1. |
Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. |
Bacaj T, etal., PLoS Biol. 2015 Oct 5;13(10):e1002267. doi: 10.1371/journal.pbio.1002267. eCollection 2015 Oct.
|
2. |
Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. |
Bakkaloglu B, etal., Am J Hum Genet. 2008 Jan;82(1):165-73. doi: 10.1016/j.ajhg.2007.09.017.
|
3. |
Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms. |
Bhalla A, etal., J Biol Chem. 2008 Aug 1;283(31):21799-807. doi: 10.1074/jbc.M709628200. Epub 2008 May 28.
|
4. |
A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerization. |
Chapman ER, etal., J Biol Chem. 1996 Mar 8;271(10):5844-9. doi: 10.1074/jbc.271.10.5844.
|
5. |
Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin. |
Chapman ER, etal., J Biol Chem. 1998 Dec 4;273(49):32966-72.
|
6. |
Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel. |
Charvin N, etal., EMBO J. 1997 Aug 1;16(15):4591-6.
|
7. |
Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain. |
Cheng Y, etal., Protein Sci. 2004 Oct;13(10):2665-72. Epub 2004 Aug 31.
|
8. |
Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex. |
Choi UB, etal., Nat Struct Mol Biol. 2010 Mar;17(3):318-24. doi: 10.1038/nsmb.1763. Epub 2010 Feb 21.
|
9. |
Direct interaction of the rab3 effector rim with ca2+ channels, snap-25, and synaptotagmin. |
Coppola T, etal., J Biol Chem 2001 Aug 31;276(35):32756-62.
|
10. |
Rab3A Inhibition of Ca2+ -Dependent Dopamine Release From PC12 Cells Involves Interaction With Synaptotagmin I. |
Dai Z, etal., J Cell Biochem. 2017 Nov;118(11):3696-3705. doi: 10.1002/jcb.26016. Epub 2017 May 16.
|
11. |
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. |
Davletov BA and Sudhof TC, J Biol Chem. 1993 Dec 15;268(35):26386-90.
|
12. |
Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I. |
Evans GJ and Morgan A, Biochem J 2002 Jun 1;364(Pt 2):343-7.
|
13. |
RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells. |
Fukuda M Biochem J. 2004 Jun 15;380(Pt 3):875-9.
|
14. |
Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. |
Fukuda M, etal., J Biol Chem. 2002 Feb 15;277(7):4601-4. Epub 2001 Dec 21.
|
15. |
The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complex. |
Galli T, etal., J Biol Chem. 1996 Jan 26;271(4):2193-8.
|
16. |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
|
17. |
Rat ISS GO annotations from GOA human gene data--August 2006 |
GOA data from the GO Consortium
|
18. |
Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. |
Harada A, etal., J Biol Chem 2000 Nov 24;275(47):36885-91.
|
19. |
Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells. |
Hayashi T, etal., Biochem Biophys Res Commun. 2012 Mar 16;419(3):511-6. doi: 10.1016/j.bbrc.2012.02.047. Epub 2012 Feb 15.
|
20. |
The calcium sensor synaptotagmin 1 is expressed and regulated in hippocampal postsynaptic spines. |
Hussain S, etal., Hippocampus. 2017 Nov;27(11):1168-1177. doi: 10.1002/hipo.22761. Epub 2017 Jul 24.
|
21. |
The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis. |
Jarousse N and Kelly RB, J Cell Biol. 2001 Aug 20;154(4):857-66. Epub 2001 Aug 13.
|
22. |
Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2. |
Jung N, etal., J Cell Biol. 2007 Dec 31;179(7):1497-510. doi: 10.1083/jcb.200708107.
|
23. |
Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. |
Ko J, etal., EMBO J. 2009 Oct 21;28(20):3244-55. doi: 10.1038/emboj.2009.249. Epub 2009 Sep 3.
|
24. |
The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. |
Krapivinsky G, etal., Neuron. 2006 Nov 9;52(3):485-96.
|
25. |
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
|
26. |
The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor. |
Lai Y and Shin YK, Biochem J. 2012 Apr 1;443(1):223-9. doi: 10.1042/BJ20112044.
|
27. |
Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. |
Li C, etal., Nature 1995 Jun 15;375(6532):594-9.
|
28. |
A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. |
Li H, etal., Nat Cell Biol. 2013 Jul;15(7):773-85. doi: 10.1038/ncb2791. Epub 2013 Jun 23.
|
29. |
A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes. |
Maienschein V, etal., Glia. 1999 May;26(3):233-44.
|
30. |
Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. |
Matthew WD, etal., J Cell Biol. 1981 Oct;91(1):257-69.
|
31. |
Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. |
Maximov A, etal., J Cell Biol. 2007 Jan 1;176(1):113-24. Epub 2006 Dec 26.
|
32. |
The juxtamembrane region of synaptotagmin 1 interacts with dynamin 1 and regulates vesicle fission during compensatory endocytosis in endocrine cells. |
McAdam RL, etal., J Cell Sci. 2015 Jun 15;128(12):2229-35. doi: 10.1242/jcs.161505. Epub 2015 May 11.
|
33. |
Rat ISS GO annotations from MGI mouse gene data--August 2006 |
MGD data from the GO Consortium
|
34. |
JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release. |
Mori Y, etal., EMBO J. 2008 Jan 9;27(1):76-87. Epub 2007 Nov 29.
|
35. |
Electronic Transfer of LocusLink and RefSeq Data |
NCBI rat LocusLink and RefSeq merged data July 26, 2002
|
36. |
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. |
Perin MS, etal., Nature 1990 May 17;345(6272):260-3.
|
37. |
GOA pipeline |
RGD automated data pipeline
|
38. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
|
39. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
|
40. |
Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltage-sensitive sodium channels. |
Sampo B, etal., Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3666-71.
|
41. |
Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin. |
Schivell AE, etal., J Biol Chem. 1996 Nov 1;271(44):27770-5.
|
42. |
Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions. |
Shin OH, etal., Neuron. 2003 Jan 9;37(1):99-108.
|
43. |
Molecular anatomy of a trafficking organelle. |
Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
|
44. |
Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism. |
Tang X, etal., Int J Biol Macromol. 2017 Mar;96:736-742. doi: 10.1016/j.ijbiomac.2016.12.074. Epub 2017 Jan 3.
|
45. |
Functional and biochemical analysis of the C2 domains of synaptotagmin IV. |
Thomas DM, etal., Mol Biol Cell. 1999 Jul;10(7):2285-95.
|
46. |
Two synaptotagmin genes, Syt1 and Syt4, are differentially regulated in adult brain and during postnatal development following kainic acid-induced seizures. |
Tocco G, etal., Brain Res Mol Brain Res 1996 Sep 1;40(2):229-39.
|
47. |
Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. |
Tokumaru H, etal., Brain Cell Biol. 2008 Dec;36(5-6):173-89. doi: 10.1007/s11068-008-9032-9. Epub 2009 Jan 9.
|
48. |
Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. |
Tucker WC, etal., J Cell Biol. 2003 Jul 21;162(2):199-209. Epub 2003 Jul 14.
|
49. |
Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold. |
van den Bogaart G, etal., J Biol Chem. 2012 May 11;287(20):16447-53. doi: 10.1074/jbc.M112.343418. Epub 2012 Mar 23.
|
50. |
Cis- and trans-membrane interactions of synaptotagmin-1. |
Vennekate W, etal., Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):11037-42. doi: 10.1073/pnas.1116326109. Epub 2012 Jun 18.
|
51. |
Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating. |
Walther K, etal., EMBO Rep. 2001 Jul;2(7):634-40. Epub 2001 Jul 3.
|
52. |
Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. |
Wang Z and Chapman ER, J Biol Chem. 2010 Oct 1;285(40):30759-66. doi: 10.1074/jbc.M110.137745. Epub 2010 Aug 5.
|
53. |
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. |
Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
|
54. |
Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin. |
Willshaw A, etal., FEBS Lett. 2004 Feb 13;559(1-3):13-21.
|
55. |
The synaptotagmins: calcium sensors for vesicular trafficking. |
Yoshihara M and Montana ES, Neuroscientist. 2004 Dec;10(6):566-74.
|
56. |
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. |
Yun HJ, etal., Exp Mol Med. 2013 Aug 16;45:e36. doi: 10.1038/emm.2013.68.
|
57. |
Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells. |
Zhang Z, etal., Mol Biol Cell. 2011 Jul 1;22(13):2324-36. doi: 10.1091/mbc.E11-02-0159. Epub 2011 May 5.
|
58. |
Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. |
Zhou Q, etal., Nature. 2015 Sep 3;525(7567):62-7. doi: 10.1038/nature14975. Epub 2015 Aug 17.
|
59. |
Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles. |
Zhu D, etal., Biochem Biophys Res Commun. 2007 Oct 5;361(4):922-7. Epub 2007 Jul 25.
|