Rtn2 (reticulon 2) - Rat Genome Database

Name: Rtn2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Rtn2 (reticulon 2) Rattus norvegicus

Analyze

Symbol:

Rtn2

Name:

reticulon 2

RGD ID:

1303245

Description:

Acts upstream of or within protein transport. Located in cell surface and endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 12. Orthologous to human RTN2 (reticulon 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

formerly RTN2w; neuroendocrine-specific protein-like 1; neuroendocrine-specific protein-like I; NSP-like 1; NSP-like protein 1; NSP-like protein I; NSPLI; reticulon 2 (Z-band associated protein); reticulon-2; RTN2-B

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RTN2 (reticulon 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Rtn2 (reticulon 2 (Z-band associated protein))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rtn2 (reticulon 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RTN2 (reticulon 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rtn2 (reticulon 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RTN2 (reticulon 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RTN2 (reticulon 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rtn2 (reticulon 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RTN2 (reticulon 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rtn2 (reticulon 2 (Z-band associated protein))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rtn2b (reticulon 2b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Caenorhabditis elegans (roundworm):	ret-1	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Rtnl1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	rtn2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	88,063,124 - 88,076,082 (+)	NCBI		GRCr8
mRatBN7.2	1	78,935,056 - 78,948,069 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	78,935,104 - 78,948,069 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	84,324,335 - 84,337,063 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	92,881,890 - 92,894,670 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	86,079,422 - 86,092,150 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	80,195,594 - 80,208,449 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	80,195,532 - 80,208,448 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	81,462,077 - 81,474,932 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	78,647,099 - 78,660,389 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	78,725,036 - 78,738,491 (+)	NCBI
Celera	1	73,397,564 - 73,410,355 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 10 (ISO)

hereditary spastic paraplegia 12 (ISO)

paraplegia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (EXP,ISO)

aristolochic acid A (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (EXP,ISO)

butanal (ISO)

cadmium dichloride (EXP)

calcitriol (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

deguelin (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

dioxygen (ISO)

dorsomorphin (ISO)

ethanol (ISO)

gallic acid (ISO)

gentamycin (EXP)

indometacin (ISO)

methimazole (EXP)

methotrexate (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

pentanal (ISO)

picoxystrobin (ISO)

pioglitazone (ISO)

potassium dichromate (ISO)

propanal (ISO)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sotorasib (ISO)

sulforaphane (ISO)

temozolomide (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thalidomide (ISO)

thioacetamide (EXP)

trametinib (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

gene expression (ISO)

intracellular protein transmembrane transport (ISO,ISS)

negative regulation of amyloid-beta formation (ISO,ISS)

protein transport (IDA)

regulation of glucose import (ISO,ISS)

Cellular Component

cell surface (IDA)

cytoskeleton (IEA)

endoplasmic reticulum (IDA,ISO)

endoplasmic reticulum membrane (IBA)

intermediate filament (ISO,ISS)

sarcoplasmic reticulum membrane (IEA)

T-tubule (IEA,ISO,ISS)

terminal cisterna (ISO,ISS)

Z disc (IEA,ISO,ISS)

Molecular Function

protein binding (IPI,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.	Liu Y, etal., J Biol Chem. 2008 Mar 7;283(10):6561-71. doi: 10.1074/jbc.M708096200. Epub 2007 Dec 20.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:12832288	PMID:19720795	PMID:22232211

Genomics

Comparative Map Data

Rtn2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	88,063,124 - 88,076,082 (+)	NCBI		GRCr8
mRatBN7.2	1	78,935,056 - 78,948,069 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	78,935,104 - 78,948,069 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	84,324,335 - 84,337,063 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	92,881,890 - 92,894,670 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	86,079,422 - 86,092,150 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	80,195,594 - 80,208,449 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	80,195,532 - 80,208,448 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	81,462,077 - 81,474,932 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	78,647,099 - 78,660,389 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	78,725,036 - 78,738,491 (+)	NCBI
Celera	1	73,397,564 - 73,410,355 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

