Aurkaip1 (aurora kinase A interacting protein 1) - Rat Genome Database

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Gene: Aurkaip1 (aurora kinase A interacting protein 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Aurkaip1 (Ensembl: Ccnl2)
Name: aurora kinase A interacting protein 1 (Ensembl:cyclin L2)
RGD ID: 1303211
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of RNA splicing and regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nuclear speck. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Orthologous to human AURKAIP1 (aurora kinase A interacting protein 1); INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Akip; aurora kinase A-interacting protein; aurora-A kinase interacting protein; MGC94202; small ribosomal subunit protein mS38
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,717,349 - 171,719,123 (+)NCBIGRCr8
mRatBN7.25166,435,177 - 166,436,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,417,508 - 166,436,882 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5169,140,352 - 169,141,748 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,961,773 - 170,963,169 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,924,304 - 170,925,700 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,274,433 - 173,276,170 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,256,637 - 173,276,169 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,750,100 - 176,751,785 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,684,455 - 172,685,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,694,949 - 172,696,345 (+)NCBI
Celera5164,636,220 - 164,637,616 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. Kiat LS, etal., J Biol Chem 2002 Nov 22;277(47):45558-65. Epub 2002 Sep 18.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:18614015  


Genomics

Variants

.
Variants in Aurkaip1
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:32
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000025952
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
AA819020  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,436,448 - 166,436,736 (+)MAPPERmRatBN7.2
Rnor_6.05173,275,731 - 173,276,018NCBIRnor6.0
Rnor_5.05176,751,346 - 176,751,633UniSTSRnor5.0
RGSC_v3.45172,685,412 - 172,685,699UniSTSRGSC3.4
Celera5164,637,177 - 164,637,464UniSTS
RH 3.4 Map51162.8UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001004237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: NM_001004237   ⟹   NP_001004237
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,717,727 - 171,719,123 (+)NCBI
mRatBN7.25166,435,492 - 166,436,888 (+)NCBI
Rnor_6.05173,274,774 - 173,276,170 (+)NCBI
Rnor_5.05176,750,100 - 176,751,785 (+)NCBI
RGSC_v3.45172,684,455 - 172,685,851 (+)RGD
Celera5164,636,220 - 164,637,616 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239546   ⟹   XP_006239608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,717,349 - 171,719,118 (+)NCBI
mRatBN7.25166,435,177 - 166,436,888 (+)NCBI
Rnor_6.05173,274,493 - 173,276,170 (+)NCBI
Rnor_5.05176,750,100 - 176,751,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239547   ⟹   XP_006239609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,717,349 - 171,719,118 (+)NCBI
mRatBN7.25166,435,203 - 166,436,888 (+)NCBI
Rnor_6.05173,274,485 - 173,276,170 (+)NCBI
Rnor_5.05176,750,100 - 176,751,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239548   ⟹   XP_006239610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,717,349 - 171,719,118 (+)NCBI
mRatBN7.25166,435,230 - 166,436,888 (+)NCBI
Rnor_6.05173,274,512 - 173,276,170 (+)NCBI
Rnor_5.05176,750,100 - 176,751,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764351   ⟹   XP_008762573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,717,365 - 171,719,118 (+)NCBI
mRatBN7.25166,435,199 - 166,436,888 (+)NCBI
Rnor_6.05173,274,433 - 173,276,170 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063287502   ⟹   XP_063143572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,717,376 - 171,719,118 (+)NCBI
RefSeq Acc Id: XM_063287503   ⟹   XP_063143573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,717,349 - 171,719,118 (+)NCBI
RefSeq Acc Id: XM_063287504   ⟹   XP_063143574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,717,349 - 171,719,118 (+)NCBI
RefSeq Acc Id: XM_063287505   ⟹   XP_063143575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,717,349 - 171,719,118 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001004237   ⟸   NM_001004237
- UniProtKB: Q6AY68 (UniProtKB/TrEMBL),   F7EYT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239609   ⟸   XM_006239547
- Peptide Label: isoform X2
- UniProtKB: Q6AY68 (UniProtKB/TrEMBL),   F7EYT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239608   ⟸   XM_006239546
- Peptide Label: isoform X2
- UniProtKB: Q6AY68 (UniProtKB/TrEMBL),   F7EYT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239610   ⟸   XM_006239548
- Peptide Label: isoform X2
- UniProtKB: Q6AY68 (UniProtKB/TrEMBL),   F7EYT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762573   ⟸   XM_008764351
- Peptide Label: isoform X2
- UniProtKB: Q6AY68 (UniProtKB/TrEMBL),   F7EYT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063143575   ⟸   XM_063287505
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063143573   ⟸   XM_063287503
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063143574   ⟸   XM_063287504
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063143572   ⟸   XM_063287502
- Peptide Label: isoform X1
Protein Domains
Cyclin C-terminal   Cyclin-like   Ribosomal protein mS38 C-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694332
Promoter ID:EPDNEW_R4857
Type:initiation region
Name:Aurkaip1_1
Description:aurora kinase A interacting protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4856  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05173,274,735 - 173,274,795EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303211 AgrOrtholog
BioCyc Gene G2FUF-38895 BioCyc
Ensembl Genes ENSRNOG00000018691 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025531.7 UniProtKB/TrEMBL
  ENSRNOT00000025952.5 UniProtKB/TrEMBL
  ENSRNOT00000089936.2 UniProtKB/TrEMBL
Gene3D-CATH Cyclin-like UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7129954 IMAGE-MGC_LOAD
InterPro Cyclin-like UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  Cyclin/Ssn8 UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
  DUF1713_mit UniProtKB/TrEMBL
KEGG Report rno:298687 UniProtKB/TrEMBL
MGC_CLONE MGC:94202 IMAGE-MGC_LOAD
NCBI Gene 298687 ENTREZGENE
PANTHER AURORA KINASE A-INTERACTING PROTEIN UniProtKB/TrEMBL
  AURORA KINASE A-INTERACTING PROTEIN UniProtKB/TrEMBL
  CYCLIN-L2 UniProtKB/TrEMBL
  PTHR10026 UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
  DUF1713 UniProtKB/TrEMBL
PhenoGen Aurkaip1 PhenoGen
PIRSF Cyclin_L UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018691 RatGTEx
SMART CYCLIN UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
  DUF1713 UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/TrEMBL
UniProt A0A0H2UHQ5_RAT UniProtKB/TrEMBL
  A0A8L2QZY3_RAT UniProtKB/TrEMBL
  A6IUT2_RAT UniProtKB/TrEMBL
  F7EYT4 ENTREZGENE, UniProtKB/TrEMBL
  Q6AY68 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Aurkaip1  aurora kinase A interacting protein 1  Akip  aurora-A kinase interacting protein  Symbol and Name updated 1299863 APPROVED
2005-02-09 Akip    MGC94202  aurora-A kinase interacting protein  Symbol updated 1299863 APPROVED