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Gene: Katna1 (katanin catalytic subunit A1) Rattus norvegicus

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Symbol:

Katna1

Name:

katanin catalytic subunit A1

RGD ID:

1303062

Description:

Predicted to enable several functions, including ATP hydrolysis activity; dynein complex binding activity; and microtubule severing ATPase activity. Involved in microtubule severing and negative regulation of neuron projection development. Located in growth cone and neuronal cell body. Orthologous to human KATNA1 (katanin catalytic subunit A1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

katanin; katanin p60 (ATPase-containing) subunit A1; katanin p60 ATPase-containing subunit A1; katanin p60 subunit A 1; katanin p60 subunit A1; microtubule severing protein; p60 katanin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KATNA1 (katanin catalytic subunit A1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Katna1 (katanin p60 (ATPase-containing) subunit A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Katna1 (katanin catalytic subunit A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100991443 (katanin p60 ATPase-containing subunit A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KATNA1 (katanin catalytic subunit A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Katna1 (katanin catalytic subunit A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KATNA1 (katanin catalytic subunit A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KATNA1 (katanin catalytic subunit A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Katna1 (katanin catalytic subunit A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Katna1 (katanin catalytic subunit A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KATNA1 (katanin catalytic subunit A1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Katna1 (katanin p60 (ATPase-containing) subunit A1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	katna1 (katanin p60 (ATPase containing) subunit A 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mei-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mei-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Kat60	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Kat60	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	kat-60L1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	katna1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	4,022,886 - 4,064,513 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	4,022,876 - 4,064,512 (+)	Ensembl				GRCr8
mRatBN7.2	1	2,202,501 - 2,244,132 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	2,202,490 - 2,244,131 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	1,852,360 - 1,893,967 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	7,852,762 - 7,894,369 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	2,134,465 - 2,176,074 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	1,826,170 - 1,867,786 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	1,825,872 - 1,867,787 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	3,522,927 - 3,564,344 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	2,394,947 - 2,436,574 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	751,300 - 792,888 (+)	NCBI		Celera
RGSC_v3.1	1	2,394,946 - 2,436,572 (+)	NCBI
Cytogenetic Map	1	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-palmitoylglycerol (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (EXP)

caffeine (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

diazinon (EXP)

dicrotophos (ISO)

dieldrin (EXP)

diethylstilbestrol (EXP)

dimethyl sulfoxide (ISO)

ethanol (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

methyl methanesulfonate (ISO)

nickel dichloride (EXP)

okadaic acid (ISO)

paracetamol (ISO)

paraquat (EXP)

phenobarbital (ISO)

sodium arsenite (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

cytoplasmic microtubule organization (IEA,ISO)

intracellular protein localization (ISO)

microtubule bundle formation (ISO)

microtubule cytoskeleton organization (IEA)

microtubule severing (IBA,IDA,IEA,ISO)

negative regulation of neuron projection development (IDA)

neuron migration (ISO)

Cellular Component

axon (IDA,ISO)

centriolar satellite (IEA,ISO)

centrosome (IEA,ISO)

Cul3-RING ubiquitin ligase complex (ISS)

cytoplasm (IBA,IEA,ISO,ISS)

growth cone (IDA)

lipid droplet (ISO)

microtubule (IEA)

midbody (IEA,ISO,ISS)

mitotic spindle pole (IEA,ISO,ISS)

neuronal cell body (IDA)

nucleus (ISO)

plasma membrane (ISO)

spindle (IBA,IEA,ISO,ISS)

spindle pole (IEA,ISO,ISS)

Molecular Function

ATP binding (IEA,TAS)

ATP hydrolysis activity (IBA,IEA,ISO,TAS)

dynein complex binding (ISO)

isomerase activity (IEA)

microtubule binding (IEA,ISO)

microtubule severing ATPase activity (IBA,IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

protein heterodimerization activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules.	Karabay A, etal., J Neurosci 2004 Jun 23;24(25):5778-88.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Regulation of microtubule severing by katanin subunits during neuronal development.	Yu W, etal., J Neurosci. 2005 Jun 8;25(23):5573-83.

Additional References at PubMed

PMID:8889548	PMID:10209026	PMID:10445032	PMID:10751153	PMID:12477932	PMID:16203747	PMID:16554463	PMID:18234839	PMID:19261606	PMID:20530212	PMID:23904609	PMID:24303010
PMID:26929214	PMID:31963385	PMID:34260930

Genomics

Comparative Map Data

Katna1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	4,022,886 - 4,064,513 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	4,022,876 - 4,064,512 (+)	Ensembl				GRCr8
mRatBN7.2	1	2,202,501 - 2,244,132 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	2,202,490 - 2,244,131 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	1,852,360 - 1,893,967 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	7,852,762 - 7,894,369 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	2,134,465 - 2,176,074 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	1,826,170 - 1,867,786 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	1,825,872 - 1,867,787 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	3,522,927 - 3,564,344 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	2,394,947 - 2,436,574 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	751,300 - 792,888 (+)	NCBI		Celera
RGSC_v3.1	1	2,394,946 - 2,436,572 (+)	NCBI
Cytogenetic Map	1	p13	NCBI

KATNA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	149,594,873 - 149,648,990 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	149,594,873 - 149,648,972 (-)	Ensembl			hg38	GRCh38
GRCh37	6	149,916,009 - 149,969,850 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	149,957,865 - 150,001,421 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	149,957,864 - 150,001,421	NCBI
Celera	6	150,651,214 - 150,694,812 (-)	NCBI		Celera
Cytogenetic Map	6	q25.1	NCBI
HuRef	6	147,482,647 - 147,536,579 (-)	NCBI		HuRef
CHM1_1	6	150,180,715 - 150,234,615 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	150,794,606 - 150,848,774 (-)	NCBI		T2T-CHM13v2.0

Katna1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	7,601,748 - 7,638,913 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	7,601,764 - 7,638,914 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	7,725,990 - 7,763,150 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	7,726,000 - 7,763,150 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	7,445,798 - 7,482,948 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	7,416,212 - 7,453,339 (+)	NCBI		MGSCv36	mm8
Celera	10	7,603,717 - 7,641,580 (+)	NCBI		Celera
Cytogenetic Map	10	A1	NCBI
cM Map	10	2.32	NCBI

Katna1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	11,623,697 - 11,660,344 (+)	Ensembl
ChiLan1.0	NW_004955439	11,620,285 - 11,658,797 (+)	NCBI	ChiLan1.0	ChiLan1.0

LOC100991443
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	169,620,373 - 169,739,960 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	167,513,943 - 167,567,919 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	147,413,892 - 147,467,587 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	152,119,206 - 152,173,349 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	152,119,206 - 152,173,113 (-)	Ensembl			panPan2	panpan1.1
PanPan1.1 Ensembl	6	152,182,394 - 152,239,276 (-)	Ensembl			panPan2	panpan1.1

KATNA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	40,376,153 - 40,422,679 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	40,373,904 - 40,422,627 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	41,213,485 - 41,260,274 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	40,556,065 - 40,602,855 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	40,552,688 - 40,602,870 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	40,432,197 - 40,478,742 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	40,297,210 - 40,343,704 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	40,638,095 - 40,684,879 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Katna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	135,305,920 - 135,347,263 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	2,557,808 - 2,599,116 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	2,557,827 - 2,599,050 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KATNA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	16,321,355 - 16,360,798 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	16,330,854 - 16,360,801 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	18,657,447 - 18,665,635 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KATNA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	21,979,755 - 22,040,247 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	21,993,836 - 22,044,525 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	198,000,241 - 198,064,124 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Katna1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624785	8,419,159 - 8,464,757 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624785	8,419,646 - 8,464,757 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Katna1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	229,277,604 - 229,320,214 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Katna1
389 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	23
Count of miRNA genes:	23
Interacting mature miRNAs:	23
Transcripts:	ENSRNOT00000020417
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600360	Mcs16	Mammary carcinoma susceptibility QTL 16	2.4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	1	26564886	Rat
70179	Xhs2	X-ray hypersensitivity QTL 2	3.2		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	1	1	43965634	Rat
1354647	Despr8	Despair related QTL 8		0.0000341	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	1	26564886	Rat
2317755	Glom22	Glomerulus QTL 22	3.8		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	1	1	34184556	Rat
1300170	Rf6	Renal function QTL 6	3.14		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	1	1	28483164	Rat

Markers in Region

D1Rat246

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	4,064,771 - 4,065,001 (+)	Marker Load Pipeline
mRatBN7.2	1	2,244,390 - 2,244,622 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	1,868,045 - 1,868,274	NCBI	Rnor6.0
Rnor_5.0	1	3,564,603 - 3,564,832	UniSTS	Rnor5.0
RGSC_v3.4	1	2,436,833 - 2,437,062	UniSTS	RGSC3.4
RGSC_v3.4	1	2,436,832 - 2,437,062	RGD	RGSC3.4
Celera	1	793,147 - 793,378	UniSTS
RGSC_v3.1	1	2,436,833 - 2,437,062	RGD
RH 3.4 Map	1	16.7	RGD
RH 3.4 Map	1	16.7	UniSTS
SHRSP x BN Map	1	0.04	RGD
SHRSP x BN Map	1	0.04	UniSTS
Cytogenetic Map	1	p13	UniSTS

RH135174

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	2,236,558 - 2,236,730 (+)	MAPPER	mRatBN7.2
mRatBN7.2	10	13,963,333 - 13,963,513 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	14,304,307 - 14,304,486	NCBI	Rnor6.0
Rnor_6.0	1	1,860,218 - 1,860,389	NCBI	Rnor6.0
Rnor_5.0	10	14,120,323 - 14,120,502	UniSTS	Rnor5.0
Rnor_5.0	1	3,556,975 - 3,557,146	UniSTS	Rnor5.0
RGSC_v3.4	10	14,191,417 - 14,191,596	UniSTS	RGSC3.4
RGSC_v3.4	1	2,428,995 - 2,429,166	UniSTS	RGSC3.4
Celera	1	785,348 - 785,519	UniSTS
Celera	10	13,642,544 - 13,642,723	UniSTS
Cytogenetic Map	1	p13	UniSTS
Cytogenetic Map	10	q12	UniSTS

RH125418

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	2,236,467 - 2,236,568 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	1,860,127 - 1,860,227	NCBI	Rnor6.0
Rnor_5.0	1	3,556,884 - 3,556,984	UniSTS	Rnor5.0
RGSC_v3.4	1	2,428,904 - 2,429,004	UniSTS	RGSC3.4
Celera	1	785,257 - 785,357	UniSTS
Cytogenetic Map	1	p13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY621629	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BI302698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020417 ⟹ ENSRNOP00000020417

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	4,022,876 - 4,064,512 (+)	Ensembl
mRatBN7.2 Ensembl	1	2,202,490 - 2,244,123 (+)	Ensembl
Rnor_6.0 Ensembl	1	1,825,872 - 1,867,787 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099868 ⟹ ENSRNOP00000092318

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	4,022,886 - 4,064,512 (+)	Ensembl
mRatBN7.2 Ensembl	1	2,216,935 - 2,244,131 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000127125 ⟹ ENSRNOP00000111113

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	4,022,876 - 4,064,512 (+)	Ensembl

RefSeq Acc Id:

NM_001004217 ⟹ NP_001004217

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	4,022,886 - 4,064,513 (+)	NCBI
mRatBN7.2	1	2,202,501 - 2,244,132 (+)	NCBI
Rnor_6.0	1	1,826,170 - 1,867,786 (+)	NCBI
Rnor_5.0	1	3,522,927 - 3,564,344 (+)	NCBI
RGSC_v3.4	1	2,394,947 - 2,436,574 (+)	RGD
Celera	1	751,300 - 792,888 (+)	RGD

Sequence:

show sequence

GTGGGAGGAGGACCCAGTAAGAGGGGCTTGCCGGGTTTGATTTCAAGTTGGCAGCGACCAAGAA
CTGCGGTGCCCGCGGGCCTCGACCGTGCGGCTCGCGGAGCTCCGAGCGAGACGCCGCGGCCCGG
GCCTCATTCCCCGCCACGCGGCGGACAGCGTGTCCTGGAGCCTGGGCTGCACCAGCTTACGGAT
GAGCATGAGTCTTCTAATGATTACTGAGAATGTAAAATTGGCTCGTGAGTATGCATTGCTGGGA
AACTATGACTCTGCAATGGTCTATTATCAGGGAGTTCTTGACCAAATTAACAAGTATCTATACT
CAGTCAAAGATACACACCTCCATCAGAAATGGCAACAGGTTTGGCAGGAAATAAACGTGGAAGC
TAAGCATGTTAAGGAGATCATGAAAACACTGGAGAGCTTTAAACTGGACAGCACTTCTTTGAAA
GCTGCACAGCATGAGCTTCCGTCCTCGGAAGGAGAAGTCTGGTCTTTGCCGGTACCTGTTGAAA
GGAGACCCTTACCAGGACCTAGGAAGCGCCAGTCTACTCAGCACAGTGACCCTAAGCCACACAG
TAACCGGCCAGGCGCAGTCGTCAGAGCTCATCGACCATCTGCACAGAGTCTGCACAGCGACAGA
GGCAAAGCTGTTCGTAGTCGTGAAAAGAAAGAGCAGAGTAAGGGCAGAGAGGAAAAGAACAAAT
TACCTGCTGCAGTTACAGAACCAGAGGCAAATAAATTTGATAGCACGGGGTATGACAAGGACTT
AGTAGAAGCTTTGGAAAGAGATATAATTTCTCAGAATCCCAACGTTCGGTGGTATGATATTGCT
GATTTAGTAGAAGCTAAAAAGTTGCTTCAGGAAGCAGTGGTGTTACCAATGTGGATGCCAGAAT
TCTTTAAGGGCATTAGGAGACCATGGAAAGGTGTGCTGATGGTTGGCCCACCTGGCACTGGAAA
GACCCTCCTTGCTAAAGCAGTTGCCACAGAATGCAAGACAACGTTCTTCAATGTCTCTTCATCC
ACTCTGACTTCCAAATACAGAGGAGAGTCTGAGAAGCTTGTCCGTCTTCTGTTTGAAATGGCTC
GGTTTTACTCCCCAGCTACCATATTTATTGATGAGATAGATTCCATCTGCAGCCGCCGAGGAAC
TTCTGAAGAGCATGAAGCAAGCCGAAGGGTGAAAGCTGAGCTGCTGGTTCAGATGGATGGTGTT
GGAGGTGCCTCAGAAAATGACGACCCTTCCAAGATGGTCATGGTTCTGGCGGCCACTAATTTCC
CATGGGACATAGATGAGGCTTTAAGGCGTCGTCTGGAGAAAAGAATCTATATTCCGTTACCATC
AGCAAAAGGCAGAGAAGAACTGTTAAGAATAAGTCTACGAGAGCTGGAATTGGCTGATGATGTT
AACCTTGCAAGCATAGCAGAAAACATGGAAGGCTACTCAGGTGCAGACATTACCAATGTATGCA
GGGATGCGTCCTTGATGGCCATGAGACGCCGTATTGAGGGTCTAACCCCAGAAGAAATCCGGAA
CCTTTCAAGAGAAGAAATGCACATGCCTACCACCATGGAGGATTTTGAAATGGCTTTAAAGAAG
GTCTCCAAATCAGTATCAGCTGCAGACATTGAGAGATACGAGAAATGGATAGTTGAGTTTGGAT
CATGCTAGCTAAGTTCTCACATGTAAACTGTGAGAAATCTGCCTTAAGTCTTTGAAAATAATTA
AATGTAGTATTTCAGTGCATTGAGTGCCATATTTTTTTGAACTTTGATAATGGTGTGATATTTA
AATTCTTTCTGGTGCTTAATAAAGACAATATTTTTAAACTGCAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004217	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97929	(Get FASTA)	NCBI Sequence Viewer
	AAT44333	(Get FASTA)	NCBI Sequence Viewer
	EDL93689	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020417
GenBank Protein	Q6E0V2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001004217 ⟸ NM_001004217

- UniProtKB:

Q4V7G3 (UniProtKB/Swiss-Prot), Q6E0V2 (UniProtKB/Swiss-Prot), Z4YNM2 (UniProtKB/TrEMBL), A6JP17 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSMSLLMITENVKLAREYALLGNYDSAMVYYQGVLDQINKYLYSVKDTHLHQKWQQVWQEINVE
AKHVKEIMKTLESFKLDSTSLKAAQHELPSSEGEVWSLPVPVERRPLPGPRKRQSTQHSDPKPH
SNRPGAVVRAHRPSAQSLHSDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDSTGYDKD
LVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTG
KTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRG
TSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLP
SAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIR
NLSREEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIVEFGSC

hide sequence

Ensembl Acc Id:

ENSRNOP00000020417 ⟸ ENSRNOT00000020417

Ensembl Acc Id:

ENSRNOP00000092318 ⟸ ENSRNOT00000099868

Ensembl Acc Id:

ENSRNOP00000111113 ⟸ ENSRNOT00000127125

Protein Domains

AAA+ ATPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6E0V2-F1-model_v2	AlphaFold	Q6E0V2	1-491	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689481

Promoter ID:

EPDNEW_R5

Type:

initiation region

Name:

Katna1_1

Description:

katanin catalytic subunit A1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	1,826,160 - 1,826,220	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303062	AgrOrtholog
BioCyc Gene	G2FUF-62449	BioCyc
Ensembl Genes	ENSRNOG00000014996	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000020417	ENTREZGENE
Gene3D-CATH	1.10.8.60	UniProtKB/Swiss-Prot
	3.40.50.300	UniProtKB/Swiss-Prot
	Phosphotransferase system, lactose/cellobiose-type IIA subunit	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7444887	IMAGE-MGC_LOAD
InterPro	AAA+_ATPase	UniProtKB/Swiss-Prot
	AAA_lid_3	UniProtKB/Swiss-Prot
	ATPase_AAA_core	UniProtKB/Swiss-Prot
	ATPase_AAA_CS	UniProtKB/Swiss-Prot
	KATNA1	UniProtKB/Swiss-Prot
	KATNA1_MIT	UniProtKB/Swiss-Prot
	KTNA1_AAA_dom	UniProtKB/Swiss-Prot
	MT-severing_AAA_ATPase	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
	Vps4_C	UniProtKB/Swiss-Prot
KEGG Report	rno:292464	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:116039	IMAGE-MGC_LOAD
NCBI Gene	292464	ENTREZGENE
PANTHER	AAA DOMAIN-CONTAINING	UniProtKB/Swiss-Prot
	KATANIN P60 ATPASE-CONTAINING SUBUNIT A1	UniProtKB/Swiss-Prot
Pfam	AAA	UniProtKB/Swiss-Prot
	AAA_lid_3	UniProtKB/Swiss-Prot
	KATNA1_MIT	UniProtKB/Swiss-Prot
	Vps4_C	UniProtKB/Swiss-Prot
PhenoGen	Katna1	PhenoGen
PROSITE	AAA	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000014996	RatGTEx
SMART	AAA	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A8I6GK45_RAT	UniProtKB/TrEMBL
	A0ABK0M265_RAT	UniProtKB/TrEMBL
	A6JP17	ENTREZGENE, UniProtKB/TrEMBL
	KTNA1_RAT	UniProtKB/Swiss-Prot
	Q4V7G3	ENTREZGENE
	Q6E0V2	ENTREZGENE
	Z4YNM2	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	Q4V7G3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-29	Katna1	katanin catalytic subunit A1	Katna1	katanin p60 (ATPase-containing) subunit A1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Katna1	katanin p60 (ATPase-containing) subunit A1		katanin p60 subunit A 1	Name updated	1299863	APPROVED
2005-02-14	Katna1	katanin p60 subunit A 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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