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Gene: Slc4a5 (solute carrier family 4 member 5) Rattus norvegicus

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Symbol:

Slc4a5

Name:

solute carrier family 4 member 5

RGD ID:

1303009

Description:

Predicted to enable sodium:bicarbonate symporter activity. Predicted to be involved in several processes, including bicarbonate transport; regulation of intracellular pH; and renal system process. Predicted to act upstream of or within several processes, including cerebrospinal fluid secretion; mitochondrion distribution; and retina development in camera-type eye. Located in basolateral plasma membrane. Orthologous to human SLC4A5 (solute carrier family 4 member 5); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH acetamide; bisphenol A; bromobenzene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

electrogenic sodium bicarbonate cotransporter 4; electrogenic sodium bicarbonate cotransporter NBC4c; NBC4; sodium bicarbonate transporter 4; solute carrier family 4, sodium bicarbonate cotransporter, member 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC4A5 (solute carrier family 4 member 5)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Slc4a5 (solute carrier family 4, sodium bicarbonate cotransporter, member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc4a5 (solute carrier family 4 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC4A5 (solute carrier family 4 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC4A5 (solute carrier family 4 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc4a5 (solute carrier family 4 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC4A5 (solute carrier family 4 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC4A5 (solute carrier family 4 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc4a5 (solute carrier family 4 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Slc4a5 (solute carrier family 4 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SLC4A4 (solute carrier family 4 member 4)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	SLC4A5 (solute carrier family 4 member 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc4a5 (solute carrier family 4, sodium bicarbonate cotransporter, member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc4a5 (solute carrier family 4 member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BOR1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BOR1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Ndae1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ndae1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	abts-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	abts-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Danio rerio (zebrafish):	slc4a5a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc4a5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc4a5	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	117,267,803 - 117,368,024 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	117,267,822 - 117,368,024 (+)	Ensembl				GRCr8
mRatBN7.2	4	115,710,101 - 115,810,330 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	115,725,592 - 115,810,323 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	121,202,308 - 121,287,313 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	116,977,485 - 117,062,485 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	115,591,931 - 115,676,855 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	114,918,488 - 115,002,290 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	114,918,488 - 115,002,300 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	179,507,406 - 179,590,656 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	117,432,385 - 117,515,453 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	104,719,746 - 104,803,062 (+)	NCBI		Celera
RGSC_v3.1	4	117,676,865 - 117,759,934 (+)	NCBI
Cytogenetic Map	4	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

butan-1-ol (ISO)

Butylbenzyl phthalate (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

clorgyline (ISO)

D-glucose (ISO)

diiodine (ISO)

dioxygen (ISO)

folic acid (ISO)

fulvestrant (ISO)

genistein (EXP)

glucose (ISO)

glycidol (EXP)

lead diacetate (EXP)

malathion (ISO)

O-methyleugenol (ISO)

ozone (ISO)

paraquat (EXP)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

pioglitazone (ISO)

propanal (ISO)

S-nitrosoglutathione (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bicarbonate transport (IBA)

cerebrospinal fluid secretion (ISO)

epithelial cell development (ISO)

mitochondrion distribution (ISO)

monoatomic anion transmembrane transport (IEA)

monoatomic anion transport (IEA,TAS)

monoatomic cation homeostasis (IEA)

monoatomic ion transport (IEA,ISO)

regulation of gene expression (ISO)

regulation of intracellular pH (IBA)

regulation of pH (TAS)

regulation of systemic arterial blood pressure (ISO)

renal system process (IBA,ISO)

retina development in camera-type eye (ISO)

sodium ion transmembrane transport (IEA)

sodium ion transport (IEA)

transmembrane transport (IBA,IEA)

Cellular Component

apical plasma membrane (IEA,ISO,ISS)

basolateral plasma membrane (IDA,IEA)

membrane (IEA)

plasma membrane (IBA)

Molecular Function

antiporter activity (IEA)

monoatomic anion transmembrane transporter activity (IEA)

secondary active transmembrane transporter activity (IEA)

sodium:bicarbonate symporter activity (IBA,ISO,ISS)

solute:inorganic anion antiporter activity (IEA,TAS)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid transport pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression and localization of rat NBC4c in liver and renal uroepithelium.	Abuladze N, etal., Am J Physiol Cell Physiol 2004 Sep;287(3):C781-9. Epub 2004 May 19.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17715183	PMID:21705333	PMID:22082831	PMID:23205667

Genomics

Comparative Map Data

Slc4a5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	117,267,803 - 117,368,024 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	117,267,822 - 117,368,024 (+)	Ensembl				GRCr8
mRatBN7.2	4	115,710,101 - 115,810,330 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	115,725,592 - 115,810,323 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	121,202,308 - 121,287,313 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	116,977,485 - 117,062,485 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	115,591,931 - 115,676,855 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	114,918,488 - 115,002,290 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	114,918,488 - 115,002,300 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	179,507,406 - 179,590,656 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	117,432,385 - 117,515,453 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	104,719,746 - 104,803,062 (+)	NCBI		Celera
RGSC_v3.1	4	117,676,865 - 117,759,934 (+)	NCBI
Cytogenetic Map	4	q34	NCBI

SLC4A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	74,216,242 - 74,343,416 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	74,216,242 - 74,343,416 (-)	Ensembl			hg38	GRCh38
GRCh37	2	74,443,369 - 74,570,543 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	74,296,877 - 74,424,042 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	74,360,215 - 74,481,317	NCBI
Celera	2	74,274,548 - 74,401,724 (-)	NCBI		Celera
Cytogenetic Map	2	p13.1	NCBI
HuRef	2	74,179,673 - 74,306,847 (-)	NCBI		HuRef
CHM1_1	2	74,372,727 - 74,499,962 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	74,224,993 - 74,351,975 (-)	NCBI		T2T-CHM13v2.0

Slc4a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	83,184,561 - 83,281,927 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	83,196,810 - 83,281,927 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	83,207,580 - 83,304,945 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	83,219,828 - 83,304,945 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	83,187,369 - 83,254,939 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	83,171,116 - 83,269,155 (+)	NCBI		MGSCv36	mm8
Celera	6	85,218,567 - 85,286,029 (+)	NCBI		Celera
Cytogenetic Map	6	C3	NCBI
cM Map	6	35.94	NCBI

Slc4a5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	11,449,819 - 11,535,379 (+)	Ensembl
ChiLan1.0	NW_004955424	11,426,020 - 11,537,141 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC4A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	52,051,754 - 52,171,182 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	52,054,507 - 52,173,935 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	74,288,481 - 74,428,014 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	75,795,839 - 75,915,842 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	75,798,510 - 75,888,448 (-)	Ensembl			panPan2	panpan1.1

SLC4A5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	48,769,963 - 48,882,201 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	48,797,807 - 48,880,441 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	48,415,721 - 48,523,894 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	49,633,737 - 49,741,999 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	49,646,207 - 49,741,175 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	48,650,512 - 48,758,615 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	48,716,975 - 48,825,438 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	49,275,214 - 49,383,455 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc4a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	10,146,778 - 10,262,042 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936556	475,394 - 577,168 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936556	475,856 - 577,160 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC4A5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	68,692,693 - 68,819,293 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	68,733,379 - 68,819,293 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	71,905,020 - 71,977,516 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC4A5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	32,923,507 - 33,060,085 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	79,103,896 - 79,251,010 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc4a5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	29,146,873 - 29,266,050 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624749	29,148,666 - 29,264,193 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc4a5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	62,922,742 - 62,986,795 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc4a5
193 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	86
Count of miRNA genes:	74
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000014249
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631689	Scl4	Serum cholesterol level QTL 4	1.9	0.008	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	96731383	141731383	Rat
1582232	Gluco25	Glucose level QTL 25	3.6	0.0023	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	86583980	149763391	Rat
2302049	Pia32	Pristane induced arthritis QTL 32	5.1	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	107346299	152346299	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	39431983	123203361	Rat
1578655	Bmd11	Bone mineral density QTL 11	11		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	4	92406430	137406430	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
1357342	Bw40	Body weight QTL 40		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	4	74233320	119233320	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
631556	Bp135	Blood pressure QTL 135		0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	80212111	119233320	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
2306545	Iddm39	Insulin dependent diabetes mellitus QTL 39			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	78687630	123687630	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
7207480	Bss105	Bone structure and strength QTL 105	8.1		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	4	111383604	156383604	Rat
70167	Bw22	Body weight QTL 22	3.1		body mass (VT:0001259)	body weight (CMO:0000012)	4	74233320	119233320	Rat
731165	Uae21	Urinary albumin excretion QTL 21	2.4	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	108206096	153206096	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	106848959	168870974	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94638356	168870820	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	74169813	134199155	Rat
634334	Xhs3	X-ray hypersensitivity QTL 3	10		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	86058928	131411333	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	75939858	140508796	Rat
1549832	Bss3	Bone structure and strength QTL 3	11		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	4	111383604	156383604	Rat
70177	Xhs1	X-ray hypersensitivity QTL 1	25.1		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	82944895	154403548	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	45429897	149763204	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
61476	Aia3	Adjuvant induced arthritis QTL 3	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	75939858	140508796	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
1641919	Alc22	Alcohol consumption QTL 22		0.0005	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	65060960	127749483	Rat
631662	Hcar2	Hepatocarcinoma resistance QTL 2	3.1	0.0003	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	84349032	129349032	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63245026	129846354	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86709649	168870974	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	57664252	127749483	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	45429897	149763204	Rat
2306899	Bp338	Blood pressure QTL 338		0.071	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	82336765	127336765	Rat
2293840	Kiddil9	Kidney dilation QTL 9	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	4	113634167	149763391	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	116184844	161184844	Rat
1578670	Bss14	Bone structure and strength QTL 14	16.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	4	88883695	133883695	Rat
70201	Gcr1	Gastric cancer resistance QTL 1	2.7		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	4	103834277	148834277	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	40490442	117737312	Rat
12798523	Anxrr56	Anxiety related response QTL 56	2.83	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	86583980	131583980	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	57613339	151163960	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
1578662	Bss15	Bone structure and strength QTL 15	19.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	4	88883695	133883695	Rat

Markers in Region

D4Rat180

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	4	117,354,734 - 117,354,984 (+)	Marker Load Pipeline
mRatBN7.2	4	115,797,041 - 115,797,291 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	114,990,330 - 114,990,579	NCBI	Rnor6.0
Rnor_5.0	4	179,578,851 - 179,579,100	UniSTS	Rnor5.0
RGSC_v3.4	4	117,503,262 - 117,503,512	RGD	RGSC3.4
RGSC_v3.4	4	117,503,263 - 117,503,512	UniSTS	RGSC3.4
Celera	4	104,791,156 - 104,791,405	UniSTS
RGSC_v3.1	4	117,747,743 - 117,747,993	RGD
SHRSP x BN Map	4	52.08	UniSTS
SHRSP x BN Map	4	52.08	RGD
Cytogenetic Map	4	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	3	42	157	83	82	51	75	51	6	288	140	5	141	80	89	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_212512	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB118905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC110623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC117925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY496959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000014249 ⟹ ENSRNOP00000014249

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	117,267,822 - 117,368,024 (+)	Ensembl
mRatBN7.2 Ensembl	4	115,725,592 - 115,808,993 (+)	Ensembl
Rnor_6.0 Ensembl	4	114,918,488 - 115,002,300 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082336 ⟹ ENSRNOP00000074224

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	117,267,822 - 117,368,024 (+)	Ensembl
mRatBN7.2 Ensembl	4	115,761,255 - 115,804,821 (+)	Ensembl
Rnor_6.0 Ensembl	4	114,935,970 - 115,002,296 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103469 ⟹ ENSRNOP00000085872

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	117,283,294 - 117,362,514 (+)	Ensembl
mRatBN7.2 Ensembl	4	115,725,592 - 115,804,821 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112426 ⟹ ENSRNOP00000091246

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	117,267,822 - 117,368,024 (+)	Ensembl
mRatBN7.2 Ensembl	4	115,725,592 - 115,810,323 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000148874 ⟹ ENSRNOP00000103810

