Ago4 (argonaute RISC component 4) - Rat Genome Database

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Gene: Ago4 (argonaute RISC component 4) Rattus norvegicus
Analyze
Symbol: Ago4
Name: argonaute RISC component 4
RGD ID: 1304583
Description: Predicted to enable RNA binding activity and RNA endonuclease activity. Predicted to be involved in negative regulation of gene expression. Predicted to act upstream of or within several processes, including male gonad development; meiotic nuclear division; and miRNA metabolic process. Predicted to be located in P-body. Predicted to be part of RISC complex and RISC-loading complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human AGO4 (argonaute RISC component 4); PARTICIPATES IN microRNA pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: argonaute 4, RISC catalytic component; argonaute RISC catalytic component 4; Eif2c4; eukaryotic translation initiation factor 2C, 4; LOC102554576; LOC298533; protein argonaute-4; protein argonaute-4-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,064,949 - 144,110,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5144,064,949 - 144,110,402 (-)EnsemblGRCr8
mRatBN7.25138,780,446 - 138,825,898 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5138,783,069 - 138,825,632 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5141,477,953 - 141,523,412 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,247,944 - 143,293,406 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,248,730 - 143,294,206 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05144,501,875 - 144,557,165 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,504,938 - 144,556,889 (-)Ensemblrn6Rnor6.0
Rnor_5.05148,269,991 - 148,328,500 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45145,857,594 - 145,902,950 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5137,279,250 - 137,322,143 (-)NCBICelera
RGSC_v3.15145,866,645 - 145,932,628 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
fonofos  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (ISO)
pentanal  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
terbufos  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytoplasmic ribonucleoprotein granule  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)
P-body  (IEA,ISO)
ribonucleoprotein complex  (IEA)
RISC complex  (IBA,IEA,ISO)
RISC-loading complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Argonaute proteins at a glance. Ender C and Meister G, J Cell Sci. 2010 Jun 1;123(Pt 11):1819-23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:15260970   PMID:18771919   PMID:19536157   PMID:19898466   PMID:19946888   PMID:19966796   PMID:22795694   PMID:22863743  


Genomics

Comparative Map Data
Ago4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,064,949 - 144,110,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5144,064,949 - 144,110,402 (-)EnsemblGRCr8
mRatBN7.25138,780,446 - 138,825,898 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5138,783,069 - 138,825,632 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5141,477,953 - 141,523,412 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,247,944 - 143,293,406 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,248,730 - 143,294,206 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05144,501,875 - 144,557,165 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,504,938 - 144,556,889 (-)Ensemblrn6Rnor6.0
Rnor_5.05148,269,991 - 148,328,500 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45145,857,594 - 145,902,950 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5137,279,250 - 137,322,143 (-)NCBICelera
RGSC_v3.15145,866,645 - 145,932,628 (-)NCBI
Cytogenetic Map5q36NCBI
AGO4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38135,807,636 - 35,857,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl135,808,016 - 35,857,890 (+)Ensemblhg38GRCh38
GRCh37136,273,237 - 36,323,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,046,415 - 36,093,775 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34135,942,920 - 35,990,281NCBI
Celera134,548,288 - 34,595,633 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef134,391,417 - 34,441,140 (+)NCBIHuRef
CHM1_1136,390,239 - 36,439,851 (+)NCBICHM1_1
T2T-CHM13v2.0135,670,525 - 35,720,783 (+)NCBIT2T-CHM13v2.0
Ago4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394126,383,280 - 126,427,379 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4126,383,334 - 126,427,265 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384126,489,487 - 126,533,586 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,489,541 - 126,533,472 (-)Ensemblmm10GRCm38
MGSCv374126,166,785 - 126,210,702 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364125,994,456 - 126,035,544 (-)NCBIMGSCv36mm8
Celera4124,826,342 - 124,870,087 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map460.9NCBI
Ago4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545213,882,416 - 13,922,590 (+)Ensembl
ChiLan1.0NW_00495545213,882,416 - 13,922,590 (+)NCBIChiLan1.0ChiLan1.0
LOC100977537
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21190,990,660 - 191,040,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,111,850 - 190,161,908 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,072,045 - 35,122,418 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1136,249,040 - 36,299,259 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl136,249,038 - 36,299,259 (+)EnsemblpanPan2panpan1.1
AGO4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,325,899 - 6,351,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,329,413 - 6,356,676 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha156,569,069 - 6,608,633 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0156,462,261 - 6,501,884 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl156,281,474 - 6,502,020 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,315,003 - 6,354,575 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,383,741 - 6,423,313 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,398,098 - 6,437,686 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ago4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505852,510,754 - 52,548,926 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647418,335,531 - 18,370,077 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647418,335,536 - 18,371,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGO4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl691,973,119 - 92,012,990 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1691,967,499 - 92,013,030 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2685,255,835 - 85,296,920 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103225126
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12097,001,484 - 97,056,131 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2097,003,566 - 97,056,051 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603319,672,650 - 19,725,326 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ago4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476418,838,920 - 18,883,894 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476418,838,887 - 18,883,915 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ago4
326 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:376
Count of miRNA genes:210
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000035373
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000035373   ⟹   ENSRNOP00000029180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5144,064,949 - 144,110,402 (-)Ensembl
mRatBN7.2 Ensembl5138,783,069 - 138,825,632 (-)Ensembl
Rnor_6.0 Ensembl5144,504,938 - 144,556,889 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl119,638,520 - 19,640,329 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl119,638,106 - 19,640,329 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl119,638,520 - 19,640,329 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102420   ⟹   ENSRNOP00000082106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5138,783,069 - 138,816,719 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107462   ⟹   ENSRNOP00000077417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5144,064,949 - 144,110,402 (-)Ensembl
mRatBN7.2 Ensembl5138,783,069 - 138,825,632 (-)Ensembl
RefSeq Acc Id: NM_001394371   ⟹   NP_001381300
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,064,949 - 144,110,402 (-)NCBI
mRatBN7.25138,780,446 - 138,825,898 (-)NCBI
RefSeq Acc Id: XM_039109632   ⟹   XP_038965560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,064,949 - 144,110,155 (-)NCBI
mRatBN7.25138,780,450 - 138,825,889 (-)NCBI
RefSeq Acc Id: XM_063287441   ⟹   XP_063143511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,064,949 - 144,110,422 (-)NCBI
RefSeq Acc Id: XM_063287442   ⟹   XP_063143512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,080,283 - 144,110,155 (-)NCBI
RefSeq Acc Id: XM_063287443   ⟹   XP_063143513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,085,501 - 144,110,155 (-)NCBI
RefSeq Acc Id: XM_063287444   ⟹   XP_063143514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,064,949 - 144,087,464 (-)NCBI
Ensembl Acc Id: ENSRNOP00000029180   ⟸   ENSRNOT00000035373
RefSeq Acc Id: XP_038965560   ⟸   XM_039109632
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y5S8 (UniProtKB/TrEMBL),   A0A8I5ZTW0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082106   ⟸   ENSRNOT00000102420
Ensembl Acc Id: ENSRNOP00000077417   ⟸   ENSRNOT00000107462
RefSeq Acc Id: NP_001381300   ⟸   NM_001394371
- UniProtKB: F1LUQ5 (UniProtKB/TrEMBL),   A0A8I5ZTW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143511   ⟸   XM_063287441
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZTW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143514   ⟸   XM_063287444
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063143512   ⟸   XM_063287442
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063143513   ⟸   XM_063287443
- Peptide Label: isoform X4
Protein Domains
PAZ   Piwi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LUQ5-F1-model_v2 AlphaFold F1LUQ5 1-597 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304583 AgrOrtholog
BioCyc Gene G2FUF-39886 BioCyc
Ensembl Genes ENSRNOG00000025596 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000051380 Ensembl
Ensembl Transcript ENSRNOT00000035373 ENTREZGENE
  ENSRNOT00000035373.7 UniProtKB/TrEMBL
  ENSRNOT00000107462 ENTREZGENE
  ENSRNOT00000107462.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
  paz domain UniProtKB/TrEMBL
InterPro AGO4 UniProtKB/TrEMBL
  ArgoL1 UniProtKB/TrEMBL
  ArgoL2 UniProtKB/TrEMBL
  Argonaute_Mid_dom UniProtKB/TrEMBL
  Argonaute_N UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  PAZ_dom_sf UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
  Piwi_ago-like UniProtKB/TrEMBL
  RNaseH-like UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
NCBI Gene 298533 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/TrEMBL
Pfam ArgoL1 UniProtKB/TrEMBL
  ArgoL2 UniProtKB/TrEMBL
  ArgoMid UniProtKB/TrEMBL
  ArgoN UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
PhenoGen Ago4 PhenoGen
PROSITE PAZ UniProtKB/TrEMBL
  PIWI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025596 RatGTEx
  ENSRNOG00000051380 RatGTEx
SMART DUF1785 UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
Superfamily-SCOP PAZ UniProtKB/TrEMBL
  RNaseH_fold UniProtKB/TrEMBL
UniProt A0A8I5Y5S8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTW0 ENTREZGENE
  F1LUQ5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ago4  argonaute RISC component 4  LOC102554576  protein argonaute-4-like  Data merged from RGD:7706370 737654 PROVISIONAL
2019-03-26 Ago4  argonaute RISC component 4  Ago4  argonaute RISC catalytic component 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-12-04 Ago4  argonaute RISC catalytic component 4  Ago4  argonaute 4, RISC catalytic component  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 Ago4  argonaute 4, RISC catalytic component  Ago4  argonaute RISC catalytic component 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102554576  protein argonaute-4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-03-13 Ago4  argonaute RISC catalytic component 4  Eif2c4  eukaryotic translation initiation factor 2C, 4  Name and Symbol changed 629549 APPROVED
2008-04-30 Eif2c4  eukaryotic translation initiation factor 2C, 4   Eif2c4_predicted  eukaryotic translation initiation factor 2C, 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Eif2c4_predicted  eukaryotic translation initiation factor 2C, 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED