Slc25a4 (solute carrier family 25 member 4) - Rat Genome Database

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Gene: Slc25a4 (solute carrier family 25 member 4) Rattus norvegicus
Analyze
Symbol: Slc25a4
Name: solute carrier family 25 member 4
RGD ID: 620352
Description: Enables enzyme binding activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitochondrial membrane permeability involved in apoptotic process; and positive regulation of cell growth involved in cardiac muscle cell development. Located in membrane raft; mitochondrial inner membrane; and mitochondrial outer membrane. Biomarker of alcoholic cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4); PARTICIPATES IN electron transport chain pathway; calcium/calcium-mediated signaling pathway; Huntington's disease pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenine nucleotide translocator 1; adenine nucleotide translocator), member 4; ADP,ATP carrier protein 1; ADP/ATP translocase 1; ANT 1; Ant1; mitochondrial adenine nucleotide translocator; solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81652,805,521 - 52,809,316 (+)NCBIGRCr8
mRatBN7.21646,072,935 - 46,076,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,072,939 - 46,076,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1651,474,917 - 51,478,712 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01654,843,795 - 54,847,590 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01650,114,293 - 50,118,088 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01649,266,903 - 49,270,698 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1649,266,903 - 49,270,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01648,981,600 - 48,985,395 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41649,353,476 - 49,357,271 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11649,353,550 - 49,357,346 (+)NCBI
Celera1644,072,219 - 44,076,014 (+)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyhexenal  (EXP)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aniline  (ISO)
antimycin A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
bongkrekic acid  (EXP)
cadmium atom  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
Carboxyatractyloside  (EXP)
CGP 52608  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
closantel  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
daunorubicin  (EXP)
deguelin  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
fenofibrate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
Mesaconitine  (EXP)
N(4)-hydroxycytidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
okadaic acid  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (EXP)
PhIP  (EXP)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
puerarin  (EXP)
pyrazinecarboxamide  (EXP)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
sodium arsenate  (ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (ISO)
sulfasalazine  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
toluene  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interaction between NH(2)-tau fragment and Abeta in Alzheimer's disease mitochondria contributes to the synaptic deterioration. Amadoro G, etal., Neurobiol Aging. 2012 Apr;33(4):833.e1-25. doi: 10.1016/j.neurobiolaging.2011.08.001. Epub 2011 Sep 29.
2. Chemical, immunological, enzymatic, and genetic approaches to studying the arrangement of the peptide chain of the ADP/ATP carrier in the mitochondrial membrane. Brandolin G, etal., J Bioenerg Biomembr 1993 Oct;25(5):459-72.
3. Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport. Buck CR, etal., Exp Neurol. 2003 Jun;181(2):149-58.
4. Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity. Colell A, etal., J Biol Chem. 2003 Sep 5;278(36):33928-35. Epub 2003 Jun 23.
5. A novel ANT1 gene mutation with probable germline mosaicism in autosomal dominant progressive external ophthalmoplegia. Deschauer M, etal., Neuromuscul Disord. 2005 Apr;15(4):311-5. Epub 2005 Jan 28.
6. Mitochondrial disease in mouse results in increased oxidative stress. Esposito LA, etal., Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4820-5.
7. Mitochondrial and sarcoplasmic reticulum abnormalities in cancer cachexia: altered energetic efficiency? Fontes-Oliveira CC, etal., Biochim Biophys Acta. 2013 Mar;1830(3):2770-8. doi: 10.1016/j.bbagen.2012.11.009.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Muscle/heart isoform of mitochondrial adenine nucleotide translocase (ANT1) is transiently expressed during perinatal development in rat liver. Grado A, etal., FEBS Lett. 1998 Jan 16;421(3):213-6.
11. Apoptosis in pressure overload-induced cardiac hypertrophy is mediated, in part, by adenine nucleotide translocator-1. Hang T, etal., Ann Clin Lab Sci. 2006 Winter;36(1):88-95.
12. Transgenic overexpression of the adenine nucleotide translocase 1 protects cardiomyocytes against TGFbeta1-induced apoptosis by stabilization of the mitochondrial permeability transition pore. Heger J, etal., J Mol Cell Cardiol. 2012 Jul;53(1):73-81. doi: 10.1016/j.yjmcc.2012.04.013. Epub 2012 Apr 28.
13. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. Jacotot E, etal., J Exp Med. 2000 Jan 3;191(1):33-46.
14. Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2. Jacotot E, etal., J Exp Med. 2001 Feb 19;193(4):509-19.
15. Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. Jing L, etal., Med Sci Monit. 2011 Jan;17(1):BR1-9.
16. Increased levels of adenine nucleotide translocator 1 protein and response to oxidative stress are early events in facioscapulohumeral muscular dystrophy muscle. Laoudj-Chenivesse D, etal., J Mol Med. 2005 Mar;83(3):216-24. Epub 2004 Nov 17.
17. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
18. The effect of 17-methoxyl-7-hydroxy-benzene-furanchalcone on NF-kappaB and the inflammatory response during myocardial ischemia reperfusion injury in rats. Liang X, etal., J Cardiovasc Pharmacol. 2014 Jan;63(1):68-75. doi: 10.1097/FJC.0000000000000027.
19. Mitochondrial targeted cyclophilin d protects cells from cell death by peptidyl prolyl isomerization. Lin DT and Lechleiter JD, J Biol Chem 2002 Aug 23;277(34):31134-41.
20. Epitope mapping of mitochondrial adenine nucleotide translocase-1 in idiopathic dilated cardiomyopathy. Manchado C, etal., J Mol Cell Cardiol. 2002 May;34(5):571-82.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Effect of antioxidant diets on mitochondrial gene expression in rat brain during aging. Nicoletti VG, etal., Neurochem Res. 2005 Jun-Jul;30(6-7):737-52.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Complete loss-of-function of the heart/muscle-specific adenine nucleotide translocator is associated with mitochondrial myopathy and cardiomyopathy. Palmieri L, etal., Hum Mol Genet. 2005 Oct 15;14(20):3079-88. Epub 2005 Sep 9.
26. Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria. Parker N, etal., Biochem J. 2008 May 15;412(1):131-9. doi: 10.1042/BJ20080006.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
29. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. Rardin MJ, etal., J Biol Chem. 2008 May 30;283(22):15440-50. doi: 10.1074/jbc.M709547200. Epub 2008 Apr 2.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Isolation and characterization of cDNA clones and a genomic clone encoding rat mitochondrial adenine nucleotide translocator. Shinohara Y, etal., Biochim Biophys Acta 1993 Oct 10;1152(1):192-6.
34. Autosomal dominant external ophthalmoplegia and bipolar affective disorder associated with a mutation in the ANT1 gene. Siciliano G, etal., Neuromuscul Disord. 2003 Feb;13(2):162-5.
35. Expression of mitochondrial uncoupling protein 3 and adenine nucleotide translocase 1 genes in developing rat heart: putative involvement in control of mitochondrial membrane potential. Skarka L, etal., J Mol Cell Cardiol. 2003 Mar;35(3):321-30.
36. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
37. Interleukin-1beta induces CREB-binding protein (CBP) mRNA in brain and the sequencing of rat CBP. Tang C, etal., Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):213-22. Epub 2005 Apr 25.
38. Transgenic overexpression of heart-specific adenine nucleotide translocase 1 positively affects contractile function in cardiomyocytes. Vogelpohl I, etal., Cell Physiol Biochem. 2011;27(2):121-8. doi: 10.1159/000325214. Epub 2011 Feb 11.
39. Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease. Walther T, etal., Circulation. 2007 Jan 23;115(3):333-44. Epub 2007 Jan 8.
40. Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition. Woodfield K, etal., Biochem J. 1998 Dec 1;336 ( Pt 2):287-90.
Additional References at PubMed
PMID:12865426   PMID:16507998   PMID:16554051   PMID:17485229   PMID:17634366   PMID:18350175   PMID:18614015   PMID:19800022   PMID:20131911   PMID:20348099   PMID:20833797   PMID:21630459  
PMID:23106098   PMID:24625528   PMID:24709060   PMID:25931508   PMID:26316108   PMID:26548633   PMID:26835787   PMID:27080394   PMID:27693233   PMID:29476059   PMID:30391711   PMID:31686426  
PMID:32357304  


Genomics

Comparative Map Data
Slc25a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81652,805,521 - 52,809,316 (+)NCBIGRCr8
mRatBN7.21646,072,935 - 46,076,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,072,939 - 46,076,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1651,474,917 - 51,478,712 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01654,843,795 - 54,847,590 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01650,114,293 - 50,118,088 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01649,266,903 - 49,270,698 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1649,266,903 - 49,270,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01648,981,600 - 48,985,395 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41649,353,476 - 49,357,271 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11649,353,550 - 49,357,346 (+)NCBI
Celera1644,072,219 - 44,076,014 (+)NCBICelera
Cytogenetic Map16q11NCBI
SLC25A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384185,143,266 - 185,150,382 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4185,143,266 - 185,150,382 (+)EnsemblGRCh38hg38GRCh38
GRCh374186,064,420 - 186,071,536 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364186,301,392 - 186,305,419 (+)NCBINCBI36Build 36hg18NCBI36
Build 344186,439,546 - 186,443,573NCBI
Celera4183,391,334 - 183,398,454 (+)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4181,818,234 - 181,825,547 (+)NCBIHuRef
CHM1_14186,040,918 - 186,048,039 (+)NCBICHM1_1
T2T-CHM13v2.04188,486,951 - 188,494,056 (+)NCBIT2T-CHM13v2.0
Slc25a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39846,660,205 - 46,664,099 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl846,659,834 - 46,664,321 (-)EnsemblGRCm39 Ensembl
GRCm38846,207,168 - 46,211,062 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl846,206,797 - 46,211,284 (-)EnsemblGRCm38mm10GRCm38
MGSCv37847,292,693 - 47,296,363 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36847,705,502 - 47,710,101 (-)NCBIMGSCv36mm8
MGSCv36845,369,594 - 45,374,194 (-)NCBIMGSCv36mm8
Celera848,888,832 - 48,892,502 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map826.22NCBI
Slc25a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540323,878,329 - 23,882,322 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540323,878,329 - 23,882,322 (-)NCBIChiLan1.0ChiLan1.0
SLC25A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23182,882,901 - 182,886,952 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14183,231,201 - 183,235,234 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04177,310,982 - 177,315,016 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14189,531,914 - 189,534,549 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4189,531,914 - 189,534,549 (+)Ensemblpanpan1.1panPan2
SLC25A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11645,454,660 - 45,458,606 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1645,411,810 - 45,542,162 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1645,942,189 - 45,946,135 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01647,671,404 - 47,675,349 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1647,671,405 - 47,675,335 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11645,638,494 - 45,642,440 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01646,251,541 - 46,255,470 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01646,383,474 - 46,387,417 (-)NCBIUU_Cfam_GSD_1.0
Slc25a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494333,974,957 - 33,979,529 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365544,130,459 - 4,135,044 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365544,130,461 - 4,135,046 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC25A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1546,193,746 - 46,200,987 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11546,193,498 - 46,197,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21552,922,472 - 52,926,762 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC25A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17131,102,077 - 131,106,076 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037111,362,070 - 111,369,325 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc25a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476915,989,547 - 15,997,680 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476915,989,527 - 15,993,609 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc25a4
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:114
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000014704
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat

Markers in Region
D4S3175  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,076,460 - 46,076,567 (+)MAPPERmRatBN7.2
Rnor_6.01649,270,429 - 49,270,535NCBIRnor6.0
Rnor_5.01648,985,126 - 48,985,232UniSTSRnor5.0
RGSC_v3.41649,357,002 - 49,357,108UniSTSRGSC3.4
Celera1644,075,745 - 44,075,851UniSTS
Cytogenetic Map16q11UniSTS
RH142319  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,072,182 - 46,072,373 (+)MAPPERmRatBN7.2
Rnor_6.01649,266,151 - 49,266,341NCBIRnor6.0
Rnor_5.01648,980,848 - 48,981,038UniSTSRnor5.0
RGSC_v3.41649,352,724 - 49,352,914UniSTSRGSC3.4
Celera1644,071,467 - 44,071,657UniSTS
Cytogenetic Map16q11UniSTS
Slc25a4  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41649,355,944 - 49,356,852UniSTSRGSC3.4
RGSC_v3.41649,355,944 - 49,356,851UniSTSRGSC3.4
RGSC_v3.41649,355,349 - 49,356,002UniSTSRGSC3.4
Celera1644,074,687 - 44,075,594UniSTS
Celera1644,074,092 - 44,074,745UniSTS
Celera1644,074,687 - 44,075,595UniSTS
Slc25a4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01648,984,068 - 48,984,975UniSTSRnor5.0
RGSC_v3.41649,355,944 - 49,356,851UniSTSRGSC3.4
Celera1644,074,687 - 44,075,594UniSTS
Cytogenetic Map16q11UniSTS
Slc25a4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01648,984,068 - 48,984,976UniSTSRnor5.0
RGSC_v3.41649,355,944 - 49,356,852UniSTSRGSC3.4
Celera1644,074,687 - 44,075,595UniSTS
Cytogenetic Map16q11UniSTS
SLC25A4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01648,983,473 - 48,984,126UniSTSRnor5.0
RGSC_v3.41649,355,349 - 49,356,002UniSTSRGSC3.4
Celera1644,074,092 - 44,074,745UniSTS
Cytogenetic Map16q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 43 8 11 4 8
Medium 3 50 34 19 34 70 35 41 11
Low 7 7 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D12770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000014704   ⟹   ENSRNOP00000014704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,072,939 - 46,076,733 (+)Ensembl
Rnor_6.0 Ensembl1649,266,903 - 49,270,698 (+)Ensembl
RefSeq Acc Id: NM_053515   ⟹   NP_445967
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81652,805,521 - 52,809,316 (+)NCBI
mRatBN7.21646,072,935 - 46,076,730 (+)NCBI
Rnor_6.01649,266,903 - 49,270,698 (+)NCBI
Rnor_5.01648,981,600 - 48,985,395 (+)NCBI
RGSC_v3.41649,353,476 - 49,357,271 (+)RGD
Celera1644,072,219 - 44,076,014 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445967 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH60533 (Get FASTA)   NCBI Sequence Viewer  
  BAA02237 (Get FASTA)   NCBI Sequence Viewer  
  CAA43842 (Get FASTA)   NCBI Sequence Viewer  
  EDL78880 (Get FASTA)   NCBI Sequence Viewer  
  EDL78881 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014704
  ENSRNOP00000014704.2
GenBank Protein Q05962 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_445967   ⟸   NM_053515
- UniProtKB: Q05962 (UniProtKB/Swiss-Prot),   Q6P9Y4 (UniProtKB/TrEMBL),   F7FMU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014704   ⟸   ENSRNOT00000014704

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05962-F1-model_v2 AlphaFold Q05962 1-298 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700099
Promoter ID:EPDNEW_R10623
Type:single initiation site
Name:Slc25a4_1
Description:solute carrier family 25 member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01649,266,907 - 49,266,967EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620352 AgrOrtholog
BioCyc Gene G2FUF-11338 BioCyc
Ensembl Genes ENSRNOG00000010830 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014704 ENTREZGENE
  ENSRNOT00000014704.5 UniProtKB/TrEMBL
Gene3D-CATH 1.50.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922056 IMAGE-MGC_LOAD
InterPro Aden_trnslctor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mit_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85333 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72639 IMAGE-MGC_LOAD
NCBI Gene 85333 ENTREZGENE
PANTHER ADP/ATP TRANSLOCASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45635 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Mito_carr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc25a4 PhenoGen
PRINTS ADPTRNSLCASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOCARRIER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOLCAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010830 RatGTEx
Superfamily-SCOP SSF103506 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JPP2_RAT UniProtKB/TrEMBL
  ADT1_RAT UniProtKB/Swiss-Prot
  F7FMU8 ENTREZGENE, UniProtKB/TrEMBL
  Q05962 ENTREZGENE
  Q6P9Y4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc25a4  solute carrier family 25 member 4  Slc25a4  solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Slc25a4  solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4      Name updated 1299863 APPROVED
2005-01-20 Slc25a4  solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Slc25a4  solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4      Symbol and Name status set to provisional 70820 PROVISIONAL