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	117,285,459 - 117,368,024 (+)	Ensembl

RefSeq Acc Id:

NM_212512 ⟹ NP_997677

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	117,283,294 - 117,368,024 (+)	NCBI
mRatBN7.2	4	115,725,592 - 115,810,330 (+)	NCBI
Rnor_6.0	4	114,918,488 - 115,002,290 (+)	NCBI
Rnor_5.0	4	179,507,406 - 179,590,656 (+)	NCBI
RGSC_v3.4	4	117,432,385 - 117,515,453 (+)	RGD
Celera	4	104,719,746 - 104,803,062 (+)	RGD

Sequence:

show sequence

CAGAAAGCCTTTCTGCAACCCAACGGGAGTGGAGCCAGGGGCTCTGGTCTTCCTGAGATTTGGA
GCCTGGTGTCCACTGCTAAGAACACACAGTGATGAAAGTGGAAGAGAAGGCTGGGGTCAAAAAG
CTGGAGCCCACAAGCTACAGGAGGAGACACCCAGAACAAGATTTCCCTTCAATACATATTGGCT
TTCCAGTCCCCGGTTACTCTCAAAGAAAAAGTGACTCAAAGGGACATCTTTCAGGTCTGCAAAG
AGTCCAGTGGTCCCTGCAACCGGACAAATCTCAGCAGGACCTGGCTGGTCCAGACGGGATCAAG
GCCAGCAGCCTGGGAGGCTCCGTGGATTTTACCAAAAGGATTCGGTCTCCAGCTGCTGAGCAGC
TACAGGACATCCTGGGGGAGGAAGATGAGGCTCCCAACCCCACCCTCTTCACAGAGATGGACAC
TCTACAGCATGATGGGGACCAGATGGAGTGGAAGGAATCAGCCAGGTGGATAAAATTTGAAGAA
AAGGTAGAGGAAGGAGGAGAACGCTGGAGCAAGCCCCATGTGTCCACGCTGTCCCTGCACAGCC
TCTTTGAGCTCCGCACTTGCCTGCAGACAGGGACGGTGCTGCTGGATCTGGACAGTGGCTCTCT
ACCACAGATCATAGATGATGTCATTGAGAAGCAGATAGAGGGTGGACTTCTGCGACCAGAGCTC
CGGGAAAGGGTCAGCTACGTGCTCCTGAGGAAGCATCGCCACCAAACCAAGAAGCCCATCCACC
GTTCCCTTGCAGACATTGGGAAGTCGGTTTCTACTACGAATCGCAGCTCTGCCCGGAGCCCCTC
AGCAGGCCCAACTCTGCACCACTCCACCGAGGACCTGAGGATTCGGCAAAGCACCAGCTATGGT
CATCTGTGTCATGCCCAGAGTAGAAGCATGAATGACATCTCCCATACCCCAAACACAGACCAGC
GGAAAAACAAATTCATGAAGAAGATCCCCAAGGACTCAGAAGCCTCCAACGTGCTTGTGGGCGA
GGTGGACTTCCTGGACCAGCCATTCATTGCGTTTGTTCGTCTTGCCCAGTCTTCCATGCTGGGA
GGGGTGACCGAGGTGCCTGTCCCCACCAGATTTCTGTTCATACTTCTAGGACCTTCTGGAAGAG
CAAAGTCCTACAATGAGATTGGCCGAGCCATTGCAACCCTCATGGTGGATGATCTCTTCAGCGA
TGTGGCTTATAAAGCACGGAATCGAGAAGATCTGATCGCAGGAGTTGATGAATTTCTAGATGAG
GTCATTGTCCTTCCCCCTGGAGAGTGGGATCCAAACATCAGAATTGAGCCGCCCAAGAAAGTTC
CCTCAGCCGACAAGAGGAAATCTGTGTTCTCTCTGGCAGAGCTGGGCCAGATGAATGGCTCTGT
GGGCAGAAGCGGAGCCTCGGCCGGAGGAGGCGGCAGTGGCGGAGGGGCTGGAGGCAGCGGGGCC
GGCGGAGGAGGCAGTGGCAACGAGGCTGAGATGCCAGCTATGCATGAAATTGGGGAGGAGCTGA
TCTGGACCGGAAGGTTTTTTGGAGGACTGCGTCTGGATGTAAAGAGGAAGCTGCCCTGGTTCCC
AAGTGACTTCTATGATGGCTTCCACATCCAGTCCATCTCTGCTGTCCTGTTCATCTACCTCGGC
TGTATCACCAATGCTATCACCTTCGGTGGGCTTCTGGGGGATGCCACAGACAATTATCAGGGAG
TAATGGAGAGCTTCCTGGGCACTGCCATGGCTGGCAGCTTGTTCTGCCTCTTCTCGGGGCAGCC
TCTCATCATCCTCAGCAGCACAGGACCCATCCTCATCTTTGAAAAGCTCCTCTTTGACTTCAGC
AAGGCCAATGGCCTGGACTACATGGAGTTCCGCCTCTGGATTGGTCTTCACTCAGCCATCCAAT
GCCTTATCCTGGTGGCCACAGATGCCAGCTTTATCATCAAGTATATCACCCGCTTCACCGAAGA
GGGCTTCTCCACCCTCATCAGTTTCATCTTCATCTACGACGCCATCAAAAAGATGATTGGTGCC
TTCAAATACTATCCCATTAACACGGACTTCAAGCCCGACTCCATCACCACCTACAAATGCGAGT
GCGTCGCTCCTGACACAGTGAATACAACCACTGTCAACGACTCAGCCCTGCTGGTGCCAAACAC
CAACATGTCTGTGTACACCCCCCTTAACCTCACAGCGCTGGACTGGTCTCTGCTGAGCAAGAAG
GAATGTCTGAGCTATGGGGGGCGCCTGCTTGGGAGCTCCTGCCAGTTCGTCCCCGACTTGGCCC
TCATGTCCTTCATCCTTTTCTTTGGGACTTACTCCATGACCTTGACTCTGAAGAAATTCAAATT
CAGCCGCTATTTCCCCACCAAGGTCCGAACCCTGGTGGCTGACTTCTCCATTGTTTTCTCCATC
CTGCTGTTCTGTGGAATCGATGCCTGTTTTGGCCTGCAAACCCCCAAGCTGCACGTGCCTAATG
TCATCAAGCCCACAAGGCCTGACCGAGGCTGGTTCGTTGCCCCCTTTGGGAAGAATCCTTGGTG
GGTGTACCCTGCCAGCATCCTGCCGGCCCTGCTGGTGACCATCCTGATCTTCATGGACCAGCAG
ATCACTGCTGTCATTGTCAACAGGAAGGAGAACAAGCTGAGGAAGGCCGCCGGCTACCATCTGG
ACCTGTTCTGGGTGGGCATCCTCATGGCCCTGTGCTCCTTCATGGGGCTCCCCTGGTATGTGGC
TGCCACGGTCATCTCCATCGCTCACATCGACAGCCTCAAGATGGAGACGGAGACCAGTGCCCCA
GGGGAACAGCCCCAGTTCCTGGGGGTCAGGGAGCAGAGAGTTACTGGAGTCATGGTCTTCATTC
TGACAGGCATCTCCGTCTTCCTGGCTCCTATCCTGAAGTACATCCCCATGCCAGTGCTCTATGG
TGTCTTCCTCTACATGGGTGTGGCCTCCCTGAATGGCATCCAGTTCTGGGACCGCTGTAAGCTT
TTCCTCATGCCAGCCAAGCACCAGCCGGACCATGCCTTCCTGCGCCACGTGCCCCTTCGCCGGA
TCCACCTGTTCACCCTGGTGCAGATCCTCTGCCTGGCCCTGCTCTGGATCCTTAAGTCAACCAT
GGCTGCTATCATCTTCCCGGTCATGATCCTGGGCCTAATCATTGTTCGAAGGCTCCTGGACTTG
ATTTTCTCCCAGCATGACCTGGCCTGGATTGACAATATCCTCCCAGAGAAGGAGAAAAAGGAAT
CAGACAGGAAGAAGAGGAGGAAAGAGGTCCACGAGAACACGGACAAGGAGCCCCAGTTCCTTCC
TCCCTCAGTTGTAAAGATCCCAATGGAAGGTATCCCATCTGATCCCCAAAACGGTATCCACTGT
GTTGGCAGAAAAAGATCTTCCAGTTGGAGCCACTCTCTCTGACTCCTCCTTCAGTGCCTCAGAA
CAGATAGAAGCATCACCCTGCATTTCAAAATCTCTTGTCCGGCCTCACCTGCTTTCAGCTACTC
ACGGAGTCCACTCTTCATGGTGCCACAGGTGAGGATAGAGATGGACTCTGACCTCAACCTCACA
GATGACGAGGAGGACTATGGATAAGAAGAGGTG

