Ndufa11 (NADH:ubiquinone oxidoreductase subunit A11) - Rat Genome Database

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Gene: Ndufa11 (NADH:ubiquinone oxidoreductase subunit A11) Rattus norvegicus
Analyze
Symbol: Ndufa11
Name: NADH:ubiquinone oxidoreductase subunit A11
RGD ID: 1303292
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in communication disorder and nuclear type mitochondrial complex I deficiency 14. Orthologous to human NDUFA11 (NADH:ubiquinone oxidoreductase subunit A11); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CI-B14.7; complex I-B14.7; LOC301123; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; NADH-ubiquinone oxidoreductase subunit B14.7; RE70703p-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,637,614 - 1,641,673 (+)NCBIGRCr8
mRatBN7.291,550,487 - 1,554,546 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,550,468 - 1,555,601 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,984,630 - 1,988,692 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,333,716 - 7,337,779 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,289,827 - 6,293,889 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,334,104 - 10,338,163 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,334,090 - 10,338,216 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,331,184 - 9,335,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,962,202 - 6,966,261 (-)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12611891   PMID:14651853   PMID:18614015   PMID:21700703   PMID:27626371  


Genomics

Comparative Map Data
Ndufa11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,637,614 - 1,641,673 (+)NCBIGRCr8
mRatBN7.291,550,487 - 1,554,546 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,550,468 - 1,555,601 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,984,630 - 1,988,692 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,333,716 - 7,337,779 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,289,827 - 6,293,889 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,334,104 - 10,338,163 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,334,090 - 10,338,216 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,331,184 - 9,335,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,962,202 - 6,966,261 (-)NCBICelera
Cytogenetic Map9q11NCBI
NDUFA11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38195,891,229 - 5,903,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl195,891,207 - 5,904,006 (-)EnsemblGRCh38hg38GRCh38
GRCh37195,891,240 - 5,903,801 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36195,845,686 - 5,855,025 (-)NCBINCBI36Build 36hg18NCBI36
Build 34195,845,685 - 5,855,025NCBI
Celera195,830,248 - 5,842,986 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef195,650,763 - 5,663,502 (-)NCBIHuRef
CHM1_1195,891,532 - 5,904,277 (-)NCBICHM1_1
T2T-CHM13v2.0195,878,657 - 5,891,220 (-)NCBIT2T-CHM13v2.0
Ndufa11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,024,762 - 57,031,248 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,024,767 - 57,029,141 (+)EnsemblGRCm39 Ensembl
GRCm381756,717,762 - 56,724,248 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,717,767 - 56,722,141 (+)EnsemblGRCm38mm10GRCm38
MGSCv371756,857,185 - 56,863,671 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,402,886 - 56,407,816 (+)NCBIMGSCv36mm8
Celera1761,061,897 - 61,068,383 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.47NCBI
Ndufa11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,557,016 - 3,564,999 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,557,016 - 3,564,999 (+)NCBIChiLan1.0ChiLan1.0
NDUFA11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,295,409 - 10,304,660 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,521,617 - 9,530,800 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0194,912,557 - 4,925,203 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,843,085 - 5,854,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,843,085 - 5,854,797 (-)Ensemblpanpan1.1panPan2
NDUFA11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,183,584 - 54,189,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,927,083 - 53,932,783 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,834,771 - 54,840,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,834,781 - 54,840,496 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,901,171 - 53,906,885 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02054,350,035 - 54,355,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,580,210 - 54,585,910 (+)NCBIUU_Cfam_GSD_1.0
Ndufa11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,444,923 - 214,451,109 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,383,509 - 3,390,087 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,383,674 - 3,389,862 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFA11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl273,130,403 - 73,137,916 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1273,131,029 - 73,137,921 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,675,744 - 73,682,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFA11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,517,871 - 5,529,754 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,517,797 - 5,529,455 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660812,507,925 - 2,515,866 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufa11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,319,665 - 4,328,273 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248284,319,657 - 4,328,273 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ndufa11
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:85
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000070862
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat

Markers in Region
RH143940  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,554,550 - 1,554,773 (-)MAPPERmRatBN7.2
Rnor_6.0910,333,877 - 10,334,099NCBIRnor6.0
Rnor_5.099,330,957 - 9,331,179UniSTSRnor5.0
Celera96,961,975 - 6,962,197UniSTS
Cytogenetic Map9q11UniSTS
AA818971  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map21662.03UniSTS
Cytogenetic Map9q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000070862   ⟹   ENSRNOP00000064246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,550,468 - 1,555,601 (+)Ensembl
Rnor_6.0 Ensembl910,334,090 - 10,338,216 (-)Ensembl
RefSeq Acc Id: NM_212517   ⟹   NP_997682
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,637,614 - 1,641,673 (+)NCBI
mRatBN7.291,550,487 - 1,554,546 (+)NCBI
Rnor_6.0910,334,104 - 10,338,163 (-)NCBI
Rnor_5.099,331,184 - 9,335,243 (-)NCBI
Celera96,962,202 - 6,966,261 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_997682 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP32478 (Get FASTA)   NCBI Sequence Viewer  
  EDL83610 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064246.2
GenBank Protein Q80W89 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997682   ⟸   NM_212517
- UniProtKB: Q80W89 (UniProtKB/Swiss-Prot),   A6KQV2 (UniProtKB/TrEMBL),   A0A8L2QX46 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064246   ⟸   ENSRNOT00000070862

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80W89-F1-model_v2 AlphaFold Q80W89 1-141 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696452
Promoter ID:EPDNEW_R6977
Type:initiation region
Name:Ndufa11_1
Description:NADH:ubiquinone oxidoreductase subunit A11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,338,169 - 10,338,229EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303292 AgrOrtholog
BioCyc Gene G2FUF-28516 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
Ensembl Genes ENSRNOG00000048320 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070862.3 UniProtKB/TrEMBL
InterPro NDUFA11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 301123 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR21382 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tim17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ndufa11 PhenoGen
RatGTEx ENSRNOG00000048320 RatGTEx
UniProt A0A8L2QX46 ENTREZGENE, UniProtKB/TrEMBL
  A6KQV2 ENTREZGENE, UniProtKB/TrEMBL
  NDUAB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 Ndufa11  NADH:ubiquinone oxidoreductase subunit A11  Ndufa11  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ndufa11  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11  LOC301123  RE70703p-like  Symbol and Name updated 1299863 APPROVED
2005-09-30 LOC301123        Symbol and Name status set to provisional 70820 PROVISIONAL