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Gene: Gdf1 (growth differentiation factor 1) Rattus norvegicus

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Symbol:

Gdf1

Name:

growth differentiation factor 1

RGD ID:

1304678

Description:

Predicted to enable cytokine activity. Involved in negative regulation of cardiac muscle hypertrophy. Predicted to be located in endoplasmic reticulum; extracellular region; and membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in congenital heart disease; multiple types of congenital heart defects 6; and right atrial isomerism. Orthologous to human GDF1 (growth differentiation factor 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

embryonic growth/differentiation factor 1; LOC306351

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GDF1 (growth differentiation factor 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gdf1 (growth differentiation factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GDF1 (growth differentiation factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GDF1 (growth differentiation factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gdf1 (growth differentiation factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GDF1 (growth differentiation factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GDF1 (growth differentiation factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gdf1 (growth differentiation factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gdf1 (growth differentiation factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GDF1 (growth differentiation factor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gdf1 (growth differentiation factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gdf3 (growth differentiation factor 3)	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gdf3	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gdf1	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	19,131,271 - 19,146,480 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	19,131,276 - 19,146,480 (-)	Ensembl				GRCr8
mRatBN7.2	16	19,097,309 - 19,112,519 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	19,097,314 - 19,112,519 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	19,137,150 - 19,152,310 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,269,455 - 20,284,820 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	19,190,111 - 19,205,271 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	16	19,266,239 - 19,281,603 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	16	19,139,186 - 19,154,549 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	16	19,133,148 - 19,148,511 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	16	19,275,991 - 19,291,268 (-)	NCBI		F344_StmMcwi
Rnor_6.0	16	20,845,580 - 20,860,789 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,845,576 - 20,860,767 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	20,698,122 - 20,712,564 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	19,580,807 - 19,596,415 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	19,287,577 - 19,302,834 (-)	NCBI		Celera
RGSC_v3.1	16	19,580,804 - 19,583,914 (-)	NCBI
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

annular pancreas (ISS)

Cardiomegaly (ISO)

congenital heart disease (ISO)

dextro-looped transposition of the great arteries (ISO)

dilated cardiomyopathy (ISO)

double outlet right ventricle (ISO)

liver cirrhosis (ISO)

multiple types of congenital heart defects 6 (ISO)

Myocardial Ischemia (ISO)

right atrial isomerism (ISO)

tetralogy of Fallot (ISO)

Ventricular Remodeling (ISO)

visceral heterotaxy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-amphetamine (ISO)

(S)-nicotine (ISO)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-naphthylamine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP)

cannabidiol (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP,ISO)

doxorubicin (ISO)

endosulfan (EXP)

folic acid (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

lead(0) (ISO)

N-acetyl-L-cysteine (EXP,ISO)

nicotine (ISO)

paracetamol (EXP)

permethrin (ISO)

picene (ISO)

potassium dichromate (ISO)

resveratrol (ISO)

sodium arsenite (EXP,ISO)

sunitinib (ISO)

testosterone (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to dithiothreitol (IEA)

cellular response to mycotoxin (IEA)

cellular response to UV-A (IEA)

cellular response to xenobiotic stimulus (IEA)

ceramide biosynthetic process (IEA)

endoderm development (ISO)

in utero embryonic development (ISO)

mesoderm development (ISO)

negative regulation of cardiac muscle hypertrophy (IMP)

negative regulation of D-glucose import across plasma membrane (IEA)

positive regulation of mitophagy (IEA)

signal transduction (ISO)

sphingolipid biosynthetic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

membrane (IEA)

Molecular Function

N-acyltransferase activity (IEA)

sphingosine N-acyltransferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction.	Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Low plasma growth/differentiation factor 1 levels are associated with liver fibrosis in patients with stable angina.	Hung WC, etal., J Clin Lab Anal. 2022 Nov;36(11):e24745. doi: 10.1002/jcla.24745. Epub 2022 Oct 21.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Association of growth/differentiation factor 1 gene polymorphisms with the risk of congenital heart disease in the Chinese Han population.	Sun X, etal., Mol Biol Rep. 2013 Feb;40(2):1291-9. doi: 10.1007/s11033-012-2172-0. Epub 2012 Oct 18.
9.	Association of GDF1 rs4808863 with fetal congenital heart defects: a case-control study.	Zhang J, etal., BMJ Open. 2015 Dec 11;5(12):e009352. doi: 10.1136/bmjopen-2015-009352.
10.	Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction.	Zhang Y, etal., Biochim Biophys Acta. 2014 Feb;1842(2):232-44. doi: 10.1016/j.bbadis.2013.11.018. Epub 2013 Nov 23.

Additional References at PubMed

PMID:12477932	PMID:17364820	PMID:17936261

Genomics

Comparative Map Data

Gdf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	19,131,271 - 19,146,480 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	19,131,276 - 19,146,480 (-)	Ensembl				GRCr8
mRatBN7.2	16	19,097,309 - 19,112,519 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	19,097,314 - 19,112,519 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	19,137,150 - 19,152,310 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,269,455 - 20,284,820 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	19,190,111 - 19,205,271 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	16	19,266,239 - 19,281,603 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	16	19,139,186 - 19,154,549 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	16	19,133,148 - 19,148,511 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	16	19,275,991 - 19,291,268 (-)	NCBI		F344_StmMcwi
Rnor_6.0	16	20,845,580 - 20,860,789 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,845,576 - 20,860,767 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	20,698,122 - 20,712,564 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	19,580,807 - 19,596,415 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	19,287,577 - 19,302,834 (-)	NCBI		Celera
RGSC_v3.1	16	19,580,804 - 19,583,914 (-)	NCBI
Cytogenetic Map	16	p14	NCBI

GDF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	18,868,545 - 18,896,158 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	18,868,545 - 18,896,158 (-)	Ensembl			hg38	GRCh38
GRCh37	19	18,979,354 - 19,006,967 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	18,840,354 - 18,842,116 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	18,840,353 - 18,867,953	NCBI
Celera	19	18,884,162 - 18,911,776 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	18,543,712 - 18,569,342 (-)	NCBI		HuRef
CHM1_1	19	18,979,170 - 19,006,647 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	19,004,162 - 19,031,781 (-)	NCBI		T2T-CHM13v2.0

Gdf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	70,768,425 - 70,784,242 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	70,768,425 - 70,784,242 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm39 Ensembl	8	70,768,437 - 70,784,237 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	70,315,775 - 70,331,592 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	70,315,775 - 70,331,592 (+)	Ensembl			mm10	GRCm38
GRCm38.p6 Ensembl	8	70,329,817 - 70,331,587 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	72,839,674 - 72,855,487 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	73,252,436 - 73,260,555 (+)	NCBI		MGSCv36	mm8
Celera	8	72,872,244 - 72,888,065 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.15	NCBI

GDF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	19	22,736,058 - 22,737,820 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	18,306,513 - 18,334,328 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	19,315,848 - 19,342,482 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	19,317,173 - 19,342,487 (-)	NCBI			panPan2	panpan1.1

GDF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	44,233,304 - 44,234,072 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	44,147,104 - 44,148,882 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	44,718,632 - 44,720,410 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	44,718,265 - 44,720,366 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	43,955,914 - 43,957,692 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	44,366,109 - 44,367,883 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	44,641,589 - 44,643,367 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gdf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	202,918,263 - 202,920,073 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	2,467,431 - 2,471,476 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	2,467,428 - 2,469,213 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GDF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	58,951,726 - 58,974,672 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	58,972,918 - 58,976,294 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	58,560,688 - 58,564,421 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GDF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	6	17,329,143 - 17,330,837 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666074	1,972,201 - 1,996,293 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gdf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	1,935,539 - 1,936,953 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624908	1,935,525 - 1,937,012 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gdf1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	12,585,191 - 12,588,304 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gdf1
54 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549842	Bp248	Blood pressure QTL 248		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	387123	45387123	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33425095	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39568015	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4234212	53708481	Rat
631517	Scl9	Serum cholesterol level QTL 9	3.3		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	16	15748006	25801629	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	4744222	49744222	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	1	26734272	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26734272	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	4354822	49354822	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	16	387123	45387123	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4234212	49757901	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4234212	66955197	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	16278184	27244292	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39568015	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	839086	66195506	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3386790	49757901	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3386790	26128267	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	839086	66195506	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	839086	66195506	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26734272	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17730818	72536785	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	839086	52786090	Rat
2301406	Kidm39	Kidney mass QTL 39		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	15905802	60905802	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	839086	66195506	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	3301683	48301683	Rat

Markers in Region

AI385651

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	19,097,350 - 19,097,450 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	20,845,622 - 20,845,721	NCBI	Rnor6.0
Rnor_5.0	16	20,698,164 - 20,698,263	UniSTS	Rnor5.0
RGSC_v3.4	16	19,580,849 - 19,580,948	UniSTS	RGSC3.4
Celera	16	19,287,619 - 19,287,718	UniSTS
Cytogenetic Map	16	p14	UniSTS

RH139099

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	19,097,348 - 19,097,496 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	20,845,620 - 20,845,767	NCBI	Rnor6.0
Rnor_5.0	16	20,698,162 - 20,698,309	UniSTS	Rnor5.0
RGSC_v3.4	16	19,580,847 - 19,580,994	UniSTS	RGSC3.4
Celera	16	19,287,617 - 19,287,764	UniSTS
RH 3.4 Map	16	233.4	UniSTS
Cytogenetic Map	16	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
8	12	29	78	38	41	22	81	22	220	131	11	69	51	51	19	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001044240	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128750	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ481538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027275 ⟹ ENSRNOP00000027275

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	20,845,576 - 20,860,767 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092417 ⟹ ENSRNOP00000075903

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	19,097,314 - 19,112,519 (-)	Ensembl

RefSeq Acc Id:

NM_001044240 ⟹ NP_001037705

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	19,131,271 - 19,146,480 (-)	NCBI
mRatBN7.2	16	19,097,309 - 19,112,519 (-)	NCBI
Dahl_SR_JrHsd	16	19,266,239 - 19,281,603 (-)	NCBI
Lyon_Normotensive	16	19,139,186 - 19,154,549 (-)	NCBI
Lyon_Hypertensive	16	19,133,148 - 19,148,511 (-)	NCBI
F344_StmMcwi	16	19,275,991 - 19,291,268 (-)	NCBI
Rnor_6.0	16	20,845,580 - 20,860,789 (-)	NCBI
Rnor_5.0	16	20,698,122 - 20,712,564 (-)	NCBI
RGSC_v3.4	16	19,580,807 - 19,596,415 (-)	RGD
Celera	16	19,287,577 - 19,302,834 (-)	RGD

Sequence:

show sequence

CAGCGGAGACCGCGGACGAGAGGGTAGCATGGCTGCTGCAGCGACGACCACCGGGCTCGAGGCG
CCAGAGCCCATGCCGAGTTATGCAGAGATGTTGCAACGAAGCTGGGCCTCGGCGCTGGCCGCAG
CACGGGGCTGCGGGGACTGCGGCTGGGGACTGGCGCGCCGCGGCCTGGCGGAGCACGCTCATCT
GGCTGCACCCGAGCTGCTGCTGGCCGTGCTCTGCGCTCTGGGGTGGACAGCGTTGCGCTCAGCA
GCCACCACGCGCATCTTTCGGCCCCTGGCCAAGCGGTGTCGCCTGCAGCCTAGAGACGCGGCTA
GGCTGCCTGAGAGTGCCTGGAAGCTTCTGTTCTACTTGGCCTGTTGGAGCTACTGTGCCTACCT
GCTCTTGGGCACCAGTTACCCTTTCTTCCATGACCCGCCCTCTGTCTTCTACGGCTGGAGGTCG
GGCATGGCGGTGCCCTGGGACATAGCGGTCGCCTACCTGCTGCAGGGGAGTTTCTACTGTCATT
CCGTCTATGCCACCGTGTACATGGACAGCTGGCGCAAGGACTCGGTGGTCATGCTGGTACACCA
TGTGGTCACCTTACTGCTCATCGCCTCTTCCTATGCGTTCCGATACCACAACGTGGGCCTCCTC
GTGTTCTTCCTGCATGACGTCAGCGATGTGCAGCTGGAGTTCACCAAGCTCAACATCTACTTCA
AGGCCAGGGGTGGCGCCTACCATCGATTGCACGGGCTGGTGGCCAACCTGGGCTGCCTCAGCTT
CTGCTTCTGCTGGTTCTGGTTCCGCCTCTACTGGTTCCCACTCAAGGTTCTCTATGCCACCTGG
CACTGCAGCCTGCAGTCTGTGCCTGACATTCCGTACTATTTCTTCTTCAACACTCTGCTGCTGC
TCCTCCTGGTCATGAACATCTACTGGTTCCTGTACATTGTGGCTTTTGCAGCCAAGGTGCTGAC
CGGTCAGATGCGTGAACTGGAAGACTTGCGGGAATACGACAGTCTGGAAGCGCAGACAGCCAAG
CCCTGCAGAGCTGAGAAGCCTCTAAGGAATGGCCTGGTGAAGGACAAACTCTTCTGAGTCTCTT
GTCCTCAACTCCCGCCATCCAGGACTCTGTCCCGTCCTACCTGGGATACTGGCCCCGCCCCTGG
AGACTGGACCCAGTCCCCGGAGGTCTGCTCCCACCCCTGGAGGCCTGGCCTCGCCTTTGGCGGC
ATGGCCACGCCTGCAGGACGATGGCCCCGCCCTAAGATGCAGGATGCCACCCTTCTCCAGGGAC
TCTGGCTGCCAGCAGCTCCGCCTTTCAGGTCAATTCTCGACCACCCACCTTGGGACCCAGCCCA
GTCCTGCCCTCTGGGTAAGTGGGGTCTGGACACGCCCCCTCCAGGACCTCAAAGCACCCTCGAC
CTACGGTCACCAGCCCACTGGTCCTGGACGCAGTGGACTCTGCTGACTCTCTTGGACACCGCCT
GGGAGGAAAATGCTCCCTGTCTGCCACCGTTTTTGCGACCACCTCCTCCTTCTGCTCTTGCTGC
CCTCAACGACCCTGGCCCACGCGCCAGCATCCTTGGGCCCCGCTGCCGCCCTGCTCCAGGTTCT
CGGGCTTCCCGAAACGCCCCGGAGCGTCCCCACACTCCGACCTGTGCCTCCTGTCATGTGGCGC
CTATTCCGCAGCCGCAACCCCCAGGAGGCCAGAGTGGGGCGCCCTCTGAAACCATGCCACGTGG
AGGAACTGGGGGTTGCCGGAAACATTGTGCGCCACATCCCCGACAGCGGTCTGTCCTCCAGGAT
CATACAGCCCGCCAGAACCTCAGGGCTGTGCCCCGAGTGGACCGTCGTCTTTGACCTGTCGAGC
GTGGAGCCCATAGAGCGCCCAACACGCGCGCGCCTAGAGTTGCGGCTGGAGGCTGAGAGCGAAG
ATACACGAGGGTGGGAGCTAAGCGTGGCGCTGTTGGCCGAGGCTGAGCATCCTGGGCCTGAGCT
ACTGCGCGTGCAGGCGCCACCCGGGCTGCCACTGCGCGCAGACCTACTGGGGACTGCAGTAGCG
GCTAACGCATCGGTGCCGCGCACTCTGCGCTTGGCGCTGGCGCTGCACCCTGGGGCCGCTGCAA
CCTGTGGGCGCCTGGCTGAGGCCTCGTTGCTGCTGGTGACGCTGGACCCACGCCTGTGTCCCTT
GCCGCGGTCACGGCGCCACACGGAGCCCAGGGTGGGAGGTGGTCCAGTGGGCACATGTCGCACC
CGACGGTTGCACGTGAGCTTCCGTGAGGTGGGCTGGCACCGCTGGGTGATTGCGCCGCGGGGCT
TTCTAGCCAACTTCTGCCAGGGCACGTGTGCGCTACCTGAAACACTGAGGGGACCCGGCGGGCC
GCCTGCACTTAACCACGCTGTGCTGCGCGCGCTCATGCACGCAGCTGCTCCCACCCCGGGTGTA
GGCTCGCCCTGCTGCGTGCCAGAGCGTCTGTCGCCTATCTCCGTGCTCTTCTTCGATAATAGTG
ACAACGTGGTGCTGCGCCACTACGAGGACATGGTGGTGGATGAGTGTGGCTGTCGCTGACCACC
CAGGACACCCTTTCAGGGACGGCCCCACGCGAAAAGCAGGGACCGTTTGTTCATGTTTTATTGG
TGACAAAAAGCTTAAAACAAATTTGACCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001037705	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABF19793	(Get FASTA)	NCBI Sequence Viewer
	EDL90679	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075903.3

RefSeq Acc Id:	NP_001037705 ⟸ NM_001044240
- Peptide Label:	precursor
- UniProtKB:	Q1HI69 (UniProtKB/TrEMBL), A6KA58 (UniProtKB/TrEMBL), A0A0U1RS23 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLPVCHRFCDHLLLLLLLPSTTLAHAPASLGPAAALLQVLGLPETPRSVPTLRPVPPVMWRLFR SRNPQEARVGRPLKPCHVEELGVAGNIVRHIPDSGLSSRIIQPARTSGLCPEWTVVFDLSSVEP IERPTRARLELRLEAESEDTRGWELSVALLAEAEHPGPELLRVQAPPGLPLRADLLGTAVAANA SVPRTLRLALALHPGAAATCGRLAEASLLLVTLDPRLCPLPRSRRHTEPRVGGGPVGTCRTRRL HVSFREVGWHRWVIAPRGFLANFCQGTCALPETLRGPGGPPALNHAVLRALMHAAAPTPGVGSP CCVPERLSPISVLFFDNSDNVVLRHYEDMVVDECGCR hide sequence

Ensembl Acc Id:

ENSRNOP00000027275 ⟸ ENSRNOT00000027275

Ensembl Acc Id:

ENSRNOP00000075903 ⟸ ENSRNOT00000092417

Protein Domains

TGF-beta family profile TLC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q1HI69-F1-model_v2	AlphaFold	Q1HI69	1-357	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304678	AgrOrtholog
BioCyc Gene	G2FUF-11772	BioCyc
Ensembl Genes	ENSRNOG00000020142	Ensembl
	ENSRNOG00000070518	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000092417.3	UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	Lag1/Lac1-like	UniProtKB/TrEMBL
	TGFb	UniProtKB/TrEMBL
	TGFb_CS	UniProtKB/TrEMBL
	TGFbeta	UniProtKB/TrEMBL
	TLC-dom	UniProtKB/TrEMBL
KEGG Report	rno:290658	UniProtKB/TrEMBL
	rno:306351	UniProtKB/TrEMBL
NCBI Gene	306351	ENTREZGENE
PANTHER	CERAMIDE SYNTHASE 1	UniProtKB/TrEMBL
	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1	UniProtKB/TrEMBL
	LONGEVITY ASSURANCE FACTOR 1 LAG1	UniProtKB/TrEMBL
	TGFbeta	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
	TRAM_LAG1_CLN8	UniProtKB/TrEMBL
PhenoGen	Gdf1	PhenoGen
PRINTS	INHIBINA	UniProtKB/TrEMBL
PROSITE	TGF_BETA_1	UniProtKB/TrEMBL
	TGF_BETA_2	UniProtKB/TrEMBL
	TLC	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020142	RatGTEx
	ENSRNOG00000070518	RatGTEx
SMART	TGFB	UniProtKB/TrEMBL
	TLC	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniProt	A0A0U1RS23	ENTREZGENE, UniProtKB/TrEMBL
	A6KA58	ENTREZGENE, UniProtKB/TrEMBL
	Q1HI69	ENTREZGENE
	Q1HL14_RAT	UniProtKB/TrEMBL
UniProt Secondary	Q1HI69	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Gdf1	growth differentiation factor 1	Gdf1_predicted	growth differentiation factor 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Gdf1_predicted	growth differentiation factor 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

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