Gc (GC, vitamin D binding protein) - Rat Genome Database

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Gene: Gc (GC, vitamin D binding protein) Rattus norvegicus
Analyze
Symbol: Gc
Name: GC, vitamin D binding protein
RGD ID: 2667
Description: Enables vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Located in axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein); INTERACTS WITH 1-naphthyl isothiocyanate; 2,6-dinitrotoluene; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DBP; DBP02; gc-globulin; group specific component; group-specific component; Group-specific component (vitamin D-binding protein); RATDBP02; VDB; Vdbp; vitamin D-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Scl11  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81418,916,255 - 18,951,670 (+)NCBIGRCr8
mRatBN7.21418,632,146 - 18,667,563 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1418,632,135 - 18,667,567 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1418,622,611 - 18,658,030 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01419,941,501 - 19,976,920 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01418,653,131 - 18,688,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01420,267,023 - 20,302,577 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,266,891 - 20,302,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,173,467 - 20,209,021 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,166,243 - 20,197,060 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11420,166,180 - 20,201,613 (+)NCBI
Celera1417,992,337 - 18,027,605 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium silicate  (ISO)
calcium(0)  (EXP)
carbon atom  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chromium trinitrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
diquat  (ISO)
doxorubicin  (EXP,ISO)
elemental carbon  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
genistein  (EXP)
glucose  (ISO)
glyphosate  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methidathion  (ISO)
methylmercury(1+)  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
olanzapine  (ISO)
ouabain  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pyrethrins  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sarin  (EXP)
senecionine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
tacrolimus hydrate  (EXP,ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
valproic acid  (EXP)
verapamil  (EXP)
vitamin D  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gel-based proteomics of liver cancer progression in rat. Albrethsen J, etal., Biochim Biophys Acta. 2011 Oct;1814(10):1367-76. Epub 2011 Jun 6.
2. Two-dimensional difference gel electrophoresis (DiGE) analysis of plasmas from dengue fever patients. Albuquerque LM, etal., J Proteome Res. 2009 Dec;8(12):5431-41.
3. An association between Gc (vitamin D-binding protein) alleles and susceptibility to rheumatic fever. Bahr GM, etal., Immunology. 1989 May;67(1):126-8.
4. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Serum and peritoneal evaluation of vitamin D-binding protein in women with endometriosis. Borkowski J, etal., Postepy Hig Med Dosw (Online). 2008 Mar 3;62:103-9.
6. Immunochemical measurement of the vitamin D-binding protein in rat serum. Bouillon R, etal., Endocrinology. 1978 Jun;102(6):1710-5.
7. Rat vitamin D binding protein. Determination of the full-length primary structure from cloned cDNA. Cooke NE J Biol Chem 1986 Mar 5;261(7):3441-50.
8. Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D. Daiger SP, etal., Proc Natl Acad Sci U S A. 1975 Jun;72(6):2076-80.
9. Bayesian approach to searching for susceptibility genes: Gc2 and EsD1 alleles and multiple sclerosis. Di Bacco M, etal., Coll Antropol. 2002 Jun;26(1):77-84.
10. Analysis of changes in acute-phase plasma proteins in an acute inflammatory response and in rheumatoid arthritis using two-dimensional gel electrophoresis. Doherty NS, etal., Electrophoresis. 1998 Feb;19(2):355-63.
11. Association of different allelic forms of group specific component with susceptibility to and clinical manifestation of human immunodeficiency virus infection. Eales LJ, etal., Lancet. 1987 May 2;1(8540):999-1002.
12. Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease. Eloranta JJ, etal., Pharmacogenet Genomics. 2011 Sep;21(9):559-64.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Questioning the role of actinfree Gc-Globulin as actin scavenger in neurodegenerative central nervous system disease: relationship to S-100B levels and blood-brain barrier function. Gressner OA, etal., Clin Chim Acta. 2009 Feb;400(1-2):86-90. Epub 2008 Oct 30.
16. Proteomic identification of biomarkers of vascular injury. Huang NF, etal., Am J Transl Res. 2011 Feb;3(2):139-48. Epub 2010 Nov 21.
17. Genetic-biochemical criteria for individual sensitivity in development of occupational bronchopulmonary diseases. Izmerov NF, etal., Cent Eur J Public Health. 2002 Jun;10(1-2):35-41.
18. Proteomics of the injured rat sciatic nerve reveals protein expression dynamics during regeneration. Jimenez CR, etal., Mol Cell Proteomics. 2005 Feb;4(2):120-32. Epub 2004 Oct 25.
19. Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus. Jirikowski GF, etal., Histochem Cell Biol. 2009 Mar;131(3):365-70. Epub 2008 Nov 26.
20. Associations of vitamin d binding protein gene polymorphisms with the development of peripheral arthritis and uveitis in ankylosing spondylitis. Jung KH, etal., J Rheumatol. 2011 Oct;38(10):2224-9. Epub 2011 Aug 15.
21. Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study. Kurylowicz A, etal., Exp Clin Endocrinol Diabetes. 2006 Jun;114(6):329-35.
22. Association of circulating 25-hydroxyvitamin D levels with hypertension and blood pressure values in Korean adults: A Mendelian randomization study on a subset of the Korea National Health and Nutrition Survey 2011-2012 population. Kwak SY, etal., Nutr Res Pract. 2019 Dec;13(6):498-508. doi: 10.4162/nrp.2019.13.6.498. Epub 2019 Aug 13.
23. Changes with malnutrition in the concentration of plasma vitamin D binding protein in growing rats. Laing CJ and Fraser DR, Br J Nutr. 2002 Aug;88(2):133-9.
24. Relationship between group-specific component protein and the development of asthma. Lee SH, etal., Am J Respir Crit Care Med. 2011 Sep 1;184(5):528-36.
25. Induction of cytosolic receptors for 1 alpha, 25-dihydroxyvitamin D3 in the immature rat uterus by oestradiol. Levy J, etal., J Endocrinol. 1984 Mar;100(3):265-9.
26. Proteomic profiles of bronchoalveolar lavage fluid from patients with ventilator-associated pneumonia by gel-assisted digestion and 2-D-LC/MS/MS. Lu YT, etal., Proteomics Clin Appl. 2008 Sep;2(9):1208-22. doi: 10.1002/prca.200800069. Epub 2008 Aug 7.
27. Vitamin-D dysregulation in early- and late-onset preeclampsia: A gestational-age matched study. Martin CB, etal., J Steroid Biochem Mol Biol. 2020 Oct;203:105729. doi: 10.1016/j.jsbmb.2020.105729. Epub 2020 Jul 15.
28. The vitamin D-binding protein, alpha-fetoprotein, albumin multigene family: detection of transcripts in multiple tissues. McLeod JF and Cooke NE, J Biol Chem 1989 Dec 25;264(36):21760-9.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS. Niino M, etal., J Neuroimmunol. 2002 Jun;127(1-2):177-9.
32. 1,25-Dihydroxyvitamin D and vitamin D-binding protein are both decreased in streptozotocin-diabetic rats. Nyomba BL, etal., Endocrinology. 1985 Jun;116(6):2483-8.
33. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. The HLA-DQB alleles and amino acid variants of the vitamin D-binding protein in diabetic patients in Alsace. Ongagna JC, etal., Clin Biochem. 2001 Feb;34(1):59-63.
36. Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers. Ottervald J, etal., J Proteomics. 2010 Apr 18;73(6):1117-32. Epub 2010 Jan 20.
37. Proteomic analysis of vitreous from diabetic macular edema. Ouchi M, etal., Exp Eye Res. 2005 Aug;81(2):176-82.
38. A polymorphism within the vitamin D-binding protein gene is associated with Graves' disease but not with Hashimoto's thyroiditis. Pani MA, etal., J Clin Endocrinol Metab. 2002 Jun;87(6):2564-7.
39. Association of single nucleotide polymorphisms in VDR and DBP genes with HBV-related hepatocellular carcinoma risk in a Chinese population. Peng Q, etal., PLoS One. 2014 Dec 26;9(12):e116026. doi: 10.1371/journal.pone.0116026. eCollection 2014.
40. Alteration of DBP levels in CSF of patients with MS by proteomics analysis. Qin Z, etal., Cell Mol Neurobiol. 2009 Mar;29(2):203-10. Epub 2008 Sep 19.
41. The rat vitamin D binding protein (Gc-globulin) gene. Structural analysis, functional and evolutionary correlations. Ray K, etal., J Biol Chem 1991 Apr 5;266(10):6221-9.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Protein expression profiles in pediatric multiple sclerosis: potential biomarkers. Rithidech KN, etal., Mult Scler. 2009 Apr;15(4):455-64.
46. Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment. Rozek W, etal., J Proteome Res. 2007 Nov;6(11):4189-99. Epub 2007 Oct 12.
47. Vitamin D binding protein variants and the risk of COPD. Schellenberg D, etal., Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):957-61.
48. Increased turnover of Gc-globulin in patients with hepatic encephalopathy. Schiodt FV, etal., Scand J Gastroenterol. 2001 Sep;36(9):998-1003.
49. Acute-phase proteins before cerebral ischemia in stroke-prone rats: identification by proteomics. Sironi L, etal., Stroke. 2001 Mar;32(3):753-60.
50. Vitamin D-binding protein gene transcription is regulated by the relative abundance of hepatocyte nuclear factors 1alpha and 1beta. Song YH, etal., J Biol Chem 1998 Oct 23;273(43):28408-18.
51. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
52. Electrophoretic mobility shift assay identifies vitamin D binding protein (Gc-globulin) in human, rat, and mouse sera. Tang WX, etal., Anal Biochem. 1996 Jun 1;237(2):245-51.
53. Vitamin D and bone mineral homeostasis during pregnancy in the diabetic BB rat. Verhaeghe J, etal., Endocrinology. 1986 Mar;118(3):1019-25.
54. Differential proteomic characterization between normal peritoneal fluid and diabetic peritoneal dialysate. Wang HY, etal., Nephrol Dial Transplant. 2010 Jun;25(6):1955-63. Epub 2010 Jan 6.
55. Serum proteomic analysis of extracorporeal shock wave therapy-enhanced diabetic wound healing in a streptozotocin-induced diabetes model. Yang MY, etal., Plast Reconstr Surg. 2014 Jan;133(1):59-68. doi: 10.1097/01.prs.0000439050.08733.cf.
Additional References at PubMed
PMID:3713442   PMID:11799400   PMID:12119014   PMID:15225763   PMID:16502470   PMID:22516433   PMID:23339019   PMID:23376485   PMID:23533145   PMID:31792309  


Genomics

Comparative Map Data
Gc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81418,916,255 - 18,951,670 (+)NCBIGRCr8
mRatBN7.21418,632,146 - 18,667,563 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1418,632,135 - 18,667,567 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1418,622,611 - 18,658,030 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01419,941,501 - 19,976,920 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01418,653,131 - 18,688,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01420,267,023 - 20,302,577 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,266,891 - 20,302,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,173,467 - 20,209,021 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,166,243 - 20,197,060 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11420,166,180 - 20,201,613 (+)NCBI
Celera1417,992,337 - 18,027,605 (+)NCBICelera
Cytogenetic Map14p22NCBI
GC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38471,741,693 - 71,805,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl471,741,696 - 71,804,041 (-)EnsemblGRCh38hg38GRCh38
GRCh37472,607,410 - 72,671,237 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36472,826,274 - 72,868,752 (-)NCBINCBI36Build 36hg18NCBI36
Build 34472,972,446 - 73,014,923NCBI
Celera469,964,129 - 70,006,624 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef468,412,706 - 68,476,557 (-)NCBIHuRef
CHM1_1472,643,398 - 72,707,216 (-)NCBICHM1_1
T2T-CHM13v2.0475,084,117 - 75,147,957 (-)NCBIT2T-CHM13v2.0
Gc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39589,565,370 - 89,605,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl589,565,381 - 89,605,757 (-)EnsemblGRCm39 Ensembl
GRCm38589,417,511 - 89,457,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl589,417,522 - 89,457,898 (-)EnsemblGRCm38mm10GRCm38
MGSCv37589,846,547 - 89,886,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36590,492,721 - 90,532,964 (-)NCBIMGSCv36mm8
Celera587,554,559 - 87,593,435 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.32NCBI
Gc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554471,361,566 - 1,402,491 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554471,361,698 - 1,400,633 (+)NCBIChiLan1.0ChiLan1.0
GC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2358,270,055 - 58,332,433 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1458,466,887 - 58,529,283 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0452,431,196 - 52,473,762 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1458,749,384 - 58,792,073 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl458,729,236 - 58,792,073 (+)Ensemblpanpan1.1panPan2
GC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11360,795,305 - 60,828,038 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1360,795,305 - 60,827,929 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1360,528,533 - 60,561,906 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01361,603,086 - 61,636,545 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1361,603,088 - 61,652,533 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11361,215,897 - 61,249,598 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01360,708,804 - 60,742,244 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01361,856,182 - 61,889,922 (-)NCBIUU_Cfam_GSD_1.0
Gc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528514,767,874 - 14,809,615 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365983,219,991 - 3,261,629 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365983,220,029 - 3,256,091 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl868,326,299 - 68,360,262 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1868,326,293 - 68,360,262 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2872,227,896 - 72,261,806 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1720,254,604 - 20,298,384 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl720,253,879 - 20,298,265 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660842,553,410 - 2,596,840 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248903,226,900 - 3,318,316 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248903,274,239 - 3,318,281 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gc
386 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000004174
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141757341219726296Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat

Markers in Region
D14Mgh3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21418,631,345 - 18,631,470 (+)MAPPERmRatBN7.2
Rnor_6.01420,266,223 - 20,266,347NCBIRnor6.0
Rnor_5.01420,172,667 - 20,172,791UniSTSRnor5.0
RGSC_v3.41420,165,393 - 20,165,518RGDRGSC3.4
RGSC_v3.41420,165,394 - 20,165,518UniSTSRGSC3.4
RGSC_v3.11420,165,393 - 20,165,518RGD
Celera1417,991,537 - 17,991,661UniSTS
RH 3.4 Map14265.8UniSTS
RH 3.4 Map14265.8RGD
RH 2.0 Map14260.2RGD
Cytogenetic Map14p22UniSTS
D14Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21418,644,043 - 18,644,232 (+)MAPPERmRatBN7.2
Rnor_6.01420,278,921 - 20,279,109NCBIRnor6.0
Rnor_5.01420,185,365 - 20,185,553UniSTSRnor5.0
RGSC_v3.41420,178,091 - 20,178,280RGDRGSC3.4
RGSC_v3.41420,178,092 - 20,178,280UniSTSRGSC3.4
RGSC_v3.11420,178,091 - 20,178,280RGD
Celera1418,004,268 - 18,004,454UniSTS
RH 3.4 Map14264.4UniSTS
RH 3.4 Map14264.4RGD
RH 2.0 Map14263.7RGD
Cytogenetic Map14p22UniSTS
D14Arb17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21418,644,012 - 18,644,233 (+)MAPPERmRatBN7.2
Rnor_6.01420,278,890 - 20,279,110NCBIRnor6.0
Rnor_5.01420,185,334 - 20,185,554UniSTSRnor5.0
RGSC_v3.41420,178,060 - 20,178,281RGDRGSC3.4
RGSC_v3.41420,178,061 - 20,178,281UniSTSRGSC3.4
RGSC_v3.11420,178,060 - 20,178,281RGD
Celera1418,004,237 - 18,004,455UniSTS
SHRSP x BN Map146.9UniSTS
SHRSP x BN Map146.9RGD
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 27 27 27
Medium 1 17 14 14 2 2 1 9 2 3 2
Low 7 13 18 6 7 14 22 27 5 6
Below cutoff 3 4 1 10 4 9 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH002167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000004174   ⟹   ENSRNOP00000004174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1418,632,135 - 18,667,567 (+)Ensembl
Rnor_6.0 Ensembl1420,266,891 - 20,302,581 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098849   ⟹   ENSRNOP00000083512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1418,642,699 - 18,658,586 (+)Ensembl
RefSeq Acc Id: NM_012564   ⟹   NP_036696
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81418,916,255 - 18,951,670 (+)NCBI
mRatBN7.21418,632,146 - 18,667,563 (+)NCBI
Rnor_6.01420,267,023 - 20,302,577 (+)NCBI
Rnor_5.01420,173,467 - 20,209,021 (+)NCBI
RGSC_v3.41420,166,243 - 20,197,060 (+)RGD
Celera1417,992,337 - 18,027,605 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036696   ⟸   NM_012564
- Peptide Label: precursor
- UniProtKB: P04276 (UniProtKB/Swiss-Prot),   Q68FY4 (UniProtKB/TrEMBL),   A6KKH1 (UniProtKB/TrEMBL),   F7FJ08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004174   ⟸   ENSRNOT00000004174
RefSeq Acc Id: ENSRNOP00000083512   ⟸   ENSRNOT00000098849
Protein Domains
Albumin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04276-F1-model_v2 AlphaFold P04276 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699237
Promoter ID:EPDNEW_R9761
Type:initiation region
Name:Gc_1
Description:GC, vitamin D binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01420,267,014 - 20,267,074EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2667 AgrOrtholog
BioCyc Gene G2FUF-16172 BioCyc
Ensembl Genes ENSRNOG00000003119 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004174 ENTREZGENE
  ENSRNOT00000004174.5 UniProtKB/TrEMBL
  ENSRNOT00000098849.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.246.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130137 IMAGE-MGC_LOAD
InterPro ALB/AFP/VDB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serum_albumin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serum_albumin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serum_albumin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VitD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VitD-bind_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24384 UniProtKB/TrEMBL
MGC_CLONE MGC:93612 IMAGE-MGC_LOAD
NCBI Gene 24384 ENTREZGENE
PANTHER PTHR11385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11385:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serum_albumin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VitD-bind_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gc PhenoGen
PRINTS SERUMALBUMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VITAMNDBNDNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALBUMIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALBUMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003119 RatGTEx
SMART ALBUMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZW66_RAT UniProtKB/TrEMBL
  A6KKH1 ENTREZGENE, UniProtKB/TrEMBL
  A6KKH2_RAT UniProtKB/TrEMBL
  A6KKH3_RAT UniProtKB/TrEMBL
  F7FJ08 ENTREZGENE, UniProtKB/TrEMBL
  P04276 ENTREZGENE
  Q68FY4 ENTREZGENE
  VTDB_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q68FY4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Gc  GC, vitamin D binding protein  Gc  group specific component  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gc  Group-specific component (vitamin D-binding protein)      Symbol and Name status set to approved 70586 APPROVED