hide sequence

RefSeq Acc Id:

XM_039107330 ⟹ XP_038963258

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	117,267,803 - 117,368,024 (+)	NCBI
mRatBN7.2	4	115,710,101 - 115,810,330 (+)	NCBI

RefSeq Acc Id:

XM_039107331 ⟹ XP_038963259

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	117,267,806 - 117,366,677 (+)	NCBI
mRatBN7.2	4	115,710,105 - 115,810,330 (+)	NCBI

RefSeq Acc Id:

XM_039107332 ⟹ XP_038963260

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	117,300,098 - 117,368,024 (+)	NCBI
mRatBN7.2	4	115,742,396 - 115,810,330 (+)	NCBI

RefSeq Acc Id:

XM_039107333 ⟹ XP_038963261

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	117,299,891 - 117,368,024 (+)	NCBI
mRatBN7.2	4	115,742,189 - 115,810,330 (+)	NCBI

RefSeq Acc Id:

XM_063285798 ⟹ XP_063141868

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	117,267,805 - 117,363,499 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_997677	(Get FASTA)	NCBI Sequence Viewer
	XP_038963258	(Get FASTA)	NCBI Sequence Viewer
	XP_038963259	(Get FASTA)	NCBI Sequence Viewer
	XP_038963260	(Get FASTA)	NCBI Sequence Viewer
	XP_038963261	(Get FASTA)	NCBI Sequence Viewer
	XP_063141868	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAS98674	(Get FASTA)	NCBI Sequence Viewer
	BAM73282	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000014249
	ENSRNOP00000074224
	ENSRNOP00000085872
	ENSRNOP00000091246
GenBank Protein	Q6RI88	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_997677 ⟸ NM_212512

- UniProtKB:

Q6RI88 (UniProtKB/Swiss-Prot), A0A8L2Q6Y5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKVEEKAGVKKLEPTSYRRRHPEQDFPSIHIGFPVPGYSQRKSDSKGHLSGLQRVQWSLQPDKS
QQDLAGPDGIKASSLGGSVDFTKRIRSPAAEQLQDILGEEDEAPNPTLFTEMDTLQHDGDQMEW
KESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEK
QIEGGLLRPELRERVSYVLLRKHRHQTKKPIHRSLADIGKSVSTTNRSSARSPSAGPTLHHSTE
DLRIRQSTSYGHLCHAQSRSMNDISHTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIA
FVRLAQSSMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNRED
LIAGVDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGRSGASAGGG
GSGGGAGGSGAGGGGSGNEAEMPAMHEIGEELIWTGRFFGGLRLDVKRKLPWFPSDFYDGFHIQ
SISAVLFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPI
LIFEKLLFDFSKANGLDYMEFRLWIGLHSAIQCLILVATDASFIIKYITRFTEEGFSTLISFIF
IYDAIKKMIGAFKYYPINTDFKPDSITTYKCECVAPDTVNTTTVNDSALLVPNTNMSVYTPLNL
TALDWSLLSKKECLSYGGRLLGSSCQFVPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRT
LVADFSIVFSILLFCGIDACFGLQTPKLHVPNVIKPTRPDRGWFVAPFGKNPWWVYPASILPAL
LVTILIFMDQQITAVIVNRKENKLRKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHID
SLKMETETSAPGEQPQFLGVREQRVTGVMVFILTGISVFLAPILKYIPMPVLYGVFLYMGVASL
NGIQFWDRCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLALLWILKSTMAAIIFPVMIL
GLIIVRRLLDLIFSQHDLAWIDNILPEKEKKESDRKKRRKEVHENTDKEPQFLPPSVVKIPMEG
IPSDPQNGIHCVGRKRSSSWSHSL

hide sequence

Ensembl Acc Id:

ENSRNOP00000074224 ⟸ ENSRNOT00000082336

Ensembl Acc Id:

ENSRNOP00000014249 ⟸ ENSRNOT00000014249

RefSeq Acc Id:	XP_038963258 ⟸ XM_039107330
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q6Y5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963259 ⟸ XM_039107331
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2Q6Y5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963261 ⟸ XM_039107333
- Peptide Label:	isoform X3
- UniProtKB:	L0N559 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963260 ⟸ XM_039107332
- Peptide Label:	isoform X3
- UniProtKB:	L0N559 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000091246 ⟸ ENSRNOT00000112426

Ensembl Acc Id:

ENSRNOP00000085872 ⟸ ENSRNOT00000103469

RefSeq Acc Id:	XP_063141868 ⟸ XM_063285798
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2Q6Y5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000103810 ⟸ ENSRNOT00000148874

Protein Domains

Band 3 cytoplasmic Bicarbonate transporter-like transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6RI88-F1-model_v2	AlphaFold	Q6RI88	1-1112	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693177

Promoter ID:

EPDNEW_R3700

Type:

single initiation site

Name:

Slc4a5_1

Description:

solute carrier family 4 member 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	114,936,004 - 114,936,064	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303009	AgrOrtholog
BioCyc Gene	G2FUF-44013	BioCyc
Ensembl Genes	ENSRNOG00000010378	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000014249	ENTREZGENE
	ENSRNOT00000082336	ENTREZGENE
	ENSRNOT00000103469	ENTREZGENE
	ENSRNOT00000112426	ENTREZGENE
Gene3D-CATH	Helical hairpin bin	UniProtKB/Swiss-Prot
	Mannitol-specific EII, Chain A	UniProtKB/Swiss-Prot
InterPro	Band3_cytoplasmic_dom	UniProtKB/Swiss-Prot
	HCO3_transpt_C	UniProtKB/Swiss-Prot
	HCO3_transpt_euk	UniProtKB/Swiss-Prot
	Na/HCO3_transpt	UniProtKB/Swiss-Prot
	PTrfase/Anion_transptr	UniProtKB/Swiss-Prot
KEGG Report	rno:297386	UniProtKB/Swiss-Prot
NCBI Gene	297386	ENTREZGENE
PANTHER	ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4	UniProtKB/Swiss-Prot
	PTHR11453	UniProtKB/Swiss-Prot
Pfam	Band_3_cyto	UniProtKB/Swiss-Prot
	HCO3_cotransp	UniProtKB/Swiss-Prot
PhenoGen	Slc4a5	PhenoGen
PRINTS	HCO3TRNSPORT	UniProtKB/Swiss-Prot
	NAHCO3TRSPRT	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000010378	RatGTEx
Superfamily-SCOP	SSF55804	UniProtKB/Swiss-Prot
UniProt	A0A0G2K7I8_RAT	UniProtKB/TrEMBL
	A0A8I6A142_RAT	UniProtKB/TrEMBL
	A0A8I6AB89_RAT	UniProtKB/TrEMBL
	A0A8L2Q6Y5	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LJV4_RAT	UniProtKB/TrEMBL
	L0N559	ENTREZGENE, UniProtKB/TrEMBL
	Q6RI88	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Slc4a5	solute carrier family 4 member 5	Slc4a5	solute carrier family 4, sodium bicarbonate cotransporter, member 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Slc4a5	solute carrier family 4, sodium bicarbonate cotransporter, member 5			Symbol and Name status set to approved	1299863	APPROVED
2005-01-04	Slc4a5	solute carrier family 4, sodium bicarbonate cotransporter, member 5	NBC4	electrogenic sodium bicarbonate cotransporter NBC4c	Symbol and Name updated	1299863	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expressed in the liver	1303995

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)