

tetrahydrobiopterin biosynthetic process (IEA)

Cellular Component

ciliary membrane (IEA)

cilium (IBA,IEA,ISO,ISS)

Molecular Function

lyase activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:29459677

Genomics

Comparative Map Data

Txndc15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	8,903,248 - 8,915,714 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	8,903,252 - 8,916,079 (-)	Ensembl				GRCr8
mRatBN7.2	17	8,898,074 - 8,910,538 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	52,241,219 - 52,242,524 (-)	Ensembl				mRatBN7.2
mRatBN7.2 Ensembl	17	8,845,084 - 8,910,539 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	8,913,869 - 8,925,925 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	10,443,457 - 10,455,502 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	8,910,250 - 8,922,309 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	9,429,171 - 9,441,628 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	9,429,175 - 9,441,526 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	11,147,137 - 11,170,340 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	17	11,542,064 - 11,548,898 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	14,938,295 - 14,950,842 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	8,979,947 - 8,992,303 (-)	NCBI		Celera
RGSC_v3.1	17	14,938,294 - 14,950,842 (-)	NCBI
Cytogenetic Map	17	p14	NCBI

TXNDC15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	134,873,770 - 134,901,635 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	134,874,318 - 134,901,635 (+)	Ensembl			hg38	GRCh38
GRCh37	5	134,209,460 - 134,237,325 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	134,237,359 - 134,265,222 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	134,237,325 - 134,264,851	NCBI
Celera	5	130,337,761 - 130,365,637 (+)	NCBI		Celera
Cytogenetic Map	5	q31.1	NCBI
HuRef	5	129,395,781 - 129,423,417 (+)	NCBI		HuRef
CHM1_1	5	133,642,093 - 133,669,957 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	135,400,718 - 135,428,599 (+)	NCBI		T2T-CHM13v2.0

Txndc15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	55,862,463 - 55,874,040 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	55,862,463 - 55,874,040 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	55,714,650 - 55,726,227 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	55,714,650 - 55,726,227 (+)	Ensembl			mm10	GRCm38
MGSCv37	13	55,816,011 - 55,827,588 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	55,724,272 - 55,735,849 (+)	NCBI		MGSCv36	mm8
Celera	13	56,769,512 - 56,781,103 (+)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	30.06	NCBI

Txndc15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	30,067,557 - 30,086,705 (+)	Ensembl
ChiLan1.0	NW_004955408	30,067,455 - 30,087,095 (+)	NCBI	ChiLan1.0	ChiLan1.0

TXNDC15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	130,170,848 - 130,199,386 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	128,310,403 - 128,338,946 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	130,275,685 - 130,301,164 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	136,417,859 - 136,443,185 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	136,417,859 - 136,443,185 (+)	Ensembl			panPan2	panpan1.1

TXNDC15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	22,943,965 - 22,958,851 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	22,943,965 - 22,958,578 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	21,693,258 - 21,707,981 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	23,750,611 - 23,765,338 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	23,750,611 - 23,765,329 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	22,449,855 - 22,464,577 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	22,315,788 - 22,330,510 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	22,958,072 - 22,972,731 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Txndc15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	123,072,719 - 123,087,240 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936597	2,097,627 - 2,112,348 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936597	2,097,535 - 2,112,144 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TXNDC15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	137,060,893 - 137,080,106 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	137,060,988 - 137,079,288 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	142,677,073 - 142,695,376 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TXNDC15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	37,660,396 - 37,685,014 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	37,660,913 - 37,685,032 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666034	40,232,413 - 40,257,037 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Txndc15
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	12,165,445 - 12,182,691 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624733	12,164,922 - 12,182,847 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Txndc15
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	74,032,055 - 74,044,622 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Txndc15
51 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	89
Count of miRNA genes:	77
Interacting mature miRNAs:	80
Transcripts:	ENSRNOT00000000146
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	1	36045694	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	43999106	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4360057	27233623	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	1	21499218	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2120843	42054133	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4733534	49733534	Rat
1581553	Pur14	Proteinuria QTL 14	5.3	0.0001	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	17	7985243	16523460	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	8574342	32199534	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	6221998	58177198	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38037084	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31706603	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4733534	49733534	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	43999106	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4360057	27233623	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	43999106	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2120843	22087569	Rat
1549900	Iddm20	Insulin dependent diabetes mellitus QTL 20	3.7		pancreas integrity trait (VT:0010560)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	17	1	22181410	Rat
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22877318	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001443812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC139608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000146 ⟹ ENSRNOP00000000146