RTN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	45,485,294 - 45,497,047 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	45,485,294 - 45,497,055 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	45,988,552 - 46,000,305 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	50,680,390 - 50,692,153 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	50,680,389 - 50,692,153	NCBI
Celera	19	42,794,649 - 42,806,419 (-)	NCBI		Celera
Cytogenetic Map	19	q13.32	NCBI
HuRef	19	42,418,168 - 42,429,756 (-)	NCBI		HuRef
CHM1_1	19	45,991,794 - 46,003,559 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	48,312,543 - 48,326,854 (-)	NCBI		T2T-CHM13v2.0

Rtn2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	19,016,549 - 19,030,089 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	19,016,549 - 19,030,085 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	19,282,624 - 19,296,164 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	19,282,624 - 19,296,160 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	19,868,016 - 19,881,509 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	18,441,189 - 18,454,682 (+)	NCBI		MGSCv36	mm8
Celera	7	16,679,800 - 16,713,582 (+)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	9.54	NCBI

Rtn2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955574	1,071 - 21,117 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955574	1,543 - 11,476 (-)	NCBI	ChiLan1.0	ChiLan1.0

RTN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	51,645,690 - 51,658,924 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	53,517,190 - 53,530,413 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	42,434,085 - 42,446,862 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	51,030,708 - 51,043,404 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	51,030,708 - 51,043,404 (-)	Ensembl	panpan1.1		panPan2

Rtn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	17,567,224 - 17,575,639 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936706	1,913,842 - 1,922,772 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936706	1,913,852 - 1,922,982 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RTN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	51,854,998 - 51,875,169 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	51,855,844 - 51,864,753 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

RTN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	38,931,473 - 38,943,057 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	38,931,348 - 38,942,886 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	18,551,246 - 18,564,389 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rtn2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624907	2,344,134 - 2,352,199 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624907	2,345,223 - 2,350,844 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rtn2
26 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	48
Count of miRNA genes:	41
Interacting mature miRNAs:	46
Transcripts:	ENSRNOT00000022528
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	509108	86060548	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	11481312	82174945	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	11481312	82174945	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	11481312	82174945	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	11481312	82174945	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	22340647	102268831	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	30882023	123479925	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	32737273	90665040	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	34836858	79836858	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	34836858	79836858	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	34836858	79836858	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43284731	118944897	Rat
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43284731	118944897	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43284731	118944897	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	43284731	118944897	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43284731	118944897	Rat
2302059	Pia36	Pristane induced arthritis QTL 36	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	43333002	88333002	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	49361465	82174945	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	49393172	94393172	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	53863041	90532583	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	53895117	82174945	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	53895117	82174945	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	56732668	98773277	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	56949932	101949932	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
1300121	Hrtrt1	Heart rate QTL 1	3.7		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	65789093	115540829	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	66023617	118608521	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	72197680	90508767	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	77494165	122494165	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	77857876	122857876	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	77876254	106047988	Rat
61344	Bp29	Blood pressure QTL 29	7.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	78350581	123350581	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	78430536	123430536	Rat
61433	Cia2	Collagen induced arthritis QTL 2	5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	78430754	91209302	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	78479925	123479925	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		43	2	2		2	8	11	74		8	4	8
Low	3		41	26	18	26				30	30	7
Below cutoff			14	13	1	13				5	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_201562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY279211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC129079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BK001788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000022528 ⟹ ENSRNOP00000022528

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	78,935,104 - 78,948,030 (+)	Ensembl
Rnor_6.0 Ensembl	1	80,195,532 - 80,208,448 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101499 ⟹ ENSRNOP00000092461

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	78,943,076 - 78,948,069 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000115756 ⟹ ENSRNOP00000092160

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	78,943,077 - 78,947,979 (+)	Ensembl

RefSeq Acc Id:

NM_201562 ⟹ NP_963856

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	88,063,292 - 88,076,082 (+)	NCBI
mRatBN7.2	1	78,935,277 - 78,948,069 (+)	NCBI
Rnor_6.0	1	80,195,594 - 80,208,449 (+)	NCBI
Rnor_5.0	1	81,462,077 - 81,474,932 (+)	NCBI
RGSC_v3.4	1	78,647,099 - 78,660,389 (+)	RGD
Celera	1	73,397,564 - 73,410,355 (+)	RGD

Sequence:

show sequence

ATGGGGCAGGTCCTGCCGGTCTTCGCCCACTGCAAAGAAGCTCCATCTACAGCCTCTTCTACCC
CCGATTCCACGGAAGGAGGGAATGACGACTCGGATTTTCGGGAGCTGCACACAGCCCGGGAATT
CTCGGAGGACGAAGAGGAGGAGACTACATCGCAGGACTGGGGCACCCCCAGGGAGCTGACCTTT
TCCTACATTGCCTTCGACGGCGTGGTGGGCTCTGGGGGCCGTAGGGATTCAGTTGTTCGTCGTC
CCAGGCCCCAGGGACGTTCAGTCTCAGAACCAAGGGACCCACCCCCACAGCCCAGCCTGGGTGA
CAGCTTGGAGAGTATCCCTAGTCTGAGCCAGTCCCCAGAGCCGGGGCGTCGCGGTGACCCAGAC
ACTGTACCTCCAGCTGAGCGCCCGCTGGAGGAACTGAGGCTTCGGCTGGACCAGCTTGGCTGGG
CTGTCCGGAGTGCGGGATCTGGGGAGGATTCGGCCACCAGCAGCTCTACCCCGCTGGAAAATGA
GGAGCCGGATGGATTGGAGGCCAGCGAGGCTGGAGAGACGAATCTGGAACTCCGACTTGCTCAG
CCTCTACATTTGCAATTTGAGGGCTTGACTCCTCAGCTTAGCCCGAGCTCCGGGATTCCCCAGG
CGCATACCCCATCCCCACAGAGATCTCAAGATTTGAACACCGGTCCTGATGAGCCGCTGCCGAA
TGGGGAAGGAGAACATTGGCGGCTGCTGGAGCAGGAGCCAATCACGGCCCAGTGCCTCAATAGC
ACAGACCAATCAGAATTCACGTTGGAGCCGCTCCTTCTAGTGGCAGACCTGTTGTACTGGAAGG
ACACCAGGACGTCGGGAGCCATCTTCACGGGCCTCATGGCCTCTCTCCTCTGCCTCCTGCACTT
TAGCATCGTGTCCGTGGCTGCGCACCTGGCCCTGCTGGGTCTCTGCGCCACCATCTCTCTCAGG
GTTTACCGCAAAGTGCTGCAGGCCGTGCACCGGGGCGACGGCACCAACCCTTTCCAGGCTTACC
TGGACATGGACCTGACCCTGACTCGGGAGCAGACAGAACGTTTGTCCCAGCAGATTGCCTCCCA
CGTGGTCTCCACGGCCACACAGCTGCGGCATTTCTTCCTCGTAGAAGACCTGGTGGATTCTCTC
AAGCTGGCTCTTCTCTTCTACATCTTGACCTTCGTGGGAGCCATCTTTAACGGCTTGACTCTTG
TCATCTTGGGAGTGGTTGCTTTGTTCACCGTCCCCCTTCTGTACAGACAACATCAGGCCCAGAT
TGACCAGTATGTGGGGTTGGTGACCAGCCAGTTGAGCCACATCAAAGCTAAGATCCGAGCTAAG
ATCCCGGGGACCGGAACCCTTGCCCCAGCAGCATCAGTCTCCGGATCCAAAGCCAAAGCCGAAT
GAGAAGGGTGTCTTTGCCCGAGGGACGCCTGCCACACCCCAGCAGCCCTCTTCCCTTTCATTTC
CCGTGCATCCACACCCTCTCCCACTCGGCCGAGCCATTTCCCAGTGGGAAGTGCCTGAGCGACC
CAGACTACATTTCCTAAGAGGCTCTGCTCTAAGAGTCCAGGAAAAGACCATGCTCCTTGGCCGC
GGAGCCTGCTGGGACTTGTAGTTGAATAGTGAGGACGCTGCTCTGCACTTCCGTGACCCGCCGC
TGGAGGCGCCGTGAGGGGTTGGTGTCTCTGAGGCCACCAACCCCTGTGCTGGGGCTTTGCATGG
GGCCCAGGCGAGCCTTGAGCTTGGATTTACACTGTAATAAAGATTCCTGTGGAAAATTCACTGC
CTTCTATGCTTTAAAGTCCTTTCACTTACACCTTCCTACATTGAAAAAAATTAAAACAAACAAA
TAAAAACGTAAAAAACCTAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017589116 ⟹ XP_017444605

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	88,071,002 - 88,075,996 (+)	NCBI
mRatBN7.2	1	78,942,989 - 78,948,066 (+)	NCBI
Rnor_6.0	1	80,203,409 - 80,208,367 (+)	NCBI

Sequence:

show sequence

GCCATTGGTTAGGTTACAAAGGGGCCCTTCCCCTCTGCTCTTTCCCTCGGGTCCTTCTCAAGTG
GGCAAAATCCCCAGGACTGGGCGTCTGCAACCGTTCTCTCGGAGCCAAGATGGGGAGTAAAGTG
GCAGACCTGTTGTACTGGAAGGACACCAGGACGTCGGGAGCCATCTTCACGGGCCTCATGGCCT
CTCTCCTCTGCCTCCTGCACTTTAGCATCGTGTCCGTGGCTGCGCACCTGGCCCTGCTGGGTCT
CTGCGCCACCATCTCTCTCAGGGTTTACCGCAAAGTGCTGCAGGCCGTGCACCGGGGCGACGGC
ACCAACCCTTTCCAGGCTTACCTGGACATGGACCTGACCCTGACTCGGGAGCAGACAGAACGTT
TGTCCCAGCAGATTGCCTCCCACGTGGTCTCCACGGCCACACAGCTGCGGCATTTCTTCCTCGT
AGAAGACCTGGTGGATTCTCTCAAGCTGGCTCTTCTCTTCTACATCTTGACCTTCGTGGGAGCC
ATCTTTAACGGCTTGACTCTTGTCATCTTGGGAGTGGTTGCTTTGTTCACCGTCCCCCTTCTGT
ACAGACAACATCAGGCCCAGATTGACCAGTATGTGGGGTTGGTGACCAGCCAGTTGAGCCACAT
CAAAGCTAAGATCCGAGCTAAGATCCCGGGGACCGGAACCCTTGCCCCAGCAGCATCAGTCTCC
GGATCCAAAGCCAAAGCCGAATGAGAAGGGTGTCTTTGCCCGAGGGACGCCTGCCACACCCCAG
CAGCCCTCTTCCCTTTCATTTCCCGTGCATCCACACCCTCTCCCACTCGGCCGAGCCATTTCCC
AGTGGGAAGTGCCTGAGCGACCCAGACTACATTTCCTAAGAGGCTCTGCTCTAAGAGTCCAGGA
AAAGACCATGCTCCTTGGCCGCGGAGCCTGCTGGGACTTGTAGTTGAATAGTGAGGACGCTGCT
CTGCACTTCCGTGACCCGCCGCTGGAGGCGCCGTGAGGGGTTGGTGTCTCTGAGGCCACCAACC
CCTGTGCTGGGGCTTTGCATGGGGCCCAGGCGAGCCTTGAGCTTGGATTTACACTGTAATAAAG
ATTCCTGTGGAAAATTCACTGC

hide sequence

RefSeq Acc Id:

XM_039111299 ⟹ XP_038967227

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	88,063,124 - 88,071,088 (+)	NCBI
mRatBN7.2	1	78,935,056 - 78,943,030 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_963856	(Get FASTA)	NCBI Sequence Viewer
	XP_017444605	(Get FASTA)	NCBI Sequence Viewer
	XP_038967227	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI29080	(Get FASTA)	NCBI Sequence Viewer
	AAQ18231	(Get FASTA)	NCBI Sequence Viewer
	DAA01961	(Get FASTA)	NCBI Sequence Viewer
	EDM08213	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022528
	ENSRNOP00000022528.5
	ENSRNOP00000092160.1
	ENSRNOP00000092461
	ENSRNOP00000092461.1
	ENSRNOP00055047059
	ENSRNOP00060047177
	ENSRNOP00065044458
GenBank Protein	Q6WN19	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_963856 ⟸ NM_201562

- UniProtKB:

F1LM00 (UniProtKB/Swiss-Prot), Q6WN19 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEDEEEETTSQDWGTPRELTF
SYIAFDGVVGSGGRRDSVVRRPRPQGRSVSEPRDPPPQPSLGDSLESIPSLSQSPEPGRRGDPD
TVPPAERPLEELRLRLDQLGWAVRSAGSGEDSATSSSTPLENEEPDGLEASEAGETNLELRLAQ
PLHLQFEGLTPQLSPSSGIPQAHTPSPQRSQDLNTGPDEPLPNGEGEHWRLLEQEPITAQCLNS
TDQSEFTLEPLLLVADLLYWKDTRTSGAIFTGLMASLLCLLHFSIVSVAAHLALLGLCATISLR
VYRKVLQAVHRGDGTNPFQAYLDMDLTLTREQTERLSQQIASHVVSTATQLRHFFLVEDLVDSL
KLALLFYILTFVGAIFNGLTLVILGVVALFTVPLLYRQHQAQIDQYVGLVTSQLSHIKAKIRAK
IPGTGTLAPAASVSGSKAKAE

hide sequence

RefSeq Acc Id:	XP_017444605 ⟸ XM_017589116
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6AVP6 (UniProtKB/TrEMBL), A0A8I6AD60 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGSKVADLLYWKDTRTSGAIFTGLMASLLCLLHFSIVSVAAHLALLGLCATISLRVYRKVLQAV HRGDGTNPFQAYLDMDLTLTREQTERLSQQIASHVVSTATQLRHFFLVEDLVDSLKLALLFYIL TFVGAIFNGLTLVILGVVALFTVPLLYRQHQAQIDQYVGLVTSQLSHIKAKIRAKIPGTGTLAP AASVSGSKAKAE hide sequence

RefSeq Acc Id:

ENSRNOP00000022528 ⟸ ENSRNOT00000022528

RefSeq Acc Id:	XP_038967227 ⟸ XM_039111299
- Peptide Label:	isoform X1
- UniProtKB:	A6J8M1 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000092461 ⟸ ENSRNOT00000101499

RefSeq Acc Id:

ENSRNOP00000092160 ⟸ ENSRNOT00000115756

Protein Domains

Reticulon

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6WN19-F1-model_v2	AlphaFold	Q6WN19	1-469	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303245	AgrOrtholog
BioCyc Gene	G2FUF-60516	BioCyc
Ensembl Genes	ENSRNOG00000016603	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055032929	UniProtKB/Swiss-Prot
	ENSRNOG00060032928	UniProtKB/Swiss-Prot
	ENSRNOG00065031307	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000022528	ENTREZGENE
	ENSRNOT00000022528.7	UniProtKB/Swiss-Prot
	ENSRNOT00000101499.1	UniProtKB/TrEMBL
	ENSRNOT00000115756.1	UniProtKB/TrEMBL
	ENSRNOT00055056963	UniProtKB/Swiss-Prot
	ENSRNOT00060057097	UniProtKB/Swiss-Prot
	ENSRNOT00065054028	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.5.2480	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8370402	IMAGE-MGC_LOAD
InterPro	Reticulon	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RTN1-4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:308410	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156538	IMAGE-MGC_LOAD
NCBI Gene	308410	ENTREZGENE
PANTHER	RETICULON-2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RETICULON-LIKE PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Reticulon	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Rtn2	PhenoGen
PROSITE	RETICULON	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016603	RatGTEx
	ENSRNOG00055032929	RatGTEx
	ENSRNOG00060032928	RatGTEx
	ENSRNOG00065031307	RatGTEx
UniProt	A0A8I6AD60	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AVP6	ENTREZGENE, UniProtKB/TrEMBL
	A6J8M1	ENTREZGENE, UniProtKB/TrEMBL
	F1LM00	ENTREZGENE
	Q6WN19	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	F1LM00	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-30	Rtn2	reticulon 2	Rtn2	reticulon 2 (Z-band associated protein)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-30	Rtn2				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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