Abhd12b (abhydrolase domain containing 12B) - Rat Genome Database

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Gene: Abhd12b (abhydrolase domain containing 12B) Rattus norvegicus
Analyze
Symbol: Abhd12b
Name: abhydrolase domain containing 12B
RGD ID: 1303145
Description: Predicted to enable monoacylglycerol lipase activity and phosphatidylcholine lysophospholipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ABHD12B (abhydrolase domain containing 12B); INTERACTS WITH bisphenol A; 2-hydroxypropanoic acid (ortholog); 3-phenylprop-2-enal (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: abhydrolase domain-containing protein 12B; Bem46l3; serine protease BEM46-like 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8694,404,594 - 94,432,395 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl694,404,594 - 94,432,395 (+)EnsemblGRCr8
mRatBN7.2688,668,627 - 88,696,435 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl688,668,642 - 88,696,458 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx689,067,929 - 89,095,671 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0689,367,386 - 89,395,122 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0688,806,908 - 88,834,654 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0692,568,975 - 92,596,327 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl692,568,975 - 92,596,327 (+)Ensemblrn6Rnor6.0
Rnor_5.06102,016,360 - 102,043,712 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4692,270,150 - 92,296,907 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera687,163,225 - 87,190,437 (+)NCBICelera
RGSC_v3.1692,279,609 - 92,300,363 (+)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Abhd12b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8694,404,594 - 94,432,395 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl694,404,594 - 94,432,395 (+)EnsemblGRCr8
mRatBN7.2688,668,627 - 88,696,435 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl688,668,642 - 88,696,458 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx689,067,929 - 89,095,671 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0689,367,386 - 89,395,122 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0688,806,908 - 88,834,654 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0692,568,975 - 92,596,327 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl692,568,975 - 92,596,327 (+)Ensemblrn6Rnor6.0
Rnor_5.06102,016,360 - 102,043,712 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4692,270,150 - 92,296,907 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera687,163,225 - 87,190,437 (+)NCBICelera
RGSC_v3.1692,279,609 - 92,300,363 (+)NCBI
Cytogenetic Map6q24NCBI
ABHD12B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381450,872,053 - 50,904,970 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1450,872,053 - 50,904,970 (+)Ensemblhg38GRCh38
GRCh371451,338,771 - 51,371,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361450,408,628 - 50,441,438 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341450,408,627 - 50,441,438NCBI
Celera1431,205,922 - 31,238,736 (+)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1431,464,434 - 31,497,262 (+)NCBIHuRef
CHM1_11451,277,383 - 51,310,199 (+)NCBICHM1_1
T2T-CHM13v2.01445,078,480 - 45,111,409 (+)NCBIT2T-CHM13v2.0
Abhd12b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391270,200,898 - 70,236,870 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1270,200,916 - 70,230,661 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381270,154,124 - 70,190,096 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1270,154,142 - 70,183,887 (+)Ensemblmm10GRCm38
MGSCv371271,255,158 - 71,284,193 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361271,255,158 - 71,284,193 (+)NCBIMGSCv36mm8
Celera1271,215,144 - 71,284,636 (+)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1228.96NCBI
Abhd12b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,007,989 - 12,037,005 (-)Ensembl
ChiLan1.0NW_00495540912,007,471 - 12,036,999 (-)NCBIChiLan1.0ChiLan1.0
ABHD12B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21552,004,502 - 52,042,222 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11451,221,027 - 51,258,729 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01431,459,836 - 31,494,138 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11449,760,119 - 49,792,963 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1449,760,119 - 49,792,963 (+)EnsemblpanPan2panpan1.1
ABHD12B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1827,239,900 - 27,264,615 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl827,240,153 - 27,264,680 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha826,987,414 - 27,019,452 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0827,412,696 - 27,445,173 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl827,419,001 - 27,450,036 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1827,067,340 - 27,100,295 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0827,140,675 - 27,172,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0827,485,290 - 27,520,417 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Abhd12b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864059,438,210 - 59,462,680 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649514,729,594 - 14,753,102 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649514,728,885 - 14,753,188 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABHD12B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1180,639,898 - 180,661,065 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11180,635,479 - 180,662,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21200,922,668 - 200,949,737 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABHD12B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12427,952,072 - 27,987,645 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2427,953,124 - 27,987,443 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605316,250,498 - 16,283,625 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abhd12b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473118,029,116 - 18,058,081 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473118,028,573 - 18,058,331 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Abhd12b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1783,838,802 - 83,869,658 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Abhd12b
153 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:32
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000036933
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 3 6 63 49 49 21 22 21 6 86 45 46 5 31 28 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000036933   ⟹   ENSRNOP00000037957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl688,674,721 - 88,696,166 (+)Ensembl
Rnor_6.0 Ensembl692,568,975 - 92,596,327 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111205   ⟹   ENSRNOP00000085771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl694,404,594 - 94,432,395 (+)Ensembl
mRatBN7.2 Ensembl688,668,642 - 88,696,458 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120024   ⟹   ENSRNOP00000078863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl694,404,634 - 94,432,395 (+)Ensembl
mRatBN7.2 Ensembl688,668,667 - 88,696,458 (+)Ensembl
RefSeq Acc Id: NM_001395730   ⟹   NP_001382659
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8694,404,594 - 94,432,395 (+)NCBI
mRatBN7.2688,668,627 - 88,696,435 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001382659 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51914 (Get FASTA)   NCBI Sequence Viewer  
  EDM03542 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078863.1
  ENSRNOP00000085771
  ENSRNOP00000085771.1
Ensembl Acc Id: ENSRNOP00000037957   ⟸   ENSRNOT00000036933
Ensembl Acc Id: ENSRNOP00000085771   ⟸   ENSRNOT00000111205
Ensembl Acc Id: ENSRNOP00000078863   ⟸   ENSRNOT00000120024
RefSeq Acc Id: NP_001382659   ⟸   NM_001395730
- UniProtKB: A0A8I6A330 (UniProtKB/TrEMBL)
Protein Domains
Serine aminopeptidase S33

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LZ64-F1-model_v2 AlphaFold F1LZ64 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303145 AgrOrtholog
BioCyc Gene G2FUF-37215 BioCyc
Ensembl Genes ENSRNOG00000026855 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000111205 ENTREZGENE
  ENSRNOT00000111205.2 UniProtKB/TrEMBL
  ENSRNOT00000120024.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Hydrolase_4 UniProtKB/TrEMBL
NCBI Gene 408202 ENTREZGENE
PANTHER ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PROTEIN ABHD12B UniProtKB/TrEMBL
Pfam Hydrolase_4 UniProtKB/TrEMBL
PhenoGen Abhd12b PhenoGen
RatGTEx ENSRNOG00000026855 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A8I5ZLV6_RAT UniProtKB/TrEMBL
  A0A8I6A330 ENTREZGENE, UniProtKB/TrEMBL
  Q6IE05_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-05 Abhd12b  abhydrolase domain containing 12B  Bem46l3  serine protease BEM46-like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-14 Bem46l3  serine protease BEM46-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL