Hspa14 (heat shock protein family A (Hsp70) member 14) - Rat Genome Database

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Gene: Hspa14 (heat shock protein family A (Hsp70) member 14) Rattus norvegicus
Analyze
Symbol: Hspa14
Name: heat shock protein family A (Hsp70) member 14
RGD ID: 1303296
Description: Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Predicted to be involved in protein refolding. Predicted to be active in cytosol; nucleus; and plasma membrane. Predicted to colocalize with ribosome. Orthologous to human HSPA14 (heat shock protein family A (Hsp70) member 14); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: heat shock 70 kDa protein 14; heat shock 70kDa protein 14; heat shock protein 14; heat shock protein family A, member 14; heat shock protein family A, member 14; heat shock protein hsp70-related protein; MGC94119
RGD Orthologs
Human
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81779,638,106 - 79,658,888 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1779,638,058 - 79,658,885 (+)EnsemblGRCr8
mRatBN7.21774,728,945 - 74,749,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1774,728,899 - 74,749,727 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1778,182,245 - 78,202,904 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01782,030,435 - 82,051,223 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01776,065,679 - 76,086,340 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01778,735,630 - 78,756,412 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1778,735,598 - 78,756,399 (+)Ensemblrn6Rnor6.0
Rnor_5.01780,379,450 - 80,400,361 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41785,848,593 - 85,869,375 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1774,114,843 - 74,135,523 (+)NCBICelera
RGSC_v3.11785,859,425 - 85,880,206 (+)NCBI
Cytogenetic Map17q12.3NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IBA,IEA,ISO,ISS)
nucleus  (IBA)
plasma membrane  (IBA)
protein folding chaperone complex  (IEA,ISO)
ribosome  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:16002468   PMID:19946888   PMID:21231916  


Genomics

Comparative Map Data
Hspa14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81779,638,106 - 79,658,888 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1779,638,058 - 79,658,885 (+)EnsemblGRCr8
mRatBN7.21774,728,945 - 74,749,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1774,728,899 - 74,749,727 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1778,182,245 - 78,202,904 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01782,030,435 - 82,051,223 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01776,065,679 - 76,086,340 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01778,735,630 - 78,756,412 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1778,735,598 - 78,756,399 (+)Ensemblrn6Rnor6.0
Rnor_5.01780,379,450 - 80,400,361 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41785,848,593 - 85,869,375 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1774,114,843 - 74,135,523 (+)NCBICelera
RGSC_v3.11785,859,425 - 85,880,206 (+)NCBI
Cytogenetic Map17q12.3NCBI
HSPA14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381014,838,306 - 14,871,741 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1014,838,306 - 14,871,741 (+)Ensemblhg38GRCh38
GRCh371014,880,305 - 14,913,740 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map10p13NCBI
HuRef1014,790,806 - 14,824,297 (+)NCBIHuRef
CHM1_11014,880,558 - 14,914,138 (+)NCBICHM1_1
T2T-CHM13v2.01014,852,271 - 14,885,706 (+)NCBIT2T-CHM13v2.0
Hspa14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542919,533,524 - 19,578,532 (-)Ensembl
ChiLan1.0NW_00495542919,533,586 - 19,577,834 (-)NCBIChiLan1.0ChiLan1.0
HSPA14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2827,363,943 - 27,397,539 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11027,369,271 - 27,402,867 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01014,841,964 - 14,875,368 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11015,169,747 - 15,204,263 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1015,169,747 - 15,204,263 (+)EnsemblpanPan2panpan1.1
Hspa14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093446,855,875 - 6,889,042 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366131,406,406 - 1,439,885 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366131,406,412 - 1,436,729 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1046,928,377 - 46,931,656 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1 Ensembl1046,904,311 - 46,935,280 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11046,908,161 - 46,935,323 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21051,640,132 - 51,667,452 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1914,861,069 - 14,893,508 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl914,861,211 - 14,893,677 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605120,400,042 - 20,432,448 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624805623,149 - 660,922 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624805623,223 - 660,974 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hspa14
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1149,935,360 - 9,956,169 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hspa14
256 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:38
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000020384, ENSRNOT00000020854
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)177061350286062352Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020854   ⟹   ENSRNOP00000020854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1779,638,058 - 79,658,885 (+)Ensembl
mRatBN7.2 Ensembl1774,728,899 - 74,749,727 (+)Ensembl
Rnor_6.0 Ensembl1778,735,598 - 78,756,399 (+)Ensembl
RefSeq Acc Id: NM_001004257   ⟹   NP_001004257
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81779,638,106 - 79,658,888 (+)NCBI
mRatBN7.21774,728,945 - 74,749,727 (+)NCBI
Rnor_6.01778,735,630 - 78,756,412 (+)NCBI
Rnor_5.01780,379,450 - 80,400,361 (+)NCBI
RGSC_v3.41785,848,593 - 85,869,375 (+)RGD
Celera1774,114,843 - 74,135,523 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001004257 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79118 (Get FASTA)   NCBI Sequence Viewer  
  EDL78689 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020854
  ENSRNOP00000020854.3
GenBank Protein Q6AYB4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001004257   ⟸   NM_001004257
- UniProtKB: Q6AYB4 (UniProtKB/Swiss-Prot),   A6JM12 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020854   ⟸   ENSRNOT00000020854

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYB4-F1-model_v2 AlphaFold Q6AYB4 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700580
Promoter ID:EPDNEW_R11104
Type:initiation region
Name:Hspa14_1
Description:heat shock protein family A, member 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01778,735,612 - 78,735,672EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303296 AgrOrtholog
BioCyc Gene G2FUF-8653 BioCyc
Ensembl Genes ENSRNOG00000015212 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020854 ENTREZGENE
  ENSRNOT00000020854.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.30.30 UniProtKB/Swiss-Prot
  3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
  Substrate Binding Domain Of DNAk, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126497 IMAGE-MGC_LOAD
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Heat_shock_70_CS UniProtKB/Swiss-Prot
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot
  Hsp_70_fam UniProtKB/Swiss-Prot
  HSPA14_NBD UniProtKB/Swiss-Prot
KEGG Report rno:307133 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94119 IMAGE-MGC_LOAD
NCBI Gene 307133 ENTREZGENE
PANTHER PTHR19375 UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot
PhenoGen Hspa14 PhenoGen
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot
PROSITE HSP70_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015212 RatGTEx
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot
  SSF53067 UniProtKB/Swiss-Prot
UniProt A6JM12 ENTREZGENE, UniProtKB/TrEMBL
  HSP7E_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Hspa14  heat shock protein family A (Hsp70) member 14  Hspa14  heat shock protein family A, member 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Hspa14  heat shock protein family A, member 14  Hspa14  heat shock protein 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Hspa14  heat shock protein 14  Hspa14  heat shock 70kDa protein 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hspa14  heat shock 70kDa protein 14    heat shock protein hsp70-related protein  Name updated 1299863 APPROVED
2005-09-30 Hspa14        Symbol and Name status set to provisional 70820 PROVISIONAL