Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Chchd6 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CHCHD6 mRNA | CTD | PMID:36331819 | 1,2-dichloroethane | decreases expression | ISO | Chchd6 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of CHCHD6 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | ISO | Chchd6 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CHCHD6 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Chchd6 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of CHCHD6 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | Chchd6 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHCHD6 mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of CHCHD6 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Chchd6 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHCHD6 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CHCHD6 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Chchd6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CHCHD6 mRNA | CTD | PMID:21570461 | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of CHCHD6 mRNA | CTD | PMID:21346803 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of CHCHD6 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of CHCHD6 mRNA | CTD | PMID:21346803 | 2-amino-4,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2-amino-4 and 6-dinitrotoluene affects the expression of CHCHD6 mRNA | CTD | PMID:21346803 | 3H-1,2-dithiole-3-thione | increases expression | EXP | | 6480464 | 1 and 2-dithiol-3-thione results in increased expression of CHCHD6 mRNA | CTD | PMID:19162173 | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of CHCHD6 mRNA | CTD | PMID:21346803 | 7,12-dimethyltetraphene | decreases expression | ISO | Chchd6 (Mus musculus) | 6480464 | 9 more ... | CTD | PMID:32553695 | acrolein | multiple interactions | ISO | CHCHD6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CHCHD6 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CHCHD6 mRNA | CTD | PMID:32699268 | aflatoxin B1 | decreases expression | ISO | Chchd6 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of CHCHD6 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | CHCHD6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of CHCHD6 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | CHCHD6 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of CHCHD6 intron | CTD | PMID:30157460 | alpha-pinene | multiple interactions | ISO | CHCHD6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CHCHD6 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CHCHD6 mRNA | CTD | PMID:32699268 | aristolochic acid A | decreases expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of CHCHD6 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | decreases expression | ISO | Chchd6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of CHCHD6 mRNA | CTD | PMID:19770486 and PMID:21715664 | benzo[a]pyrene | decreases methylation | ISO | CHCHD6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of CHCHD6 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | CHCHD6 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of CHCHD6 intron and Benzo(a)pyrene affects the methylation of CHCHD6 promoter | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | decreases expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of CHCHD6 mRNA | CTD | PMID:20064835 and PMID:26238291 | benzo[a]pyrene | multiple interactions | ISO | Chchd6 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CHCHD6 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | Chchd6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of CHCHD6 mRNA | CTD | PMID:22228805 | benzo[e]pyrene | increases methylation | ISO | CHCHD6 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of CHCHD6 intron | CTD | PMID:30157460 | beta-naphthoflavone | decreases expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | beta-Naphthoflavone results in decreased expression of CHCHD6 mRNA | CTD | PMID:32858204 | bis(2-chloroethyl) sulfide | decreases expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | Mustard Gas results in decreased expression of CHCHD6 mRNA | CTD | PMID:25102026 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CHCHD6 mRNA | CTD | PMID:25181051 | bisphenol A | decreases methylation | ISO | CHCHD6 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of CHCHD6 gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | ISO | CHCHD6 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of CHCHD6 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CHCHD6 mRNA | CTD | PMID:32145629 and PMID:34947998 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of CHCHD6 gene | CTD | PMID:28505145 | carbon nanotube | increases expression | ISO | Chchd6 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | carbon nanotube | decreases expression | ISO | Chchd6 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of CHCHD6 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | CHCHD6 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CHCHD6 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | ISO | Chchd6 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of CHCHD6 mRNA | CTD | PMID:32715474 | chromium(6+) | affects expression | ISO | Chchd6 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of CHCHD6 mRNA | CTD | PMID:28472532 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of CHCHD6 mRNA | CTD | PMID:22023808 | cisplatin | multiple interactions | ISO | CHCHD6 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of CHCHD6 mRNA | CTD | PMID:27392435 | cisplatin | decreases expression | ISO | Chchd6 (Mus musculus) | 6480464 | Cisplatin results in decreased expression of CHCHD6 mRNA | CTD | PMID:24280081 and PMID:25270620 | cisplatin | decreases expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of CHCHD6 mRNA | CTD | PMID:24280081 more ... | clofibrate | multiple interactions | ISO | Chchd6 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of CHCHD6 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CHCHD6 mRNA] | CTD | PMID:17585979 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CHCHD6 mRNA | CTD | PMID:17602206 | cyclosporin A | increases expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of CHCHD6 mRNA | CTD | PMID:20106945 | dibutyl phthalate | decreases expression | ISO | Chchd6 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of CHCHD6 mRNA | CTD | PMID:21266533 | ethanol | affects expression | ISO | Chchd6 (Mus musculus) | 6480464 | Ethanol affects the expression of CHCHD6 mRNA | CTD | PMID:30319688 | ethanol | increases expression | ISO | Chchd6 (Mus musculus) | 6480464 | Ethanol results in increased expression of CHCHD6 mRNA | CTD | PMID:30319688 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of CHCHD6 mRNA | CTD | PMID:24136188 | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of CHCHD6 mRNA | CTD | PMID:23962444 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of CHCHD6 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Chchd6 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CHCHD6 mRNA | CTD | PMID:22206623 | fulvestrant | multiple interactions | ISO | CHCHD6 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of CHCHD6 gene | CTD | PMID:31601247 | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of CHCHD6 mRNA | CTD | PMID:24136188 | hydrogen peroxide | affects expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of CHCHD6 mRNA | CTD | PMID:21179406 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of CHCHD6 mRNA | CTD | PMID:21396975 | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CHCHD6 mRNA | CTD | PMID:22129741 | inulin | multiple interactions | ISO | Chchd6 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of CHCHD6 mRNA | CTD | PMID:36331819 | lead(0) | affects expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | Lead affects the expression of CHCHD6 mRNA | CTD | PMID:28903495 | methapyrilene | increases methylation | ISO | CHCHD6 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of CHCHD6 intron | CTD | PMID:30157460 | methidathion | decreases expression | ISO | Chchd6 (Mus musculus) | 6480464 | methidathion results in decreased expression of CHCHD6 mRNA | CTD | PMID:34813904 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of CHCHD6 gene | CTD | PMID:35440735 | mono(2-ethylhexyl) phthalate | decreases expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of CHCHD6 mRNA | CTD | PMID:36314267 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of CHCHD6 mRNA | CTD | PMID:28801915 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CHCHD6 mRNA and [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CHCHD6 mRNA | CTD | PMID:17602206 and PMID:22129741 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of CHCHD6 mRNA | CTD | PMID:24136188 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of CHCHD6 mRNA | CTD | PMID:24136188 | ozone | multiple interactions | ISO | CHCHD6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CHCHD6 mRNA more ... | CTD | PMID:32699268 | paracetamol | multiple interactions | ISO | Chchd6 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of CHCHD6 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CHCHD6 mRNA] | CTD | PMID:17585979 | paracetamol | affects expression | ISO | Chchd6 (Mus musculus) | 6480464 | Acetaminophen affects the expression of CHCHD6 mRNA | CTD | PMID:17562736 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of CHCHD6 mRNA | CTD | PMID:32680482 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Chchd6 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CHCHD6 mRNA more ... | CTD | PMID:36331819 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of CHCHD6 mRNA | CTD | PMID:19162173 | phenacetin | increases expression | EXP | | 6480464 | Phenacetin results in increased expression of CHCHD6 mRNA | CTD | PMID:17698508 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CHCHD6 mRNA | CTD | PMID:19162173 | phenylephrine | increases expression | EXP | | 6480464 | Phenylephrine results in increased expression of CHCHD6 mRNA | CTD | PMID:18158353 | phenylhydrazine | increases expression | EXP | | 6480464 | phenylhydrazine results in increased expression of CHCHD6 mRNA | CTD | PMID:17698508 | pioglitazone | decreases expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | Pioglitazone results in decreased expression of CHCHD6 mRNA | CTD | PMID:30031879 | piperonyl butoxide | increases expression | EXP | | 6480464 | Piperonyl Butoxide results in increased expression of CHCHD6 mRNA | CTD | PMID:22484513 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of CHCHD6 mRNA | CTD | PMID:19162173 and PMID:22484513 | pirinixic acid | increases expression | ISO | Chchd6 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of CHCHD6 mRNA | CTD | PMID:18301758 more ... | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of CHCHD6 mRNA | CTD | PMID:19162173 | temozolomide | decreases expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of CHCHD6 mRNA | CTD | PMID:31758290 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of CHCHD6 mRNA | CTD | PMID:31150632 | thapsigargin | decreases expression | ISO | Chchd6 (Mus musculus) | 6480464 | Thapsigargin results in decreased expression of CHCHD6 protein | CTD | PMID:24648495 | titanium dioxide | decreases expression | ISO | Chchd6 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of CHCHD6 mRNA | CTD | PMID:23557971 | Triptolide | increases expression | EXP | | 6480464 | triptolide results in increased expression of CHCHD6 protein | CTD | PMID:32519852 | troglitazone | increases expression | ISO | Chchd6 (Mus musculus) | 6480464 | troglitazone results in increased expression of CHCHD6 mRNA | CTD | PMID:28973697 | urethane | decreases expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | Urethane results in decreased expression of CHCHD6 mRNA | CTD | PMID:28818685 | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of CHCHD6 mRNA | CTD | PMID:24136188 | valproic acid | affects expression | ISO | Chchd6 (Mus musculus) | 6480464 | Valproic Acid affects the expression of CHCHD6 mRNA | CTD | PMID:17963808 | valproic acid | affects expression | ISO | CHCHD6 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CHCHD6 mRNA | CTD | PMID:25979313 | valproic acid | decreases methylation | ISO | CHCHD6 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of CHCHD6 gene | CTD | PMID:29154799 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of CHCHD6 mRNA | CTD | PMID:22615374 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of CHCHD6 gene | CTD | PMID:31682807 | |