Anp32a (acidic nuclear phosphoprotein 32 family member A) - Rat Genome Database

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Gene: Anp32a (acidic nuclear phosphoprotein 32 family member A) Rattus norvegicus
Analyze
Symbol: Anp32a
Name: acidic nuclear phosphoprotein 32 family member A
RGD ID: 11508551
Description: Enables integrin binding activity. Involved in negative regulation of neuron projection development and negative regulation of protein acetylation. Predicted to be located in endoplasmic reticulum and nuclear matrix. Predicted to be active in nucleus and perinuclear region of cytoplasm; PARTICIPATES IN CRM1 export pathway; INTERACTS WITH (+)-schisandrin B; 1-bromopropane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leucine-rich acidic nuclear protein; Acid nuclear phosphoprotein 32 (leucine rich); acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic leucine-rich nuclear phosphoprotein 32 family member A; Anp32; Lanp; leucine-rich acidic nuclear protein LANP; NEWGENE_2116
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8871,724,578 - 71,760,922 (+)NCBIGRCr8
mRatBN7.2862,829,099 - 62,865,443 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl862,827,456 - 62,865,443 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0867,295,578 - 67,333,075 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl867,295,727 - 67,333,247 (+)EnsemblRnor6.0rn6Rnor6.0
Celera862,259,758 - 62,282,038 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetazolamide  (ISO)
aconitine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IDA)
cytoplasm  (ISO,ISS)
endoplasmic reticulum  (ISO,ISS)
nuclear matrix  (ISO)
nucleus  (IBA,IEA,ISO,ISS)
perinuclear region of cytoplasm  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A. Buttner B, etal., Biochemistry. 2005 May 10;44(18):6938-47.
2. The protective role of Hepatopoietin Cn on liver injury induced by carbon tetrachloride in rats*. Cui CP, etal., Hepatol Res. 2009 Feb;39(2):200-6. doi: 10.1111/j.1872-034X.2008.00447.x. Epub 2008 Nov 26.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. CXCL12-mediated regulation of ANP32A/Lanp, a component of the inhibitor of histone acetyl transferase (INHAT) complex, in cortical neurons. Khan MZ, etal., J Neuroimmune Pharmacol. 2011 Mar;6(1):163-70. doi: 10.1007/s11481-010-9228-5. Epub 2010 Jul 9.
5. Neuronal differentiation is regulated by leucine-rich acidic nuclear protein (LANP), a member of the inhibitor of histone acetyltransferase complex. Kular RK, etal., J Biol Chem. 2009 Mar 20;284(12):7783-92. doi: 10.1074/jbc.M806150200. Epub 2009 Jan 9.
6. The Anp32 family of proteins containing leucine-rich repeats. Matilla A and Radrizzani M, Cerebellum. 2005;4(1):7-18.
7. A nuclear factor containing the leucine-rich repeats expressed in murine cerebellar neurons. Matsuoka K, etal., Proc Natl Acad Sci U S A 1994 Oct 11;91(21):9670-4.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Integrin alpha3beta1 interacts with I1PP2A/lanp and phosphatase PP1. Mutz D, etal., J Neurosci Res. 2006 Dec;84(8):1759-70.
10. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Aging- and injury-related differential apoptotic response in the dentate gyrus of the hippocampus in rats following brain trauma. Sun D, etal., Front Aging Neurosci. 2013 Dec 18;5:95. doi: 10.3389/fnagi.2013.00095. eCollection 2013.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10715114   PMID:12477932   PMID:29476059  


Genomics

Comparative Map Data
Anp32a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8871,724,578 - 71,760,922 (+)NCBIGRCr8
mRatBN7.2862,829,099 - 62,865,443 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl862,827,456 - 62,865,443 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0867,295,578 - 67,333,075 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl867,295,727 - 67,333,247 (+)EnsemblRnor6.0rn6Rnor6.0
Celera862,259,758 - 62,282,038 (+)NCBICelera
Cytogenetic Map8q24NCBI
ANP32A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381568,778,535 - 68,820,895 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1568,778,535 - 68,820,897 (-)EnsemblGRCh38hg38GRCh38
GRCh371569,070,874 - 69,113,234 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361566,859,259 - 66,900,277 (-)NCBINCBI36Build 36hg18NCBI36
Celera1545,960,069 - 46,002,437 (-)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1545,904,161 - 45,946,285 (-)NCBIHuRef
CHM1_11569,188,422 - 69,230,804 (-)NCBICHM1_1
T2T-CHM13v2.01566,601,108 - 66,643,452 (-)NCBIT2T-CHM13v2.0
Anp32a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39962,248,637 - 62,286,084 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl962,248,575 - 62,286,094 (+)EnsemblGRCm39 Ensembl
GRCm38962,341,343 - 62,378,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl962,341,293 - 62,378,812 (+)EnsemblGRCm38mm10GRCm38
MGSCv37962,189,150 - 62,226,609 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36962,139,434 - 62,176,808 (+)NCBIMGSCv36mm8
Celera959,566,749 - 59,603,984 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map933.68NCBI
Anp32a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554507,449,368 - 7,484,524 (+)NCBIChiLan1.0ChiLan1.0
ANP32A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21658,041,165 - 58,083,326 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11562,214,683 - 62,256,684 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01547,736,770 - 47,778,763 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11566,502,285 - 66,541,169 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1566,502,285 - 66,511,637 (-)Ensemblpanpan1.1panPan2
ANP32A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13032,741,582 - 32,778,883 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3032,741,582 - 32,798,188 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3032,675,311 - 32,712,209 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03032,937,949 - 32,974,641 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3032,936,945 - 32,974,785 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13032,864,791 - 32,901,681 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03032,929,138 - 32,965,760 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03033,173,390 - 33,210,300 (-)NCBIUU_Cfam_GSD_1.0
Anp32a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640110,753,915 - 110,786,939 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647128,601,816 - 28,635,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANP32A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11166,664,251 - 166,703,814 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21184,592,896 - 184,629,890 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANP32A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12614,650,600 - 14,691,108 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2614,653,745 - 14,691,492 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048126,780,938 - 126,821,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anp32a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247814,441,238 - 4,477,004 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247814,365,378 - 4,477,004 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Anp32a
158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:14
Count of miRNA genes:13
Interacting mature miRNAs:14
Transcripts:ENSRNOT00000020443
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 70 84 64 35 64 4 146 65 66 22
Low 13 26 17 1 17 12 14 2 4 13 12
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020443   ⟹   ENSRNOP00000020443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl862,830,807 - 62,864,492 (+)Ensembl
Rnor_6.0 Ensembl867,295,727 - 67,333,247 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098357   ⟹   ENSRNOP00000086330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl862,831,538 - 62,865,443 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103076   ⟹   ENSRNOP00000081689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl862,827,456 - 62,865,443 (+)Ensembl
RefSeq Acc Id: NM_012903   ⟹   NP_037035
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8871,724,578 - 71,760,922 (+)NCBI
mRatBN7.2862,829,099 - 62,865,443 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000020443   ⟸   ENSRNOT00000020443
RefSeq Acc Id: ENSRNOP00000081689   ⟸   ENSRNOT00000103076
RefSeq Acc Id: ENSRNOP00000086330   ⟸   ENSRNOT00000098357
RefSeq Acc Id: NP_037035   ⟸   NM_012903
- UniProtKB: Q5PPH9 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
LRRCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49911-F1-model_v2 AlphaFold P49911 1-247 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696053
Promoter ID:EPDNEW_R6577
Type:initiation region
Name:Anp32a_1
Description:acidic nuclear phosphoprotein 32 family member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0867,295,704 - 67,295,764EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000014846 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020443.7 UniProtKB/TrEMBL
  ENSRNOT00000098357.1 UniProtKB/TrEMBL
  ENSRNOT00000103076 ENTREZGENE
  ENSRNOT00000103076.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7308609 IMAGE-MGC_LOAD
InterPro AN32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25379 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105504 IMAGE-MGC_LOAD
NCBI Gene Anp32a ENTREZGENE
PANTHER ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Anp32a PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014846 RatGTEx
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208008
UniProt A0A8I5ZVJ3_RAT UniProtKB/TrEMBL
  A0A8I6A5S9_RAT UniProtKB/TrEMBL
  A6J579_RAT UniProtKB/TrEMBL
  A6J581_RAT UniProtKB/TrEMBL
  AN32A_RAT UniProtKB/Swiss-Prot
  F7EL36_RAT UniProtKB/TrEMBL
  P49911 ENTREZGENE
  Q5PPH9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-10 Anp32a  acidic nuclear phosphoprotein 32 family member A  NEWGENE_2116  acidic nuclear phosphoprotein 32 family member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-02-10 NEWGENE_2116  acidic nuclear phosphoprotein 32 family member A  Anp32a  acidic nuclear phosphoprotein 32 family member A  Data merged from RGD:2116 737654 PROVISIONAL
2015-11-12 Anp32a  acidic nuclear phosphoprotein 32 family member A  Anp32a  acidic (leucine-rich) nuclear phosphoprotein 32 family, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Anp32a  acidic (leucine-rich) nuclear phosphoprotein 32 family, member A    acidic nuclear phosphoprotein 32 family, member A  Name updated 1299863 APPROVED
2003-04-09 Anp32a  acidic nuclear phosphoprotein 32 family, member A  Anp32  Acid nuclear phosphoprotein 32 (leucine rich)  Symbol and Name updated 629477 APPROVED
2002-06-10 Anp32  Acid nuclear phosphoprotein 32 (leucine rich)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the nucleus 632206
gene_expression expressed in cerebellar Purkinje cells 632206
gene_process may be involved in of cerebellar neuron differentiation 632206