Cryab (crystallin, alpha B) - Rat Genome Database

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Gene: Cryab (crystallin, alpha B) Rattus norvegicus
Analyze
Symbol: Cryab
Name: crystallin, alpha B
RGD ID: 2414
Description: Enables microtubule binding activity. Involved in several processes, including response to estradiol; response to hydrogen peroxide; and stress-activated MAPK cascade. Located in several cellular components, including dendritic spine; myofibril; and perikaryon. Biomarker of cataract and macular degeneration. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAB (crystallin alpha B); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AACRYA; alpha B-crystallin; alpha(B)-crystallin; alpha-crystallin B chain; crystallin alpha polypeptide 2; crystallin, alpha polypeptide 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,989,885 - 59,995,532 (+)NCBIGRCr8
mRatBN7.2851,093,441 - 51,099,161 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,093,441 - 51,099,157 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,601,359 - 56,605,151 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,880,286 - 54,884,078 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,744,541 - 52,748,333 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,178,543 - 55,182,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,178,289 - 55,182,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,776,100 - 53,779,780 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,107,824 - 54,111,502 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1854,126,302 - 54,130,559 (+)NCBI
Celera850,642,744 - 50,646,745 (+)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-diaminotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-nitroquinoline N-oxide  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
arecoline  (ISO)
aristolochic acid A  (EXP)
arotinoid acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Aurin  (ISO)
azetidinecarboxylic acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (EXP,ISO)
bromoacetate  (ISO)
bucladesine  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
captan  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (EXP)
CHIR 99021  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dihydroxyacetone  (ISO)
Diisodecyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
glutathione  (EXP)
glycidol  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
iopamidol  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
lead nitrate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese(II) chloride  (EXP)
masoprocol  (EXP)
melittin  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methanol  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP)
morphine  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
ochratoxin A  (EXP)
orphenadrine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
prostaglandin A1  (EXP)
prostaglandin A2  (EXP)
prostaglandin D2  (EXP)
prostaglandin E2  (EXP)
prostaglandin J2  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
scopolamine  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium nitrate  (ISO)
sodium tungstate  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
ursodeoxycholic acid  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zinc atom  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of the specifically targeted lysine residues in the glycation dependent loss of chaperone activity of alpha A- and alpha B-crystallins. Abraham EC, etal., Mol Cell Biochem. 2008 Mar;310(1-2):235-9. Epub 2007 Dec 25.
2. Oxidative stress and calpain inhibition induce alpha B-crystallin phosphorylation via p38-MAPK and calcium signalling pathways in H9c2 cells. Aggeli IK, etal., Cell Signal. 2008 Jul;20(7):1292-302. Epub 2008 Mar 4.
3. alpha B subunit of lens-specific protein alpha-crystallin is present in other ocular and non-ocular tissues. Bhat SP and Nagineni CN, Biochem Biophys Res Commun 1989 Jan 16;158(1):319-25.
4. Aging skeletal muscle shows a drastic increase in the small heat shock proteins alphaB-crystallin/HspB5 and cvHsp/HspB7. Doran P, etal., Eur J Cell Biol. 2007 Oct;86(10):629-40. Epub 2007 Aug 29.
5. alphaB-Crystallin-coated MAP microtubule resists nocodazole and calcium-induced disassembly. Fujita Y, etal., J Cell Sci. 2004 Apr 1;117(Pt 9):1719-26. Epub 2004 Mar 9.
6. Small heat shock protein alphaB-crystallin is part of cell cycle-dependent Golgi reorganization. Gangalum RK, etal., J Biol Chem. 2004 Oct 15;279(42):43374-7. Epub 2004 Aug 31.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin. Golenhofen N, etal., J Mol Cell Cardiol 2002 Mar;34(3):309-19.
10. Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage. Hsu JT, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2982-7. Epub 2007 Feb 9.
11. Multiple mRNAs of rat brain alpha-crystallin B chain result from alternative transcriptional initiation. Iwaki A, etal., J Biol Chem 1990 Dec 25;265(36):22197-203.
12. Disulfide cross-links in the interaction of a cataract-linked alphaA-crystallin mutant with betaB1-crystallin. Kumar MS, etal., FEBS Lett. 2009 Jan 5;583(1):175-9. doi: 10.1016/j.febslet.2008.11.047. Epub 2008 Dec 9.
13. Alpha B-crystallin suppresses pressure overload cardiac hypertrophy. Kumarapeli AR, etal., Circ Res. 2008 Dec 5;103(12):1473-82. Epub 2008 Oct 30.
14. AlphaB-crystallin inhibits glucose-induced apoptosis in vascular endothelial cells. Liu B, etal., Biochem Biophys Res Commun. 2004 Aug 13;321(1):254-8.
15. Abundance and location of the small heat shock proteins HSP25 and alphaB-crystallin in rat and human heart. Lutsch G, etal., Circulation. 1997 Nov 18;96(10):3466-76.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. The mitochondria-targeted antioxidant SkQ1 restores aB-crystallin expression and protects against AMD-like retinopathy in OXYS rats. Muraleva NA, etal., Cell Cycle. 2014;13(22):3499-505. doi: 10.4161/15384101.2014.958393.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Changes in physicochemical parameters and alpha-crystallin expression in the lens during cataract development in OXYS rats. 5. Rumyantseva YV, etal., Biochemistry (Mosc). 2008 Nov;73(11):1176-82.
26. Phosphorylation-dependent subcellular localization of the small heat shock proteins HspB1/Hsp25 and HspB5/alphaB-crystallin in cultured hippocampal neurons. Schmidt T, etal., Histochem Cell Biol. 2012 Sep;138(3):407-18. doi: 10.1007/s00418-012-0964-x. Epub 2012 May 23.
27. Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation. Sugiyama Y, etal., J Biol Chem. 2000 Jan 14;275(2):1095-104.
Additional References at PubMed
PMID:1764082   PMID:1765091   PMID:1783614   PMID:8282729   PMID:8639509   PMID:10751411   PMID:11687538   PMID:12235146   PMID:12546709   PMID:12601044   PMID:14575708   PMID:14627610  
PMID:14752512   PMID:15308659   PMID:15856211   PMID:16303126   PMID:16439475   PMID:16675842   PMID:16680485   PMID:17092938   PMID:17196975   PMID:17438522   PMID:17634366   PMID:17893660  
PMID:18191123   PMID:18330356   PMID:18566458   PMID:19056867   PMID:19340546   PMID:19379782   PMID:19464326   PMID:19558454   PMID:19646995   PMID:19651604   PMID:20587334   PMID:20723582  
PMID:20802487   PMID:21311744   PMID:21423662   PMID:21464278   PMID:21617129   PMID:21777656   PMID:21975426   PMID:22143763   PMID:22153508   PMID:23071119   PMID:23106396   PMID:23153557  
PMID:23188086   PMID:23212619   PMID:23264262   PMID:23376485   PMID:23386121   PMID:23508955   PMID:23533145   PMID:23542032   PMID:23543138   PMID:23546289   PMID:23559016   PMID:24103517  
PMID:24183572   PMID:24464634   PMID:24466295   PMID:25319025   PMID:25596465   PMID:26465331   PMID:26475352   PMID:26708692   PMID:27085702   PMID:27226619   PMID:27264546   PMID:27851782  
PMID:28425051   PMID:28502773   PMID:29542021   PMID:30246229   PMID:30463298   PMID:31970633   PMID:32016842   PMID:32554860   PMID:33220080   PMID:35352799  


Genomics

Comparative Map Data
Cryab
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,989,885 - 59,995,532 (+)NCBIGRCr8
mRatBN7.2851,093,441 - 51,099,161 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,093,441 - 51,099,157 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,601,359 - 56,605,151 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,880,286 - 54,884,078 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,744,541 - 52,748,333 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,178,543 - 55,182,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,178,289 - 55,182,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,776,100 - 53,779,780 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,107,824 - 54,111,502 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1854,126,302 - 54,130,559 (+)NCBI
Celera850,642,744 - 50,646,745 (+)NCBICelera
Cytogenetic Map8q23NCBI
CRYAB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811111,908,564 - 111,923,740 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11111,908,564 - 111,923,722 (-)EnsemblGRCh38hg38GRCh38
GRCh3711111,779,288 - 111,794,464 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,284,560 - 111,287,683 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411111,284,559 - 111,287,683NCBI
Celera11108,932,558 - 108,935,681 (-)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,703,256 - 107,706,379 (-)NCBIHuRef
CHM1_111111,662,430 - 111,665,553 (-)NCBICHM1_1
T2T-CHM13v2.011111,918,808 - 111,933,984 (-)NCBIT2T-CHM13v2.0
Cryab
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,657,251 - 50,667,936 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,662,625 - 50,667,936 (+)EnsemblGRCm39 Ensembl
GRCm38950,745,951 - 50,756,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,751,325 - 50,756,636 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,560,863 - 50,564,738 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,504,988 - 50,508,863 (+)NCBIMGSCv36mm8
Celera948,039,922 - 48,043,797 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Cryab
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,625,363 - 13,640,426 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,626,018 - 13,629,495 (-)NCBIChiLan1.0ChiLan1.0
CRYAB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,659,159 - 112,682,506 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,753,439 - 113,756,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011106,795,406 - 106,800,019 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,639,442 - 110,644,245 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,639,442 - 110,644,272 (-)Ensemblpanpan1.1panPan2
