Anp32a (acidic nuclear phosphoprotein 32 family member A) - Rat Genome Database

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Gene: Anp32a (acidic nuclear phosphoprotein 32 family member A) Rattus norvegicus
Analyze
Symbol: Anp32a
Name: acidic nuclear phosphoprotein 32 family member A
RGD ID: 11508551
Description: Enables integrin binding activity. Involved in negative regulation of plasma membrane bounded cell projection assembly and negative regulation of protein modification process. Located in chromatin. Orthologous to several human genes including ANP32A (acidic nuclear phosphoprotein 32 family member A); PARTICIPATES IN CRM1 export pathway; INTERACTS WITH (+)-schisandrin B; 1-bromopropane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acid nuclear phosphoprotein 32 (leucine rich); acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic leucine-rich nuclear phosphoprotein 32 family member A; Anp32; Lanp; leucine-rich acidic nuclear protein; leucine-rich acidic nuclear protein LANP; NEWGENE_2116
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8871,724,578 - 71,760,922 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl871,724,531 - 71,760,922 (+)EnsemblGRCr8
mRatBN7.2862,829,099 - 62,865,443 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl862,827,456 - 62,865,443 (+)EnsemblmRatBN7.2
Dahl_SR_JrHsd872,540,049 - 72,576,370 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive874,700,400 - 74,737,226 (+)NCBILyon_Normotensive
Lyon_Hypertensive873,164,037 - 73,200,372 (+)NCBILyon_Hypertensive
F344_StmMcwi864,582,675 - 64,619,009 (+)NCBIF344_StmMcwi
Rnor_6.0867,295,578 - 67,333,075 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl867,295,727 - 67,333,247 (+)Ensemblrn6Rnor6.0
Celera862,259,758 - 62,282,038 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetazolamide  (ISO)
aconitine  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IDA)
cytoplasm  (IEA,ISO,ISS)
cytosol  (ISO)
endoplasmic reticulum  (IEA,ISO,ISS)
nuclear matrix  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO,ISS)
perinuclear region of cytoplasm  (IBA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A. Buttner B, etal., Biochemistry. 2005 May 10;44(18):6938-47.
2. The protective role of Hepatopoietin Cn on liver injury induced by carbon tetrachloride in rats*. Cui CP, etal., Hepatol Res. 2009 Feb;39(2):200-6. doi: 10.1111/j.1872-034X.2008.00447.x. Epub 2008 Nov 26.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. CXCL12-mediated regulation of ANP32A/Lanp, a component of the inhibitor of histone acetyl transferase (INHAT) complex, in cortical neurons. Khan MZ, etal., J Neuroimmune Pharmacol. 2011 Mar;6(1):163-70. doi: 10.1007/s11481-010-9228-5. Epub 2010 Jul 9.
5. Neuronal differentiation is regulated by leucine-rich acidic nuclear protein (LANP), a member of the inhibitor of histone acetyltransferase complex. Kular RK, etal., J Biol Chem. 2009 Mar 20;284(12):7783-92. doi: 10.1074/jbc.M806150200. Epub 2009 Jan 9.
6. The Anp32 family of proteins containing leucine-rich repeats. Matilla A and Radrizzani M, Cerebellum. 2005;4(1):7-18.
7. A nuclear factor containing the leucine-rich repeats expressed in murine cerebellar neurons. Matsuoka K, etal., Proc Natl Acad Sci U S A 1994 Oct 11;91(21):9670-4.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Integrin alpha3beta1 interacts with I1PP2A/lanp and phosphatase PP1. Mutz D, etal., J Neurosci Res. 2006 Dec;84(8):1759-70.
10. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Aging- and injury-related differential apoptotic response in the dentate gyrus of the hippocampus in rats following brain trauma. Sun D, etal., Front Aging Neurosci. 2013 Dec 18;5:95. doi: 10.3389/fnagi.2013.00095. eCollection 2013.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10715114   PMID:12477932   PMID:28131823   PMID:29476059  


Genomics

Comparative Map Data
Anp32a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8871,724,578 - 71,760,922 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl871,724,531 - 71,760,922 (+)EnsemblGRCr8
mRatBN7.2862,829,099 - 62,865,443 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl862,827,456 - 62,865,443 (+)EnsemblmRatBN7.2
Dahl_SR_JrHsd872,540,049 - 72,576,370 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive874,700,400 - 74,737,226 (+)NCBILyon_Normotensive
Lyon_Hypertensive873,164,037 - 73,200,372 (+)NCBILyon_Hypertensive
F344_StmMcwi864,582,675 - 64,619,009 (+)NCBIF344_StmMcwi
Rnor_6.0867,295,578 - 67,333,075 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl867,295,727 - 67,333,247 (+)Ensemblrn6Rnor6.0
Celera862,259,758 - 62,282,038 (+)NCBICelera
Cytogenetic Map8q24NCBI
ANP32A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381568,778,535 - 68,820,895 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1568,778,534 - 68,820,924 (-)Ensemblhg38GRCh38
GRCh371569,070,874 - 69,113,234 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361566,859,259 - 66,900,277 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1545,960,069 - 46,002,437 (-)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1545,904,161 - 45,946,285 (-)NCBIHuRef
CHM1_11569,188,422 - 69,230,804 (-)NCBICHM1_1
T2T-CHM13v2.01566,601,108 - 66,643,452 (-)NCBIT2T-CHM13v2.0
Anp32a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39962,248,637 - 62,286,084 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl962,248,575 - 62,286,094 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38962,341,343 - 62,378,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl962,341,293 - 62,378,812 (+)Ensemblmm10GRCm38
MGSCv37962,189,150 - 62,226,609 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36962,139,434 - 62,176,808 (+)NCBIMGSCv36mm8
Celera959,566,749 - 59,603,984 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map933.68NCBI
Anp32a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554507,449,220 - 7,484,859 (+)Ensembl
ChiLan1.0NW_0049554507,449,368 - 7,484,524 (+)NCBIChiLan1.0ChiLan1.0
ANP32A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21658,041,165 - 58,083,326 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11562,214,683 - 62,256,684 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01547,736,770 - 47,778,763 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11566,502,285 - 66,541,169 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1566,502,285 - 66,511,637 (-)EnsemblpanPan2panpan1.1
ANP32A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13032,741,582 - 32,778,883 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3032,741,582 - 32,798,188 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3032,675,311 - 32,712,209 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03032,937,949 - 32,974,641 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3032,936,945 - 32,974,785 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13032,864,791 - 32,901,681 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03032,929,138 - 32,965,760 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03033,173,390 - 33,210,300 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Anp32a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640110,753,915 - 110,786,939 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647128,601,659 - 28,634,483 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647128,601,816 - 28,635,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANP32A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11166,664,251 - 166,703,814 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21184,592,896 - 184,629,890 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANP32A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12614,650,600 - 14,691,108 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2614,653,745 - 14,691,492 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048126,780,938 - 126,821,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anp32a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247814,441,238 - 4,477,004 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247814,365,378 - 4,477,004 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Anp32a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1856,645,637 - 56,682,824 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Anp32a
303 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:14
Count of miRNA genes:13
Interacting mature miRNAs:14
Transcripts:ENSRNOT00000020443
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 25 19 196 361 178 177 123 162 117 28 691 422 11 321 125 149 60 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020443   ⟹   ENSRNOP00000020443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl871,724,927 - 71,760,373 (+)Ensembl
mRatBN7.2 Ensembl862,830,807 - 62,864,492 (+)Ensembl
Rnor_6.0 Ensembl867,295,727 - 67,333,247 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098357   ⟹   ENSRNOP00000086330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl871,726,285 - 71,760,922 (+)Ensembl
mRatBN7.2 Ensembl862,831,538 - 62,865,443 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103076   ⟹   ENSRNOP00000081689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl871,724,531 - 71,760,920 (+)Ensembl
mRatBN7.2 Ensembl862,827,456 - 62,865,443 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132943   ⟹   ENSRNOP00000100513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl871,725,413 - 71,760,373 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000147823   ⟹   ENSRNOP00000112814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl871,728,763 - 71,760,922 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149041   ⟹   ENSRNOP00000106830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl871,743,538 - 71,760,922 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000161309   ⟹   ENSRNOP00000105193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl871,727,640 - 71,760,373 (+)Ensembl
RefSeq Acc Id: NM_012903   ⟹   NP_037035
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8871,724,578 - 71,760,922 (+)NCBI
mRatBN7.2862,829,099 - 62,865,443 (+)NCBI
Dahl_SR_JrHsd872,540,049 - 72,576,370 (+)NCBI
Lyon_Normotensive874,700,400 - 74,737,226 (+)NCBI
Lyon_Hypertensive873,164,037 - 73,200,372 (+)NCBI
F344_StmMcwi864,582,675 - 64,619,009 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037035 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87686 (Get FASTA)   NCBI Sequence Viewer  
  BAA06908 (Get FASTA)   NCBI Sequence Viewer  
  EDL95752 (Get FASTA)   NCBI Sequence Viewer  
  EDL95753 (Get FASTA)   NCBI Sequence Viewer  
  EDL95754 (Get FASTA)   NCBI Sequence Viewer  
  EDL95755 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000081689
GenBank Protein P49911 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000020443   ⟸   ENSRNOT00000020443
Ensembl Acc Id: ENSRNOP00000081689   ⟸   ENSRNOT00000103076
Ensembl Acc Id: ENSRNOP00000086330   ⟸   ENSRNOT00000098357
RefSeq Acc Id: NP_037035   ⟸   NM_012903
- UniProtKB: Q5PPH9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000105193   ⟸   ENSRNOT00000161309
Ensembl Acc Id: ENSRNOP00000112814   ⟸   ENSRNOT00000147823
Ensembl Acc Id: ENSRNOP00000100513   ⟸   ENSRNOT00000132943
Ensembl Acc Id: ENSRNOP00000106830   ⟸   ENSRNOT00000149041
Protein Domains
LRRCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49911-F1-model_v2 AlphaFold P49911 1-247 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696053
Promoter ID:EPDNEW_R6577
Type:initiation region
Name:Anp32a_1
Description:acidic nuclear phosphoprotein 32 family member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0867,295,704 - 67,295,764EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:11508551 AgrOrtholog
Ensembl Genes ENSRNOG00000014846 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000103076 ENTREZGENE
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7308609 IMAGE-MGC_LOAD
InterPro AN32 UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25379 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105504 IMAGE-MGC_LOAD
NCBI Gene Anp32a ENTREZGENE
PANTHER ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A UniProtKB/Swiss-Prot
  PTHR11375 UniProtKB/Swiss-Prot
Pfam LRR_9 UniProtKB/Swiss-Prot
PhenoGen Anp32a PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014846 RatGTEx
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
TIGR TC208008
UniProt A0A8I6A5S9_RAT UniProtKB/TrEMBL
  A0ABK0L5R2_RAT UniProtKB/TrEMBL
  A0ABK0L6U8_RAT UniProtKB/TrEMBL
  A0ABK0LSB6_RAT UniProtKB/TrEMBL
  A0ABK0M3Y1_RAT UniProtKB/TrEMBL
  A6J579_RAT UniProtKB/TrEMBL
  A6J581_RAT UniProtKB/TrEMBL
  AN32A_RAT UniProtKB/Swiss-Prot
  F7EL36_RAT UniProtKB/TrEMBL
  P49911 ENTREZGENE
  Q5PPH9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-10 Anp32a  acidic nuclear phosphoprotein 32 family member A  NEWGENE_2116  acidic nuclear phosphoprotein 32 family member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-02-10 NEWGENE_2116  acidic nuclear phosphoprotein 32 family member A  Anp32a  acidic nuclear phosphoprotein 32 family member A  Data merged from RGD:2116 737654 PROVISIONAL
2015-11-12 Anp32a  acidic nuclear phosphoprotein 32 family member A  Anp32a  acidic (leucine-rich) nuclear phosphoprotein 32 family, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Anp32a  acidic (leucine-rich) nuclear phosphoprotein 32 family, member A    acidic nuclear phosphoprotein 32 family, member A  Name updated 1299863 APPROVED
2003-04-09 Anp32a  acidic nuclear phosphoprotein 32 family, member A  Anp32  Acid nuclear phosphoprotein 32 (leucine rich)  Symbol and Name updated 629477 APPROVED
2002-06-10 Anp32  Acid nuclear phosphoprotein 32 (leucine rich)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the nucleus 632206
gene_expression expressed in cerebellar Purkinje cells 632206
gene_process may be involved in of cerebellar neuron differentiation 632206