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Gene: Emcn (endomucin) Rattus norvegicus

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Symbol:

Emcn

Name:

endomucin

RGD ID:

1303218

Description:

Predicted to enable carbohydrate binding activity. Predicted to be involved in angiogenesis; cell-cell adhesion; and regulation of cell adhesion. Predicted to act upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in plasma membrane. Orthologous to human EMCN (endomucin); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC94175; sialomucin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EMCN (endomucin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Emcn (endomucin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Emcn (endomucin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EMCN (endomucin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EMCN (endomucin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Emcn (endomucin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EMCN (endomucin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EMCN (endomucin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Emcn (endomucin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Emcn (endomucin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Emcn (endomucin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	EMCN (endomucin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	228,564,445 - 228,644,370 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	228,564,430 - 228,645,155 (+)	Ensembl				GRCr8
mRatBN7.2	2	225,891,100 - 225,970,932 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	225,891,100 - 225,970,929 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	233,632,075 - 233,711,964 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	231,531,827 - 231,611,726 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	226,396,447 - 226,476,340 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	242,634,319 - 242,715,489 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	242,634,399 - 242,714,182 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	261,184,257 - 261,264,437 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	234,892,271 - 234,972,226 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	218,061,273 - 218,141,092 (+)	NCBI		Celera
RGSC_v3.1	2	234,879,010 - 234,958,963 (+)	NCBI
Cytogenetic Map	2	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

thyroid gland carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(S)-nicotine (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,6-dinitrotoluene (EXP)

3,7-dihydropurine-6-thione (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

bleomycin A2 (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cannabidiol (ISO)

chlorpyrifos (ISO)

chrysene (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

cyclosporin A (EXP)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP)

diethylstilbestrol (EXP)

dioxygen (ISO)

diquat (ISO)

diuron (EXP)

fipronil (EXP)

FR900359 (ISO)

fulvestrant (ISO)

furan (EXP)

glycidol (EXP)

indoles (EXP)

lead diacetate (EXP)

mercaptopurine (EXP)

N,N-diethyl-m-toluamide (EXP)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

nicotine (ISO)

nitrofen (EXP)

oxaliplatin (EXP)

ozone (EXP,ISO)

paracetamol (ISO)

permethrin (EXP)

phenobarbital (ISO)

purine-6-thiol (EXP)

rotenone (EXP,ISO)

silicon dioxide (EXP)

Soman (EXP)

tetrachloromethane (EXP)

tetraphene (ISO)

topotecan (EXP)

Tributyltin oxide (ISO)

trichostatin A (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

vinclozolin (EXP)

warfarin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (IEA,ISO,ISS)

cell-cell adhesion (IEA,ISO,ISS)

hematopoietic stem cell homeostasis (ISO)

regulation of cell adhesion (IEA,ISO,ISS)

Cellular Component

membrane (IEA)

plasma membrane (IEA,ISO,ISS)

Molecular Function

carbohydrate binding (IEA,ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin.	Morgan SM, etal., Blood 1999 Jan 1;93(1):165-75.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Nine Genes Mediate the Therapeutic Effects of Iodine-131 Radiotherapy in Thyroid Carcinoma Patients.	Shuwen H, etal., Dis Markers. 2020 Jun 16;2020:9369341. doi: 10.1155/2020/9369341. eCollection 2020.
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334

Genomics

Comparative Map Data

Emcn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	228,564,445 - 228,644,370 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	228,564,430 - 228,645,155 (+)	Ensembl				GRCr8
mRatBN7.2	2	225,891,100 - 225,970,932 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	225,891,100 - 225,970,929 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	233,632,075 - 233,711,964 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	231,531,827 - 231,611,726 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	226,396,447 - 226,476,340 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	242,634,319 - 242,715,489 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	242,634,399 - 242,714,182 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	261,184,257 - 261,264,437 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	234,892,271 - 234,972,226 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	218,061,273 - 218,141,092 (+)	NCBI		Celera
RGSC_v3.1	2	234,879,010 - 234,958,963 (+)	NCBI
Cytogenetic Map	2	q43	NCBI

