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Gene: Knstrn (kinetochore-localized astrin/SPAG5 binding protein) Rattus norvegicus

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Symbol:

Knstrn

Name:

kinetochore-localized astrin/SPAG5 binding protein

RGD ID:

1303240

Description:

Predicted to enable microtubule plus-end binding activity and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Predicted to be located in microtubule organizing center and ruffle. Predicted to be active in kinetochore and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in actinic keratosis and skin squamous cell carcinoma. Orthologous to human KNSTRN (kinetochore localized astrin (SPAG5) binding protein); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

C15orf23; kinastrin; kinetochore-localized astrin-binding protein; kinetochore-localized astrin/SPAG5-binding protein; MGC94986; putative TRAF4-associated factor 1; SKAP; small kinetochore-associated protein; TRAF4 associated factor 1; TRAF4-associated factor 1; Traf4af1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	126,254,633 - 126,274,412 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	126,254,663 - 126,274,418 (+)	Ensembl				GRCr8
mRatBN7.2	3	105,800,762 - 105,820,555 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	105,800,954 - 105,820,715 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	109,473,818 - 109,493,495 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	118,069,366 - 118,089,043 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	115,729,728 - 115,749,405 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	110,618,256 - 110,638,024 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	110,618,298 - 110,638,046 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	117,157,742 - 117,177,511 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	105,322,270 - 105,341,927 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	104,715,313 - 104,733,650 (+)	NCBI		Celera
RGSC_v3.1	3	105,218,697 - 105,238,354 (+)	NCBI
Cytogenetic Map	3	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

actinic keratosis (ISO)

COVID-19 (ISO)

Roifman-Chitayat Syndrome (ISO)

skin squamous cell carcinoma (ISO)

squamous cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,1-dichloroethene (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (EXP,ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrolein (ISO)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

coumarin (ISO)

coumestrol (ISO)

CU-O LINKAGE (ISO)

Cuprizon (EXP)

daidzein (ISO)

daidzein 7-O-beta-D-glucoside (ISO)

DDE (ISO)

diallyl trisulfide (EXP,ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP)

dichloroacetic acid (ISO)

dicrotophos (ISO)

dioxygen (EXP)

Enterolactone (ISO)

fenvalerate (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

furan (EXP)

genistein (ISO)

genistein 7-O-beta-D-glucoside (ISO)

gentamycin (EXP)

glycidol (EXP)

glycitein (ISO)

glycitin (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

indole-3-methanol (EXP)

irinotecan (EXP)

ivermectin (ISO)

ketamine (EXP)

leflunomide (ISO)

lidocaine (EXP)

methamphetamine (EXP)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monobenzyl phthalate (ISO)

Monobutylphthalate (ISO)

monoethyl phthalate (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-nitrosodiethylamine (EXP)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

palbociclib (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulforaphane (ISO)

sunitinib (ISO)

tebufenpyrad (ISO)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

thiram (ISO)

titanium dioxide (EXP,ISO)

topotecan (EXP)

tributylstannane (EXP)

trichloroethene (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

trovafloxacin (ISO)

tunicamycin (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

cell migration (IEA,ISO)

cellular response to epidermal growth factor stimulus (IEA,ISO)

chromosome segregation (IEA,ISO,ISS)

microtubule cytoskeleton organization (IEA,ISO)

mitotic sister chromatid segregation (IBA,IEA,ISO,ISS)

regulation of attachment of spindle microtubules to kinetochore (IBA,IEA,ISO,ISS)

spindle organization (IBA,IEA,ISO,ISS)

Cellular Component

centriolar satellite (IBA,IEA,ISO)

kinetochore (IBA,IEA,ISO,ISS)

microtubule (IEA)

microtubule organizing center (IEA,ISO)

microtubule plus-end (IBA,IEA,ISO,ISS)

mitotic spindle (IBA,IEA,ISO,ISS)

nucleus (IEA)

ruffle (IEA,ISO)

spindle pole (IEA)

Molecular Function

microtubule plus-end binding (IEA,ISO)

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma.	Lee CS, etal., Nat Genet. 2014 Oct;46(10):1060-2. doi: 10.1038/ng.3091. Epub 2014 Sep 7.
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma.	Schmitz L, etal., J Eur Acad Dermatol Venereol. 2019 Aug;33(8):1535-1540. doi: 10.1111/jdv.15615. Epub 2019 May 8.
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:21402792	PMID:28351621

Genomics

Comparative Map Data

Knstrn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	126,254,633 - 126,274,412 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	126,254,663 - 126,274,418 (+)	Ensembl				GRCr8
mRatBN7.2	3	105,800,762 - 105,820,555 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	105,800,954 - 105,820,715 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	109,473,818 - 109,493,495 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	118,069,366 - 118,089,043 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	115,729,728 - 115,749,405 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	110,618,256 - 110,638,024 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	110,618,298 - 110,638,046 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	117,157,742 - 117,177,511 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	105,322,270 - 105,341,927 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	104,715,313 - 104,733,650 (+)	NCBI		Celera
RGSC_v3.1	3	105,218,697 - 105,238,354 (+)	NCBI
Cytogenetic Map	3	q35	NCBI

KNSTRN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	40,382,721 - 40,394,288 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	40,382,721 - 40,394,288 (+)	Ensembl			hg38	GRCh38
GRCh37	15	40,674,922 - 40,686,489 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	38,462,285 - 38,473,299 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	15	38,462,315 - 38,473,179	NCBI
Celera	15	17,440,907 - 17,452,474 (+)	NCBI		Celera
Cytogenetic Map	15	q15.1	NCBI
HuRef	15	17,518,353 - 17,529,919 (+)	NCBI		HuRef
CHM1_1	15	40,794,787 - 40,806,354 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	38,189,915 - 38,201,483 (+)	NCBI		T2T-CHM13v2.0

Knstrn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	118,644,470 - 118,667,691 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	118,644,484 - 118,684,438 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	118,813,988 - 118,837,210 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	118,814,003 - 118,853,957 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	118,639,739 - 118,661,948 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	118,505,444 - 118,526,080 (+)	NCBI		MGSCv36	mm8
Celera	2	119,968,365 - 119,990,208 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	59.46	NCBI

Knstrn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	7,311,627 - 7,321,553 (+)	Ensembl
ChiLan1.0	NW_004955416	7,311,483 - 7,322,272 (+)	NCBI	ChiLan1.0	ChiLan1.0

KNSTRN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	29,616,720 - 29,628,312 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	33,768,188 - 33,779,777 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	19,316,854 - 19,328,425 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	37,572,017 - 37,583,614 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

KNSTRN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	7,562,738 - 7,573,514 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	7,562,807 - 7,572,950 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	7,616,615 - 7,627,396 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	7,688,596 - 7,699,369 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	7,688,665 - 7,720,482 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	7,613,042 - 7,623,767 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	7,719,023 - 7,729,782 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	7,847,773 - 7,858,567 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Knstrn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	85,988,287 - 86,000,646 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	3,838,612 - 3,848,751 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	3,838,507 - 3,849,521 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KNSTRN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	130,916,146 - 130,930,078 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	130,916,956 - 130,930,172 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	145,996,324 - 146,015,175 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KNSTRN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	42,620,401 - 42,631,932 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	42,621,084 - 42,631,822 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	98,332,517 - 98,344,414 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Knstrn
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	96,989,743 - 97,009,109 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Knstrn
131 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	218
Count of miRNA genes:	152
Interacting mature miRNAs:	169
Transcripts:	ENSRNOT00000012454
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	96509147	141509147	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	73592512	136118980	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	122654702	136118980	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	116582412	136118980	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	85062224	136118980	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	85062224	136118980	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	104545086	149545086	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	81425008	141509147	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	70845569	136091483	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	93829559	138829559	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	112250810	157250810	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	101255536	134750886	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	96509147	141509147	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	117537367	162537367	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	110225882	155225882	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	81541464	126563126	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	90755164	141509147	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	125814931	139636791	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	110634702	155634702	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	116188400	161188400	Rat

Markers in Region

RH131720

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	105,820,186 - 105,820,369 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	110,637,690 - 110,637,872	NCBI	Rnor6.0
Rnor_5.0	3	117,177,177 - 117,177,359	UniSTS	Rnor5.0
RGSC_v3.4	3	105,341,671 - 105,341,853	UniSTS	RGSC3.4
Celera	3	104,733,394 - 104,733,576	UniSTS
RH 3.4 Map	3	913.8	UniSTS
Cytogenetic Map	3	q35	UniSTS

AU019491

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	105,820,104 - 105,820,215 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	110,637,608 - 110,637,718	NCBI	Rnor6.0
Rnor_5.0	3	117,177,095 - 117,177,205	UniSTS	Rnor5.0
RGSC_v3.4	3	105,341,589 - 105,341,699	UniSTS	RGSC3.4
Celera	3	104,733,312 - 104,733,422	UniSTS
Cytogenetic Map	3	q35	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012454 ⟹ ENSRNOP00000012454

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	126,254,665 - 126,274,418 (+)	Ensembl
mRatBN7.2 Ensembl	3	105,800,954 - 105,820,715 (+)	Ensembl
Rnor_6.0 Ensembl	3	110,618,298 - 110,638,046 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000131514 ⟹ ENSRNOP00000104011

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	126,254,663 - 126,274,347 (+)	Ensembl

RefSeq Acc Id:

NM_001004264 ⟹ NP_001004264

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,254,696 - 126,274,346 (+)	NCBI
mRatBN7.2	3	105,800,791 - 105,820,443 (+)	NCBI
Rnor_6.0	3	110,618,293 - 110,637,946 (+)	NCBI
Rnor_5.0	3	117,157,742 - 117,177,511 (+)	NCBI
RGSC_v3.4	3	105,322,270 - 105,341,927 (+)	RGD
Celera	3	104,715,313 - 104,733,650 (+)	RGD

Sequence:

show sequence

GCCCAGTGCACCCCTAGCCCGGCCTTGACCAGCAGGCTGGAGCAACACCCTACGAACCTTCCGT
ACAGCATGGCGACTCACAAGGCCGAGGCACAGGAGACAGACTTCCGTACAACAGGGCCGCCCAC
AGACTTGGAACAGTGCCCCTTTCCGCCCAGCTCCCGGAAGTTTCCTTTTGAAAGCGTGGCGGCA
GACTCTACTGAGGGCTGGGCAGTTGCTGCGGAGCATCATTTGAAAAGGAGCGGAGAGGACGGCG
GATGGGAGCAGCCGGCATCGGGGGTCGAGCCAAGCCGCCCGACTACGATGGCCAGTTCTAAGAC
GGTGTGCGACGCGCAGCCCCATTCGATGCCGAGCTGCGGCTTGTCCGCAGATACACAAACTCGA
GCTACTTCTAAGCTACCTGTTAAATCCAAAGACGCTGAGATGCTTAGACATCTTCATACGGGAG
GCTTAGAGCCTGACGTTACAAAAGTCACCAAACCAAGACGAGAGAACGGGCAGGGGAAAGCTGC
GGAGACTGCCAGCCGGAGGAACATCAGAAGCAGCTACAAACCACTGAGTAAGCAAAAGCCAGAG
GAGGATCTGAAGGATAAAAACGAGCTGCTGGAGGCTGTCAACAAGCAGCTACACCAGAAGCTGA
CAGAGACTCAGGGAGAGCTGAAGGACCTGACACAGAAGGTGGAGCTCCTGGAGAAGTTTCAGGA
TAACTGCTTAGCAATTTTGGAGAGCAAAGGTCTCAACTCAGGCCAAGAGACCCAGGAATCAAAG
CAGGAACCCAGCACAGATCCCACGGACTCCATGCTGCTGCTAGAAACTTTGAAAGATGAACTGA
AGCTTTTCAATGAAACTGCCAAGAAGCAGATGGAGGAGCTACAGGCCTTGAAGGTGAAGTTGAA
GTTGAAAGAAAAAGAAAGGATCCAGTTCCTGGAACAGCAAACCTTAGGTAAGGACGAAGCCAGT
GACTTCACAATAATCCTGGAGGAAATGGAGCAGCTCTTAGAAATGTAATGCAAGGCAAGCGTCC
AGACAGCTTCTTCCTGCATAAACTCTCATCGGAGGCCACTTAGGATATCTTCAAGGACTCACCG
TCCCTTAGGTAAAGACCTTCTGTAGCAGTTGATCCGATAAGGGCAGTTGATGCTGGGGGTCCTC
CTTTAAGCAGATTGCCCCACCTTCAGATGGCTCAGCTCTCCTGCAAGAGAGGAACCTGGGAGTT
TGACTCCACTTCCTGCACAACAGAGAGAGCAACAACCTTAGAACTAGGATAGTAAACCAGCCAT
GGAGACTCTCGAGACTCTTACTTGGAAACACGGGAGGAAAGCCCACACCGAGACAGCACGTGCG
CTGTGCGGGAGCTGTCACTTCAAGCTATGCTGTCCCCTTTGTCTGGTTGAGCTAAGTTTATGAA
CTTGAAATCCTTGAAGTCTTTTGGCGTAATAAATTGGGTGGAGGTAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006234757 ⟹ XP_006234819

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,254,657 - 126,274,412 (+)	NCBI
mRatBN7.2	3	105,800,762 - 105,820,555 (+)	NCBI
Rnor_6.0	3	110,618,256 - 110,638,024 (+)	NCBI
Rnor_5.0	3	117,157,742 - 117,177,511 (+)	NCBI

Sequence:

show sequence

AATGTGACAGGGTGGCTCAATAGCTCCATTCAAACCAGCCCAGTGCACCCCTAGCCCGGCCTTG
ACCAGCAGGCTGGAGCAACACCCTACGAACCTTCCGTACAGCATGGCGACTCACAAGGCCGAGG
CACAGGAGACAGACTTCCGTACAACAGGGCCGCCCACAGACTTGGAACAGTGCCCCTTTCCGCC
CAGCTCCCGGAAGTTTCCTTTTGAAAGCGTGGCGGCAGACTCTACTGAGGGCTGGGCAGTTGCT
GCGGAGCATCATTTGAAAAGGAGCGGAGAGGACGGCGGATGGGAGCAGCCGGCATCGGGGGTCG
AGCCAAGCCGCCCGACTACGATGGCCAGTTCTAAGACGGTGTGCGACGCGCAGCCCCATTCGAT
GCCGAGCTGCGGCTTGTCCGCAGATACACAAACTCGAGCTACTTCTAAGCTACCTGTTAAATCC
AAAGACGCTGAGATGCTTAGACATCTTCATACGGGAGGCTTAGAGCCTGACGTTACAAAAGTCA
CCAAACCAAGACGAGAGAACGGGCAGGGGAAAGCTGCGGAGACTGCCAGCCGGAGGAACATCAG
AAGCAGCTACAAACCACTGAGTAAGCAAAAGCCAGAGGAGGATCTGAAGGATAAAAACGAGCTG
CTGGAGGCTGTCAACAAGCAGCTACACCAGAAGCTGACAGAGACTCAGGGAGAGCTGAAGGACC
TGACACAGAAGGTGGAGCTCCTGGAGAAGTTTCAGGATAACTGCTTAGCAATTTTGGAGAGCAA
AGGTCTCAACTCAGGCCAAGAGACCCAGGAATCAAAGCAGGAACCCAGCACAGATCCCACGGAC
TCCATGCTGCTGCTAGAAACTTTGAAAGATGAACTGAAGCTTTTCAATGAAACTGCCAAGAAGC
AGATGGAGGAGCTACAGGACCTTGCTATGCAGTCCCAGGATGATCCTCTTGCCTCTTCGCTGGG
ATTACAGGGCCTTGAAGGTGAAGTTGAAGTTGAAAGAAAAAGAAAGGATCCAGTTCCTGGAACA
GCAAACCTTAGGTAAGGACGAAGCCAGTGACTTCACAATAATCCTGGAGGAAATGGAGCAGCTC
TTAGAAATGTAATGCAAGGCAAGCGTCCAGACAGCTTCTTCCTGCATAAACTCTCATCGGAGGC
CACTTAGGATATCTTCAAGGACTCACCGTCCCTTAGGTAAAGACCTTCTGTAGCAGTTGATCCG
ATAAGGGCAGTTGATGCTGGGGGTCCTCCTTTAAGCAGATTGCCCCACCTTCAGATGGCTCAGC
TCTCCTGCAAGAGAGGAACCTGGGAGTTTGACTCCACTTCCTGCACAACAGAGAGAGCAACAAC
CTTAGAACTAGGATAGTAAACCAGCCATGGAGACTCTCGAGACTCTTACTTGGAAACACGGGAG
GAAAGCCCACACCGAGACAGCACGTGCGCTGTGCGGGAGCTGTCACTTCAAGCTATGCTGTCCC
CTTTGTCTGGTTGAGCTAAGTTTATGAACTTGAAATCCTTGAAGTCTTTTGGCGTAATAAATTG
GGTGGAGGTATACAGAGTAATGCCTAACTGAAACTATACCTAGAGCTTTTGGAATAAATATCTC
CATGAATGTTAATATTCTGACTAA

hide sequence

RefSeq Acc Id:

XM_006234758 ⟹ XP_006234820

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,254,667 - 126,274,412 (+)	NCBI
mRatBN7.2	3	105,800,908 - 105,820,555 (+)	NCBI
Rnor_6.0	3	110,618,465 - 110,638,024 (+)	NCBI
Rnor_5.0	3	117,157,742 - 117,177,511 (+)	NCBI

Sequence:

show sequence

CTTTTGAAAGCGTGGCGGCAGACTCTACTGAGGGCTGGGCAGTTGCTGCGGAGCATCATTTGAA
AAGGAGCGGAGAGGACGGCGGATGGGAGCAGCCGGCATCGGGGTTAGGCCCTACGGGGTCGAGC
CAAGCCGCCCGACTACGATGGCCAGTTCTAAGACGGTGTGCGACGCGCAGCCCCATTCGATGCC
GAGCTGCGGCTTGTCCGCAGATACACAAACTCGAGCTACTTCTAAGCTACCTGTTAAATCCAAA
GACGCTGAGATGCTTAGACATCTTCATACGGGAGGCTTAGAGCCTGACGTTACAAAAGTCACCA
AACCAAGACGAGAGAACGGGCAGGGGAAAGCTGCGGAGACTGCCAGCCGGAGGAACATCAGAAG
CAGCTACAAACCACTGAGTAAGCAAAAGCCAGAGGAGGATCTGAAGGATAAAAACGAGCTGCTG
GAGGCTGTCAACAAGCAGCTACACCAGAAGCTGACAGAGACTCAGGGAGAGCTGAAGGACCTGA
CACAGAAGGTGGAGCTCCTGGAGAAGTTTCAGGATAACTGCTTAGCAATTTTGGAGAGCAAAGG
TCTCAACTCAGGCCAAGAGACCCAGGAATCAAAGCAGGAACCCAGCACAGATCCCACGGACTCC
ATGCTGCTGCTAGAAACTTTGAAAGATGAACTGAAGCTTTTCAATGAAACTGCCAAGAAGCAGA
TGGAGGAGCTACAGGCCTTGAAGGTGAAGTTGAAGTTGAAAGAAAAAGAAAGGATCCAGTTCCT
GGAACAGCAAACCTTAGGTAAGGACGAAGCCAGTGACTTCACAATAATCCTGGAGGAAATGGAG
CAGCTCTTAGAAATGTAATGCAAGGCAAGCGTCCAGACAGCTTCTTCCTGCATAAACTCTCATC
GGAGGCCACTTAGGATATCTTCAAGGACTCACCGTCCCTTAGGTAAAGACCTTCTGTAGCAGTT
GATCCGATAAGGGCAGTTGATGCTGGGGGTCCTCCTTTAAGCAGATTGCCCCACCTTCAGATGG
CTCAGCTCTCCTGCAAGAGAGGAACCTGGGAGTTTGACTCCACTTCCTGCACAACAGAGAGAGC
AACAACCTTAGAACTAGGATAGTAAACCAGCCATGGAGACTCTCGAGACTCTTACTTGGAAACA
CGGGAGGAAAGCCCACACCGAGACAGCACGTGCGCTGTGCGGGAGCTGTCACTTCAAGCTATGC
TGTCCCCTTTGTCTGGTTGAGCTAAGTTTATGAACTTGAAATCCTTGAAGTCTTTTGGCGTAAT
AAATTGGGTGGAGGTATACAGAGTAATGCCTAACTGAAACTATACCTAGAGCTTTTGGAATAAA
TATCTCCATGAATGTTAATATTCTGACTAA

hide sequence

RefSeq Acc Id:

XM_063283710 ⟹ XP_063139780

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,254,633 - 126,274,412 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001004264	(Get FASTA)	NCBI Sequence Viewer
	XP_006234819	(Get FASTA)	NCBI Sequence Viewer
	XP_006234820	(Get FASTA)	NCBI Sequence Viewer
	XP_063139780	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79438	(Get FASTA)	NCBI Sequence Viewer
	EDL79882	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012454
	ENSRNOP00000104011
GenBank Protein	Q6AXN6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001004264 ⟸ NM_001004264

- UniProtKB:

Q6AXN6 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MATHKAEAQETDFRTTGPPTDLEQCPFPPSSRKFPFESVAADSTEGWAVAAEHHLKRSGEDGGW
EQPASGVEPSRPTTMASSKTVCDAQPHSMPSCGLSADTQTRATSKLPVKSKDAEMLRHLHTGGL
EPDVTKVTKPRRENGQGKAAETASRRNIRSSYKPLSKQKPEEDLKDKNELLEAVNKQLHQKLTE
TQGELKDLTQKVELLEKFQDNCLAILESKGLNSGQETQESKQEPSTDPTDSMLLLETLKDELKL
FNETAKKQMEELQALKVKLKLKEKERIQFLEQQTLGKDEASDFTIILEEMEQLLEM

hide sequence

RefSeq Acc Id:

XP_006234819 ⟸ XM_006234757

- Peptide Label:

isoform X1

- Sequence:

show sequence

MATHKAEAQETDFRTTGPPTDLEQCPFPPSSRKFPFESVAADSTEGWAVAAEHHLKRSGEDGGW
EQPASGVEPSRPTTMASSKTVCDAQPHSMPSCGLSADTQTRATSKLPVKSKDAEMLRHLHTGGL
EPDVTKVTKPRRENGQGKAAETASRRNIRSSYKPLSKQKPEEDLKDKNELLEAVNKQLHQKLTE
TQGELKDLTQKVELLEKFQDNCLAILESKGLNSGQETQESKQEPSTDPTDSMLLLETLKDELKL
FNETAKKQMEELQDLAMQSQDDPLASSLGLQGLEGEVEVERKRKDPVPGTANLR

hide sequence

RefSeq Acc Id:	XP_006234820 ⟸ XM_006234758
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2Q5L7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGAAGIGVRPYGVEPSRPTTMASSKTVCDAQPHSMPSCGLSADTQTRATSKLPVKSKDAEMLRH LHTGGLEPDVTKVTKPRRENGQGKAAETASRRNIRSSYKPLSKQKPEEDLKDKNELLEAVNKQL HQKLTETQGELKDLTQKVELLEKFQDNCLAILESKGLNSGQETQESKQEPSTDPTDSMLLLETL KDELKLFNETAKKQMEELQALKVKLKLKEKERIQFLEQQTLGKDEASDFTIILEEMEQLLEM hide sequence

Ensembl Acc Id:

ENSRNOP00000012454 ⟸ ENSRNOT00000012454

RefSeq Acc Id:	XP_063139780 ⟸ XM_063283710
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000104011 ⟸ ENSRNOT00000131514

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AXN6-F1-model_v2	AlphaFold	Q6AXN6	1-312	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692313

Promoter ID:

EPDNEW_R2838

Type:

initiation region

Name:

Knstrn_1

Description:

kinetochore-localized astrin/SPAG5 binding protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	110,618,264 - 110,618,324	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303240	AgrOrtholog
BioCyc Gene	G2FUF-48228	BioCyc
Ensembl Genes	ENSRNOG00000009334	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000012454	ENTREZGENE
	ENSRNOT00000131514	ENTREZGENE
IMAGE_CLONE	IMAGE:7115344	IMAGE-MGC_LOAD
InterPro	SKAP	UniProtKB/Swiss-Prot
KEGG Report	rno:311325	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94986	IMAGE-MGC_LOAD
NCBI Gene	311325	ENTREZGENE
PANTHER	PTHR31940	UniProtKB/Swiss-Prot
	SMALL KINETOCHORE-ASSOCIATED PROTEIN	UniProtKB/Swiss-Prot
PhenoGen	Knstrn	PhenoGen
RatGTEx	ENSRNOG00000009334	RatGTEx
UniProt	A0A8L2Q5L7	ENTREZGENE, UniProtKB/TrEMBL
	Q6AXN6	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-12-18	Knstrn	kinetochore-localized astrin/SPAG5 binding protein	Traf4af1	TRAF4 associated factor 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Traf4af1	TRAF4 associated factor 1			Symbol updated	1299863	APPROVED
2005-09-30	C15orf23				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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