Gene:	ACLY ( Homo sapiens ) ATP citrate lyase
Description:	ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Synonyms:	ATPCL; ACL; CLATP;
Gene Type:	protein-coding
Additional Data
Homologs
Mus musculus: Acly     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Rattus norvegicus: Acly     See the Rat gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Acly genome assembly 3.1 10 89435312 - 89485719     Rat Celera Assembly 10 84129406 - 84179897     RGSC genome assembly v3.4 10 89420941 - 89471349     Cytogenetic 10 q32.1 Mus musculus Acly Mouse genome assembly build 36.1 11 100337670 - 100389215     Cytogenetic 11 11 D Homo sapiens ACLY human genome assembly 17 37276706 - 37328798     Human genome assembly build 36.2 17 37276705 - 37328798     Cytogenetic 17 q12-q21   View comparative maps:      NCBI MapViewer
Annotation
Molecular Function	Gene Ontology succinate-CoA ligase (ADP-forming) activity,  protein binding,  citrate (pro-3S)-lyase activity ...  (details...)
Biological Process	Gene Ontology coenzyme A metabolic process,  metabolic process,  cellular carbohydrate metabolic process ...  (details...)
Cellular Component	Gene Ontology cytoplasm,  citrate lyase complex,  cytosol (details...)
Disease	Ontology Dentin Dysplasia (details...)
Phenotype	Ontology abnormal avoidance learning behavior (details...)
External Links
Databases	DATABASE ID SOURCE OMIM: 108728 ENTREZGENE HGNC ID: ACLY ENTREZGENE Entrez Gene: ACLY ENTREZGENE KEGG Report: hsa:47 ENTREZGENE HomoloGene Group ID: 854 ENTREZGENE HPRD ID: 00155 ENTREZGENE KEGG Pathway: 00720 ENTREZGENE KEGG Pathway: 00020 ENTREZGENE
Sequences	Nucleotide: BG037168 Get FASTA Search GEO Profiles Nucleotide: AK304802 Get FASTA Search GEO Profiles Nucleotide: AC091172 Get FASTA Search GEO Profiles Nucleotide: AK312315 Get FASTA Search GEO Profiles Nucleotide: BC006195 Get FASTA Search GEO Profiles Nucleotide: CH471152 Get FASTA Search GEO Profiles Nucleotide: NM_198830 Get FASTA Search GEO Profiles Nucleotide: U18197 Get FASTA Search GEO Profiles Nucleotide: AB210035 Get FASTA Search GEO Profiles Nucleotide: X64330 Get FASTA Search GEO Profiles Nucleotide: AK295675 Get FASTA Search GEO Profiles Nucleotide: AK095084 Get FASTA Search GEO Profiles Nucleotide: NM_001096 Get FASTA Search GEO Profiles (View all 13 Nucleotide Accessions) Protein: NP_942127 Get FASTA Protein: NP_001087 Get FASTA Protein: EAW60777 Get FASTA Protein: EAW60778 Get FASTA Protein: EAW60779 Get FASTA Protein: EAW60780 Get FASTA Protein: EAW60781 Get FASTA Protein: BAE06117 Get FASTA Protein: BAC04484 Get FASTA Protein: BAG58532 Get FASTA Protein: BAG65552 Get FASTA Protein: AAH06195 Get FASTA Protein: AAB60340 Get FASTA Protein: CAA45614 Get FASTA Protein: P53396 Get FASTA Protein: Q4LE36 Get FASTA Protein: Q8N9C4 Get FASTA (View all 17 Protein Accessions)
Clusters	UniGene: 387567
References
Curated References	4 references in RGD related to ACLY
Other References	21 other references at PubMed related to ACLY
Database Information
RGD ID	10065
History	No Nomenclature events are recorded for this object