Krt86 (keratin 86) - Rat Genome Database

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Gene: Krt86 (keratin 86) Rattus norvegicus
Analyze
Symbol: Krt86
Name: keratin 86
RGD ID: 1303215
Description: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in breast cancer; hair disease; and monilethrix. Orthologous to several human genes including KRT86 (keratin 86); INTERACTS WITH alpha-Zearalanol; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kb26; keratin 86, type II; keratin, type II cuticular Hb6; type II keratin Kb26
RGD Orthologs
Human
Mouse
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,470,224 - 134,476,873 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,470,224 - 134,476,873 (+)EnsemblGRCr8
mRatBN7.27132,591,489 - 132,598,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,591,545 - 132,598,021 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,393,227 - 134,399,888 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,622,747 - 136,629,412 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,532,533 - 136,539,194 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,122,285 - 143,128,932 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,122,269 - 143,128,932 (+)Ensemblrn6Rnor6.0
Rnor_5.07140,922,818 - 140,929,091 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,222,555 - 140,228,828 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,054,496 - 129,060,769 (+)NCBICelera
RGSC_v3.17140,298,991 - 140,305,265 (+)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, etal., Eur J Cell Biol 2004 Feb;83(1):19-26.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix. Winter H, etal., Nat Genet. 1997 Aug;16(4):372-4.
Additional References at PubMed
PMID:18420582   PMID:23376485   PMID:23580065  


Genomics

Comparative Map Data
Krt86
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,470,224 - 134,476,873 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,470,224 - 134,476,873 (+)EnsemblGRCr8
mRatBN7.27132,591,489 - 132,598,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,591,545 - 132,598,021 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,393,227 - 134,399,888 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,622,747 - 136,629,412 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,532,533 - 136,539,194 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,122,285 - 143,128,932 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,122,269 - 143,128,932 (+)Ensemblrn6Rnor6.0
Rnor_5.07140,922,818 - 140,929,091 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,222,555 - 140,228,828 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,054,496 - 129,060,769 (+)NCBICelera
RGSC_v3.17140,298,991 - 140,305,265 (+)NCBI
Cytogenetic Map7q36NCBI
KRT86
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,274,645 - 52,309,163 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,249,300 - 52,309,163 (+)Ensemblhg38GRCh38
GRCh371252,668,429 - 52,702,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,981,916 - 50,989,214 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341250,981,915 - 50,989,212NCBI
Celera1251,498,324 - 51,499,639 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,729,376 - 49,736,676 (+)NCBIHuRef
CHM1_11252,662,295 - 52,669,596 (+)NCBICHM1_1
T2T-CHM13v2.01252,238,211 - 52,273,084 (+)NCBIT2T-CHM13v2.0
Krt86
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,371,359 - 101,377,864 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,371,359 - 101,377,867 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3815101,473,478 - 101,479,983 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,473,478 - 101,479,986 (+)Ensemblmm10GRCm38
MGSCv3715101,303,909 - 101,310,414 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615101,301,512 - 101,308,017 (+)NCBIMGSCv36mm8
Celera15103,622,148 - 103,628,624 (+)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1556.9NCBI
KRT86
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,760,351 - 2,767,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,486,343 - 43,493,377 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0272,759,708 - 2,766,856 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,656,611 - 2,826,996 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,776,476 - 2,783,534 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,762,436 - 2,769,583 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,884,460 - 43,891,615 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC106507258
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1517,624,096 - 17,631,111 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,085,293 - 18,093,365 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT86
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,447,294 - 48,456,141 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037197,635,841 - 197,644,177 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Krt86
36 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:74
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000045495, ENSRNOT00000067422
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
11 3 15 34 9 11 3 2 3 5 51 24 6 23 10 58 8

Sequence


Ensembl Acc Id: ENSRNOT00000045495   ⟹   ENSRNOP00000039183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,591,545 - 132,598,021 (+)Ensembl
Rnor_6.0 Ensembl7143,122,341 - 143,128,518 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000067422   ⟹   ENSRNOP00000060052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,470,224 - 134,476,873 (+)Ensembl
mRatBN7.2 Ensembl7132,591,545 - 132,597,824 (+)Ensembl
Rnor_6.0 Ensembl7143,122,341 - 143,128,614 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081386   ⟹   ENSRNOP00000068808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,470,224 - 134,476,555 (+)Ensembl
mRatBN7.2 Ensembl7132,591,545 - 132,597,824 (+)Ensembl
Rnor_6.0 Ensembl7143,122,341 - 143,128,614 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082542   ⟹   ENSRNOP00000071675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,591,545 - 132,595,947 (+)Ensembl
Rnor_6.0 Ensembl7143,122,269 - 143,128,932 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118585   ⟹   ENSRNOP00000084590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,591,545 - 132,596,514 (+)Ensembl
RefSeq Acc Id: NM_001008810   ⟹   NP_001008810
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,470,224 - 134,476,873 (+)NCBI
mRatBN7.27132,591,489 - 132,598,142 (+)NCBI
Rnor_6.07143,122,341 - 143,128,614 (+)NCBI
Rnor_5.07140,922,818 - 140,929,091 (+)NCBI
RGSC_v3.47140,222,555 - 140,228,828 (+)RGD
Celera7129,054,496 - 129,060,769 (+)RGD
Sequence:
RefSeq Acc Id: XM_039079713   ⟹   XP_038935641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,470,280 - 134,476,873 (+)NCBI
mRatBN7.27132,591,545 - 132,598,142 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001008810 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935641 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAF75862 (Get FASTA)   NCBI Sequence Viewer  
  DAA02220 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060052
  ENSRNOP00000060052.4
  ENSRNOP00000068808.1
RefSeq Acc Id: NP_001008810   ⟸   NM_001008810
- UniProtKB: A0A0G2QC11 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060052   ⟸   ENSRNOT00000067422
Ensembl Acc Id: ENSRNOP00000039183   ⟸   ENSRNOT00000045495
Ensembl Acc Id: ENSRNOP00000071675   ⟸   ENSRNOT00000082542
Ensembl Acc Id: ENSRNOP00000068808   ⟸   ENSRNOT00000081386
RefSeq Acc Id: XP_038935641   ⟸   XM_039079713
- Peptide Label: isoform X1
- UniProtKB: F7F801 (UniProtKB/TrEMBL),   A7M778 (UniProtKB/TrEMBL),   E9PT97 (UniProtKB/TrEMBL),   A0A0G2QC11 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084590   ⟸   ENSRNOT00000118585
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IG10-F1-model_v2 AlphaFold Q6IG10 1-517 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695677
Promoter ID:EPDNEW_R6199
Type:single initiation site
Name:Krt86_1
Description:keratin 86
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,122,263 - 143,122,323EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303215 AgrOrtholog
BioCyc Gene G2FUF-31982 BioCyc
Ensembl Genes ENSRNOG00000008367 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067422 ENTREZGENE
  ENSRNOT00000067422.6 UniProtKB/TrEMBL
  ENSRNOT00000081386.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
InterPro Growth_fac_rcpt_N_dom UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/TrEMBL
  Intermediate_filament_CS UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
  Keratin_II UniProtKB/TrEMBL
KEGG Report rno:407760 UniProtKB/TrEMBL
NCBI Gene 407760 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KERATIN, TYPE II CUTICULAR HB1 UniProtKB/TrEMBL
Pfam Filament UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
PhenoGen Krt86 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/TrEMBL
PROSITE IF_ROD_2 UniProtKB/TrEMBL
  PS00226 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008367 RatGTEx
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A0G2QC11 ENTREZGENE, UniProtKB/TrEMBL
  A7M778 ENTREZGENE, UniProtKB/TrEMBL
  E9PT97 ENTREZGENE
  F7F801 ENTREZGENE
  Q6IG10_RAT UniProtKB/TrEMBL
UniProt Secondary E9PT97 UniProtKB/TrEMBL
  F7F801 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Krt86  keratin 86  Krt86  keratin 86, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt86  keratin 86, type II  Krt86  keratin 86  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Krt86  keratin 86  Kb26  type II keratin Kb26  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Kb26  type II keratin Kb26      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Kb26  type II keratin Kb26      Symbol and Name status set to provisional 70820 PROVISIONAL