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Gene: Cog6 (component of oligomeric golgi complex 6) Rattus norvegicus

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Symbol:

Cog6

Name:

component of oligomeric golgi complex 6

RGD ID:

1303283

Description:

Predicted to be involved in Golgi organization; glycosylation; and retrograde transport, vesicle recycling within Golgi. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIl. Orthologous to human COG6 (component of oligomeric golgi complex 6); INTERACTS WITH 2,6-dinitrotoluene; acetamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

COG complex subunit 6; conserved oligomeric Golgi complex subunit 6; MGC94990

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	COG6 (component of oligomeric golgi complex 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cog6 (component of oligomeric golgi complex 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cog6 (component of oligomeric golgi complex 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	COG6 (component of oligomeric golgi complex 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	COG6 (component of oligomeric golgi complex 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cog6 (component of oligomeric golgi complex 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	COG6 (component of oligomeric golgi complex 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	COG6 (component of oligomeric golgi complex 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cog6 (component of oligomeric golgi complex 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cog6 (component of oligomeric golgi complex 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	COG6 (component of oligomeric golgi complex 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cog6 (component of oligomeric golgi complex 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cog6 (component of oligomeric golgi complex 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1968	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	COG6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cogc-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	cogc-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cog6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cog6	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	139,212,459 - 139,249,505 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	139,211,678 - 139,249,737 (-)	Ensembl				GRCr8
mRatBN7.2	2	137,062,127 - 137,099,176 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	137,061,346 - 137,099,190 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	143,639,424 - 143,676,204 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	141,751,508 - 141,788,288 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	136,383,282 - 136,420,047 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	142,197,566 - 142,235,054 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	142,196,754 - 142,235,066 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	161,882,713 - 161,921,014 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	142,767,258 - 142,804,731 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	131,560,563 - 131,597,609 (-)	NCBI		Celera
RGSC_v3.1	2	142,717,222 - 142,754,694 (-)	NCBI
Cytogenetic Map	2	q26	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital disorder of glycosylation (ISO)

congenital disorder of glycosylation type IIl (ISO)

genetic disease (ISO)

hypohidrosis (ISO)

intellectual disability (ISO)

Shaheen Syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

acetamide (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

genistein (EXP)

hydrogen peroxide (ISO)

ketamine (EXP)

methyl methanesulfonate (ISO)

nefazodone (EXP)

paracetamol (ISO)

potassium chromate (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

testosterone (ISO)

thapsigargin (ISO)

triphenyl phosphate (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Golgi organization (IEA,ISO)

intra-Golgi vesicle-mediated transport (IBA,IEA)

protein transport (IEA)

retrograde transport, vesicle recycling within Golgi (IEA,ISO,ISS)

Cellular Component

Golgi membrane (IEA)

Golgi transport complex (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15047703	PMID:20605848

Genomics

Comparative Map Data

Cog6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	139,212,459 - 139,249,505 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	139,211,678 - 139,249,737 (-)	Ensembl				GRCr8
mRatBN7.2	2	137,062,127 - 137,099,176 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	137,061,346 - 137,099,190 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	143,639,424 - 143,676,204 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	141,751,508 - 141,788,288 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	136,383,282 - 136,420,047 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	142,197,566 - 142,235,054 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	142,196,754 - 142,235,066 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	161,882,713 - 161,921,014 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	142,767,258 - 142,804,731 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	131,560,563 - 131,597,609 (-)	NCBI		Celera
RGSC_v3.1	2	142,717,222 - 142,754,694 (-)	NCBI
Cytogenetic Map	2	q26	NCBI

COG6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	39,655,627 - 39,791,666 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	39,655,627 - 39,791,666 (+)	Ensembl			hg38	GRCh38
GRCh37	13	40,229,764 - 40,365,803 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	39,127,814 - 39,224,633 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	13	39,127,813 - 39,224,632	NCBI
Celera	13	21,282,474 - 21,418,517 (+)	NCBI		Celera
Cytogenetic Map	13	q14.11	NCBI
HuRef	13	21,028,744 - 21,165,223 (+)	NCBI		HuRef
CHM1_1	13	40,197,304 - 40,333,343 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	13	38,874,034 - 39,010,137 (+)	NCBI		T2T-CHM13v2.0

Cog6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	52,889,544 - 52,924,644 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	52,889,296 - 52,924,658 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	52,982,123 - 53,017,223 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	52,981,875 - 53,017,237 (-)	Ensembl			mm10	GRCm38
MGSCv37	3	52,786,045 - 52,821,145 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	53,070,095 - 53,105,130 (-)	NCBI		MGSCv36	mm8
Celera	3	52,710,466 - 52,745,600 (-)	NCBI		Celera
Cytogenetic Map	3	C	NCBI
cM Map	3	24.1	NCBI

Cog6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	6,637,327 - 6,703,828 (-)	Ensembl
ChiLan1.0	NW_004955431	6,641,116 - 6,703,797 (-)	NCBI	ChiLan1.0	ChiLan1.0

COG6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	39,186,623 - 39,283,189 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	30,291,470 - 30,399,625 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	20,872,151 - 20,973,658 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	39,459,424 - 39,556,002 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	39,459,424 - 39,591,666 (+)	Ensembl			panPan2	panpan1.1

COG6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	1,428,277 - 1,524,734 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	1,331,966 - 1,524,747 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	1,471,940 - 1,621,602 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	1,472,981 - 1,622,702 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	1,472,081 - 1,622,745 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	1,375,174 - 1,524,816 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	1,368,146 - 1,517,792 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	1,434,939 - 1,584,610 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cog6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	162,511,267 - 162,585,473 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936565	5,996,270 - 6,069,426 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936565	5,996,031 - 6,069,517 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COG6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	14,576,214 - 14,649,795 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	11	14,576,194 - 14,737,836 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	14,710,709 - 14,979,188 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

COG6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	18,034,004 - 18,170,050 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	18,034,066 - 18,130,060 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666057	26,108,592 - 26,245,376 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cog6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624748	444,784 - 520,804 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cog6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	101,412,945 - 101,448,974 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cog6
265 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	30
Count of miRNA genes:	28
Interacting mature miRNAs:	30
Transcripts:	ENSRNOT00000018385
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	105628029	150628029	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1358360	Sradr2	Stress Responsive Adrenal Weight QTL 2	10.24		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	2	124103798	154505346	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	138595962	205135428	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	124537199	209621565	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	122597372	215234002	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
2317886	Alcrsp23	Alcohol response QTL 23	2.4	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	95142371	140142371	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	139067258	192287892	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1582257	Gluco21	Glucose level QTL 21	3.1	0.0035	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	120039407	159440891	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1359035	Bp276	Blood pressure QTL 276			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	100807373	145807373	Rat
8662836	Vetf8	Vascular elastic tissue fragility QTL 8	0.66		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	106869825	151869825	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
5135226	Leukc2	Leukocyte quantity QTL 2			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	2	120039407	151869825	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	93602631	145807373	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	139067258	184067258	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
7488933	Bp368	Blood pressure QTL 368		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	104957381	149957381	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
738007	Anxrr7	Anxiety related response QTL 7	4.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	120339555	165339555	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
1581552	Pur12	Proteinuria QTL 12	5.19	0.0009	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	2	114032149	150226270	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	114440891	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1354594	Despr10	Despair related QTL 10		2e-06	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	2	116804572	161804572	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	61051541	143746880	Rat

Markers in Region

RH134230

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	137,061,411 - 137,061,618 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	142,196,851 - 142,197,057	NCBI	Rnor6.0
Rnor_5.0	2	161,882,783 - 161,882,989	UniSTS	Rnor5.0
RGSC_v3.4	2	142,766,543 - 142,766,749	UniSTS	RGSC3.4
Celera	2	131,559,848 - 131,560,054	UniSTS
RH 3.4 Map	2	850.8	UniSTS
Cytogenetic Map	2	q26	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079442	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018385 ⟹ ENSRNOP00000018385

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	139,211,678 - 139,249,737 (-)	Ensembl
mRatBN7.2 Ensembl	2	137,061,346 - 137,099,190 (-)	Ensembl
Rnor_6.0 Ensembl	2	142,196,754 - 142,235,066 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098369 ⟹ ENSRNOP00000079046

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	139,212,461 - 139,249,505 (-)	Ensembl
mRatBN7.2 Ensembl	2	137,062,129 - 137,099,176 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105660 ⟹ ENSRNOP00000084043

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	139,212,461 - 139,249,505 (-)	Ensembl
mRatBN7.2 Ensembl	2	137,062,129 - 137,099,176 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000129251 ⟹ ENSRNOP00000111417

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	139,215,075 - 139,249,505 (-)	Ensembl

RefSeq Acc Id:

NM_001004262 ⟹ NP_001004262

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	139,212,459 - 139,249,505 (-)	NCBI
mRatBN7.2	2	137,062,127 - 137,099,176 (-)	NCBI
Rnor_6.0	2	142,197,566 - 142,235,054 (-)	NCBI
Rnor_5.0	2	161,882,713 - 161,921,014 (-)	NCBI
RGSC_v3.4	2	142,767,258 - 142,804,731 (-)	RGD
Celera	2	131,560,563 - 131,597,609 (-)	RGD

Sequence:

show sequence

CGATGGCTGACACCAGCGGGGAGGTGGCGGCGGTCCCCGCCTCCGGGGCCGCCAATGGCCTCAG
CAATGGGGCTGGCGCGACCCCAGCGCAGCCCAACAACCCGCTGTCGCGCAAGCTGCACAAGATC
CTGGAAACGCGGCTTGAAAATGACAAGGAGATGTTGGAAGCTCTCAAGGCCCTCTCAGCCTTTT
TTGTTGAAAATAGTTTGCGGACTCGACGGAATCTACGCGGTGATATTGAACGTAGAAGCTTAGC
CATCAATGAGGAATTTGTAAGCATTTTCAAAGATGTAAAGGAGGAACTCGAAAGCATCAATGAA
GACGTACAAGCAATGAGCAGCTGCTGTCAGGACATGACAAGCCGCTTACAGGCAGCAAAGGAAC
AGACTCAAGATTTAATAGTAAAGACCACTAAGCTTCAAGCGGAAAACCAAAGACTAGAAATTAG
AGCACAAGTTGCAGATGCCTTTTTATCCAAGTTCCAGTTGACTTCTGATGAAATGACTCTCCTC
CGAGGTACAAGAGGAGGCCCCGTTACTGAGGACTTTTTCAAGGCTTTGGGAAGAGTGAAACAAA
TTCATAATGACGTCAAAGTTCTTTTGAGAACCAACCAGCAGACGGCAGGTTTGGAGATTATGGA
ACAGATGGCCTTGCTTCAAGAAACTGCTTATGAAAGACTTTACCGGTGGGCTCAAAGCGAGTGC
AGAGCACTGACTCAGGAGTCCTGTGATGTGTCTGCGGTGTTAACTCAGGCCATGGAAGCCCTGC
AGGACAGGCCTGTCTTGTACAAGTATACCTTAGATGAATTTGGAACGGCCAGGCGAAGCACTGT
GGTTCGTGGGTTTATTGATGCTCTTACAAGAGGAGGGCCAGGAGGTACACCTAGACCCATTGAA
ATGCACTCCCATGACCCGCTGAGGTATGTGGGAGACATGCTGGCCTGGCTCCATCAAGCTACTG
CCTCTGAGAAGGAACATCTGGAAGCTCTCTTAAAGCATGTAACTGCACAGGGTGTTAAAGAAAA
TATTCAAGAAGTTGTTGGGCATATCACCGAGGGTGTGTGTCGGCCTCTAAAGGTTCGAATTGAA
CAAGTAATACTTGCTGAACCTGGGGCAGTGTTATTATATAAAATTTCTAACCTCCTCAAGTTTT
ACCACCATACCATCAGTGGCATTGTTGGAAATAGTGCAGCTACTCTACTGACAACAATTGAAGA
AATGCACTTGCTAAGCAAAAAAATATTCTTCAGTAGCTTGAGTCTCCATGCGAATAAACTGATG
GACAAGATCGAGCTCCCACCACCTGACCTCGGACCCAGTTCTGCCCTGAGTCAGACCCTCACTT
TGCTGCGGGACGTTCTGGCCTCACATGATTCTTCAGTGGTCCCCTTGGATGCTCGGCAAGCTGA
CTTTGTGCAGGTTTTGTCATGTGTCCTGGATCCTCTCCTCCAGATGTGCACAGTGTCAGCCAGC
AATTTAGGCACCGCTGACATGGCCACGTTCATGGTCAATTCACTGTACATGATGAAGACGACAC
TGGCTCTGTTTGAATTCACAGACAGGCGCCTGGAAATGCTTCAGTTTCAGATCGAAGCCCATCT
GGACACTCTTATCAATGAGCAAGCCTCTTACGTTTTAACTAGAGTGGGCTTGAGTTACATCTAC
AACACGATACAGCAGCATAGGCCTGATCAGGGCTCCTTAGCCAGTATGCCCAACCTAGATTCTG
TGGCGCTGAAGGCTGCAATGGCTCAGTTCGACCGCTACCTCTCAGCCCCAGATCACCTGCTGAT
GCCACAGCTGAACTCCCTCCTCAGTGCCACCGTGAAGGAGCAGATTATAAAGCAGTCTACGGAG
CTCGTCTGCAGAGCCTACGGGGAGGTGCATGCAGCCGTGATGAATCCAGTCAACGCGTACAAAG
ACCCGGAGAGCATCCTTCACAGGTCACCCGAGCAGGTGAAGACGCTGCTCTCTTGATGTTGATG
GCGTTTGCAGAGTATTGCTGCCTGGCAACAGCACCAAGGGTGGTTTGGGCTTTTAATCTATGAG
TCTTTACCTTGAAGATTGAGAGTTAATAGTTTTCCTTGTATGGGGTTGTAGGTCAATTTCTCCC
ATTCTCAGCTAACTTGGAGGTAAATCAATATTGACTTGAAAAAAAAAAAAAAAAAAAAAAAAAA
A

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004262	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79442	(Get FASTA)	NCBI Sequence Viewer
	EDM14961	(Get FASTA)	NCBI Sequence Viewer
	EDM14962	(Get FASTA)	NCBI Sequence Viewer
	EDM14963	(Get FASTA)	NCBI Sequence Viewer
	EDM14964	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000079046
GenBank Protein	Q68FP9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001004262 ⟸ NM_001004262

- UniProtKB:

Q68FP9 (UniProtKB/Swiss-Prot), A0A8I6G9T5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADTSGEVAAVPASGAANGLSNGAGATPAQPNNPLSRKLHKILETRLENDKEMLEALKALSAFF
VENSLRTRRNLRGDIERRSLAINEEFVSIFKDVKEELESINEDVQAMSSCCQDMTSRLQAAKEQ
TQDLIVKTTKLQAENQRLEIRAQVADAFLSKFQLTSDEMTLLRGTRGGPVTEDFFKALGRVKQI
HNDVKVLLRTNQQTAGLEIMEQMALLQETAYERLYRWAQSECRALTQESCDVSAVLTQAMEALQ
DRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATA
SEKEHLEALLKHVTAQGVKENIQEVVGHITEGVCRPLKVRIEQVILAEPGAVLLYKISNLLKFY
HHTISGIVGNSAATLLTTIEEMHLLSKKIFFSSLSLHANKLMDKIELPPPDLGPSSALSQTLTL
LRDVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSASNLGTADMATFMVNSLYMMKTTL
ALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRVGLSYIYNTIQQHRPDQGSLASMPNLDSV
ALKAAMAQFDRYLSAPDHLLMPQLNSLLSATVKEQIIKQSTELVCRAYGEVHAAVMNPVNAYKD
PESILHRSPEQVKTLLS

hide sequence

Ensembl Acc Id:

ENSRNOP00000018385 ⟸ ENSRNOT00000018385

Ensembl Acc Id:

ENSRNOP00000079046 ⟸ ENSRNOT00000098369

Ensembl Acc Id:

ENSRNOP00000084043 ⟸ ENSRNOT00000105660

Ensembl Acc Id:

ENSRNOP00000111417 ⟸ ENSRNOT00000129251

Protein Domains

Conserved oligomeric complex COG6 N-terminal Conserved Oligomeric Golgi complex subunit 6 C-

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68FP9-F1-model_v2	AlphaFold	Q68FP9	1-657	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691321

Promoter ID:

EPDNEW_R1846

Type:

multiple initiation site

Name:

Cog6_1

Description:

component of oligomeric golgi complex 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	142,235,064 - 142,235,124	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303283	AgrOrtholog
BioCyc Gene	G2FUF-53103	BioCyc
Ensembl Genes	ENSRNOG00000013660	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000098369	ENTREZGENE
IMAGE_CLONE	IMAGE:7115484	IMAGE-MGC_LOAD
InterPro	COG6	UniProtKB/Swiss-Prot
	COG6_C	UniProtKB/Swiss-Prot
	COG6_N	UniProtKB/Swiss-Prot
KEGG Report	rno:310411	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94990	IMAGE-MGC_LOAD
NCBI Gene	310411	ENTREZGENE
PANTHER	CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6	UniProtKB/Swiss-Prot
	PTHR21506	UniProtKB/Swiss-Prot
Pfam	COG6	UniProtKB/Swiss-Prot
	COG6_C	UniProtKB/Swiss-Prot
PhenoGen	Cog6	PhenoGen
RatGTEx	ENSRNOG00000013660	RatGTEx
SMART	COG6	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZM11_RAT	UniProtKB/TrEMBL
	A0A8I6G9T5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QA73_RAT	UniProtKB/TrEMBL
	A0ABK0LKE8_RAT	UniProtKB/TrEMBL
	A6JV88_RAT	UniProtKB/TrEMBL
	A6JV89_RAT	UniProtKB/TrEMBL
	A6JV90_RAT	UniProtKB/TrEMBL
	A6JV91_RAT	UniProtKB/TrEMBL
	COG6_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Cog6	component of oligomeric golgi complex 6			Symbol and Name status set to approved	1299863	APPROVED
2005-09-30	Cog6				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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