Krt2 (keratin 2) - Rat Genome Database

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Gene: Krt2 (keratin 2) Rattus norvegicus
Analyze
Symbol: Krt2
Name: keratin 2
RGD ID: 1303297
Description: Predicted to enable cytoskeletal protein binding activity. Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including keratinocyte activation; keratinocyte migration; and keratinocyte proliferation. Predicted to act upstream of or within keratinocyte development. Predicted to be located in cornified envelope and cytoplasm. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in bullous congenital ichthyosiform erythroderma and ichthyosis. Orthologous to human KRT2 (keratin 2); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CK 2e; CK-2e; cytokeratin-2e; epithelial keratin-2e; K2e; Kb2; keratin 2, type II; keratin, type II cytoskeletal 2 epidermal; keratin-2 epidermis; keratin-2e; type II keratin Kb2; type-II keratin Kb2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,819,584 - 134,826,736 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,819,584 - 134,827,011 (-)EnsemblGRCr8
mRatBN7.27132,940,879 - 132,948,031 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,940,862 - 132,947,963 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,702,372 - 134,709,508 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,931,896 - 136,939,028 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,910,509 - 136,917,679 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,412,858 - 143,420,463 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,412,858 - 143,420,027 (-)Ensemblrn6Rnor6.0
Rnor_5.07141,211,053 - 141,218,655 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,500,902 - 140,507,590 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,381,180 - 129,387,868 (-)NCBICelera
RGSC_v3.17140,577,338 - 140,584,027 (-)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cornified envelope  (IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
intermediate filament  (IEA)
keratin filament  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens. Rothnagel JA, etal., Nat Genet. 1994 Aug;7(4):485-90.
Additional References at PubMed
PMID:7543090   PMID:12598329   PMID:15057822   PMID:15085952   PMID:15737202   PMID:19199708   PMID:19946888   PMID:21630459   PMID:23376485   PMID:23533145   PMID:23580065   PMID:24751727  
PMID:26603179  


Genomics

Comparative Map Data
Krt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,819,584 - 134,826,736 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,819,584 - 134,827,011 (-)EnsemblGRCr8
mRatBN7.27132,940,879 - 132,948,031 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,940,862 - 132,947,963 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,702,372 - 134,709,508 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,931,896 - 136,939,028 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,910,509 - 136,917,679 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,412,858 - 143,420,463 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,412,858 - 143,420,027 (-)Ensemblrn6Rnor6.0
Rnor_5.07141,211,053 - 141,218,655 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,500,902 - 140,507,590 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,381,180 - 129,387,868 (-)NCBICelera
RGSC_v3.17140,577,338 - 140,584,027 (-)NCBI
Cytogenetic Map7q36NCBI
KRT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,644,558 - 52,652,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,644,558 - 52,652,211 (-)Ensemblhg38GRCh38
GRCh371253,038,342 - 53,045,995 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,324,609 - 51,332,226 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341251,324,609 - 51,332,226NCBI
Celera1252,684,582 - 52,692,199 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,082,187 - 50,089,804 (-)NCBIHuRef
CHM1_11253,005,187 - 53,012,804 (-)NCBICHM1_1
T2T-CHM13v2.01252,609,117 - 52,616,770 (-)NCBIT2T-CHM13v2.0
Krt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,719,124 - 101,727,391 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,719,124 - 101,726,604 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3815101,810,689 - 101,818,956 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,810,689 - 101,818,169 (-)Ensemblmm10GRCm38
MGSCv3715101,641,120 - 101,648,600 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615101,638,733 - 101,646,169 (-)NCBIMGSCv36mm8
Celera15103,963,224 - 103,970,674 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.03NCBI
Krt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555473,027,767 - 3,035,244 (-)Ensembl
ChiLan1.0NW_0049555473,027,767 - 3,035,244 (-)NCBIChiLan1.0ChiLan1.0
KRT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,544,450 - 41,552,120 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,541,213 - 41,548,883 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,111,978 - 36,119,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,889,586 - 36,897,274 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,889,619 - 36,896,813 (+)EnsemblpanPan2panpan1.1
KRT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,447,854 - 2,454,492 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,799,509 - 43,806,126 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0272,447,655 - 2,454,776 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1272,463,994 - 2,470,611 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,449,101 - 2,455,769 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,197,879 - 44,204,549 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Krt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,103,733 - 63,110,578 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,054,708 - 10,061,021 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,054,708 - 10,061,021 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,984,316 - 17,992,092 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1517,984,316 - 17,992,092 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,425,807 - 18,485,348 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,780,378 - 48,789,540 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,780,388 - 48,788,085 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037197,284,151 - 197,291,922 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624904761,073 - 768,153 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624904760,957 - 768,153 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Krt2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11261,258,906 - 261,266,065 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Krt2
48 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000042180
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 67 131 90 90 59 18 59 6 230 117 11 103 36 76 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000082863   ⟹   ENSRNOP00000070051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,819,584 - 134,827,011 (-)Ensembl
mRatBN7.2 Ensembl7132,940,862 - 132,947,963 (-)Ensembl
Rnor_6.0 Ensembl7143,412,858 - 143,420,027 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159241   ⟹   ENSRNOP00000108142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,819,592 - 134,827,011 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000166403   ⟹   ENSRNOP00000107170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,819,584 - 134,827,011 (-)Ensembl
RefSeq Acc Id: NM_001008899   ⟹   NP_001008899
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,819,584 - 134,826,736 (-)NCBI
mRatBN7.27132,940,879 - 132,948,031 (-)NCBI
Rnor_6.07143,413,271 - 143,419,959 (-)NCBI
Rnor_5.07141,211,053 - 141,218,655 (-)NCBI
RGSC_v3.47140,500,902 - 140,507,590 (-)RGD
Celera7129,381,180 - 129,387,868 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008899 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA02228 (Get FASTA)   NCBI Sequence Viewer  
  EDL86878 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070051
GenBank Protein Q6IG02 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008899   ⟸   NM_001008899
- UniProtKB: A0A0G2JWX4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070051   ⟸   ENSRNOT00000082863
Ensembl Acc Id: ENSRNOP00000108142   ⟸   ENSRNOT00000159241
Ensembl Acc Id: ENSRNOP00000107170   ⟸   ENSRNOT00000166403
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IG02-F1-model_v2 AlphaFold Q6IG02 1-685 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695680
Promoter ID:EPDNEW_R6205
Type:single initiation site
Name:Krt2_1
Description:keratin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,420,024 - 143,420,084EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303297 AgrOrtholog
BioCyc Gene G2FUF-31963 BioCyc
Ensembl Genes ENSRNOG00000009563 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000082863 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
  Keratin_II UniProtKB/Swiss-Prot
KEGG Report rno:406228 UniProtKB/Swiss-Prot
NCBI Gene 406228 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  KERATIN, TYPE II CYTOSKELETAL 2 EPIDERMAL UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
PhenoGen Krt2 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009563 RatGTEx
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
UniProt A0A0G2JWX4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LN45_RAT UniProtKB/TrEMBL
  A0ABK0LQI1_RAT UniProtKB/TrEMBL
  K22E_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Krt2  keratin 2  Krt2  keratin 2, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt2  keratin 2, type II  Krt2  keratin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Krt2  keratin 2  Kb2  type II keratin Kb2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Kb2        Symbol and Name status set to provisional 70820 PROVISIONAL