Wfdc6b (WAP four-disulfide core domain 6B) - Rat Genome Database

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Gene: Wfdc6b (WAP four-disulfide core domain 6B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Wfdc6b
Name: WAP four-disulfide core domain 6B
RGD ID: 1303277
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of flagellated sperm motility. Predicted to be located in extracellular region. Predicted to be active in extracellular space; INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: WAP four-disulfide core 6-like 1; WAP four-disulfide core domain protein 6B; Wfdc6l1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,758,317 - 173,766,797 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3173,757,930 - 173,766,471 (+)EnsemblGRCr8
mRatBN7.23153,339,051 - 153,346,940 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,339,110 - 153,347,132 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3157,149,285 - 157,155,854 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,648,250 - 165,654,819 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,391,877 - 163,398,598 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,071,019 - 161,078,173 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,071,019 - 161,078,173 (+)Ensemblrn6Rnor6.0
Rnor_5.03167,249,154 - 167,256,308 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43155,634,498 - 155,641,866 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3151,948,390 - 151,955,168 (+)NCBICelera
RGSC_v3.13155,540,533 - 155,547,902 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:89
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000048654
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 44 9 18 5 1 5 1 36 2 42 26 59 13

Sequence


Ensembl Acc Id: ENSRNOT00000037518   ⟹   ENSRNOP00000036161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,757,930 - 173,766,279 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000048654   ⟹   ENSRNOP00000042819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,758,390 - 173,766,471 (+)Ensembl
mRatBN7.2 Ensembl3153,339,140 - 153,347,132 (+)Ensembl
Rnor_6.0 Ensembl3161,071,019 - 161,078,173 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097649   ⟹   ENSRNOP00000086668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,339,110 - 153,346,632 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156375   ⟹   ENSRNOP00000104311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,757,930 - 173,766,279 (+)Ensembl
RefSeq Acc Id: NM_001413016   ⟹   NP_001399945
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,758,390 - 173,766,279 (+)NCBI
mRatBN7.23153,339,051 - 153,346,940 (+)NCBI
RefSeq Acc Id: XM_063284322   ⟹   XP_063140392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,758,317 - 173,766,797 (+)NCBI
Ensembl Acc Id: ENSRNOP00000042819   ⟸   ENSRNOT00000048654
Ensembl Acc Id: ENSRNOP00000086668   ⟸   ENSRNOT00000097649
RefSeq Acc Id: NP_001399945   ⟸   NM_001413016
- Peptide Label: precursor
- UniProtKB: A0A8I6A6P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140392   ⟸   XM_063284322
- Peptide Label: isoform X1
- UniProtKB: Q6IE19 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104311   ⟸   ENSRNOT00000156375
Ensembl Acc Id: ENSRNOP00000036161   ⟸   ENSRNOT00000037518
Protein Domains
BPTI/Kunitz inhibitor   WAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE19-F1-model_v2 AlphaFold Q6IE19 1-182 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303277 AgrOrtholog
BioCyc Gene G2FUF-46844 BioCyc
Ensembl Genes ENSRNOG00000031823 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000042526 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037518 ENTREZGENE
  ENSRNOT00000037518.7 UniProtKB/TrEMBL
  ENSRNOT00000048654 ENTREZGENE
  ENSRNOT00000048654.3 UniProtKB/TrEMBL
  ENSRNOT00000097649.2 UniProtKB/TrEMBL
  ENSRNOT00000156375.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.410.10 UniProtKB/TrEMBL
  4.10.75.10 UniProtKB/TrEMBL
InterPro Elafin-like_sf UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  Prot_inh_Kunz-m UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
  Serpin_venom_toxin UniProtKB/TrEMBL
  Whey_acidic_protein_4-diS_core UniProtKB/TrEMBL
NCBI Gene 408225 ENTREZGENE
PANTHER EPPIN UniProtKB/TrEMBL
  WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 6A UniProtKB/TrEMBL
  WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 6B UniProtKB/TrEMBL
Pfam Kunitz_BPTI UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
PhenoGen Wfdc6b PhenoGen
PRINTS BASICPTASE UniProtKB/TrEMBL
PROSITE BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031823 RatGTEx
  ENSRNOG00000042526 RatGTEx
SMART SM00131 UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_Kunz-m UniProtKB/TrEMBL
  SSF57256 UniProtKB/TrEMBL
UniProt A0A8I6A6P2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LRJ2_RAT UniProtKB/TrEMBL
  F1LVU2_RAT UniProtKB/TrEMBL
  Q6IE19 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Wfdc6b  WAP four-disulfide core domain 6B  Wfdc6l1  WAP four-disulfide core 6-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-14 Wfdc6l1  WAP four-disulfide core 6-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL