Tmprss11c (transmembrane protease, serine 11C) - Rat Genome Database

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Gene: Tmprss11c (transmembrane protease, serine 11C) Rattus norvegicus
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Symbol: Tmprss11c
Name: transmembrane protease, serine 11C
RGD ID: 1302967
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in self proteolysis. Predicted to be located in dendrite and perikaryon. Predicted to be active in plasma membrane. Orthologous to human TMPRSS11CP (transmembrane serine protease 11C, pseudogene); INTERACTS WITH cadmium dichloride; furan; Butylbenzyl phthalate (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: airway trypsin-like 3; Hatl3
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81422,136,865 - 22,195,312 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1422,136,865 - 22,195,312 (+)EnsemblGRCr8
mRatBN7.21421,782,076 - 21,840,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,782,124 - 21,837,793 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1422,132,069 - 22,187,882 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,450,984 - 23,506,801 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,982,086 - 22,037,897 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01423,405,717 - 23,461,384 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,405,717 - 23,461,384 (+)Ensemblrn6Rnor6.0
Rnor_5.01423,301,899 - 23,365,783 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41423,549,197 - 23,606,057 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1421,252,744 - 21,308,228 (+)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
dendrite  (IEA,ISO)
extracellular region  (IEA)
membrane  (IEA)
perikaryon  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18215125  


Genomics

Comparative Map Data
Tmprss11c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81422,136,865 - 22,195,312 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1422,136,865 - 22,195,312 (+)EnsemblGRCr8
mRatBN7.21421,782,076 - 21,840,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,782,124 - 21,837,793 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1422,132,069 - 22,187,882 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,450,984 - 23,506,801 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,982,086 - 22,037,897 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01423,405,717 - 23,461,384 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,405,717 - 23,461,384 (+)Ensemblrn6Rnor6.0
Rnor_5.01423,301,899 - 23,365,783 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41423,549,197 - 23,606,057 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1421,252,744 - 21,308,228 (+)NCBICelera
Cytogenetic Map14p21NCBI
TMPRSS11CP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38467,765,914 - 67,774,454 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl467,766,480 - 67,773,854 (-)Ensemblhg38GRCh38
GRCh37468,631,632 - 68,640,172 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera466,094,006 - 66,102,544 (-)NCBICelera
Cytogenetic Map4q13.2NCBI
HuRef464,544,777 - 64,553,340 (-)NCBIHuRef
CHM1_1468,668,744 - 68,677,284 (-)NCBICHM1_1
T2T-CHM13v2.0471,209,021 - 71,217,574 (-)NCBIT2T-CHM13v2.0
Tmprss11c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39586,376,600 - 86,437,167 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl586,379,340 - 86,437,167 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38586,231,481 - 86,289,308 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,231,481 - 86,289,308 (-)Ensemblmm10GRCm38
MGSCv37586,660,506 - 86,718,333 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36587,306,313 - 87,363,821 (-)NCBIMGSCv36mm8
Celera583,464,185 - 83,522,538 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI

Variants

.
Variants in Tmprss11c
395 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:101
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000002743, ENSRNOT00000029805
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 5 23 32 20 8 14 8 2 64 33 8 18 29 12 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000029805   ⟹   ENSRNOP00000035600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1422,136,865 - 22,195,312 (+)Ensembl
mRatBN7.2 Ensembl1421,782,124 - 21,837,793 (+)Ensembl
Rnor_6.0 Ensembl1423,405,717 - 23,461,384 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094058   ⟹   ENSRNOP00000079095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1422,136,865 - 22,195,312 (+)Ensembl
mRatBN7.2 Ensembl1421,782,124 - 21,837,793 (+)Ensembl
RefSeq Acc Id: NM_001003979   ⟹   NP_001003979
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81422,136,865 - 22,195,312 (+)NCBI
mRatBN7.21421,782,076 - 21,840,517 (+)NCBI
Rnor_6.01423,405,717 - 23,461,384 (+)NCBI
Rnor_5.01423,301,899 - 23,365,783 (+)NCBI
RGSC_v3.41423,549,197 - 23,606,057 (+)RGD
Celera1421,252,744 - 21,308,228 (+)RGD
Sequence:
RefSeq Acc Id: NM_001412525   ⟹   NP_001399454
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81422,136,865 - 22,195,312 (+)NCBI
mRatBN7.21421,782,076 - 21,840,517 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001003979 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399454 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51904 (Get FASTA)   NCBI Sequence Viewer  
  EDL89837 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035600
  ENSRNOP00000035600.2
  ENSRNOP00000079095
  ENSRNOP00000079095.1
RefSeq Acc Id: NP_001003979   ⟸   NM_001003979
- Peptide Label: isoform 2
- UniProtKB: Q6IE15 (UniProtKB/TrEMBL),   F7FFT3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035600   ⟸   ENSRNOT00000029805
Ensembl Acc Id: ENSRNOP00000079095   ⟸   ENSRNOT00000094058
RefSeq Acc Id: NP_001399454   ⟸   NM_001412525
- Peptide Label: isoform 1
- UniProtKB: A0A8I5ZM18 (UniProtKB/TrEMBL)
Protein Domains
Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE15-F1-model_v2 AlphaFold Q6IE15 1-418 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302967 AgrOrtholog
BioCyc Gene G2FUF-16070 BioCyc
Ensembl Genes ENSRNOG00000033910 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029805 ENTREZGENE
  ENSRNOT00000029805.4 UniProtKB/TrEMBL
  ENSRNOT00000094058 ENTREZGENE
  ENSRNOT00000094058.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  3.30.70.960 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  Ser_protease_TM_TMPRSS11A UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:408213 UniProtKB/TrEMBL
NCBI Gene 408213 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED UniProtKB/TrEMBL
Pfam SEA UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PhenoGen Tmprss11c PhenoGen
PIRSF TMPRSS11ABCDE UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE SEA UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033910 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
  SSF82671 UniProtKB/TrEMBL
UniProt A0A8I5ZM18 ENTREZGENE, UniProtKB/TrEMBL
  F7FFT3 ENTREZGENE, UniProtKB/TrEMBL
  Q6IE15 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-13 Tmprss11bnl1  transmembrane protease, serine 11B N terminal like 1  Tmprss11b  transmembrane protease, serine 11B  Name and Symbol changed 629549 APPROVED
2015-08-13 Tmprss11c  transmembrane protease, serine 11C  Tmprss11bnl  transmembrane protease, serine 11B N terminal like  Name and Symbol changed 629549 APPROVED
2015-08-13 Tmprss11bnl  transmembrane protease, serine 11B N terminal like  Tmprss11bnl1  transmembrane protease, serine 11B N terminal like 1  Name and Symbol changed 629549 APPROVED
2013-02-04 Tmprss11b  transmembrane protease, serine 11B  Tmprss11c  transmembrane protease, serine 11c  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Tmprss11c  transmembrane protease, serine 11c  Hatl3  airway trypsin-like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-14 Hatl3  airway trypsin-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL