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Gene: Edem2 (ER degradation enhancing alpha-mannosidase like protein 2) Rattus norvegicus

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Symbol:

Edem2

Name:

ER degradation enhancing alpha-mannosidase like protein 2

RGD ID:

1303074

Description:

Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; positive regulation of retrograde protein transport, ER to cytosol; and ubiquitin-dependent glycoprotein ERAD pathway. Predicted to be located in endoplasmic reticulum quality control compartment and membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ER degradation enhancer, mannosidase alpha-like 2; ER degradation-enhancing alpha-mannosidase-like 2; ER degradation-enhancing alpha-mannosidase-like protein 2; ER degradation-enhancing-mannosidase-like protein 2; MGC93956; RGD1303074; similar to putative alpha-mannosidase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	164,661,741 - 164,687,559 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	164,661,742 - 164,687,559 (-)	Ensembl				GRCr8
mRatBN7.2	3	144,201,604 - 144,227,423 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	144,201,605 - 144,227,485 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	148,067,877 - 148,093,692 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	156,685,165 - 156,710,982 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	154,424,668 - 154,450,485 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	151,232,741 - 151,258,559 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	151,232,751 - 151,258,580 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	157,597,580 - 157,623,398 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	146,215,243 - 146,241,062 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	142,925,873 - 142,951,681 (-)	NCBI		Celera
RGSC_v3.1	3	146,120,865 - 146,146,684 (-)	NCBI
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

chlorpyrifos (ISO)

clofibrate (ISO)

cobalt dichloride (EXP)

Cuprizon (EXP)

cyclosporin A (ISO)

DDE (ISO)

dexamethasone (ISO)

endosulfan (EXP)

fenthion (ISO)

fulvestrant (ISO)

glafenine (EXP)

indometacin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (ISO)

nimesulide (EXP)

pirinixic acid (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

testosterone (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (EXP,ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate metabolic process (IEA)

endoplasmic reticulum mannose trimming (IEA,ISO)

ERAD pathway (IEA,ISO)

positive regulation of retrograde protein transport, ER to cytosol (IEA,ISO)

response to unfolded protein (IEA)

Cellular Component

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum quality control compartment (IEA)

membrane (IEA)

Molecular Function

calcium ion binding (IEA)

hydrolase activity (IEA)

hydrolase activity, acting on glycosyl bonds (IEA)

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (IEA,ISO)

metal ion binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Endoplasmic Reticulum-associated degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15537790	PMID:24200403	PMID:25092655

Genomics

Comparative Map Data

Edem2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	164,661,741 - 164,687,559 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	164,661,742 - 164,687,559 (-)	Ensembl				GRCr8
mRatBN7.2	3	144,201,604 - 144,227,423 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	144,201,605 - 144,227,485 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	148,067,877 - 148,093,692 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	156,685,165 - 156,710,982 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	154,424,668 - 154,450,485 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	151,232,741 - 151,258,559 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	151,232,751 - 151,258,580 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	157,597,580 - 157,623,398 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	146,215,243 - 146,241,062 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	142,925,873 - 142,951,681 (-)	NCBI		Celera
RGSC_v3.1	3	146,120,865 - 146,146,684 (-)	NCBI
Cytogenetic Map	3	q42	NCBI

EDEM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	35,115,364 - 35,147,336 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	35,115,360 - 35,147,358 (-)	Ensembl			hg38	GRCh38
GRCh37	20	33,703,167 - 33,735,139 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	33,166,831 - 33,198,804 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	20	33,166,830 - 33,198,804	NCBI
Celera	20	30,452,013 - 30,484,015 (-)	NCBI		Celera
Cytogenetic Map	20	q11.22	NCBI
HuRef	20	30,481,484 - 30,513,486 (-)	NCBI		HuRef
CHM1_1	20	33,603,981 - 33,636,229 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	36,836,129 - 36,868,105 (-)	NCBI		T2T-CHM13v2.0

Edem2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	155,543,593 - 155,571,395 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	155,543,597 - 155,571,395 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	155,701,673 - 155,729,475 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	155,701,677 - 155,729,475 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	155,527,409 - 155,555,211 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	155,393,468 - 155,420,827 (-)	NCBI		MGSCv36	mm8
Celera	2	161,634,017 - 161,661,816 (-)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	77.26	NCBI

Edem2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	26,242,986 - 26,273,297 (+)	Ensembl
ChiLan1.0	NW_004955422	26,243,034 - 26,271,849 (+)	NCBI	ChiLan1.0	ChiLan1.0

EDEM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	40,847,884 - 40,879,826 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	40,840,988 - 40,872,861 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	31,443,590 - 31,475,430 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	32,567,799 - 32,598,998 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	32,567,799 - 32,598,998 (-)	Ensembl			panPan2	panpan1.1

EDEM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	24,137,228 - 24,165,995 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	24,137,228 - 24,165,968 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	23,783,395 - 23,812,161 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	24,829,442 - 24,858,209 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	24,829,443 - 24,858,192 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	24,116,522 - 24,145,265 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	24,211,487 - 24,240,251 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	24,650,576 - 24,679,330 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC101973161
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	173,144,037 - 173,171,273 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	5,578,236 - 5,605,810 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	5,578,267 - 5,605,512 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EDEM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	38,480,044 - 38,515,227 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	38,483,190 - 38,515,243 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	43,680,501 - 43,712,377 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EDEM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	39,417,994 - 39,452,398 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	39,417,590 - 39,452,497 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	87,359,738 - 87,392,953 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Edem2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	4,259,605 - 4,292,518 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624842	4,259,551 - 4,288,181 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Edem2
187 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	14
Count of miRNA genes:	12
Interacting mature miRNAs:	14
Transcripts:	ENSRNOT00000026120
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141555229	186555229	Rat
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	141555229	186555229	Rat
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	141555229	186555229	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	151075912	189428310	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	141555229	186555229	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	141555229	186555229	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161492708	189428310	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	141555229	186555229	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161799493	176036425	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	161799270	187311134	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
1582213	Insul6	Insulin level QTL 6	3.7	0.0009	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	141508991	166376254	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	152055202	189428310	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	142898802	187898802	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	145335553	189428310	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
1582256	Insul9	Insulin level QTL 9	4.4	0.0016	blood insulin amount (VT:0001560)	absolute change in serum insulin level (CMO:0002038)	3	155759447	189428310	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	139299381	184299381	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	141508991	177728348	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	137114333	182114333	Rat
1582248	Insul7	Insulin level QTL 7	3.9	0.0041	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	151075912	189428310	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	151075912	189428310	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	141555229	186555229	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	144575244	189428310	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	160357340	167835660	Rat

Markers in Region

BF400733

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	144,223,748 - 144,223,908 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	151,254,885 - 151,255,044	NCBI	Rnor6.0
Rnor_5.0	3	157,619,724 - 157,619,883	UniSTS	Rnor5.0
RGSC_v3.4	3	146,237,388 - 146,237,547	UniSTS	RGSC3.4
Celera	3	142,948,007 - 142,948,166	UniSTS
RH 3.4 Map	3	1300.6	UniSTS
Cytogenetic Map	3	q42	UniSTS

RH130626

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	164,661,805 - 164,661,937 (+)	Marker Load Pipeline
mRatBN7.2	3	144,201,668 - 144,201,800 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	151,232,806 - 151,232,937	NCBI	Rnor6.0
Rnor_5.0	3	157,597,645 - 157,597,776	UniSTS	Rnor5.0
RGSC_v3.4	3	146,215,308 - 146,215,439	UniSTS	RGSC3.4
Celera	3	142,925,938 - 142,926,069	UniSTS
RH 3.4 Map	3	1303.6	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004230	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026120 ⟹ ENSRNOP00000026120

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	164,661,742 - 164,687,559 (-)	Ensembl
mRatBN7.2 Ensembl	3	144,201,606 - 144,227,485 (-)	Ensembl
Rnor_6.0 Ensembl	3	151,232,751 - 151,258,580 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112705 ⟹ ENSRNOP00000089512

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	164,661,742 - 164,687,496 (-)	Ensembl
mRatBN7.2 Ensembl	3	144,201,605 - 144,227,360 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000147338 ⟹ ENSRNOP00000108538

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	164,661,742 - 164,687,559 (-)	Ensembl

RefSeq Acc Id:

NM_001004230 ⟹ NP_001004230

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	164,661,741 - 164,687,559 (-)	NCBI
mRatBN7.2	3	144,201,604 - 144,227,423 (-)	NCBI
Rnor_6.0	3	151,232,741 - 151,258,559 (-)	NCBI
Rnor_5.0	3	157,597,580 - 157,623,398 (-)	NCBI
RGSC_v3.4	3	146,215,243 - 146,241,062 (-)	RGD
Celera	3	142,925,873 - 142,951,681 (-)	RGD

Sequence:

show sequence

CGGAGAATGAGCGGGTGGCCGTGGCTGCAGCTGCTGCGGCGGCACTGACAGGACACGAGCTCTA
TGCCTTTCCGGCTGCTTATCCCGCTCGGCCTCGTGTGCGTGCTGCTGCCCCTGCACCATGGTGC
GCCAGGCCCCGAAGGCACCGCGCCCGACCCCGCCCACTACAGGGAGCGAGTCAAGGCCATGTTC
TACCACGCCTACGACAGTTACCTGGAAAATGCCTTTCCCTACGATGAGCTGAGACCTCTCACCT
GTGACGGGCACGACACCTGGGGCAGTTTTTCTCTGACACTGATTGATGCCCTGGACACCTTGCT
GATTTTGGGGAATACCTCTGAATTCCAAAGAGTGGTGGAGGTTCTCCAGGACAACGTGGACTTT
GATATCGACGTCAATGCCTCTGTGTTCGAAACCAACATCCGAGTGGTAGGAGGACTCCTTTCTG
CTCACCTCTTGTCAAAGAAGGCTGGTGTGGAGGTGGAAGCTGGATGGCCTTGTTCTGGACCTCT
CCTCAGGATGGCGGAGGAAGCAGCCCGAAAACTCCTCCCAGCGTTTCAGACCCCCACGGGCATG
CCCTATGGAACTGTGAACCTGCTTCATGGCGTGAACCCTGGAGAGACTCCTGTTACCTGTACAG
CAGGGATTGGGACCTTCATTGTGGAATTTGCTACCCTGAGCAGCCTCACCGGTGACCCTGTGTT
TGAAGATGTGGCCAGAGTGGCCCTGATGCGCCTCTGGGAGAGCCGGTCAGATATTGGGCTGGTC
GGCAATCACATCGATGTGCTCACTGGCAAATGGGTGGCTCAGGACGCAGGCATCGGGGCTGGTG
TGGATTCCTATTTTGAGTACCTGGTAAAAGGAGCCATCCTCCTTCAGGATAAGAAGCTCATGGC
CATGTTTCTAGAGTACAACAAAGCCATCCGGAATTACACGCACTTCGATGACTGGTACCTCTGG
GTGCAGATGTACAAGGGGACCGTGTCCATGCCTGTCTTCCAGTCCTTGGAGGCCTACTGGCCTG
GTCTTCAGAGCCTTATTGGGGATATTGACAATGCCATGAGAACCTTCCTCAACTACTACACTGT
ATGGAAGCAGTTTGGGGGGCTGCCAGAATTCTACAACATTCCTCAGGGATACACAGTGGAGAAG
CGAGAAGGCTACCCACTCCGACCGGAGCTCATCGAGAGCGCAATGTACCTCTACCGTGCCACAG
GGGATCCCACTCTCTTAGAACTGGGGAGAGATGCTGTGGAGTCCATTGAGAAAATCAGCAAGGT
GGAGTGCGGGTTCGCCACGATCAAGGACCTCCGGGATCACAAACTTGACAACCGCATGGAGTCT
TTCTTCCTGGCCGAGACTGTGAAATACCTCTACCTTCTGTTTCACCCAAACAACTTCATCCACA
ACAATGGCTCCACTTTTGACTCTGTGATGACCCCCCATGGGGAGTGCATCCTGGGAGCTGGGGG
CTACATCTTCAACACGGAAGCTCACCCCATCGACCCTGCCGCCTTGCACTGTTGCCGGAGGCTG
AAGGAAGAGCAGTGGGAAGTGGAGGACTTGATAAAGGAGTTCTACTCTCTCAGACAGAGCAGGT
CAAGAGCTCAGAGAAAGACAGTGAGTTCGGGGCCCTGGGAGCCCCCAGCAGGGCCAGGCACACT
CTCCTCACCTGAAAACCAGCCCAGGGAGAAGCAGCCTGCCAGGCAGAGAGCCCCGCTCCTCAGC
TGCCCCAGCCAGCCCTTCACTTCTAAACTGGCCCTGCTAGGCCAGGTTTTCCTAGACTCCTCAT
AACCACTGGATAATTTTTTTAATTTTTATTTTTTTGAGACTGAGCTATAATAATAAATCTGCTT
TTAGCTATCAGGTTTTAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004230	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79029	(Get FASTA)	NCBI Sequence Viewer
	EDL85901	(Get FASTA)	NCBI Sequence Viewer
	EDL85902	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026120
	ENSRNOP00000026120.4
	ENSRNOP00000089512.1
	ENSRNOP00000108538.1

RefSeq Acc Id:	NP_001004230 ⟸ NM_001004230
- Peptide Label:	precursor
- UniProtKB:	Q6AYI8 (UniProtKB/TrEMBL), A6KI53 (UniProtKB/TrEMBL), A0A8I6AA03 (UniProtKB/TrEMBL), F7FAW8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPFRLLIPLGLVCVLLPLHHGAPGPEGTAPDPAHYRERVKAMFYHAYDSYLENAFPYDELRPLT CDGHDTWGSFSLTLIDALDTLLILGNTSEFQRVVEVLQDNVDFDIDVNASVFETNIRVVGGLLS AHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCT AGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAG VDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTHFDDWYLWVQMYKGTVSMPVFQSLEAYWP GLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRAT GDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFHPNNFIH NNGSTFDSVMTPHGECILGAGGYIFNTEAHPIDPAALHCCRRLKEEQWEVEDLIKEFYSLRQSR SRAQRKTVSSGPWEPPAGPGTLSSPENQPREKQPARQRAPLLSCPSQPFTSKLALLGQVFLDSS hide sequence

Ensembl Acc Id:

ENSRNOP00000026120 ⟸ ENSRNOT00000026120

Ensembl Acc Id:

ENSRNOP00000089512 ⟸ ENSRNOT00000112705

Ensembl Acc Id:

ENSRNOP00000108538 ⟸ ENSRNOT00000147338

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AYI8-F1-model_v2	AlphaFold	Q6AYI8	1-576	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692587

Promoter ID:

EPDNEW_R3112

Type:

initiation region

Name:

Edem2_1

Description:

ER degradation enhancing alpha-mannosidase like protein 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	151,258,575 - 151,258,635	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303074	AgrOrtholog
BioCyc Gene	G2FUF-47121	BioCyc
Ensembl Genes	ENSRNOG00000019299	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026120	ENTREZGENE
	ENSRNOT00000026120.7	UniProtKB/TrEMBL
	ENSRNOT00000112705.2	UniProtKB/TrEMBL
	ENSRNOT00000147338.1	UniProtKB/TrEMBL
Gene3D-CATH	1.50.10.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7114041	IMAGE-MGC_LOAD
InterPro	6hp_glycosidase-like_sf	UniProtKB/TrEMBL
	EDEM1/2/3	UniProtKB/TrEMBL
	Glyco_hydro_47	UniProtKB/TrEMBL
	Seven-hairpin_glycosidases	UniProtKB/TrEMBL
KEGG Report	rno:296304	UniProtKB/TrEMBL
MGC_CLONE	MGC:93956	IMAGE-MGC_LOAD
NCBI Gene	296304	ENTREZGENE
PANTHER	ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2	UniProtKB/TrEMBL
	PTHR45679	UniProtKB/TrEMBL
Pfam	Glyco_hydro_47	UniProtKB/TrEMBL
PhenoGen	Edem2	PhenoGen
PRINTS	GLYHDRLASE47	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019299	RatGTEx
Superfamily-SCOP	Glyco_hydro_47	UniProtKB/TrEMBL
UniProt	A0A8I6AA03	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LCS9_RAT	UniProtKB/TrEMBL
	A6KI53	ENTREZGENE, UniProtKB/TrEMBL
	F7FAW8	ENTREZGENE, UniProtKB/TrEMBL
	Q6AYI8	ENTREZGENE
UniProt Secondary	Q6AYI8	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-13	Edem2	ER degradation enhancing alpha-mannosidase like protein 2	Edem2	ER degradation enhancer, mannosidase alpha-like 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Edem2	ER degradation enhancer, mannosidase alpha-like 2	RGD1303074	similar to putative alpha-mannosidase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	RGD1303074	similar to putative alpha-mannosidase	MGC93956		Symbol updated	1299863	APPROVED
2005-09-30	MGC93956				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)