EMCN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	100,395,341 - 100,518,022 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	100,395,341 - 100,880,126 (-)	Ensembl			hg38	GRCh38
GRCh37	4	101,316,498 - 101,439,179 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	101,538,004 - 101,658,202 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	98,613,843 - 98,736,427 (-)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI
HuRef	4	97,054,787 - 97,177,386 (-)	NCBI		HuRef
CHM1_1	4	101,293,076 - 101,415,800 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	103,710,663 - 103,833,329 (-)	NCBI		T2T-CHM13v2.0

Emcn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	137,046,824 - 137,136,830 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	137,046,828 - 137,137,946 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	137,341,062 - 137,431,069 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	137,341,067 - 137,432,185 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	137,004,042 - 137,094,033 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	137,278,530 - 137,368,456 (+)	NCBI		MGSCv36	mm8
Celera	3	143,770,513 - 143,859,589 (+)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI
cM Map	3	63.65	NCBI

Emcn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955496	7,413,190 - 7,499,937 (+)	Ensembl
ChiLan1.0	NW_004955496	7,413,228 - 7,498,983 (+)	NCBI	ChiLan1.0	ChiLan1.0

EMCN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	98,472,000 - 98,600,507 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	98,758,149 - 98,886,633 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	92,813,553 - 92,942,098 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	103,474,788 - 103,603,125 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	103,474,788 - 103,603,125 (-)	Ensembl			panPan2	panpan1.1

EMCN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	22,225,159 - 22,320,240 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	22,226,042 - 22,320,063 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	19,573,324 - 19,697,121 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	22,421,149 - 22,540,785 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	22,446,561 - 22,540,615 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	22,397,364 - 22,521,292 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	22,183,328 - 22,303,339 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	17,563,776 - 17,683,700 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Emcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	19,204,631 - 19,310,390 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936520	2,547,963 - 2,653,861 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936520	2,548,042 - 2,653,649 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EMCN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	120,145,804 - 120,230,944 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	120,174,091 - 120,227,971 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	129,169,164 - 129,176,656 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EMCN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	48,523,083 - 48,637,662 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	48,520,708 - 48,637,631 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	26,994,482 - 27,110,633 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Emcn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624830	6,917,405 - 7,002,024 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624830	6,917,397 - 7,001,915 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Emcn
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	21,688,617 - 21,781,257 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Emcn
785 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	55
Count of miRNA genes:	49
Interacting mature miRNAs:	52
Transcripts:	ENSRNOT00000035700
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631563	Hcuc3	Hepatic copper content QTL 3	3.87		liver copper amount (VT:0003065)	liver copper weight to liver dry weight ratio (CMO:0001512)	2	212145502	231732847	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	184482291	229482291	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	210956252	251712708	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	202029709	236904960	Rat
8693697	Alc36	Alcohol consumption QTL 36	2	0.592	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	219814164	239320906	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	214404877	251712708	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204795005	249795005	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	214404877	251712708	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	218051934	251712708	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	186850607	231850607	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	192287802	237287802	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	214404877	251712708	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	214404877	251712708	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	196140964	251540988	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	205135267	250135267	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	221088977	243501206	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	192287802	229609668	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	188565047	233565047	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	184856304	229856304	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	184856304	229856304	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	203664411	248664411	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	184856304	229856304	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	214404877	251712708	Rat
8693622	Alc26	Alcohol consumption QTL 26	2.4	0.667	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	223810546	243965570	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166372086	229820014	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	192287802	237287802	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	184856304	229856304	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
1359019	Hrtrt19	Heart rate QTL 19	2.9		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	221270493	228950743	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	159440760	228950743	Rat

Markers in Region

RH137100

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	225,970,767 - 225,970,928 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	242,714,021 - 242,714,181	NCBI	Rnor6.0
Rnor_5.0	2	261,264,132 - 261,264,292	UniSTS	Rnor5.0
RGSC_v3.4	2	234,972,062 - 234,972,222	UniSTS	RGSC3.4
Celera	2	218,140,928 - 218,141,088	UniSTS
RH 3.4 Map	2	1600.7	UniSTS
Cytogenetic Map	2	q43	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	157	91	90	59	34	59	6	298	134	11	132	81	92	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233366	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000035700 ⟹ ENSRNOP00000033031

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	228,564,430 - 228,644,366 (+)	Ensembl
mRatBN7.2 Ensembl	2	225,891,100 - 225,970,929 (+)	Ensembl
Rnor_6.0 Ensembl	2	242,634,399 - 242,714,182 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117162 ⟹ ENSRNOP00000097837

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	228,564,523 - 228,638,035 (+)	Ensembl
mRatBN7.2 Ensembl	2	225,891,100 - 225,964,597 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000125911 ⟹ ENSRNOP00000099736

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	228,564,523 - 228,645,155 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000142209 ⟹ ENSRNOP00000109793

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	228,564,494 - 228,645,155 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000148343 ⟹ ENSRNOP00000099669

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	228,564,523 - 228,633,534 (+)	Ensembl

RefSeq Acc Id:

NM_001004228 ⟹ NP_001004228

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	228,564,539 - 228,644,370 (+)	NCBI
mRatBN7.2	2	225,891,100 - 225,970,932 (+)	NCBI
Rnor_6.0	2	242,634,399 - 242,714,185 (+)	NCBI
Rnor_5.0	2	261,184,257 - 261,264,437 (+)	NCBI
RGSC_v3.4	2	234,892,271 - 234,972,226 (+)	RGD
Celera	2	218,061,273 - 218,141,092 (+)	RGD

Sequence:

show sequence

TTCCATTTGCTCATACGGCCTGGTCAGGCTGGGAGGAATCGCTCCCTGCCTTACCCGGGAGAGC
AAAGCCACTGAGAACATCCCGGGCACCATGCGGCTGCTTCAAGTGACTGCTCTCTTCTTCCTTT
TGTCCAACAGTCTATGCCGTGGTGAGAACAGCAAAGCACTGACAGAAACATCCACAACAAAAGC
ATCGGCTACAACACCAGACATGGTGTCAATCACAAACAAATCAACAGGCGGAACACCTCCTAAA
GGAACGACCAACAGTGCAACACCCAAAACACCTTTGATGCCAGCACTTGATTCACCGACAACAC
CAAAACATGAAACAACAACTCGTGGTGTCATAAAGAATGAAGTTTCCACTATAAAAACAACAGT
GGCAAATCCTACCATTTCGAATGCTGTTTCAACACTCTCAAGTCCCCAGAACAAGACGGAGAAT
CAGAGTTCAATCAGGACAACAGAAATATCAGGTACCAATCAACTGCCAGATGACCAAAAACCAA
AGACGACCGAGACGCCCTCTGCATCGCTAACAACTGCAAAAACCATCTCACAGATTCAGGATAC
TGAGGATGGGAAGATCACAGCCACTACATCAACCACCCCCTCCTATTCCAGTGTTATTTTGCCC
GTGGTTATCGCGCTGATTGTTATAACAGTCTTGGTGTTTACTCTGGTGGGCTTGTATCGAATAT
GCTGGAAAAGAGACCCAGGCACTCCAGAAAGTGGAAATGATCAGCCTCAGTCTGATAAAGAGAG
TGTAAAGCTGCTCACCGTTAAGACAATCTCTCATGAGTCTGGCGAACACTCTGCACAGGGGAAA
GCCAAGAACTGACATCGTGATGGATCCTCCTTACACCTGGGCAATAAATAAGCTTCATCTTCAG
CTTCTAAACTCCAAGGGTGGAGAAAAGAAAGTCCTCGGAACCGATACAATTTCCAATCTTCTCA
CCAGTCTACGCGAGTTGCCTGTCCCAGCAAAGGAATGACATACTATCACCTGATAGAATCATAA
AGAACTCTGGACATCTTCTGTGTGAGACGTAGAAAATCAAACAACTCTAGTTTTCAAGGACTTT
TCTAGGAGGAACCGTGATCCCCCAGCCTGGGCAGGTAGCCTGCTGAGTTTAGACATGCCTTAGC
TGAGTCTAGACTTCCGGGTTTTATAGCCGCGATCTGTGGAGACTTGCCTGTTTTCTTTGTGTTC
TTATGTTAGCCATTGTCGGTATTTATTGTTTCCCACTGTGTTAATGCAGGGCGTTTTGCAAGTG
TGTTAATAAATGTTAAGTAGAAATCATGCCATGTTTCTCTGTAGAGACAGGTATGTTATTCATG
TTTTCAGGTGTTACTTTTAATAAATCATGGCTGTACTCAGCATGCTAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063281668 ⟹ XP_063137738

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	228,564,445 - 228,644,370 (+)	NCBI

RefSeq Acc Id:

XM_063281669 ⟹ XP_063137739

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	228,564,445 - 228,644,370 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001004228	(Get FASTA)	NCBI Sequence Viewer
	XP_063137738	(Get FASTA)	NCBI Sequence Viewer
	XP_063137739	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79155	(Get FASTA)	NCBI Sequence Viewer
	EDL82285	(Get FASTA)	NCBI Sequence Viewer
	EDL82286	(Get FASTA)	NCBI Sequence Viewer
	EDL82287	(Get FASTA)	NCBI Sequence Viewer
	EDL82288	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000033031
	ENSRNOP00000033031.3
	ENSRNOP00000099736
	ENSRNOP00000109793
GenBank Protein	Q6AY82	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001004228 ⟸ NM_001004228
- Peptide Label:	precursor
- UniProtKB:	Q6AY82 (UniProtKB/Swiss-Prot), A6HW00 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRLLQVTALFFLLSNSLCRGENSKALTETSTTKASATTPDMVSITNKSTGGTPPKGTTNSATPK TPLMPALDSPTTPKHETTTRGVIKNEVSTIKTTVANPTISNAVSTLSSPQNKTENQSSIRTTEI SGTNQLPDDQKPKTTETPSASLTTAKTISQIQDTEDGKITATTSTTPSYSSVILPVVIALIVIT VLVFTLVGLYRICWKRDPGTPESGNDQPQSDKESVKLLTVKTISHESGEHSAQGKAKN hide sequence

Ensembl Acc Id:

ENSRNOP00000033031 ⟸ ENSRNOT00000035700

Ensembl Acc Id:

ENSRNOP00000097837 ⟸ ENSRNOT00000117162

RefSeq Acc Id:	XP_063137738 ⟸ XM_063281668
- Peptide Label:	isoform X1
- UniProtKB:	A6HW00 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063137739 ⟸ XM_063281669
- Peptide Label:	isoform X2
- UniProtKB:	A6HW01 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000099736 ⟸ ENSRNOT00000125911

Ensembl Acc Id:

ENSRNOP00000099669 ⟸ ENSRNOT00000148343

Ensembl Acc Id:

ENSRNOP00000109793 ⟸ ENSRNOT00000142209

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AY82-F1-model_v2	AlphaFold	Q6AY82	1-250	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691776

Promoter ID:

EPDNEW_R2301

Type:

single initiation site

Name:

Emcn_1

Description:

endomucin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	242,634,385 - 242,634,445	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303218	AgrOrtholog
BioCyc Gene	G2FUF-51117	BioCyc
Ensembl Genes	ENSRNOG00000022910	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000035700	ENTREZGENE
	ENSRNOT00000035700.4	UniProtKB/Swiss-Prot
	ENSRNOT00000125911	ENTREZGENE
	ENSRNOT00000142209	ENTREZGENE
IMAGE_CLONE	IMAGE:7128709	IMAGE-MGC_LOAD
InterPro	Endomucin	UniProtKB/Swiss-Prot
KEGG Report	rno:295490	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94175	IMAGE-MGC_LOAD
NCBI Gene	295490	ENTREZGENE
PANTHER	ENDOMUCIN	UniProtKB/Swiss-Prot
	PTHR15869	UniProtKB/Swiss-Prot
Pfam	Endomucin	UniProtKB/Swiss-Prot
PhenoGen	Emcn	PhenoGen
RatGTEx	ENSRNOG00000022910	RatGTEx
UniProt	A0A8I6ARX5_RAT	UniProtKB/TrEMBL
	A0ABK0KXX6_RAT	UniProtKB/TrEMBL
	A0ABK0LHR7_RAT	UniProtKB/TrEMBL
	A0ABK0M3G1_RAT	UniProtKB/TrEMBL
	A6HVZ9_RAT	UniProtKB/TrEMBL
	A6HW00	ENTREZGENE, UniProtKB/TrEMBL
	A6HW01	ENTREZGENE, UniProtKB/TrEMBL
	A6HW02_RAT	UniProtKB/TrEMBL
	MUCEN_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-02-17	Emcn		MGC94175	endomucin	Symbol updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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