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	8,903,252 - 8,915,722 (-)	Ensembl
mRatBN7.2 Ensembl	17	8,898,078 - 8,910,431 (-)	Ensembl
Rnor_6.0 Ensembl	17	9,429,175 - 9,441,526 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000071426 ⟹ ENSRNOP00000067457

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	8,903,252 - 8,916,079 (-)	Ensembl
mRatBN7.2 Ensembl	17	8,845,214 - 8,910,539 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100127 ⟹ ENSRNOP00000090384

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	8,845,084 - 8,896,398 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109385 ⟹ ENSRNOP00000096138

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	52,241,219 - 52,242,524 (-)	Ensembl

RefSeq Acc Id:

NM_001024998 ⟹ NP_001020169

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	8,903,252 - 8,915,603 (-)	NCBI
mRatBN7.2	17	8,898,078 - 8,910,431 (-)	NCBI
Rnor_6.0	17	9,429,175 - 9,441,526 (-)	NCBI
Rnor_5.0	17	11,147,137 - 11,170,340 (-)	NCBI
Rnor_5.0	17	11,542,064 - 11,548,898 (-)	NCBI
RGSC_v3.4	17	14,938,295 - 14,950,842 (-)	RGD
Celera	17	8,979,947 - 8,992,303 (-)	RGD

Sequence:

show sequence

GACTCCGGTTGCTGTGCGCCGGTTGTCTTCCACCGCGGTGGCTGTCGCCGCGGCTCCCTGTCGC
GCGCCATGCAACTCCTATGCTGGTGGCAAATACTGCTGTGGGTGCTGGGCCTTCCGGCCCGCGG
CCTGGAGGAGGACAGTGGTCACACGTGGCAGGAGGAGCGGCCAGTCCCAGCTCTCCAGGTTGGA
TCTGTGTACCTGAATGAAGAGGAGGCTGCACAGGGCCATCGGGTCCAGGCAAGAGTGGCGGAGC
CCTCTGAGGCCTCTCTGGGTCCCCGCGGAGATCCCATGGTGGTGCTGTCGGTGATTCCCGGGGC
AGCTGAGGACCAACGGAGCACCGAGGCCCACGATGGCACCTGCAGTGCGCAGGGAGACGAAGAC
CCGCGCTGCGGTGGCCGAGAGAACCTCTTCGGGCTTCAGGGTGCAGGCGGCTTCCAGGATCGGG
AAGAGGAGTACTATGCCGAGCCTGGAGTGGCAGAGGCCGAGCCCGTAGCCACTGAGGATGCCAA
CAGCACCGACAGCCTCAAGTCCCCCAAGGTGAACTGTGAGGAGAGGAATGTGACCGGGCTAGAA
AACTTCACTCTGAAGATTTTAAATATGTCCCAGGACCTCATGGATTTCCTAAACCCAAATGGTA
GTGACTGTACGCTGGTCCTCTTCTATACCCCATGGTGCCGATTCTCTGCCAGCCTGGCTCCTCA
TTTTAACTCCCTGCCTCGCGCATTTCCAACACTCGGCTTTTTGGCTCTGGATGCATCTCAGCAC
AGCAGCCTTTCTACCAGATTTGGCACTGTAGCTGTCCCTAACATTTTGTTATTTCAAGGAGCCA
AACCAATGGCGAGGTTTAACCATACAGATCGAACCTTGGAAACACTGAAAATCTTCATTTTCAA
TCAGACAGGTATAGAAGCCAAGAAAAATGTGGTGGTAACGCAGGCTGACCAACTGGGCCCGCTC
CCCAGCACGTTGGTAAAGACTGTGGATTGGCTGCTTGTGTTTTCCTTGTTCTTTTTAATTAGTT
TCATTATGTACGCTACCATCCGCACTGAGAGTATCCGGTGGCTGATTCCAGGACAAGAGCAGGA
ACACGCAGAGTAGAGACAGAACTGAACCCGAACACGTGGGGTCTTAGCCCTGCGGACTTAGCAT
TACAGCGGCTAACGTGTGGACTTGCCACGGAAGTCAGGTTCAAGAATCATGTTCTTGTTGAACT
ACTGAAAGGCTGAAAAGATTTCATTTAAATGTGTTTTTACTGTGACAATTAGCAGATGCAAAAG
TGTCCACTAGAATTGACTGTTCTTGTTTTTAATACTTGAACATAATGAATGAATTTCTCTTCTA
GTGTTGTTAAGCAGGAAAGTTGCTGTATGACAGGTGGAACTTCCCGGGAAGCATGGGCTAGGAC
AGGAAGTGTGGGCTACGATGGGGAGCATGGGCTAGGACAGGAAGTGTGGGACGGGATGGCAAAG
TGTGCGTCTACCACAGGACCAGGTGAAAAATAAAGTCACTGAAAGAATTAAAAAAAAAAAAAAA
AAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008771497 ⟹ XP_008769719

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	8,903,248 - 8,915,714 (-)	NCBI
mRatBN7.2	17	8,898,074 - 8,910,538 (-)	NCBI
Rnor_6.0	17	9,429,171 - 9,441,628 (-)	NCBI

Sequence:

show sequence

AAGATGGCCGCTGCCGCGGCTGCCAGGAGTCAACATGGCGGCCCGCGGCCACGCCTGCGCTCTC
GGCTCTCCTCCCCCTAGTCTTGCTGGGGTTGGGGGCGCGACTCCGGTTGCTGTGCGCCGGTTGT
CTTCCACCGCGGTGGCTGTCGCCGCGGCTCCCTGTCGCGCGCCATGCAACTCCTATGCTGGTGG
CAAATACTGCTGTGGGTGCTGGGCCTTCCGGCCCGCGGCCTGGAGGTTGCAGAGGACAGTGGTC
ACACGTGGCAGGAGGAGCGGCCAGTCCCAGCTCTCCAGGTTGGATCTGTGTACCTGAATGAAGA
GGAGGCTGCACAGGGCCATCGGGTCCAGGCAAGAGTGGCGGAGCCCTCTGAGGCCTCTCTGGGT
CCCCGCGGAGATCCCATGGTGGTGCTGTCGGTGATTCCCGGGGCAGCTGAGGACCAACGGAGCA
CCGAGGCCCACGATGGCACCTGCAGTGCGCAGGGAGACGAAGACCCGCGCTGCGGTGGCCGAGA
GAACCTCTTCGGGCTTCAGGGTGCAGGCGGCTTCCAGGATCGGGAAGAGGAGTACTATGCCGAG
CCTGGAGTGGCAGAGGCCGAGCCCGTAGCCACTGAGGATGCCAACAGCACCGACAGCCTCAAGT
CCCCCAAGGTGAACTGTGAGGAGAGGAATGTGACCGGGCTAGAAAACTTCACTCTGAAGATTTT
AAATATGTCCCAGGACCTCATGGATTTCCTAAACCCAAATGGTAGTGACTGTACGCTGGTCCTC
TTCTATACCCCATGGTGCCGATTCTCTGCCAGCCTGGCTCCTCATTTTAACTCCCTGCCTCGCG
CATTTCCAACACTCGGCTTTTTGGCTCTGGATGCATCTCAGCACAGCAGCCTTTCTACCAGATT
TGGCACTGTAGCTGTCCCTAACATTTTGTTATTTCAAGGAGCCAAACCAATGGCGAGGTTTAAC
CATACAGATCGAACCTTGGAAACACTGAAAATCTTCATTTTCAATCAGACAGGTATAGAAGCCA
AGAAAAATGTGGTGGTAACGCAGGCTGACCAACTGGGCCCGCTCCCCAGCACGTTGGTAAAGAC
TGTGGATTGGCTGCTTGTGTTTTCCTTGTTCTTTTTAATTAGTTTCATTATGTACGCTACCATC
CGCACTGAGAGTATCCGGTGGCTGATTCCAGGACAAGAGCAGGAACACGCAGAGTAGAGACAGA
ACTGAACCCGAACACGTGGGGTCTTAGCCCTGCGGACTTAGCATTACAGCGGCTAACGTGTGGA
CTTGCCACGGAAGTCAGGTTCAAGAATCATGTTCTTGTTGAACTACTGAAAGGCTGAAAAGATT
TCATTTAAATGTGTTTTTACTGTGACAATTAGCAGATGCAAAAGTGTCCACTAGAATTGACTGT
TCTTGTTTTTAATACTTGAACATAATGAATGAATTTCTCTTCTAGTGTTGTTAAGCAGGAAAGT
TGCTGTATGACAGGTGGAACTTCCCGGGAAGCATGGGCTAGGACAGGAAGTGTGGGCTACGATG
GGGAGCATGGGCTAGGACAGGAAGTGTGGGACGGGATGGCAAAGTGTGCGTCTACCACAGGACC
AGGTGAAAAATAAAGTCACTGAAAGAATTCAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001020169	(Get FASTA)	NCBI Sequence Viewer
	NP_001430741	(Get FASTA)	NCBI Sequence Viewer
	XP_008769719	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91340	(Get FASTA)	NCBI Sequence Viewer
	EDL93957	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000146
	ENSRNOP00000000146.6
GenBank Protein	Q5BJT4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001020169 ⟸ NM_001024998
- Peptide Label:	precursor
- UniProtKB:	Q5BJT4 (UniProtKB/Swiss-Prot), A0A8I6AP63 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQLLCWWQILLWVLGLPARGLEEDSGHTWQEERPVPALQVGSVYLNEEEAAQGHRVQARVAEPS EASLGPRGDPMVVLSVIPGAAEDQRSTEAHDGTCSAQGDEDPRCGGRENLFGLQGAGGFQDREE EYYAEPGVAEAEPVATEDANSTDSLKSPKVNCEERNVTGLENFTLKILNMSQDLMDFLNPNGSD CTLVLFYTPWCRFSASLAPHFNSLPRAFPTLGFLALDASQHSSLSTRFGTVAVPNILLFQGAKP MARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQLGPLPSTLVKTVDWLLVFSLFFLISFI MYATIRTESIRWLIPGQEQEHAE hide sequence

RefSeq Acc Id:	XP_008769719 ⟸ XM_008771497
- Peptide Label:	isoform X1
- UniProtKB:	A6KAP9 (UniProtKB/TrEMBL), A0A8I6AP63 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQLLCWWQILLWVLGLPARGLEVAEDSGHTWQEERPVPALQVGSVYLNEEEAAQGHRVQARVAE PSEASLGPRGDPMVVLSVIPGAAEDQRSTEAHDGTCSAQGDEDPRCGGRENLFGLQGAGGFQDR EEEYYAEPGVAEAEPVATEDANSTDSLKSPKVNCEERNVTGLENFTLKILNMSQDLMDFLNPNG SDCTLVLFYTPWCRFSASLAPHFNSLPRAFPTLGFLALDASQHSSLSTRFGTVAVPNILLFQGA KPMARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQLGPLPSTLVKTVDWLLVFSLFFLIS FIMYATIRTESIRWLIPGQEQEHAE hide sequence

Ensembl Acc Id:

ENSRNOP00000000146 ⟸ ENSRNOT00000000146

Ensembl Acc Id:

ENSRNOP00000090384 ⟸ ENSRNOT00000100127

Ensembl Acc Id:

ENSRNOP00000067457 ⟸ ENSRNOT00000071426

Ensembl Acc Id:

ENSRNOP00000096138 ⟸ ENSRNOT00000109385

Protein Domains

Thioredoxin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5BJT4-F1-model_v2	AlphaFold	Q5BJT4	1-343	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700295

Promoter ID:

EPDNEW_R10818

Type:

initiation region

Name:

Txndc15_1

Description:

thioredoxin domain containing 15

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	9,441,516 - 9,441,576	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304696	AgrOrtholog
BioCyc Gene	G2FUF-10222	BioCyc
Ensembl Genes	ENSRNOG00000000133	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00000069255	Ensembl
Ensembl Transcript	ENSRNOT00000000146	ENTREZGENE
	ENSRNOT00000000146.8	UniProtKB/Swiss-Prot
Gene3D-CATH	Glutaredoxin	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7315216	IMAGE-MGC_LOAD
InterPro	Thioredoxin-like_sf	UniProtKB/Swiss-Prot
	Thioredoxin_domain	UniProtKB/Swiss-Prot
	TXNDC15	UniProtKB/Swiss-Prot
KEGG Report	rno:307180	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109343	IMAGE-MGC_LOAD
NCBI Gene	307180	ENTREZGENE
PANTHER	PTHR14684	UniProtKB/Swiss-Prot
	THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15	UniProtKB/Swiss-Prot
Pfam	Thioredoxin	UniProtKB/Swiss-Prot
PhenoGen	Txndc15	PhenoGen
PROSITE	THIOREDOXIN_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000133	RatGTEx
	ENSRNOG00000069255	RatGTEx
Superfamily-SCOP	SSF52833	UniProtKB/Swiss-Prot
UniProt	A0A8I6AP63	ENTREZGENE
	A6KAP9	ENTREZGENE, UniProtKB/TrEMBL
	M0RCX0_RAT	UniProtKB/TrEMBL
	Q5BJT4	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Txndc15	thioredoxin domain containing 15	LOC103690142	uncharacterized LOC103690142	Data merged from RGD:9357931	737654	PROVISIONAL
2014-08-25	LOC103690142	uncharacterized LOC103690142			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-04	Txndc15	thioredoxin domain containing 15	RGD1304696	similar to hypothetical protein FLJ22625	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1304696	similar to hypothetical protein FLJ22625	RGD1304696_predicted	similar to hypothetical protein FLJ22625 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1304696_predicted	similar to hypothetical protein FLJ22625 (predicted)	LOC307180_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC307180_predicted	similar to hypothetical protein FLJ22625 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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