Coq4 (coenzyme Q4) - Rat Genome Database

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Gene: Coq4 (coenzyme Q4) Rattus norvegicus
Analyze
Symbol: Coq4
Name: coenzyme Q4
RGD ID: 1304638
Description: Predicted to enable 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 7 and spastic ataxia. Orthologous to human COQ4 (coenzyme Q4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; chlormequat chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase; coenzyme Q biosynthesis protein 4 homolog; coenzyme Q4 homolog; coenzyme Q4 homolog (S. cerevisiae); coenzyme Q4 homolog (yeast); LOC366013; MGC116264; ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,457,834 - 33,468,387 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl333,457,596 - 33,468,379 (+)EnsemblGRCr8
mRatBN7.2313,060,054 - 13,070,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,060,455 - 13,068,799 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx316,135,246 - 16,143,579 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0324,720,207 - 24,728,540 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0322,971,360 - 22,979,697 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,349,386 - 8,357,719 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,349,185 - 8,357,871 (+)Ensemblrn6Rnor6.0
Rnor_5.0313,692,575 - 13,700,908 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.438,775,412 - 8,783,745 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera37,838,136 - 7,846,469 (+)NCBICelera
RGSC_v3.138,775,712 - 8,784,085 (+)NCBI
Cytogenetic Map3p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18614015   PMID:25152161  


Genomics

Comparative Map Data
Coq4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,457,834 - 33,468,387 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl333,457,596 - 33,468,379 (+)EnsemblGRCr8
mRatBN7.2313,060,054 - 13,070,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,060,455 - 13,068,799 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx316,135,246 - 16,143,579 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0324,720,207 - 24,728,540 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0322,971,360 - 22,979,697 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,349,386 - 8,357,719 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,349,185 - 8,357,871 (+)Ensemblrn6Rnor6.0
Rnor_5.0313,692,575 - 13,700,908 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.438,775,412 - 8,783,745 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera37,838,136 - 7,846,469 (+)NCBICelera
RGSC_v3.138,775,712 - 8,784,085 (+)NCBI
Cytogenetic Map3p12NCBI
COQ4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,322,839 - 128,334,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,322,515 - 128,334,072 (+)Ensemblhg38GRCh38
GRCh379131,085,118 - 131,096,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,124,636 - 130,136,172 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349128,164,368 - 128,175,905NCBI
Celera9101,735,695 - 101,747,255 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,697,662 - 100,709,174 (+)NCBIHuRef
CHM1_19131,235,826 - 131,247,386 (+)NCBICHM1_1
T2T-CHM13v2.09140,529,941 - 140,541,174 (+)NCBIT2T-CHM13v2.0
Coq4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39229,677,505 - 29,687,947 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl229,677,505 - 29,687,947 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38229,787,493 - 29,797,935 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl229,787,493 - 29,797,935 (+)Ensemblmm10GRCm38
MGSCv37229,643,783 - 29,653,263 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36229,610,272 - 29,619,752 (+)NCBIMGSCv36mm8
Celera229,495,338 - 29,504,818 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map220.62NCBI
Coq4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955570837,216 - 846,653 (+)Ensembl
ChiLan1.0NW_004955570837,216 - 846,653 (+)NCBIChiLan1.0ChiLan1.0
COQ4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,017,109 - 11,029,707 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,019,458 - 11,032,056 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,444,414 - 99,457,281 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19128,111,957 - 128,124,918 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,111,957 - 128,124,918 (+)EnsemblpanPan2panpan1.1
COQ4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,182,919 - 55,194,048 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,183,354 - 55,194,006 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha954,378,354 - 54,389,250 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0956,105,495 - 56,116,394 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,104,611 - 56,116,046 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1954,865,091 - 54,876,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,179,328 - 55,190,227 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,271,260 - 55,282,157 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
COQ4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,756,685 - 268,768,343 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11268,756,690 - 268,768,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,747,002 - 302,758,980 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COQ4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,796,284 - 9,808,156 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,796,693 - 9,807,778 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660796,427,970 - 6,439,513 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Coq4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247606,548,228 - 6,557,212 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247606,545,040 - 6,557,291 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Coq4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v156,937,339 - 6,945,501 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Coq4
45 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000038602
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH131626  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,068,600 - 13,068,782 (+)MAPPERmRatBN7.2
Rnor_6.038,357,516 - 8,357,697NCBIRnor6.0
Rnor_5.0313,700,705 - 13,700,886UniSTSRnor5.0
RGSC_v3.438,783,542 - 8,783,723UniSTSRGSC3.4
Celera37,846,266 - 7,846,447UniSTS
RH 3.4 Map20493.62UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 89 59 6 353 189 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000038602   ⟹   ENSRNOP00000038869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl333,457,596 - 33,468,379 (+)Ensembl
mRatBN7.2 Ensembl313,060,455 - 13,068,799 (+)Ensembl
Rnor_6.0 Ensembl38,349,185 - 8,357,871 (+)Ensembl
RefSeq Acc Id: NM_001031662   ⟹   NP_001026832
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,458,352 - 33,466,685 (+)NCBI
mRatBN7.2313,060,471 - 13,068,804 (+)NCBI
Rnor_6.038,349,386 - 8,357,719 (+)NCBI
Rnor_5.0313,692,575 - 13,700,908 (+)NCBI
RGSC_v3.438,775,412 - 8,783,745 (+)RGD
Celera37,838,136 - 7,846,469 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105582   ⟹   XP_038961510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,458,289 - 33,468,387 (+)NCBI
mRatBN7.2313,060,054 - 13,070,502 (+)NCBI
RefSeq Acc Id: XM_063284260   ⟹   XP_063140330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,457,834 - 33,468,387 (+)NCBI
RefSeq Acc Id: XR_010064672
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,458,289 - 33,468,387 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001026832 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961510 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140330 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99123 (Get FASTA)   NCBI Sequence Viewer  
  EDL93374 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038869
GenBank Protein Q4FZU1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001026832   ⟸   NM_001031662
- Peptide Label: precursor
- UniProtKB: Q4FZU1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038869   ⟸   ENSRNOT00000038602
RefSeq Acc Id: XP_038961510   ⟸   XM_039105582
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140330   ⟸   XM_063284260
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHW2 (UniProtKB/TrEMBL),   A6JTS3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZU1-F1-model_v2 AlphaFold Q4FZU1 1-265 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304638 AgrOrtholog
BioCyc Gene G2FUF-50254 BioCyc
Ensembl Genes ENSRNOG00000026691 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000038602 ENTREZGENE
IMAGE_CLONE IMAGE:7462864 IMAGE-MGC_LOAD
InterPro Coq4 UniProtKB/Swiss-Prot
  Coq4_euk UniProtKB/Swiss-Prot
KEGG Report rno:366013 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116264 IMAGE-MGC_LOAD
NCBI Gene 366013 ENTREZGENE
PANTHER PTHR12922 UniProtKB/Swiss-Prot
  UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Coq4 UniProtKB/Swiss-Prot
PhenoGen Coq4 PhenoGen
RatGTEx ENSRNOG00000026691 RatGTEx
UniProt A0A0H2UHW2 ENTREZGENE, UniProtKB/TrEMBL
  A6JTS3 ENTREZGENE, UniProtKB/TrEMBL
  COQ4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Coq4  coenzyme Q4  Coq4  coenzyme Q4 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-15 Coq4  coenzyme Q4 homolog (S. cerevisiae)  Coq4  coenzyme Q4 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Coq4  coenzyme Q4 homolog (yeast)  Coq4_predicted  coenzyme Q4 homolog (yeast) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Coq4_predicted  coenzyme Q4 homolog (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED