Oxgr1 (oxoglutarate receptor 1) - Rat Genome Database

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Gene: Oxgr1 (oxoglutarate receptor 1) Rattus norvegicus
Analyze
Symbol: Oxgr1
Name: oxoglutarate receptor 1
RGD ID: 1303155
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human OXGR1 (oxoglutarate receptor 1); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol 3-benzoate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2-oxoglutarate receptor 1; alpha-ketoglutarate receptor 1; G protein-coupled receptor 80; G-protein coupled receptor 80; Gpr80; oxoglutarate (alpha-ketoglutarate) receptor 1; P2Y purinoceptor 15; P2Y15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815103,551,338 - 103,573,611 (-)NCBIGRCr8
mRatBN7.21597,145,947 - 97,146,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1597,144,293 - 97,166,612 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15101,065,589 - 101,066,602 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015102,178,845 - 102,179,858 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01599,114,760 - 99,115,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015105,399,596 - 105,422,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15105,401,695 - 105,402,708 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015108,805,931 - 108,826,992 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415105,089,715 - 105,090,728 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115105,105,494 - 105,106,508 (-)NCBI
Celera1595,968,176 - 95,969,189 (-)NCBICelera
Cytogenetic Map15q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine. Inbe H, etal., J Biol Chem 2004 May 7;279(19):19790-9. Epub 2004 Mar 04.
3. A novel model of spontaneous otitis media with effusion (OME) in the Oxgr1 knock-out mouse. Kerschner JE, etal., Int J Pediatr Otorhinolaryngol. 2013 Jan;77(1):79-84. doi: 10.1016/j.ijporl.2012.09.037. Epub 2012 Nov 30.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Comparative Map Data
Oxgr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815103,551,338 - 103,573,611 (-)NCBIGRCr8
mRatBN7.21597,145,947 - 97,146,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1597,144,293 - 97,166,612 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15101,065,589 - 101,066,602 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015102,178,845 - 102,179,858 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01599,114,760 - 99,115,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015105,399,596 - 105,422,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15105,401,695 - 105,402,708 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015108,805,931 - 108,826,992 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415105,089,715 - 105,090,728 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115105,105,494 - 105,106,508 (-)NCBI
Celera1595,968,176 - 95,969,189 (-)NCBICelera
Cytogenetic Map15q24NCBI
OXGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381396,985,713 - 96,994,730 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1396,985,713 - 96,994,730 (-)EnsemblGRCh38hg38GRCh38
GRCh371397,637,967 - 97,646,984 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361396,435,974 - 96,444,605 (-)NCBINCBI36Build 36hg18NCBI36
Build 341396,435,973 - 96,444,605NCBI
Celera1378,485,394 - 78,494,031 (-)NCBICelera
Cytogenetic Map13q32.1NCBI
HuRef1378,234,827 - 78,243,464 (-)NCBIHuRef
CHM1_11397,608,350 - 97,616,984 (-)NCBICHM1_1
T2T-CHM13v2.01396,189,803 - 96,198,827 (-)NCBIT2T-CHM13v2.0
Oxgr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914120,256,997 - 120,279,847 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14120,256,997 - 120,279,847 (-)EnsemblGRCm39 Ensembl
GRCm3814120,019,585 - 120,042,435 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14120,019,585 - 120,042,435 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714120,418,807 - 120,441,657 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614119,154,767 - 119,177,617 (-)NCBIMGSCv36mm8
Celera14118,578,849 - 118,602,956 (-)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1463.63NCBI
Oxgr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540413,337,607 - 13,344,789 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540413,337,607 - 13,344,789 (+)NCBIChiLan1.0ChiLan1.0
OXGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21498,502,352 - 98,511,039 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11397,171,013 - 97,179,702 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01378,145,794 - 78,154,555 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11397,302,555 - 97,311,307 (-)NCBIpanpan1.1PanPan1.1panPan2
OXGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12247,371,020 - 47,377,389 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2247,371,381 - 47,372,394 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2247,151,464 - 47,157,881 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02247,796,855 - 47,803,273 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2247,797,255 - 47,798,268 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12247,460,735 - 47,467,152 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02247,493,049 - 47,499,466 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02247,529,906 - 47,536,325 (-)NCBIUU_Cfam_GSD_1.0
Oxgr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945182,902,647 - 182,904,237 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647213,047,930 - 13,048,943 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647213,047,918 - 13,049,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OXGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11166,289,131 - 66,295,826 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
OXGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1375,709,387 - 75,718,009 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl375,709,693 - 75,710,706 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604632,153,998 - 32,156,819 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oxgr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248793,540,845 - 3,548,239 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248793,540,737 - 3,548,239 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Oxgr1
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:63
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000057564
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)158226252098288169Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)158226252098288169Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
High
Medium 14
Low 15 2
Below cutoff 1 1 1 1 1 2 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000057564   ⟹   ENSRNOP00000054374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1597,144,293 - 97,166,612 (-)Ensembl
Rnor_6.0 Ensembl15105,401,695 - 105,402,708 (-)Ensembl
RefSeq Acc Id: NM_207588   ⟹   NP_997471
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815103,552,861 - 103,553,874 (-)NCBI
mRatBN7.21597,145,947 - 97,146,960 (-)NCBI
Rnor_6.015105,401,695 - 105,402,708 (-)NCBI
Rnor_5.015108,805,931 - 108,826,992 (-)NCBI
RGSC_v3.415105,089,715 - 105,090,728 (-)RGD
Celera1595,968,176 - 95,969,189 (-)RGD
Sequence:
RefSeq Acc Id: XM_063274175   ⟹   XP_063130245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815103,551,338 - 103,573,611 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_997471   ⟸   NM_207588
- UniProtKB: Q6Y1R5 (UniProtKB/Swiss-Prot),   A6HUH9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054374   ⟸   ENSRNOT00000057564
RefSeq Acc Id: XP_063130245   ⟸   XM_063274175
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6Y1R5-F1-model_v2 AlphaFold Q6Y1R5 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303155 AgrOrtholog
BioCyc Gene G2FUF-12410 BioCyc
Ensembl Genes ENSRNOG00000037884 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055011953 UniProtKB/Swiss-Prot
  ENSRNOG00060008344 UniProtKB/Swiss-Prot
  ENSRNOG00065007876 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057564 ENTREZGENE
  ENSRNOT00000057564.2 UniProtKB/Swiss-Prot
  ENSRNOT00055020326 UniProtKB/Swiss-Prot
  ENSRNOT00060013867 UniProtKB/Swiss-Prot
  ENSRNOT00065012368 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290493 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 290493 ENTREZGENE
PANTHER 2-OXOGLUTARATE RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oxgr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2YPURNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037884 RatGTEx
  ENSRNOG00055011953 RatGTEx
  ENSRNOG00060008344 RatGTEx
  ENSRNOG00065007876 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HUH9 ENTREZGENE, UniProtKB/TrEMBL
  OXGR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Oxgr1  oxoglutarate receptor 1  Oxgr1  oxoglutarate (alpha-ketoglutarate) receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Oxgr1  oxoglutarate (alpha-ketoglutarate) receptor 1  Gpr80  G protein-coupled receptor 80  Symbol and Name updated 1299863 APPROVED
2005-02-14 Gpr80  G protein-coupled receptor 80      Symbol and Name status set to provisional 70820 PROVISIONAL