Tusc3 (tumor suppressor candidate 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tusc3 (tumor suppressor candidate 3) Rattus norvegicus
Analyze
Symbol: Tusc3
Name: tumor suppressor candidate 3
RGD ID: 1303318
Description: Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in cognition; magnesium ion transport; and protein N-linked glycosylation via asparagine. Predicted to be located in mitochondrion. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 7. Orthologous to human TUSC3 (tumor suppressor candidate 3); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; N-linked glycan biosynthetic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC94243; similar to N33 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81659,899,642 - 60,048,813 (-)NCBIGRCr8
mRatBN7.21653,196,195 - 53,345,241 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1653,196,195 - 53,344,781 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1658,496,770 - 58,645,095 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01661,915,361 - 62,063,735 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01657,130,767 - 57,279,090 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01656,248,125 - 56,396,491 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1656,247,659 - 56,396,502 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01655,949,774 - 56,097,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41656,760,904 - 56,929,685 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11656,760,980 - 56,929,760 (-)NCBI
Celera1651,081,032 - 51,229,180 (-)NCBICelera
Cytogenetic Map16q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tusc3Ratautosomal recessive intellectual developmental disorder 7  ISOTUSC3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Tusc3RatExperimental Liver Cirrhosis  ISOTUSC3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tusc3Ratautosomal recessive intellectual developmental disorder 7  ISOTUSC3 (Homo sapiens)7240710 OMIM 

1 to 20 of 82 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tusc3Rat1,2-dimethylhydrazine decreases expressionISOTusc3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of TUSC3 mRNACTDPMID:22206623
Tusc3Rat1,2-dimethylhydrazine multiple interactionsISOTusc3 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TUSC3 mRNACTDPMID:22206623
Tusc3Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of TUSC3 mRNACTDPMID:25380136 and PMID:30723492
Tusc3Rat17alpha-ethynylestradiol affects expressionISOTusc3 (Mus musculus)6480464Ethinyl Estradiol affects the expression of TUSC3 mRNACTDPMID:17555576
Tusc3Rat17alpha-ethynylestradiol multiple interactionsISOTusc3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUSC3 mRNACTDPMID:17942748
Tusc3Rat17alpha-ethynylestradiol increases expressionISOTusc3 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of TUSC3 mRNACTDPMID:17942748
Tusc3Rat17beta-estradiol decreases expressionISOTusc3 (Mus musculus)6480464Estradiol results in decreased expression of TUSC3 mRNACTDPMID:39298647
Tusc3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOTusc3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUSC3 mRNACTDPMID:17942748
Tusc3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of TUSC3 mRNACTDPMID:21215274 and PMID:34747641
Tusc3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOTusc3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of TUSC3 mRNACTDPMID:17942748
Tusc3Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of TUSC3 mRNACTDPMID:21346803
Tusc3Rat4,4'-diaminodiphenylmethane increases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in increased expression of TUSC3 mRNACTDPMID:25380136
Tusc3Rat4-hydroxyphenyl retinamide increases expressionISOTusc3 (Mus musculus)6480464Fenretinide results in increased expression of TUSC3 mRNACTDPMID:28973697
Tusc3Rat5-aza-2'-deoxycytidine multiple interactionsISOTUSC3 (Homo sapiens)6480464Decitabine inhibits the reaction [Smoke results in decreased expression of TUSC3 mRNA]CTDPMID:21095227
Tusc3Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of TUSC3 mRNACTDPMID:24780913 and PMID:30047161
Tusc3Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of TUSC3 mRNACTDPMID:31881176
Tusc3Rataflatoxin B1 decreases expressionISOTusc3 (Mus musculus)6480464Aflatoxin B1 results in decreased expression of TUSC3 mRNACTDPMID:19770486
Tusc3Rataflatoxin B1 increases expressionEXP 6480464Aflatoxin B1 results in increased expression of TUSC3 mRNACTDPMID:23630614 and PMID:25378103
Tusc3Rataflatoxin B1 decreases expressionISOTUSC3 (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of TUSC3 mRNACTDPMID:21641981
Tusc3Ratamiodarone increases expressionISOTUSC3 (Homo sapiens)6480464Amiodarone results in increased expression of TUSC3 mRNACTDPMID:19774075

1 to 20 of 82 rows

Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tusc3Ratcognition involved_inISSUniProtKB:Q134541600115GO_REF:0000024UniProtGO_REF:0000024
Tusc3Ratcognition involved_inIEAUniProtKB:Q13454 and ensembl:ENSP000004245441600115GO_REF:0000107EnsemblGO_REF:0000107
Tusc3Ratcognition involved_inISOTUSC3 (Homo sapiens)1624291 PMID:18455129RGDPMID:18455129
Tusc3Ratmagnesium ion transmembrane transport involved_inIEAGO:00150951600115GO_REF:0000108GOCGO_REF:0000108
Tusc3Ratmagnesium ion transport involved_inISOTUSC3 (Homo sapiens) and UniProtKB:Q13454-21624291UniProtKB:Q08269 and PMID:19717468RGDPMID:19717468
Tusc3Ratmagnesium ion transport acts_upstream_of_or_withinISOTUSC3 (Homo sapiens)1624291 PMID:19717468RGDPMID:19717468
Tusc3Ratmagnesium ion transport acts_upstream_of_or_withinISSUniProtKB:Q134541600115GO_REF:0000024UniProtGO_REF:0000024
Tusc3Ratmagnesium ion transport involved_inIEAUniProtKB:Q13454 and ensembl:ENSP000004245441600115GO_REF:0000107EnsemblGO_REF:0000107
Tusc3Ratmagnesium ion transport NOT|involved_inISOTUSC3 (Homo sapiens) and UniProtKB:Q13454-11624291UniProtKB:Q08269 and PMID:19717468RGDPMID:19717468
Tusc3Ratprotein glycosylation involved_inIEAUniPathway:UPA003781600115GO_REF:0000041UniProtGO_REF:0000041
Tusc3Ratprotein N-linked glycosylation via asparagine involved_inISOTUSC3 (Homo sapiens)1624291 PMID:26864433RGDPMID:26864433
Tusc3Ratprotein N-linked glycosylation via asparagine involved_inIEAUniProtKB:Q13454 and ensembl:ENSP000004245441600115GO_REF:0000107EnsemblGO_REF:0000107
Tusc3Ratprotein N-linked glycosylation via asparagine involved_inIBAPANTHER:PTN000294174 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tusc3Ratprotein N-linked glycosylation via asparagine involved_inISOTUSC3 (Canis lupus familiaris)1624291 PMID:12887896RGDPMID:12887896
1 to 14 of 14 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tusc3Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Tusc3Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Tusc3Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Tusc3Ratmitochondrion located_inISSUniProtKB:Q8BTV11600115GO_REF:0000024UniProtGO_REF:0000024
Tusc3Ratoligosaccharyltransferase complex part_ofISSUniProtKB:Q134541600115GO_REF:0000024UniProtGO_REF:0000024
Tusc3Ratoligosaccharyltransferase complex part_ofIEAUniProtKB:Q13454 and ensembl:ENSP000004245441600115GO_REF:0000107EnsemblGO_REF:0000107
Tusc3Ratoligosaccharyltransferase complex part_ofIBAPANTHER:PTN000294174 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tusc3Ratoligosaccharyltransferase complex part_ofISOTUSC3 (Homo sapiens)1624291 PMID:15835887RGDPMID:15835887

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tusc3Ratmagnesium ion transmembrane transporter activity enablesIEAUniProtKB:Q13454 and ensembl:ENSP000004245441600115GO_REF:0000107EnsemblGO_REF:0000107
Tusc3Ratoligosaccharyltransferase complex binding enablesISOTUSC3 (Canis lupus familiaris)1624291 PMID:12887896RGDPMID:12887896

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tusc3RatEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGrno:04141
Tusc3RatN-linked glycan biosynthetic pathway  IEA 6907045 KEGGrno:00510

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22. MacGrogan D, etal., Genomics 1996 Jul 1;35(1):55-65.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
PMID:12887896   PMID:14651853   PMID:15835887   PMID:18455129   PMID:19717468   PMID:24096664   PMID:26864433  



Tusc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81659,899,642 - 60,048,813 (-)NCBIGRCr8
mRatBN7.21653,196,195 - 53,345,241 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1653,196,195 - 53,344,781 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1658,496,770 - 58,645,095 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01661,915,361 - 62,063,735 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01657,130,767 - 57,279,090 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01656,248,125 - 56,396,491 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1656,247,659 - 56,396,502 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01655,949,774 - 56,097,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41656,760,904 - 56,929,685 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11656,760,980 - 56,929,760 (-)NCBI
Celera1651,081,032 - 51,229,180 (-)NCBICelera
Cytogenetic Map16q12.1NCBI
TUSC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38815,417,188 - 15,852,091 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl815,417,215 - 15,766,649 (+)EnsemblGRCh38hg38GRCh38
GRCh37815,274,697 - 15,709,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36815,442,101 - 15,666,366 (+)NCBINCBI36Build 36hg18NCBI36
Celera814,361,735 - 14,585,988 (+)NCBICelera
Cytogenetic Map8p22NCBI
HuRef813,941,421 - 14,168,441 (+)NCBIHuRef
CHM1_1815,599,058 - 15,826,084 (+)NCBICHM1_1
T2T-CHM13v2.0815,683,250 - 16,118,387 (+)NCBIT2T-CHM13v2.0
Tusc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39839,472,505 - 39,620,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl839,472,999 - 39,619,367 (+)EnsemblGRCm39 Ensembl
GRCm38839,005,351 - 39,167,050 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl839,005,845 - 39,165,114 (+)EnsemblGRCm38mm10GRCm38
MGSCv37840,068,921 - 40,193,932 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv37840,242,614 - 40,250,468 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36840,656,077 - 40,665,143 (+)NCBIMGSCv36mm8
Celera841,719,343 - 41,855,476 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
Tusc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554631,634,238 - 1,848,187 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554631,633,776 - 1,848,187 (-)NCBIChiLan1.0ChiLan1.0
TUSC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2734,010,380 - 34,230,246 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan189,748,949 - 9,968,336 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0814,795,921 - 14,988,566 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1811,603,037 - 11,745,152 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl811,603,037 - 11,745,152 (+)Ensemblpanpan1.1panPan2
TUSC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11638,798,764 - 39,086,508 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1638,862,591 - 39,084,458 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1639,270,320 - 39,564,379 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01640,842,985 - 41,131,133 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1640,906,843 - 41,149,933 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11638,937,567 - 39,219,630 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01639,494,984 - 39,776,798 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01639,618,352 - 39,900,306 (+)NCBIUU_Cfam_GSD_1.0
Tusc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494340,062,084 - 40,318,484 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365734,823,923 - 4,977,812 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365734,823,939 - 4,977,997 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUSC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl173,312,741 - 3,507,729 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1173,312,684 - 3,507,372 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2173,407,540 - 3,578,063 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TUSC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1813,669,079 - 13,875,104 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl813,669,097 - 13,874,472 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605228,435,988 - 28,643,097 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tusc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248391,125,643 - 1,453,961 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Tusc3
661 total Variants

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000017452
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 19 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat

1 to 10 of 19 rows
RH142006  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21653,196,244 - 53,196,457 (-)MAPPERmRatBN7.2
Rnor_6.01656,396,234 - 56,396,446NCBIRnor6.0
Rnor_5.01656,097,402 - 56,097,614UniSTSRnor5.0
RGSC_v3.41656,760,772 - 56,760,984UniSTSRGSC3.4
Celera1651,080,900 - 51,081,112UniSTS
RH 3.4 Map16538.1UniSTS
Cytogenetic Map16q12.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000017452   ⟹   ENSRNOP00000017452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1653,196,195 - 53,344,778 (-)Ensembl
Rnor_6.0 Ensembl1656,247,659 - 56,396,502 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085300   ⟹   ENSRNOP00000075366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1653,206,175 - 53,344,781 (-)Ensembl
Rnor_6.0 Ensembl1656,248,331 - 56,389,759 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098547   ⟹   ENSRNOP00000098003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1653,196,195 - 53,344,774 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110266   ⟹   ENSRNOP00000095905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1653,275,290 - 53,344,781 (-)Ensembl
RefSeq Acc Id: NM_001004212   ⟹   NP_001004212
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81659,899,824 - 60,048,197 (-)NCBI
mRatBN7.21653,196,377 - 53,344,763 (-)NCBI
Rnor_6.01656,248,143 - 56,396,314 (+)NCBI
Rnor_5.01655,949,774 - 56,097,482 (+)NCBI
RGSC_v3.41656,760,904 - 56,929,685 (-)RGD
Celera1651,081,032 - 51,229,180 (-)RGD
Sequence:
RefSeq Acc Id: XM_008771294   ⟹   XP_008769516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81659,899,642 - 60,048,813 (-)NCBI
mRatBN7.21653,196,195 - 53,345,241 (-)NCBI
Rnor_6.01656,248,125 - 56,396,491 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094388   ⟹   XP_038950316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81659,899,905 - 60,048,813 (-)NCBI
mRatBN7.21653,196,195 - 53,345,241 (-)NCBI
RefSeq Acc Id: XM_039094389   ⟹   XP_038950317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81659,899,905 - 60,048,813 (-)NCBI
mRatBN7.21653,196,195 - 53,345,241 (-)NCBI
RefSeq Acc Id: NP_001004212   ⟸   NM_001004212
- Peptide Label: precursor
- UniProtKB: Q6AY49 (UniProtKB/TrEMBL),   F7EPX8 (UniProtKB/TrEMBL),   A0A0G2KAE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769516   ⟸   XM_008771294
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AVS1 (UniProtKB/TrEMBL),   A0A0G2KAE2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075366   ⟸   ENSRNOT00000085300
Ensembl Acc Id: ENSRNOP00000017452   ⟸   ENSRNOT00000017452
RefSeq Acc Id: XP_038950317   ⟸   XM_039094389
- Peptide Label: isoform X2
- UniProtKB: A0A0G2KAE2 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAE2-F1-model_v2 AlphaFold A0A0G2KAE2 1-347 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700127
Promoter ID:EPDNEW_R10651
Type:initiation region
Name:Tusc3_1
Description:tumor suppressor candidate 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01656,248,181 - 56,248,241EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-11230 BioCyc
Ensembl Genes ENSRNOG00000013061 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017452 ENTREZGENE
  ENSRNOT00000017452.6 UniProtKB/TrEMBL
  ENSRNOT00000085300 ENTREZGENE
  ENSRNOT00000085300.2 UniProtKB/TrEMBL
  ENSRNOT00000098547 ENTREZGENE
  ENSRNOT00000098547.1 UniProtKB/TrEMBL
  ENSRNOT00000110266.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131345 IMAGE-MGC_LOAD
InterPro OligosaccharylTrfase_OST3/OST6 UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
KEGG Report rno:290783 UniProtKB/TrEMBL
MGC_CLONE MGC:94243 IMAGE-MGC_LOAD
NCBI Gene 290783 ENTREZGENE
PANTHER PTHR12692 UniProtKB/TrEMBL
  TUMOR SUPPRESSOR CANDIDATE 3 UniProtKB/TrEMBL
Pfam OST3_OST6 UniProtKB/TrEMBL
PhenoGen Tusc3 PhenoGen
RatGTEx ENSRNOG00000013061 RatGTEx
Superfamily-SCOP Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A0A0G2KAE2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AUC7_RAT UniProtKB/TrEMBL
  A0A8I6AVS1 ENTREZGENE, UniProtKB/TrEMBL
  A6JPW8_RAT UniProtKB/TrEMBL
  F7EPX8 ENTREZGENE, UniProtKB/TrEMBL
  Q6AY49 ENTREZGENE, UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Tusc3  tumor suppressor candidate 3  MGC94243  similar to N33 protein  Symbol and Name updated 1299863 APPROVED
2005-07-11 MGC94243  similar to N33 protein      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference