Myh6 (myosin heavy chain 6) - Rat Genome Database

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Gene: Myh6 (myosin heavy chain 6) Rattus norvegicus
Analyze
Symbol: Myh6
Name: myosin heavy chain 6
RGD ID: 62029
Description: Enables several functions, including ATP binding activity; calcium-dependent ATPase activity; and identical protein binding activity. Involved in cellular response to 3,3',5-triiodo-L-thyronine and muscle contraction. Located in myofibril. Part of muscle myosin complex. Biomarker of congestive heart failure; hypothyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; myocarditis pathway; INTERACTS WITH (R)-noradrenaline; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Myh7; myHC-alpha; MyHC-beta; MyHC-slow; Myhca; Myosin heavy chain 7; myosin heavy chain cardiac muscle adult; myosin heavy chain polypeptide 6 cardiac muscle adult; myosin heavy chain polypeptide 6 cardiac muscle alpha; myosin heavy chain, cardiac muscle alpha isoform; myosin heavy chain, polypeptide 6; myosin heavy chain, polypeptide 6, cardiac muscle, alpha; myosin, heavy chain 6, cardiac muscle, alpha; myosin, heavy polypeptide 6, cardiac muscle, alpha; myosin-6; Myosin-7
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,388,102 - 32,413,663 (-)NCBIGRCr8
mRatBN7.21528,418,120 - 28,442,316 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,417,616 - 28,441,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,263,773 - 30,287,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,410,975 - 31,434,710 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,653,709 - 29,677,297 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,605,653 - 33,629,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,605,654 - 33,629,699 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,492,599 - 37,516,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,044,506 - 33,068,098 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,060,206 - 33,083,798 (-)NCBI
Celera1527,995,918 - 28,019,393 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
atrial fibrillation  (ISO)
atrial heart septal defect  (ISO)
atrial heart septal defect 3  (ISO)
atrioventricular block  (ISO)
autosomal dominant hyaline body myopathy  (ISO)
Brain-Lung-Thyroid Syndrome  (ISO)
Brugada syndrome  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (IEP)
cardiomyopathy  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (IEP,ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO,ISS)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1EE  (ISO,ISS)
dilated cardiomyopathy 1H  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
distal myopathy  (ISO)
distal myopathy 1  (ISO)
Endotoxemia  (IEP)
Experimental Autoimmune Myocarditis  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
heart disease  (ISO)
hemiplegia  (ISO)
hyaline body myopathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 14  (ISO,ISS)
hypoplastic left heart syndrome  (ISO)
hypothyroidism  (IEP)
Left Ventricular Hypertrophy  (IEP,ISO)
left ventricular noncompaction  (ISO)
Left Ventricular Noncompaction 1  (ISO)
long QT syndrome  (ISO)
lysinuric protein intolerance  (ISO)
migraine  (ISO)
myocardial infarction  (IEP)
restrictive cardiomyopathy  (ISO)
scapuloperoneal myopathy  (ISO)
sick sinus syndrome  (ISO)
Sick Sinus Syndrome 3  (ISO)
Specific Granule Deficiency  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(R)-noradrenaline  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethyl-4-tridecylmorpholine  (ISO)
2-ethylhexan-1-ol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
angiotensin II  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
butanal  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carfilzomib  (ISO)
chromium(6+)  (ISO)
cobalt atom  (ISO)
cocaine  (EXP)
curcumin  (ISO)
daunorubicin  (EXP,ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
doxorubicin  (EXP,ISO)
dronedarone  (EXP)
Echimidine  (EXP)
enalapril  (EXP)
fenpropidin  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fructose  (ISO)
genistein  (ISO)
glyphosate  (EXP)
Heliotrine  (EXP)
icariin  (ISO)
Ile(5)-angiotensin II  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead nitrate  (EXP)
lipopolysaccharide  (ISO)
losartan  (EXP)
maraviroc  (ISO)
mercaptopurine  (EXP)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
mitoxantrone  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
Plantamajoside  (ISO)
prazosin  (EXP)
progesterone  (EXP,ISO)
purine-6-thiol  (EXP)
resveratrol  (ISO)
ribavirin  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium nitrate  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
thalidomide  (ISO)
theaflavin  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vinclozolin  (EXP)
warfarin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
muscle myosin complex  (IDA)
myofibril  (IDA,ISO)
myosin complex  (IEA,ISO)
myosin filament  (IBA,IEA)
myosin II complex  (IBA,IEA)
stress fiber  (IEA,ISO)
Z disc  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. Bachmaier K, etal., Circulation. 1999 Apr 13;99(14):1885-91.
2. Exome analysis of a family with Wolff-Parkinson-White syndrome identifies a novel disease locus. Bowles NE, etal., Am J Med Genet A. 2015 Dec;167A(12):2975-84. doi: 10.1002/ajmg.a.37297. Epub 2015 Aug 18.
3. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Bunn RC, etal., Mol Biol Cell 1999 Apr;10(4):819-32.
4. Interpreting cardiac muscle force-length dynamics using a novel functional model. Campbell KB, etal., Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1535-45.
5. Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Carniel E, etal., Circulation. 2005 Jul 5;112(1):54-9.
6. Mutation in myosin heavy chain 6 causes atrial septal defect. Ching YH, etal., Nat Genet. 2005 Apr;37(4):423-8. Epub 2005 Feb 27.
7. Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation. Chouchani ET, etal., Biochem J. 2010 Aug 15;430(1):49-59. doi: 10.1042/BJ20100633.
8. Visualization of cardiac ventricular myosin heavy chain homodimers and heterodimers by monoclonal antibody epitope mapping. Dechesne CA, etal., J Cell Biol. 1987 Dec;105(6 Pt 2):3031-7.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. A mouse model of familial hypertrophic cardiomyopathy. Geisterfer-Lowrance AA, etal., Science. 1996 May 3;272(5262):731-4.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Localization of cardiac (alpha)-myosin heavy chain mRNA is regulated by its 3' untranslated region via mechanical activity and translational block. Goldspink P, etal., J Cell Sci. 1997 Dec;110 ( Pt 23):2969-78.
13. Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure. Gupta M, etal., J Biol Chem. 2003 Nov 7;278(45):44935-48. Epub 2003 Aug 21.
14. Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. Izumo S, etal., J Clin Invest. 1987 Mar;79(3):970-7.
15. Cardiac muscle protein gene expression in the endotoxin-treated rat. Macallan DC and Griffin GE, Clin Sci (Lond). 1994 Nov;87(5):539-46.
16. Cardiac myosin heavy chain isozymic transitions during development and under pathological conditions are regulated at the level of mRNA availability. Mahdavi V, etal., Eur Heart J 1984 Dec;5 Suppl F:181-91.
17. Complete nucleotide sequence of full length cDNA for rat alpha cardiac myosin heavy chain. McNally EM, etal., Nucleic Acids Res 1989 Sep 25;17(18):7527-8.
18. Heavy long-term ethanol consumption induces an alpha- to beta-myosin heavy chain isoform transition in rat. Meehan J, etal., Basic Res Cardiol. 1999 Dec;94(6):481-8.
19. Alpha-myosin heavy chain isoform and atrial size in patients with various types of mitral valve dysfunction: a quantitative study. Mercadier JJ, etal., J Am Coll Cardiol. 1987 May;9(5):1024-30.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Molecular biological analysis of cardiac effect of high temperature in rats. Nakagawa Y, etal., Leg Med (Tokyo). 2012 Mar;14(2):63-8. doi: 10.1016/j.legalmed.2011.12.001. Epub 2012 Jan 28.
22. Myosin heavy chain gene expression in human heart failure. Nakao K, etal., J Clin Invest. 1997 Nov 1;100(9):2362-70.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly. Niimura H, etal., Circulation. 2002 Jan 29;105(4):446-51.
25. Progressive changes from young adult age to senescence in mRNA for rat cardiac myosin heavy chain genes. O'Neill L, etal., Cardioscience. 1991 Mar;2(1):1-5.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Propranolol causes a paradoxical enhancement of cardiomyocyte foetal gene response to hypertrophic stimuli. Patrizio M, etal., Br J Pharmacol. 2007 Sep;152(2):216-22. Epub 2007 Jun 25.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. Electrophoretic variants of cardiac myosin heavy chain-alpha in Sprague Dawley rats. Reiser PJ, etal., Electrophoresis. 2004 Feb;25(3):389-95.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Impact of beta-myosin heavy chain isoform expression on cross-bridge cycling kinetics. Rundell VL, etal., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H896-903. Epub 2004 Oct 7.
34. Antiplatelet therapy attenuates subcellular remodelling in congestive heart failure. Sanganalmath SK, etal., J Cell Mol Med. 2008 Sep-Oct;12(5A):1728-38. Epub 2007 Dec 14.
35. Changes in myosin and creatine kinase mRNA levels with cardiac hypertrophy and hypothyroidism. Schuyler GT and Yarbrough LR, Basic Res Cardiol. 1990 Sep-Oct;85(5):481-94.
36. Myosin filament assembly requires a cluster of four positive residues located in the rod domain. Thompson RC, etal., FEBS Lett. 2012 Sep 21;586(19):3008-12. doi: 10.1016/j.febslet.2012.06.019. Epub 2012 Jun 21.
37. Effects of triiodo-thyronine on angiotensin-induced cardiomyocyte hypertrophy: reversal of increased beta-myosin heavy chain gene expression. Wang B, etal., Can J Physiol Pharmacol. 2006 Aug-Sep;84(8-9):935-41.
38. Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation. Xu YJ, etal., J Cell Mol Med. 2004 Jan-Mar;8(1):85-92.
Additional References at PubMed
PMID:2614840   PMID:6585819   PMID:7045682   PMID:8482409   PMID:8878443   PMID:9045856   PMID:9541509   PMID:9884344   PMID:10066683   PMID:10074482   PMID:10231857   PMID:11708849  
PMID:12477932   PMID:15001446   PMID:15621050   PMID:16088376   PMID:16983074   PMID:17138609   PMID:17307996   PMID:17360443   PMID:17379774   PMID:17720185   PMID:17982008   PMID:18029400  
PMID:18429820   PMID:18631005   PMID:20833952   PMID:21126233   PMID:23382463   PMID:24137001   PMID:25865156   PMID:26342069   PMID:26945066   PMID:27018747   PMID:29293066   PMID:32987653  
PMID:35352799  


Genomics

Comparative Map Data
Myh6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,388,102 - 32,413,663 (-)NCBIGRCr8
mRatBN7.21528,418,120 - 28,442,316 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,417,616 - 28,441,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,263,773 - 30,287,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,410,975 - 31,434,710 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,653,709 - 29,677,297 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,605,653 - 33,629,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,605,654 - 33,629,699 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,492,599 - 37,516,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,044,506 - 33,068,098 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,060,206 - 33,083,798 (-)NCBI
Celera1527,995,918 - 28,019,393 (-)NCBICelera
Cytogenetic Map15p13NCBI
MYH6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,381,987 - 23,408,273 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,381,982 - 23,408,273 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,851,196 - 23,877,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,921,039 - 22,947,322 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,921,037 - 22,947,324NCBI
Celera143,713,910 - 3,740,182 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,967,617 - 3,993,925 (-)NCBIHuRef
CHM1_11423,849,871 - 23,876,158 (-)NCBICHM1_1
T2T-CHM13v2.01417,583,003 - 17,609,277 (-)NCBIT2T-CHM13v2.0
Myh6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,179,378 - 55,205,553 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,179,378 - 55,204,384 (-)EnsemblGRCm39 Ensembl
GRCm381454,941,921 - 54,968,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,941,921 - 54,966,927 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,560,758 - 55,585,444 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,896,133 - 53,920,780 (-)NCBIMGSCv36mm8
Celera1452,747,958 - 52,772,529 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.01NCBI
MYH6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,812,710 - 24,838,412 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,029,200 - 24,055,952 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,200,616 - 4,226,193 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,294,965 - 22,321,331 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,294,965 - 22,321,331 (-)Ensemblpanpan1.1panPan2
MYH6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.083,737,187 - 3,762,594 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,736,980 - 3,815,024 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,428,743 - 3,454,127 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,490,222 - 3,516,723 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,752,224 - 3,778,743 (-)NCBIUU_Cfam_GSD_1.0
LOC100736765
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,676,791 - 75,704,644 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,677,666 - 75,704,486 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,036,392 - 81,061,144 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231478
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,753,251 - 23,780,822 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,753,309 - 23,778,107 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236674616 - 9,178 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Myh6
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:71
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000023302
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
BI283646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,418,153 - 28,418,682 (+)MAPPERmRatBN7.2
Rnor_6.01533,605,687 - 33,606,215NCBIRnor6.0
Rnor_5.01537,492,633 - 37,493,161UniSTSRnor5.0
RGSC_v3.41533,044,540 - 33,045,068UniSTSRGSC3.4
Celera1527,995,952 - 27,996,480UniSTS
Cytogenetic Map15p13UniSTS
BE107704  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,417,744 - 28,417,933 (+)MAPPERmRatBN7.2
Rnor_6.01533,605,278 - 33,605,466NCBIRnor6.0
Rnor_5.01537,492,224 - 37,492,412UniSTSRnor5.0
RGSC_v3.41533,044,131 - 33,044,319UniSTSRGSC3.4
Celera1527,995,543 - 27,995,731UniSTS
Cytogenetic Map15p13UniSTS
BE101980  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,431,450 - 28,431,605 (+)MAPPERmRatBN7.2
Rnor_6.01533,619,332 - 33,619,486NCBIRnor6.0
Rnor_5.01537,505,931 - 37,506,085UniSTSRnor5.0
RGSC_v3.41533,057,838 - 33,057,992UniSTSRGSC3.4
Celera1528,009,132 - 28,009,286UniSTS
Cytogenetic Map15p13UniSTS
RH138715  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,440,516 - 28,440,722 (+)MAPPERmRatBN7.2
Rnor_6.01533,628,389 - 33,628,594NCBIRnor6.0
Rnor_5.01537,514,988 - 37,515,193UniSTSRnor5.0
RGSC_v3.41533,066,895 - 33,067,100UniSTSRGSC3.4
Celera1528,018,190 - 28,018,395UniSTS
RH 3.4 Map15259.4UniSTS
Cytogenetic Map15p13UniSTS
MYH6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,438,630 - 28,439,034 (+)MAPPERmRatBN7.2
Rnor_6.01533,626,504 - 33,626,907NCBIRnor6.0
Rnor_5.01537,513,103 - 37,513,506UniSTSRnor5.0
RGSC_v3.41533,065,010 - 33,065,413UniSTSRGSC3.4
Celera1528,016,305 - 28,016,708UniSTS
Cytogenetic Map15p13UniSTS
Myh7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,449,124 - 28,449,397 (+)MAPPERmRatBN7.2
Rnor_6.01533,636,997 - 33,637,269NCBIRnor6.0
Rnor_5.01537,523,596 - 37,523,868UniSTSRnor5.0
Celera1528,026,798 - 28,027,070UniSTS
Cytogenetic Map15p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 31
Medium 12 2 2 8 8 1 7 8 8
Low 1 30 16 15 16 3 16 13 20 3
Below cutoff 2 6 6 2 6 43 15 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF074962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY191158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000023302   ⟹   ENSRNOP00000023301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,418,114 - 28,441,720 (-)Ensembl
Rnor_6.0 Ensembl1533,605,654 - 33,629,699 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099412   ⟹   ENSRNOP00000086043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,418,114 - 28,441,720 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115198   ⟹   ENSRNOP00000089960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,417,616 - 28,441,720 (-)Ensembl
RefSeq Acc Id: NM_017239   ⟹   NP_058935
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,388,102 - 32,411,697 (-)NCBI
mRatBN7.21528,418,120 - 28,441,720 (-)NCBI
Rnor_6.01533,605,653 - 33,629,592 (-)NCBI
Rnor_5.01537,492,599 - 37,516,786 (-)NCBI
RGSC_v3.41533,044,506 - 33,068,098 (-)RGD
Celera1527,995,918 - 28,019,393 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599641   ⟹   XP_017455130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,388,102 - 32,412,346 (-)NCBI
mRatBN7.21528,418,120 - 28,441,339 (-)NCBI
Rnor_6.01533,605,653 - 33,629,730 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093219   ⟹   XP_038949147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,388,102 - 32,412,324 (-)NCBI
mRatBN7.21528,418,126 - 28,442,316 (-)NCBI
RefSeq Acc Id: XM_063274184   ⟹   XP_063130254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,388,102 - 32,412,241 (-)NCBI
RefSeq Acc Id: XM_063274185   ⟹   XP_063130255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,388,102 - 32,412,241 (-)NCBI
RefSeq Acc Id: XM_063274186   ⟹   XP_063130256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,388,102 - 32,413,663 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_058935   ⟸   NM_017239
- UniProtKB: Q63351 (UniProtKB/Swiss-Prot),   P02563 (UniProtKB/Swiss-Prot),   A6KGY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455130   ⟸   XM_017599641
- Peptide Label: isoform X2
- UniProtKB: G3V885 (UniProtKB/TrEMBL),   A0A8I6A2T6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023301   ⟸   ENSRNOT00000023302
RefSeq Acc Id: XP_038949147   ⟸   XM_039093219
- Peptide Label: isoform X1
- UniProtKB: Q63351 (UniProtKB/Swiss-Prot),   P02563 (UniProtKB/Swiss-Prot),   A6KGY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089960   ⟸   ENSRNOT00000115198
RefSeq Acc Id: ENSRNOP00000086043   ⟸   ENSRNOT00000099412
RefSeq Acc Id: XP_063130256   ⟸   XM_063274186
- Peptide Label: isoform X2
- UniProtKB: G3V885 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130255   ⟸   XM_063274185
- Peptide Label: isoform X2
- UniProtKB: G3V885 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130254   ⟸   XM_063274184
- Peptide Label: isoform X1
- UniProtKB: A6KGY0 (UniProtKB/TrEMBL)
Protein Domains
IQ   Myosin motor   Myosin N-terminal SH3-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02563-F1-model_v2 AlphaFold P02563 1-1938 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62029 AgrOrtholog
BioCyc Gene G2FUF-13763 BioCyc
Ensembl Genes ENSRNOG00000025757 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023302.3 UniProtKB/TrEMBL
  ENSRNOT00000099412 ENTREZGENE
  ENSRNOT00000099412.1 UniProtKB/TrEMBL
  ENSRNOT00000115198.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.4820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.30.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XRCC4-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29556 UniProtKB/TrEMBL
NCBI Gene 29556 ENTREZGENE
PANTHER MYOSIN HEAVY CHAIN, NON-MUSCLE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYOSIN-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Myosin_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_tail_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myh6 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025757 RatGTEx
SMART MYSc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Myosin rod fragments UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tropomyosin UniProtKB/TrEMBL
UniProt A0A8I6A2T6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GHT6_RAT UniProtKB/TrEMBL
  A6KGY0 ENTREZGENE, UniProtKB/TrEMBL
  G3V885 ENTREZGENE, UniProtKB/TrEMBL
  MYH6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63351 ENTREZGENE
UniProt Secondary Q63351 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Myh6  myosin heavy chain 6  Myh6  myosin, heavy chain 6, cardiac muscle, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Myh6  myosin, heavy chain 6, cardiac muscle, alpha  Myh6  myosin, heavy polypeptide 6, cardiac muscle, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Myh6  myosin, heavy polypeptide 6, cardiac muscle, alpha    myosin heavy chain, polypeptide 6  Name updated 1299863 APPROVED
2002-06-10 Myh6  myosin heavy chain, polypeptide 6      Name updated 70584 APPROVED
2002-02-27 Myh6  myosin heavy chain, polypeptide 6, cardiac muscle, alpha      Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the heart 729162