Sost (sclerostin) - Rat Genome Database

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Gene: Sost (sclerostin) Rattus norvegicus
Analyze
Symbol: Sost
Name: sclerostin
RGD ID: 69358
Description: Predicted to enable several functions, including BMP binding activity; DNA-binding transcription factor binding activity; and carbohydrate binding activity. Involved in ossification. Located in Golgi apparatus and extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: sclerosteosis
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,412,722 - 87,415,766 (-)NCBIGRCr8
mRatBN7.21086,912,517 - 86,915,561 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,911,517 - 86,915,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,941,934 - 91,944,978 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,417,549 - 91,420,598 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,810,861 - 86,813,910 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,897,087 - 89,900,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,897,087 - 89,900,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,689,512 - 89,692,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,023,712 - 91,026,759 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,038,081 - 91,041,129 (-)NCBI
Celera1085,631,705 - 85,634,749 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Brunkow ME, etal., Am J Hum Genet 2001 Mar;68(3):577-89.
2. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Control of the SOST bone enhancer by PTH using MEF2 transcription factors. Leupin O, etal., J Bone Miner Res. 2007 Dec;22(12):1957-67.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Noggin and sclerostin bone morphogenetic protein antagonists form a mutually inhibitory complex. Winkler DG, etal., J Biol Chem. 2004 Aug 27;279(35):36293-8. Epub 2004 Jun 14.
Additional References at PubMed
PMID:14633986   PMID:15908424   PMID:15946907   PMID:17002572   PMID:17549589   PMID:18089564   PMID:19896444   PMID:20359476   PMID:20551380   PMID:20641040   PMID:21567076   PMID:21723865  
PMID:22174402   PMID:22766096   PMID:23233270   PMID:23337040   PMID:23918385   PMID:25012661   PMID:25359699   PMID:26541456   PMID:27039006   PMID:27233518   PMID:28081119   PMID:29226516  
PMID:29240821   PMID:29472591   PMID:30699436   PMID:31112281   PMID:31330917   PMID:32844318   PMID:33508832  


Genomics

Comparative Map Data
Sost
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,412,722 - 87,415,766 (-)NCBIGRCr8
mRatBN7.21086,912,517 - 86,915,561 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,911,517 - 86,915,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,941,934 - 91,944,978 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,417,549 - 91,420,598 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,810,861 - 86,813,910 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,897,087 - 89,900,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,897,087 - 89,900,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,689,512 - 89,692,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,023,712 - 91,026,759 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,038,081 - 91,041,129 (-)NCBI
Celera1085,631,705 - 85,634,749 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
SOST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,753,738 - 43,758,791 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,753,738 - 43,758,791 (-)EnsemblGRCh38hg38GRCh38
GRCh371741,831,106 - 41,836,159 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,186,625 - 39,191,682 (-)NCBINCBI36Build 36hg18NCBI36
Build 341739,186,624 - 39,191,682NCBI
Celera1738,539,106 - 38,544,164 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1737,595,207 - 37,600,265 (-)NCBIHuRef
CHM1_11742,066,723 - 42,071,781 (-)NCBICHM1_1
T2T-CHM13v2.01744,606,296 - 44,611,349 (-)NCBIT2T-CHM13v2.0
Sost
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,853,284 - 101,857,841 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,853,284 - 101,857,841 (-)EnsemblGRCm39 Ensembl
GRCm3811101,962,458 - 101,967,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,962,458 - 101,967,015 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,823,772 - 101,828,329 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,778,626 - 101,783,105 (-)NCBIMGSCv36mm8
Celera11113,667,734 - 113,672,291 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.48NCBI
Sost
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,054,939 - 17,058,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,054,939 - 17,058,027 (-)NCBIChiLan1.0ChiLan1.0
SOST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21921,149,763 - 21,155,219 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,114,052 - 23,119,508 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,639,088 - 13,644,152 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,804,374 - 13,809,432 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,804,374 - 13,809,432 (+)Ensemblpanpan1.1panPan2
SOST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,538,713 - 19,544,650 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,539,435 - 19,544,651 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,928,494 - 18,933,390 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,234,523 - 20,239,413 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,234,719 - 20,239,089 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,087,300 - 19,092,190 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,270,262 - 19,275,387 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,415,616 - 19,420,514 (+)NCBIUU_Cfam_GSD_1.0
Sost
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,876,390 - 18,881,316 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541313,287 - 318,176 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541313,308 - 318,109 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,355,234 - 19,360,352 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,354,912 - 19,360,348 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,588,864 - 19,592,789 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,649,053 - 62,656,192 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,651,146 - 62,654,570 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607733,418,277 - 33,423,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sost
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,006,813 - 1,008,685 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,006,811 - 1,009,437 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sost
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:83
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000028238
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 26 42 34 19 34 20 22 19 3
Below cutoff 1 13 6 6 6 3 3 23 13 12 6 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028238   ⟹   ENSRNOP00000028238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1089,897,087 - 89,900,131 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099214   ⟹   ENSRNOP00000081514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,911,517 - 86,915,561 (-)Ensembl
RefSeq Acc Id: NM_030584   ⟹   NP_085073
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,412,722 - 87,415,766 (-)NCBI
mRatBN7.21086,912,517 - 86,915,561 (-)NCBI
Rnor_6.01089,897,087 - 89,900,131 (-)NCBI
Rnor_5.01089,689,512 - 89,692,559 (-)NCBI
RGSC_v3.41091,023,712 - 91,026,759 (-)RGD
Celera1085,631,705 - 85,634,749 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_085073 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK13456 (Get FASTA)   NCBI Sequence Viewer  
  EDM06161 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000081514
  ENSRNOP00000081514.1
  ENSRNOP00055047508
  ENSRNOP00060020694
  ENSRNOP00065036988
GenBank Protein Q99P67 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_085073   ⟸   NM_030584
- Peptide Label: precursor
- UniProtKB: Q99P67 (UniProtKB/Swiss-Prot),   A6HJF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028238   ⟸   ENSRNOT00000028238
RefSeq Acc Id: ENSRNOP00000081514   ⟸   ENSRNOT00000099214
Protein Domains
CTCK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99P67-F1-model_v2 AlphaFold Q99P67 1-213 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69358 AgrOrtholog
BioCyc Gene G2FUF-23135 BioCyc
Ensembl Genes ENSRNOG00000020805 Ensembl
  ENSRNOG00000071073 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055033327 UniProtKB/Swiss-Prot
  ENSRNOG00060015097 UniProtKB/Swiss-Prot
  ENSRNOG00065026159 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000099214 ENTREZGENE
  ENSRNOT00000099214.1 UniProtKB/Swiss-Prot
  ENSRNOT00055057616 UniProtKB/Swiss-Prot
  ENSRNOT00060025874 UniProtKB/Swiss-Prot
  ENSRNOT00065045106 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sclerostin/SOSTDC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:80722 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 80722 ENTREZGENE
PANTHER PTHR14903 UniProtKB/Swiss-Prot
  PTHR14903:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCLEROSTIN-RELATED UniProtKB/TrEMBL
Pfam Sclerostin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sost PhenoGen
RatGTEx ENSRNOG00000020805 RatGTEx
  ENSRNOG00000071073 RatGTEx
  ENSRNOG00055033327 RatGTEx
  ENSRNOG00060015097 RatGTEx
  ENSRNOG00065026159 RatGTEx
TIGR TC231506
UniProt A6HJF6 ENTREZGENE, UniProtKB/TrEMBL
  Q99P67 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Sost  sclerostin  Sost  sclerosteosis  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Sost  sclerosteosis  Sost  sclerostin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sost  sclerostin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog is mutated in two individuals with sclerosteosis, an autosomal recessive bone dysplasia with progressive skeletal outgrowth 68858