Chst7 (carbohydrate sulfotransferase 7) - Rat Genome Database

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Gene: Chst7 (carbohydrate sulfotransferase 7) Rattus norvegicus
Analyze
Symbol: Chst7
Name: carbohydrate sulfotransferase 7
RGD ID: 1303028
Description: Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity and chondroitin 6-sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process and chondroitin sulfate biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in trans-Golgi network. Orthologous to human CHST7 (carbohydrate sulfotransferase 7); PARTICIPATES IN chondroitin sulfate biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C6ST-2; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7; chondroitin 6-sulfotransferase 2; chondroitin 6-sulfotransferase 7; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5; glcNAc6ST-4; Gn6st-4; GST-5; MGC124926; N-acetylglucosamine 6-O-sulfotransferase 1; N-acetylglucosamine 6-O-sulfotransferase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,949,810 - 4,986,372 (-)NCBIGRCr8
mRatBN7.2X2,396,260 - 2,432,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX2,393,874 - 2,432,840 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX2,429,449 - 2,466,021 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,905,200 - 5,941,769 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X2,215,569 - 2,252,135 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X2,623,018 - 2,657,155 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX2,623,024 - 2,657,155 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X3,413,400 - 3,449,646 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X13,817,186 - 13,853,694 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X13,857,681 - 13,859,139 (-)NCBI
CeleraX2,920,778 - 2,957,095 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. Thiselton DL, etal., Genomics 2002 Apr;79(4):560-72.
Additional References at PubMed
PMID:10781596   PMID:10913333   PMID:12477932  


Genomics

Comparative Map Data
Chst7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,949,810 - 4,986,372 (-)NCBIGRCr8
mRatBN7.2X2,396,260 - 2,432,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX2,393,874 - 2,432,840 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX2,429,449 - 2,466,021 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,905,200 - 5,941,769 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X2,215,569 - 2,252,135 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X2,623,018 - 2,657,155 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX2,623,024 - 2,657,155 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X3,413,400 - 3,449,646 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X13,817,186 - 13,853,694 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X13,857,681 - 13,859,139 (-)NCBI
CeleraX2,920,778 - 2,957,095 (-)NCBICelera
Cytogenetic MapXq11NCBI
CHST7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X46,573,765 - 46,598,496 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX46,573,765 - 46,598,496 (+)EnsemblGRCh38hg38GRCh38
GRCh37X46,433,200 - 46,457,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,318,136 - 46,342,782 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X46,189,445 - 46,214,091NCBI
CeleraX50,625,034 - 50,649,680 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX44,144,475 - 44,169,440 (+)NCBIHuRef
CHM1_1X46,465,351 - 46,489,979 (+)NCBICHM1_1
T2T-CHM13v2.0X45,980,734 - 46,005,466 (+)NCBIT2T-CHM13v2.0
Chst7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X19,925,202 - 19,965,361 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX19,925,799 - 19,963,760 (+)EnsemblGRCm39 Ensembl
GRCm38X20,058,963 - 20,099,991 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,059,560 - 20,097,521 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X19,636,696 - 19,674,647 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,216,529 - 19,254,480 (+)NCBIMGSCv36mm8
CeleraX18,187,572 - 18,226,625 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX15.5NCBI
Chst7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555161,461,789 - 1,466,249 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555161,435,972 - 1,466,249 (-)NCBIChiLan1.0ChiLan1.0
CHST7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X48,202,066 - 48,227,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X48,205,739 - 48,230,385 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X39,012,011 - 39,036,655 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X46,873,703 - 46,898,117 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX46,873,942 - 46,875,436 (+)Ensemblpanpan1.1panPan2
CHST7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,209,884 - 40,239,077 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,210,096 - 40,211,556 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX14,585,620 - 14,614,974 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,343,653 - 40,372,792 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,344,040 - 40,345,500 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,332,857 - 40,362,003 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,319,916 - 40,349,073 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X40,412,644 - 40,442,007 (+)NCBIUU_Cfam_GSD_1.0
Chst7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X32,586,021 - 32,605,063 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650212,426,851 - 12,445,741 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650212,426,821 - 12,446,127 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHST7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,193,025 - 41,233,330 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X41,192,993 - 41,234,654 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,035,663 - 46,075,254 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHST7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X43,780,459 - 43,904,770 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX43,781,196 - 43,782,656 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660769,027,115 - 9,053,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chst7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,381,011 - 3,402,855 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248873,381,152 - 3,402,855 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chst7
112 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:139
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000005630
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8
Low 2 43 55 39 19 39 8 11 66 35 34 11 8
Below cutoff 1 2 2 2 4

Sequence


RefSeq Acc Id: ENSRNOT00000005630   ⟹   ENSRNOP00000005630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX2,393,874 - 2,432,840 (-)Ensembl
Rnor_6.0 EnsemblX2,623,024 - 2,657,155 (-)Ensembl
RefSeq Acc Id: NM_207600   ⟹   NP_997483
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X4,949,810 - 4,986,372 (-)NCBI
mRatBN7.2X2,396,260 - 2,432,828 (-)NCBI
Rnor_6.0X2,623,018 - 2,657,155 (-)NCBI
Rnor_5.0X3,413,400 - 3,449,646 (-)NCBI
RGSC_v3.4X13,817,186 - 13,853,694 (-)RGD
CeleraX2,920,778 - 2,957,095 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_997483 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI11080 (Get FASTA)   NCBI Sequence Viewer  
  AAP51034 (Get FASTA)   NCBI Sequence Viewer  
  EDL97689 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005630
  ENSRNOP00000005630.4
  ENSRNOP00055022738
  ENSRNOP00060032473
  ENSRNOP00065028011
GenBank Protein Q6XQG8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997483   ⟸   NM_207600
- Peptide Label: precursor
- UniProtKB: Q2TA65 (UniProtKB/Swiss-Prot),   Q6XQG8 (UniProtKB/Swiss-Prot),   A6JZU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005630   ⟸   ENSRNOT00000005630
Protein Domains
Sulfotransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6XQG8-F1-model_v2 AlphaFold Q6XQG8 1-485 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303028 AgrOrtholog
BioCyc Gene G2FUF-3170 BioCyc
BioCyc Pathway PWY-6567 [chondroitin sulfate biosynthesis] BioCyc
BioCyc Pathway Image PWY-6567 BioCyc
Ensembl Genes ENSRNOG00000004258 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055016635 UniProtKB/Swiss-Prot
  ENSRNOG00060022654 UniProtKB/Swiss-Prot
  ENSRNOG00065020594 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005630 ENTREZGENE
  ENSRNOT00000005630.6 UniProtKB/Swiss-Prot
  ENSRNOT00055028251 UniProtKB/Swiss-Prot
  ENSRNOT00060039271 UniProtKB/Swiss-Prot
  ENSRNOT00065034871 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7387313 IMAGE-MGC_LOAD
InterPro Carbohydrate_sulfotransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfotransferase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:302302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124926 IMAGE-MGC_LOAD
NCBI Gene 302302 ENTREZGENE
PANTHER CARBOHYDRATE SULFOTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOHYDRATE SULFOTRANSFERASE 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sulfotransfer_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Chst7 PhenoGen
PIRSF Carbohydrate_sulfotransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004258 RatGTEx
  ENSRNOG00055016635 RatGTEx
  ENSRNOG00060022654 RatGTEx
  ENSRNOG00065020594 RatGTEx
Superfamily-SCOP P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JZU6 ENTREZGENE, UniProtKB/TrEMBL
  CHST7_RAT UniProtKB/Swiss-Prot
  Q2TA65 ENTREZGENE
  Q6XQG8 ENTREZGENE
UniProt Secondary Q2TA65 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Chst7  carbohydrate sulfotransferase 7  Chst7  carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Chst7  carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7  Chst7  carbohydrate sulfotransferase 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-05 Chst7  carbohydrate sulfotransferase 7  Chst7  carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Chst7  carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Chst7  carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7      Symbol and Name status set to provisional 70820 PROVISIONAL