Krt76 (keratin 76) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Krt76 (keratin 76) Rattus norvegicus
Analyze
Symbol: Krt76
Name: keratin 76
RGD ID: 1303078
Description: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to act upstream of or within epidermis development; pigmentation; and sebaceous gland development. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Orthologous to human KRT76 (keratin 76); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kb9; keratin 76, type II; keratin, type II cytoskeletal 2 oral; type II keratin Kb9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,895,677 - 134,904,162 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,895,677 - 134,904,162 (-)EnsemblGRCr8
mRatBN7.27133,016,990 - 133,025,475 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,016,992 - 133,025,496 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,778,683 - 134,786,640 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,008,203 - 137,016,160 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,986,858 - 136,994,815 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,488,668 - 143,497,108 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,488,684 - 143,497,108 (-)Ensemblrn6Rnor6.0
Rnor_5.07141,286,688 - 141,294,636 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,582,232 - 140,590,180 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,455,787 - 129,463,758 (-)NCBICelera
RGSC_v3.17140,658,668 - 140,666,617 (-)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
intermediate filament  (IEA,TAS)
keratin filament  (IBA,IEA,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, etal., Eur J Cell Biol 2004 Feb;83(1):19-26.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21630459   PMID:23533145   PMID:24721909   PMID:25340873  


Genomics

Comparative Map Data
Krt76
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,895,677 - 134,904,162 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,895,677 - 134,904,162 (-)EnsemblGRCr8
mRatBN7.27133,016,990 - 133,025,475 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,016,992 - 133,025,496 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,778,683 - 134,786,640 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,008,203 - 137,016,160 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,986,858 - 136,994,815 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,488,668 - 143,497,108 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,488,684 - 143,497,108 (-)Ensemblrn6Rnor6.0
Rnor_5.07141,286,688 - 141,294,636 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,582,232 - 140,590,180 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,455,787 - 129,463,758 (-)NCBICelera
RGSC_v3.17140,658,668 - 140,666,617 (-)NCBI
Cytogenetic Map7q36NCBI
KRT76
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,768,155 - 52,777,345 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,768,155 - 52,777,345 (-)Ensemblhg38GRCh38
GRCh371253,161,939 - 53,171,129 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,448,206 - 51,457,372 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1252,808,167 - 52,817,357 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,205,903 - 50,215,092 (-)NCBIHuRef
CHM1_11253,128,708 - 53,137,898 (-)NCBICHM1_1
T2T-CHM13v2.01252,732,608 - 52,741,798 (-)NCBIT2T-CHM13v2.0
Krt76
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,792,786 - 101,801,355 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,792,786 - 101,801,355 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3815101,884,351 - 101,892,920 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,884,351 - 101,892,920 (-)Ensemblmm10GRCm38
MGSCv3715101,714,782 - 101,723,351 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615101,712,385 - 101,720,954 (-)NCBIMGSCv36mm8
Celera15104,036,162 - 104,044,727 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.1NCBI
Krt76
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545874,900 - 82,778 (-)Ensembl
ChiLan1.0NW_00495545874,368 - 82,778 (-)NCBIChiLan1.0ChiLan1.0
KRT76
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,415,390 - 41,424,576 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,412,153 - 41,421,339 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,983,069 - 35,992,201 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,761,017 - 36,770,200 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,761,017 - 36,770,200 (+)EnsemblpanPan2panpan1.1
KRT76
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,337,929 - 2,346,716 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,907,162 - 43,915,483 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0272,338,022 - 2,346,410 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,337,974 - 2,346,920 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,354,690 - 2,363,008 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,339,105 - 2,347,428 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,305,647 - 44,313,992 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
KRT76
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,899,517 - 48,910,236 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,900,530 - 48,909,246 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037197,162,545 - 197,171,876 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Krt76
88 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:43
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000048613
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 10 54 92 76 75 44 56 44 6 274 143 11 63 72 72 31 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000048613   ⟹   ENSRNOP00000046335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,895,677 - 134,904,162 (-)Ensembl
mRatBN7.2 Ensembl7133,016,992 - 133,025,496 (-)Ensembl
Rnor_6.0 Ensembl7143,488,684 - 143,497,108 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7143,489,422 - 143,491,906 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,017,466 - 133,025,146 (-)Ensembl
Rnor_6.0 Ensembl7143,492,585 - 143,496,888 (-)Ensembl
RefSeq Acc Id: NM_001008805   ⟹   NP_001008805
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,895,677 - 134,904,162 (-)NCBI
mRatBN7.27133,016,990 - 133,025,475 (-)NCBI
Rnor_6.07143,489,160 - 143,497,108 (-)NCBI
Rnor_5.07141,286,688 - 141,294,636 (-)NCBI
RGSC_v3.47140,582,232 - 140,590,180 (-)RGD
Celera7129,455,787 - 129,463,758 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595033   ⟹   XP_017450522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,895,677 - 134,903,929 (-)NCBI
mRatBN7.27133,016,990 - 133,025,242 (-)NCBI
Rnor_6.07143,488,668 - 143,496,913 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063264084   ⟹   XP_063120154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,895,677 - 134,901,177 (-)NCBI
RefSeq Acc Id: NP_001008805   ⟸   NM_001008805
- UniProtKB: Q6IFZ5 (UniProtKB/TrEMBL),   A6KCR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450522   ⟸   XM_017595033
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000046335   ⟸   ENSRNOT00000048613
RefSeq Acc Id: XP_063120154   ⟸   XM_063264084
- Peptide Label: isoform X2
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IFZ5-F1-model_v2 AlphaFold Q6IFZ5 1-581 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695682
Promoter ID:EPDNEW_R6207
Type:single initiation site
Name:Krt76_1
Description:keratin 76
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,497,169 - 143,497,229EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303078 AgrOrtholog
BioCyc Gene G2FUF-31959 BioCyc
Ensembl Genes ENSRNOG00000031785 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048613 ENTREZGENE
  ENSRNOT00000048613.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
InterPro IF_rod_dom UniProtKB/TrEMBL
  Intermediate_filament_CS UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
  Keratin_II UniProtKB/TrEMBL
KEGG Report rno:407757 UniProtKB/TrEMBL
NCBI Gene 407757 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KERATIN, TYPE II CYTOSKELETAL 2 ORAL UniProtKB/TrEMBL
Pfam Filament UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
PhenoGen Krt76 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/TrEMBL
PROSITE IF_ROD_2 UniProtKB/TrEMBL
  PS00226 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031785 RatGTEx
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/TrEMBL
UniProt A6KCR6 ENTREZGENE, UniProtKB/TrEMBL
  Q6IFZ5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Krt76  keratin 76  Krt76  keratin 76, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt76  keratin 76, type II  Krt76  keratin 76  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Krt76  keratin 76  Kb9  type II keratin Kb9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-14 Kb9  type II keratin Kb9      Symbol and Name status set to provisional 70820 PROVISIONAL