Klhl8 (kelch-like family member 8) - Rat Genome Database

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Gene: Klhl8 (kelch-like family member 8) Rattus norvegicus
Analyze
Symbol: Klhl8
Name: kelch-like family member 8
RGD ID: 1304685
Description: Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KLHL8 (kelch like family member 8); INTERACTS WITH 2,6-dinitrotoluene; acetamide; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kelch-like 8; kelch-like 8 (Drosophila); kelch-like protein 8; LOC289457
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,112,472 - 6,158,001 (+)NCBIGRCr8
mRatBN7.2145,807,795 - 5,853,325 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,807,907 - 5,853,294 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,775,288 - 5,820,881 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,075,516 - 7,121,112 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,773,843 - 5,819,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,169,517 - 7,215,025 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,169,519 - 7,215,025 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0147,159,371 - 7,204,942 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,958,124 - 7,003,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,978,904 - 7,003,611 (+)NCBI
Celera145,946,794 - 5,992,070 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19158078  


Genomics

Comparative Map Data
Klhl8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,112,472 - 6,158,001 (+)NCBIGRCr8
mRatBN7.2145,807,795 - 5,853,325 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,807,907 - 5,853,294 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,775,288 - 5,820,881 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,075,516 - 7,121,112 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,773,843 - 5,819,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,169,517 - 7,215,025 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,169,519 - 7,215,025 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0147,159,371 - 7,204,942 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,958,124 - 7,003,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,978,904 - 7,003,611 (+)NCBI
Celera145,946,794 - 5,992,070 (+)NCBICelera
Cytogenetic Map14p22NCBI
KLHL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38487,160,103 - 87,240,531 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl487,160,103 - 87,240,314 (-)EnsemblGRCh38hg38GRCh38
GRCh37488,081,255 - 88,141,770 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,301,238 - 88,360,698 (-)NCBINCBI36Build 36hg18NCBI36
Build 34488,439,392 - 88,498,853NCBI
Celera485,371,231 - 85,430,685 (-)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef483,826,503 - 83,885,876 (-)NCBIHuRef
CHM1_1488,059,619 - 88,119,078 (-)NCBICHM1_1
T2T-CHM13v2.0490,489,165 - 90,569,763 (-)NCBIT2T-CHM13v2.0
Klhl8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,009,916 - 104,059,137 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,009,839 - 104,059,125 (-)EnsemblGRCm39 Ensembl
GRCm385103,862,050 - 103,911,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5103,861,973 - 103,911,259 (-)EnsemblGRCm38mm10GRCm38
MGSCv375104,291,069 - 104,340,248 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365104,102,352 - 104,151,531 (-)NCBIMGSCv36mm8
Celera5101,168,123 - 101,217,145 (-)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.45NCBI
Klhl8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554742,652,992 - 2,710,616 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554742,652,992 - 2,710,616 (+)NCBIChiLan1.0ChiLan1.0
KLHL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2385,176,525 - 85,236,648 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1485,438,568 - 85,498,966 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0479,462,540 - 79,522,547 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1490,190,302 - 90,247,744 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,190,302 - 90,225,284 (-)Ensemblpanpan1.1panPan2
KLHL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13210,656,419 - 10,687,029 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3210,659,240 - 10,686,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3231,224,842 - 31,297,941 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03210,710,493 - 10,781,463 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3210,708,476 - 10,739,122 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13210,790,068 - 10,862,824 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03210,617,500 - 10,690,567 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03229,264,169 - 29,337,281 (+)NCBIUU_Cfam_GSD_1.0
Klhl8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405285556,977 - 576,651 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049369204,186 - 25,059 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049369204,418 - 22,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,634,209 - 131,700,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,634,171 - 131,701,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,909,603 - 140,931,918 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1735,535,406 - 35,614,934 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl735,535,230 - 35,595,201 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603714,226,547 - 14,306,636 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248723,677,397 - 3,750,867 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248723,675,248 - 3,750,852 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klhl8
324 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:422
Count of miRNA genes:235
Interacting mature miRNAs:282
Transcripts:ENSRNOT00000003026
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat

Markers in Region
BE102825  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,809,579 - 5,809,744 (+)MAPPERmRatBN7.2
Rnor_6.0147,171,285 - 7,171,449NCBIRnor6.0
Rnor_5.0147,161,137 - 7,161,301UniSTSRnor5.0
RGSC_v3.4146,959,890 - 6,960,054UniSTSRGSC3.4
Celera145,948,560 - 5,948,724UniSTS
RH 3.4 Map14115.6UniSTS
Cytogenetic Map14p22UniSTS
RH137860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,852,281 - 5,852,525 (+)MAPPERmRatBN7.2
Rnor_6.0147,213,982 - 7,214,225NCBIRnor6.0
Rnor_5.0147,203,899 - 7,204,142UniSTSRnor5.0
RGSC_v3.4147,002,587 - 7,002,830UniSTSRGSC3.4
Celera145,991,027 - 5,991,270UniSTS
RH 3.4 Map14115.7UniSTS
Cytogenetic Map14p22UniSTS
RH139108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,853,027 - 5,853,155 (+)MAPPERmRatBN7.2
Rnor_6.0147,214,728 - 7,214,855NCBIRnor6.0
Rnor_5.0147,204,645 - 7,204,772UniSTSRnor5.0
RGSC_v3.4147,003,333 - 7,003,460UniSTSRGSC3.4
Celera145,991,773 - 5,991,900UniSTS
RH 3.4 Map14116.4UniSTS
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 5 16 8 11 66 31 28 11 8
Low 2 43 52 41 3 41 8 4 13
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000003026   ⟹   ENSRNOP00000003026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,809,936 - 5,853,294 (+)Ensembl
Rnor_6.0 Ensembl147,169,519 - 7,215,025 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081600   ⟹   ENSRNOP00000070593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,807,907 - 5,853,294 (+)Ensembl
Rnor_6.0 Ensembl147,171,613 - 7,214,220 (+)Ensembl
RefSeq Acc Id: NM_001105995   ⟹   NP_001099465
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,112,489 - 6,158,001 (+)NCBI
mRatBN7.2145,807,813 - 5,853,325 (+)NCBI
Rnor_6.0147,169,519 - 7,215,025 (+)NCBI
Rnor_5.0147,159,371 - 7,204,942 (+)NCBI
RGSC_v3.4146,958,124 - 7,003,630 (+)RGD
Celera145,946,794 - 5,992,070 (+)RGD
Sequence:
RefSeq Acc Id: XM_008770004   ⟹   XP_008768226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,112,494 - 6,157,982 (+)NCBI
mRatBN7.2145,807,817 - 5,853,306 (+)NCBI
Rnor_6.0147,169,517 - 7,215,001 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008770005   ⟹   XP_008768227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,112,478 - 6,157,982 (+)NCBI
mRatBN7.2145,807,817 - 5,853,306 (+)NCBI
Rnor_6.0147,169,517 - 7,215,001 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008770006   ⟹   XP_008768228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,112,472 - 6,157,982 (+)NCBI
mRatBN7.2145,807,795 - 5,853,306 (+)NCBI
Rnor_6.0147,169,517 - 7,215,001 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063272895   ⟹   XP_063128965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,112,494 - 6,157,982 (+)NCBI
RefSeq Acc Id: XM_063272896   ⟹   XP_063128966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,112,494 - 6,157,982 (+)NCBI
RefSeq Acc Id: NP_001099465   ⟸   NM_001105995
- UniProtKB: A0A0G2JYB7 (UniProtKB/TrEMBL),   A6K5U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768226   ⟸   XM_008770004
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYB7 (UniProtKB/TrEMBL),   A6K5U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768227   ⟸   XM_008770005
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYB7 (UniProtKB/TrEMBL),   A6K5U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768228   ⟸   XM_008770006
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYB7 (UniProtKB/TrEMBL),   A6K5U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070593   ⟸   ENSRNOT00000081600
RefSeq Acc Id: ENSRNOP00000003026   ⟸   ENSRNOT00000003026
RefSeq Acc Id: XP_063128966   ⟸   XM_063272896
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYB7 (UniProtKB/TrEMBL),   A6K5U5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128965   ⟸   XM_063272895
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYB7 (UniProtKB/TrEMBL),   A6K5U5 (UniProtKB/TrEMBL)
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHE1-F1-model_v2 AlphaFold D3ZHE1 1-621 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304685 AgrOrtholog
BioCyc Gene G2FUF-16494 BioCyc
Ensembl Genes ENSRNOG00000002214 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003026.7 UniProtKB/TrEMBL
  ENSRNOT00000081600.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
KEGG Report rno:289457 UniProtKB/TrEMBL
NCBI Gene 289457 ENTREZGENE
PANTHER ACTIN-BINDING PROTEIN IPP UniProtKB/TrEMBL
  KELCH PROTEIN UniProtKB/TrEMBL
  KELCH-LIKE PROTEIN DIABLO UniProtKB/TrEMBL
  LD33804P UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PhenoGen Klhl8 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PRINTS KELCHREPEAT UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002214 RatGTEx
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
UniProt A0A0G2JYB7 ENTREZGENE, UniProtKB/TrEMBL
  A6K5U5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHE1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-06 Klhl8  kelch-like family member 8  Klhl8  kelch-like 8 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Klhl8  kelch-like 8 (Drosophila)   Klhl8_predicted  kelch-like 8 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Klhl8_predicted  kelch-like 8 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED