Cog3 (component of oligomeric golgi complex 3) - Rat Genome Database

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Pathways
Gene: Cog3 (component of oligomeric golgi complex 3) Rattus norvegicus
Analyze
Symbol: Cog3
Name: component of oligomeric golgi complex 3
RGD ID: 1304555
Description: Predicted to be involved in several processes, including Golgi vesicle transport; protein glycosylation; and protein stabilization. Predicted to be located in Golgi apparatus. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIbb. Orthologous to human COG3 (component of oligomeric golgi complex 3); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: conserved oligomeric Golgi complex subunit 3; LOC361073
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81557,389,994 - 57,480,454 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1557,390,238 - 57,480,097 (-)EnsemblGRCr8
mRatBN7.21551,020,808 - 51,071,288 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1551,020,813 - 51,070,570 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1555,177,085 - 55,226,940 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01556,295,411 - 56,345,267 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01553,115,729 - 53,165,590 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01557,753,814 - 57,805,627 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1557,755,189 - 57,805,184 (-)Ensemblrn6Rnor6.0
Rnor_5.01561,423,245 - 61,512,827 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41556,600,798 - 56,648,037 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1550,648,933 - 50,698,672 (-)NCBICelera
RGSC_v3.11556,616,577 - 56,663,817 (-)NCBI
Cytogenetic Map15q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11292827   PMID:11929878   PMID:11980916   PMID:12477932   PMID:15047703   PMID:16420527   PMID:20163571  


Genomics

Comparative Map Data
Cog3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81557,389,994 - 57,480,454 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1557,390,238 - 57,480,097 (-)EnsemblGRCr8
mRatBN7.21551,020,808 - 51,071,288 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1551,020,813 - 51,070,570 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1555,177,085 - 55,226,940 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01556,295,411 - 56,345,267 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01553,115,729 - 53,165,590 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01557,753,814 - 57,805,627 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1557,755,189 - 57,805,184 (-)Ensemblrn6Rnor6.0
Rnor_5.01561,423,245 - 61,512,827 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41556,600,798 - 56,648,037 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1550,648,933 - 50,698,672 (-)NCBICelera
RGSC_v3.11556,616,577 - 56,663,817 (-)NCBI
Cytogenetic Map15q11NCBI
COG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381345,464,939 - 45,536,701 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1345,464,898 - 45,536,701 (+)Ensemblhg38GRCh38
GRCh371346,039,074 - 46,110,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361344,937,072 - 45,008,761 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341344,937,071 - 45,008,760NCBI
Celera1327,093,707 - 27,165,437 (+)NCBICelera
Cytogenetic Map13q14.13NCBI
HuRef1326,835,726 - 26,907,070 (+)NCBIHuRef
CHM1_11346,007,708 - 46,079,775 (+)NCBICHM1_1
T2T-CHM13v2.01344,685,393 - 44,758,036 (+)NCBIT2T-CHM13v2.0
Cog3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391475,939,791 - 75,992,078 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1475,939,790 - 75,991,998 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381475,702,351 - 75,754,638 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1475,702,350 - 75,754,558 (-)Ensemblmm10GRCm38
MGSCv371476,102,158 - 76,154,300 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361474,436,525 - 74,488,671 (-)NCBIMGSCv36mm8
Celera1473,204,226 - 73,256,338 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1440.29NCBI
Cog3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555183,211,731 - 3,276,417 (+)Ensembl
ChiLan1.0NW_0049555183,211,729 - 3,276,057 (+)NCBIChiLan1.0ChiLan1.0
COG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21445,847,926 - 45,917,615 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11336,902,175 - 36,971,860 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01327,488,478 - 27,558,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
COG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1225,548,461 - 5,614,413 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl225,405,741 - 5,614,277 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha225,535,877 - 5,603,549 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0225,664,583 - 5,732,166 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl225,664,586 - 5,732,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1225,446,561 - 5,514,257 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0225,509,499 - 5,577,504 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0225,515,109 - 5,582,851 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cog3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945155,678,964 - 155,731,924 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936857101,270 - 154,199 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936857101,261 - 154,199 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,759,180 - 21,826,913 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11121,759,174 - 21,826,926 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21122,228,918 - 22,262,527 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1323,545,321 - 23,617,818 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl323,545,433 - 23,617,961 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605720,440,065 - 20,515,334 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cog3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247489,503,120 - 9,560,974 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247489,504,057 - 9,560,936 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cog3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11248,653,474 - 48,704,131 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cog3
471 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:45
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000000168
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
724545Niddm54Non-insulin dependent diabetes mellitus QTL 540.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)155720389580107161Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat

Markers in Region
RH137274  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21551,019,540 - 51,019,693 (+)MAPPERmRatBN7.2
Rnor_6.01557,753,919 - 57,754,071NCBIRnor6.0
Rnor_5.01561,461,412 - 61,461,564UniSTSRnor5.0
Celera1550,647,666 - 50,647,818UniSTS
Cytogenetic Map15q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000168   ⟹   ENSRNOP00000000168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1557,430,168 - 57,480,097 (-)Ensembl
mRatBN7.2 Ensembl1551,020,813 - 51,070,570 (-)Ensembl
Rnor_6.0 Ensembl1557,755,189 - 57,805,184 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093907   ⟹   ENSRNOP00000090801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1557,432,162 - 57,479,918 (-)Ensembl
mRatBN7.2 Ensembl1551,022,417 - 51,070,570 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102849   ⟹   ENSRNOP00000090832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1557,433,730 - 57,479,918 (-)Ensembl
mRatBN7.2 Ensembl1551,021,564 - 51,070,570 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000158343   ⟹   ENSRNOP00000103916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1557,390,238 - 57,480,071 (-)Ensembl
RefSeq Acc Id: NM_001012157   ⟹   NP_001012157
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81557,430,163 - 57,479,918 (-)NCBI
mRatBN7.21551,020,808 - 51,070,570 (-)NCBI
Rnor_6.01557,755,186 - 57,805,184 (-)NCBI
Rnor_5.01561,423,245 - 61,512,827 (-)NCBI
RGSC_v3.41556,600,798 - 56,648,037 (-)RGD
Celera1550,648,933 - 50,698,672 (-)RGD
Sequence:
RefSeq Acc Id: XM_063274434   ⟹   XP_063130504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81557,428,791 - 57,480,454 (-)NCBI
RefSeq Acc Id: XM_063274435   ⟹   XP_063130505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81557,389,994 - 57,480,448 (-)NCBI
RefSeq Acc Id: XM_063274437   ⟹   XP_063130507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81557,428,791 - 57,472,159 (-)NCBI
RefSeq Acc Id: NP_001012157   ⟸   NM_001012157
- UniProtKB: Q5XHZ8 (UniProtKB/TrEMBL),   F1LLY2 (UniProtKB/TrEMBL),   A0A8I6ABS2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000168   ⟸   ENSRNOT00000000168
Ensembl Acc Id: ENSRNOP00000090832   ⟸   ENSRNOT00000102849
Ensembl Acc Id: ENSRNOP00000090801   ⟸   ENSRNOT00000093907
RefSeq Acc Id: XP_063130505   ⟸   XM_063274435
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ABS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130504   ⟸   XM_063274434
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJ60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130507   ⟸   XM_063274437
- Peptide Label: isoform X3
- UniProtKB: A6HTT4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103916   ⟸   ENSRNOT00000158343
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XHZ8-F1-model_v2 AlphaFold Q5XHZ8 1-828 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699833
Promoter ID:EPDNEW_R10356
Type:initiation region
Name:Cog3_1
Description:component of oligomeric golgi complex 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01557,805,168 - 57,805,228EPDNEW
RGD ID:6849898
Promoter ID:EP15037
Type:single initiation site
Name:RN_COG3
Description:Transin, Matrix metalloproteinase-3, MMP3 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 173; Mammalian transin/stromelysin
Experiment Methods:Sequencing of a full-length cDNA; Primer extension
Regulation:(induced by or strongly expressed in) EGF, (induced by or strongly expressed in) transformation
Position:No map positions available.

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304555 AgrOrtholog
BioCyc Gene G2FUF-13116 BioCyc
Ensembl Genes ENSRNOG00000000155 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000168 ENTREZGENE
  ENSRNOT00000000168.8 UniProtKB/TrEMBL
  ENSRNOT00000093907 ENTREZGENE
  ENSRNOT00000093907.2 UniProtKB/TrEMBL
  ENSRNOT00000102849.2 UniProtKB/TrEMBL
  ENSRNOT00000158343 ENTREZGENE
  ENSRNOT00000158343.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133573 IMAGE-MGC_LOAD
  IMAGE:7309204 IMAGE-MGC_LOAD
InterPro COG3_C UniProtKB/TrEMBL
  COG3_N UniProtKB/TrEMBL
  Sec34 UniProtKB/TrEMBL
KEGG Report rno:361073 UniProtKB/TrEMBL
MGC_CLONE MGC:109229 IMAGE-MGC_LOAD
  MGC:95259 IMAGE-MGC_LOAD
NCBI Gene 361073 ENTREZGENE
PANTHER CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3 UniProtKB/TrEMBL
  Sec34 UniProtKB/TrEMBL
Pfam COG3_C UniProtKB/TrEMBL
  Sec34 UniProtKB/TrEMBL
PhenoGen Cog3 PhenoGen
RatGTEx ENSRNOG00000000155 RatGTEx
UniProt A0A8I6ABS2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJ60 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LEZ8_RAT UniProtKB/TrEMBL
  A0ABZ3NNA1_RAT UniProtKB/TrEMBL
  A6HTT4 ENTREZGENE, UniProtKB/TrEMBL
  F1LLY2 ENTREZGENE
  Q5BJW7_RAT UniProtKB/TrEMBL
  Q5XHZ8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LLY2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Cog3  component of oligomeric golgi complex 3  Cog3_predicted  component of oligomeric golgi complex 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cog3_predicted  component of oligomeric golgi complex 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED