Cgnl1 (cingulin-like 1) - Rat Genome Database

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Gene: Cgnl1 (cingulin-like 1) Rattus norvegicus
Analyze
Symbol: Cgnl1
Name: cingulin-like 1
RGD ID: 1304623
Description: Predicted to be involved in several processes, including negative regulation of small GTPase mediated signal transduction; negative regulation of stress fiber assembly; and protein localization to cell-cell junction. Predicted to be located in actin cytoskeleton and apical junction complex. Predicted to be part of protein-containing complex. Predicted to be active in bicellular tight junction. Orthologous to human CGNL1 (cingulin like 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cingulin-like protein 1; LOC315795; RGD1304623; similar to KIAA1749 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Cgnl1em1Mcwi ; Cgnl1em2Mcwi
Genetic Models: SS-Cgnl1em2Mcwi ; SS-Cgnl1em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8881,154,169 - 81,305,598 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl881,140,091 - 81,305,747 (-)EnsemblGRCr8
mRatBN7.2872,273,401 - 72,424,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl872,275,645 - 72,422,917 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx877,808,961 - 77,960,269 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0876,081,914 - 76,233,225 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0873,918,974 - 74,070,291 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0878,126,670 - 78,278,490 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl878,126,675 - 78,233,430 (-)Ensemblrn6Rnor6.0
Rnor_5.0874,800,532 - 74,950,938 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4876,088,865 - 76,241,145 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera869,312,951 - 69,461,916 (+)NCBICelera
RGSC_v3.1876,110,699 - 76,262,082 (-)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
L-methionine  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
p-toluidine  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15292197   PMID:21454477   PMID:22891260   PMID:22946046   PMID:25753039   PMID:33450132  


Genomics

Comparative Map Data
Cgnl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8881,154,169 - 81,305,598 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl881,140,091 - 81,305,747 (-)EnsemblGRCr8
mRatBN7.2872,273,401 - 72,424,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl872,275,645 - 72,422,917 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx877,808,961 - 77,960,269 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0876,081,914 - 76,233,225 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0873,918,974 - 74,070,291 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0878,126,670 - 78,278,490 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl878,126,675 - 78,233,430 (-)Ensemblrn6Rnor6.0
Rnor_5.0874,800,532 - 74,950,938 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4876,088,865 - 76,241,145 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera869,312,951 - 69,461,916 (+)NCBICelera
RGSC_v3.1876,110,699 - 76,262,082 (-)NCBI
Cytogenetic Map8q24NCBI
CGNL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381557,376,505 - 57,550,717 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1557,375,967 - 57,550,729 (+)Ensemblhg38GRCh38
GRCh371557,668,703 - 57,842,915 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361555,455,997 - 55,630,213 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341555,455,996 - 55,630,212NCBI
Celera1534,620,494 - 34,733,233 (+)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1534,536,943 - 34,666,534 (+)NCBIHuRef
CHM1_11557,786,868 - 57,961,094 (+)NCBICHM1_1
T2T-CHM13v2.01555,179,333 - 55,353,561 (+)NCBIT2T-CHM13v2.0
Cgnl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39971,533,789 - 71,716,582 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl971,533,791 - 71,678,884 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38971,626,507 - 71,809,300 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl971,626,509 - 71,771,602 (-)Ensemblmm10GRCm38
MGSCv37971,474,316 - 71,619,409 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36971,425,069 - 71,570,162 (-)NCBIMGSCv36mm8
MGSCv36972,265,136 - 72,410,893 (-)NCBIMGSCv36mm8
Celera968,818,887 - 68,967,230 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.85NCBI
Cgnl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545016,785,080 - 16,871,515 (-)Ensembl
ChiLan1.0NW_00495545016,785,358 - 16,913,718 (-)NCBIChiLan1.0ChiLan1.0
CGNL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21646,638,258 - 46,812,295 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11550,821,297 - 50,997,194 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01536,344,222 - 36,518,235 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11554,667,307 - 54,831,599 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1554,669,190 - 54,831,595 (+)EnsemblpanPan2panpan1.1
CGNL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13022,529,971 - 22,715,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3022,612,828 - 22,718,493 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3022,503,175 - 22,689,219 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03022,688,805 - 22,875,699 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3022,709,861 - 22,878,414 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13022,622,133 - 22,808,317 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03022,707,102 - 22,893,487 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03022,868,510 - 23,034,696 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cgnl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640100,806,405 - 100,963,332 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647118,654,426 - 18,812,846 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647118,654,485 - 18,811,395 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CGNL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1114,424,151 - 114,598,823 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11114,424,148 - 114,628,331 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21126,547,248 - 126,629,202 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CGNL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12625,957,184 - 26,130,867 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2625,956,942 - 26,067,530 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048115,199,655 - 115,356,715 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cgnl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478114,215,723 - 14,357,705 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478114,215,252 - 14,357,705 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cgnl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1865,918,398 - 66,068,814 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cgnl1
1170 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:93
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000023458
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat

Markers in Region
D8Rat31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2872,305,712 - 72,305,951 (+)MAPPERmRatBN7.2
Rnor_6.0878,158,986 - 78,159,224NCBIRnor6.0
Rnor_5.0874,918,384 - 74,918,622UniSTSRnor5.0
RGSC_v3.4876,121,178 - 76,121,417RGDRGSC3.4
RGSC_v3.4876,121,179 - 76,121,417UniSTSRGSC3.4
Celera869,429,341 - 69,429,597UniSTS
RGSC_v3.1876,140,232 - 76,140,471RGD
RH 2.0 Map8697.8RGD
SHRSP x BN Map844.82RGD
Cytogenetic Map8q24UniSTS
D8Rat182  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8881,190,251 - 81,190,465 (+)Marker Load Pipeline
mRatBN7.2872,309,483 - 72,309,697 (+)MAPPERmRatBN7.2
Rnor_6.0878,162,757 - 78,162,970NCBIRnor6.0
Rnor_5.0874,914,261 - 74,914,474UniSTSRnor5.0
RGSC_v3.4876,125,326 - 76,125,540RGDRGSC3.4
RGSC_v3.4876,125,327 - 76,125,540UniSTSRGSC3.4
Celera869,425,595 - 69,425,808UniSTS
RGSC_v3.1876,144,380 - 76,144,594RGD
SHRSP x BN Map844.82UniSTS
SHRSP x BN Map844.82RGD
Cytogenetic Map8q24UniSTS
D8Got113  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2872,393,254 - 72,393,459 (+)MAPPERmRatBN7.2
Rnor_6.0878,246,878 - 78,247,082NCBIRnor6.0
Rnor_5.0874,831,485 - 74,831,689UniSTSRnor5.0
RGSC_v3.4876,209,722 - 76,209,927RGDRGSC3.4
RGSC_v3.4876,209,723 - 76,209,927UniSTSRGSC3.4
Celera869,342,261 - 69,342,465UniSTS
RGSC_v3.1876,228,776 - 76,228,981RGD
RH 2.0 Map8704.1RGD
Cytogenetic Map8q24UniSTS
RH128265  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2872,273,605 - 72,273,793 (+)MAPPERmRatBN7.2
Rnor_6.0878,126,875 - 78,127,062NCBIRnor6.0
Rnor_5.0874,950,546 - 74,950,733UniSTSRnor5.0
RGSC_v3.4876,089,068 - 76,089,255UniSTSRGSC3.4
Celera869,461,526 - 69,461,713UniSTS
Cytogenetic Map8q24UniSTS
RH138622  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2872,309,952 - 72,310,113 (+)MAPPERmRatBN7.2
Rnor_6.0878,163,226 - 78,163,386NCBIRnor6.0
Rnor_5.0874,913,845 - 74,914,005UniSTSRnor5.0
RGSC_v3.4876,125,796 - 76,125,956UniSTSRGSC3.4
Celera869,425,179 - 69,425,339UniSTS
Cytogenetic Map8q24UniSTS
AU048682  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2872,392,744 - 72,393,040 (+)MAPPERmRatBN7.2
Rnor_6.0878,246,368 - 78,246,663NCBIRnor6.0
Rnor_5.0874,831,904 - 74,832,199UniSTSRnor5.0
RGSC_v3.4876,209,213 - 76,209,508UniSTSRGSC3.4
Celera869,342,680 - 69,342,975UniSTS
Cytogenetic Map8q24UniSTS
AU049335  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2872,360,744 - 72,360,882 (+)MAPPERmRatBN7.2
Rnor_6.0878,214,034 - 78,214,171NCBIRnor6.0
Rnor_5.0874,863,742 - 74,863,879UniSTSRnor5.0
RGSC_v3.4876,177,071 - 76,177,208UniSTSRGSC3.4
Celera869,374,639 - 69,374,776UniSTS
Cytogenetic Map8q24UniSTS
Cgnl1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2872,276,226 - 72,277,457 (+)MAPPERmRatBN7.2
Rnor_6.0878,129,496 - 78,130,726NCBIRnor6.0
Rnor_5.0874,946,882 - 74,948,112UniSTSRnor5.0
RGSC_v3.4876,091,689 - 76,092,919UniSTSRGSC3.4
Celera869,457,867 - 69,459,104UniSTS
Cytogenetic Map8q24UniSTS


Genetic Models
This gene Cgnl1 is modified in the following models/strains:
SS-Cgnl1em2Mcwi     SS-Cgnl1em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 48 59 6 312 148 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083220   ⟹   ENSRNOP00000070756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl881,140,091 - 81,305,597 (-)Ensembl
mRatBN7.2 Ensembl872,275,645 - 72,422,917 (-)Ensembl
Rnor_6.0 Ensembl878,126,675 - 78,233,430 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101468   ⟹   ENSRNOP00000095834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl881,154,169 - 81,305,597 (-)Ensembl
mRatBN7.2 Ensembl872,275,645 - 72,422,917 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113297   ⟹   ENSRNOP00000080091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl881,154,169 - 81,305,597 (-)Ensembl
mRatBN7.2 Ensembl872,275,645 - 72,422,917 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131419   ⟹   ENSRNOP00000106701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl881,154,169 - 81,305,597 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165694   ⟹   ENSRNOP00000103389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl881,154,169 - 81,305,747 (-)Ensembl
RefSeq Acc Id: NM_001108164   ⟹   NP_001101634
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8881,154,169 - 81,305,597 (-)NCBI
mRatBN7.2872,273,401 - 72,424,842 (-)NCBI
Rnor_6.0878,126,672 - 78,276,554 (-)NCBI
Rnor_5.0874,800,532 - 74,950,938 (+)NCBI
RGSC_v3.4876,088,865 - 76,241,145 (-)RGD
Celera869,312,951 - 69,461,916 (+)RGD
Sequence:
RefSeq Acc Id: NM_001389277   ⟹   NP_001376206
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8881,154,169 - 81,305,597 (-)NCBI
mRatBN7.2872,273,401 - 72,424,842 (-)NCBI
RefSeq Acc Id: XM_008766286   ⟹   XP_008764508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8881,154,169 - 81,305,598 (-)NCBI
mRatBN7.2872,273,401 - 72,424,706 (-)NCBI
Rnor_6.0878,126,670 - 78,278,377 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081510   ⟹   XP_038937438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8881,154,169 - 81,279,011 (-)NCBI
mRatBN7.2872,273,401 - 72,398,423 (-)NCBI
RefSeq Acc Id: XM_039081511   ⟹   XP_038937439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8881,154,169 - 81,257,118 (-)NCBI
mRatBN7.2872,273,401 - 72,376,374 (-)NCBI
RefSeq Acc Id: NP_001101634   ⟸   NM_001108164
- UniProtKB: D4A3V5 (UniProtKB/TrEMBL),   A6KEQ6 (UniProtKB/TrEMBL),   A0A8I6AMD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764508   ⟸   XM_008766286
- Peptide Label: isoform X1
- UniProtKB: D4A3V5 (UniProtKB/TrEMBL),   A6KEQ6 (UniProtKB/TrEMBL),   A0A8I6AMD9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070756   ⟸   ENSRNOT00000083220
RefSeq Acc Id: NP_001376206   ⟸   NM_001389277
- UniProtKB: D4A3V5 (UniProtKB/TrEMBL),   A6KEQ6 (UniProtKB/TrEMBL),   A0A8I6AMD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937438   ⟸   XM_039081510
- Peptide Label: isoform X1
- UniProtKB: D4A3V5 (UniProtKB/TrEMBL),   A6KEQ6 (UniProtKB/TrEMBL),   A0A8I6AMD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937439   ⟸   XM_039081511
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000080091   ⟸   ENSRNOT00000113297
Ensembl Acc Id: ENSRNOP00000095834   ⟸   ENSRNOT00000101468
Ensembl Acc Id: ENSRNOP00000103389   ⟸   ENSRNOT00000165694
Ensembl Acc Id: ENSRNOP00000106701   ⟸   ENSRNOT00000131419
Protein Domains
Myosin tail

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3V5-F1-model_v2 AlphaFold D4A3V5 1-1292 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304623 AgrOrtholog
BioCyc Gene G2FUF-29896 BioCyc
Ensembl Genes ENSRNOG00000054080 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083220.3 UniProtKB/TrEMBL
  ENSRNOT00000101468.2 UniProtKB/TrEMBL
  ENSRNOT00000113297.2 UniProtKB/TrEMBL
  ENSRNOT00000131419 ENTREZGENE
  ENSRNOT00000131419.1 UniProtKB/TrEMBL
  ENSRNOT00000165694 ENTREZGENE
  ENSRNOT00000165694.1 UniProtKB/TrEMBL
InterPro Myosin_tail UniProtKB/TrEMBL
KEGG Report rno:315795 UniProtKB/TrEMBL
NCBI Gene 315795 ENTREZGENE
PANTHER CINGULIN-LIKE PROTEIN 1 UniProtKB/TrEMBL
  CINGULIN-LIKE PROTEIN 1-RELATED UniProtKB/TrEMBL
Pfam Myosin_tail_1 UniProtKB/TrEMBL
PhenoGen Cgnl1 PhenoGen
RatGTEx ENSRNOG00000054080 RatGTEx
UniProt A0A8I5ZPI5_RAT UniProtKB/TrEMBL
  A0A8I6AMD9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LKA5_RAT UniProtKB/TrEMBL
  A0ABK0LNX5_RAT UniProtKB/TrEMBL
  A6KEQ6 ENTREZGENE, UniProtKB/TrEMBL
  D4A3V5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Cgnl1  cingulin-like 1  RGD1304623_predicted  similar to KIAA1749 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1304623_predicted  similar to KIAA1749 protein (predicted)  LOC315795_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC315795_predicted  similar to KIAA1749 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL