Abcg3l1 (ATP-binding cassette, subfamily G (WHITE), member 3-like 1) - Rat Genome Database

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Gene: Abcg3l1 (ATP-binding cassette, subfamily G (WHITE), member 3-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Abcg3l1
Name: ATP-binding cassette, subfamily G (WHITE), member 3-like 1
RGD ID: 1303294
Description: Predicted to enable ATPase-coupled transmembrane transporter activity; efflux transmembrane transporter activity; and riboflavin transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abcg3; ATP-binding cassette, sub-family G (WHITE), member 3; ATP-binding cassette, sub-family G (WHITE), member 3-like 1; broad substrate specificity ATP-binding cassette transporter ABCG2; LOC108352837; MGC114213; uncharacterized LOC108352837
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,429,242 - 5,481,948 (-)NCBIGRCr8
mRatBN7.2145,124,541 - 5,177,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,124,353 - 5,177,184 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,083,957 - 5,138,142 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,384,152 - 6,438,338 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,079,659 - 5,132,609 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,488,655 - 6,541,220 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,435,167 - 6,541,191 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,468,116 - 6,520,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,235,274 - 6,289,605 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,235,274 - 6,289,605 (-)NCBI
Celera145,264,279 - 5,316,838 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Abcg3l1
1547 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:9
Interacting mature miRNAs:9
Transcripts:ENSRNOT00000042532
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 18 4 17 4 1 11 11
Low 2 43 39 37 2 37 8 11 74 34 28 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042532   ⟹   ENSRNOP00000046549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,124,550 - 5,177,184 (-)Ensembl
Rnor_6.0 Ensembl146,488,656 - 6,541,171 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000061267   ⟹   ENSRNOP00000057979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,124,353 - 5,177,184 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079795   ⟹   ENSRNOP00000068906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl146,488,660 - 6,533,524 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087758   ⟹   ENSRNOP00000072108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl146,435,167 - 6,541,191 (-)Ensembl
RefSeq Acc Id: NM_001004076   ⟹   NP_001004076
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,429,242 - 5,481,876 (-)NCBI
mRatBN7.2145,124,549 - 5,177,184 (-)NCBI
Rnor_6.0146,488,656 - 6,541,171 (-)NCBI
Rnor_5.0146,468,116 - 6,520,674 (-)NCBI
RGSC_v3.4146,235,274 - 6,289,605 (-)RGD
Celera145,264,279 - 5,316,838 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599095   ⟹   XP_017454584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,429,242 - 5,481,908 (-)NCBI
mRatBN7.2145,124,541 - 5,177,231 (-)NCBI
Rnor_6.0146,488,655 - 6,541,191 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599096   ⟹   XP_017454585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,436,552 - 5,481,948 (-)NCBI
mRatBN7.2145,131,863 - 5,177,265 (-)NCBI
Rnor_6.0146,496,091 - 6,541,220 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091661   ⟹   XP_038947589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,449,154 - 5,481,947 (-)NCBI
mRatBN7.2145,144,723 - 5,177,265 (-)NCBI
RefSeq Acc Id: XM_063272892   ⟹   XP_063128962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,429,242 - 5,470,378 (-)NCBI
RefSeq Acc Id: XR_010057347
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,432,757 - 5,481,947 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001004076   ⟸   NM_001004076
- UniProtKB: Q4KM08 (UniProtKB/TrEMBL),   Q68HW7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454584   ⟸   XM_017599095
- Peptide Label: isoform X1
- UniProtKB: Q4KM08 (UniProtKB/TrEMBL),   Q68HW7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454585   ⟸   XM_017599096
- Peptide Label: isoform X2
- UniProtKB: Q68HW7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068906   ⟸   ENSRNOT00000079795
RefSeq Acc Id: ENSRNOP00000072108   ⟸   ENSRNOT00000087758
RefSeq Acc Id: ENSRNOP00000046549   ⟸   ENSRNOT00000042532
RefSeq Acc Id: XP_038947589   ⟸   XM_039091661
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000057979   ⟸   ENSRNOT00000061267
RefSeq Acc Id: XP_063128962   ⟸   XM_063272892
- Peptide Label: isoform X3
Protein Domains
ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KM08-F1-model_v2 AlphaFold Q4KM08 1-646 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699169
Promoter ID:EPDNEW_R9694
Type:initiation region
Name:Abcg3l1_1
Description:ATP-binding cassette, subfamily G , member 3-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0146,541,155 - 6,541,215EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303294 AgrOrtholog
BioCyc Gene G2FUF-16516 BioCyc
Ensembl Genes ENSRNOG00000030216 Ensembl
  ENSRNOG00000069481 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042532 ENTREZGENE
  ENSRNOT00000042532.7 UniProtKB/TrEMBL
  ENSRNOT00000061267.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100556 IMAGE-MGC_LOAD
InterPro ABC_2_trans UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABCG_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:289453 UniProtKB/TrEMBL
MGC_CLONE MGC:114213 IMAGE-MGC_LOAD
NCBI Gene 289453 ENTREZGENE
PANTHER ABC TRANSPORTER G FAMILY MEMBER 28 UniProtKB/TrEMBL
  ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 3 UniProtKB/TrEMBL
Pfam ABC2_membrane UniProtKB/TrEMBL
  ABC2_membrane_7 UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PhenoGen Abcg3l1 PhenoGen
PROSITE ABC_TRANSPORTER_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030216 RatGTEx
  ENSRNOG00000069481 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt D4A896_RAT UniProtKB/TrEMBL
  Q4KM08 ENTREZGENE, UniProtKB/TrEMBL
  Q68HW7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Abcg3l1  ATP-binding cassette, subfamily G (WHITE), member 3-like 1  LOC108352837  uncharacterized LOC108352837  Data merged from RGD:11440926 737654 PROVISIONAL
2016-08-02 LOC108352837  uncharacterized LOC108352837      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-11-16 Abcg3l1  ATP-binding cassette, subfamily G (WHITE), member 3-like 1  Abcg3l1  ATP-binding cassette, sub-family G (WHITE), member 3-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-20 Abcg3l1  ATP-binding cassette, sub-family G (WHITE), member 3-like 1  Abcg3  ATP-binding cassette, sub-family G (WHITE), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Abcg3        Symbol and Name status set to provisional 70820 PROVISIONAL