CRYAB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,181,836 - 21,185,164 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,179,936 - 21,360,132 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha521,104,096 - 21,107,406 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,204,772 - 21,208,082 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,204,907 - 21,208,076 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,266,069 - 21,269,377 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,166,521 - 21,169,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,215,316 - 21,218,626 (+)NCBIUU_Cfam_GSD_1.0
Cryab
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,169,136 - 94,173,881 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,532,812 - 2,537,495 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,532,851 - 2,536,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRYAB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,638,506 - 39,643,530 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,638,505 - 39,643,530 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,428,979 - 44,433,758 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRYAB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,258,715 - 103,263,274 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,257,347 - 103,261,990 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,707,897 - 22,722,116 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cryab
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,074,590 - 7,093,054 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,074,590 - 7,093,471 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cryab
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:85
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000059127
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat

Markers in Region
RH143847  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,093,454 - 51,093,594 (+)MAPPERmRatBN7.2
Rnor_6.0855,176,840 - 55,176,979NCBIRnor6.0
Rnor_5.0853,774,076 - 53,774,215UniSTSRnor5.0
RGSC_v3.4854,105,800 - 54,105,939UniSTSRGSC3.4
Celera850,641,041 - 50,641,180UniSTS
Cytogenetic Map8q23UniSTS
PMC123035P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,094,546 - 51,095,517 (+)MAPPERmRatBN7.2
Rnor_6.0855,177,932 - 55,178,902NCBIRnor6.0
Rnor_5.0853,775,168 - 53,776,138UniSTSRnor5.0
RGSC_v3.4854,106,892 - 54,107,862UniSTSRGSC3.4
Celera850,642,133 - 50,643,103UniSTS
Cytogenetic Map8q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 25 1 2 1
Medium 3 18 4 2 9 2 7 9 24 29 23 11 7
Low 53 39 10 39 46 6 18
Below cutoff 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK357656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000059127   ⟹   ENSRNOP00000055901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl851,093,441 - 51,099,157 (+)Ensembl
Rnor_6.0 Ensembl855,178,289 - 55,182,545 (+)Ensembl
RefSeq Acc Id: NM_012935   ⟹   NP_037067
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,991,531 - 59,995,532 (+)NCBI
mRatBN7.2851,095,158 - 51,099,161 (+)NCBI
Rnor_6.0855,178,543 - 55,182,546 (+)NCBI
Rnor_5.0853,776,100 - 53,779,780 (+)NCBI
RGSC_v3.4854,107,824 - 54,111,502 (+)RGD
Celera850,642,744 - 50,646,745 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080878   ⟹   XP_038936806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,991,469 - 59,995,532 (+)NCBI
mRatBN7.2851,095,199 - 51,099,161 (+)NCBI
RefSeq Acc Id: XM_039080879   ⟹   XP_038936807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,989,885 - 59,995,532 (+)NCBI
mRatBN7.2851,093,441 - 51,099,161 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_037067   ⟸   NM_012935
- UniProtKB: Q6LDR2 (UniProtKB/Swiss-Prot),   P23928 (UniProtKB/Swiss-Prot),   A6J4F4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000055901   ⟸   ENSRNOT00000059127
RefSeq Acc Id: XP_038936807   ⟸   XM_039080879
- Peptide Label: isoform X1
- UniProtKB: P23928 (UniProtKB/Swiss-Prot),   Q6LDR2 (UniProtKB/Swiss-Prot),   A6J4F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936806   ⟸   XM_039080878
- Peptide Label: isoform X1
- UniProtKB: P23928 (UniProtKB/Swiss-Prot),   Q6LDR2 (UniProtKB/Swiss-Prot),   A6J4F4 (UniProtKB/TrEMBL)
Protein Domains
sHSP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23928-F1-model_v2 AlphaFold P23928 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695953
Promoter ID:EPDNEW_R6477
Type:initiation region
Name:Cryab_1
Description:crystallin, alpha B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0855,178,828 - 55,178,888EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2414 AgrOrtholog
BioCyc Gene G2FUF-30550 BioCyc
Ensembl Genes ENSRNOG00000010524 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055029072 UniProtKB/Swiss-Prot
  ENSRNOG00060014408 UniProtKB/Swiss-Prot
  ENSRNOG00065017518 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000059127.4 UniProtKB/Swiss-Prot
  ENSRNOT00055050334 UniProtKB/Swiss-Prot
  ENSRNOT00060024605 UniProtKB/Swiss-Prot
  ENSRNOT00065029284 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A-crystallin/Hsp20_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACD_alphaB-crystallin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-crystallin/HSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-crystallin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP20-like_chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25420 ENTREZGENE
PANTHER ALPHA-CRYSTALLIN B CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEAT SHOCK PROTEIN HSP-12.2-RELATED UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Crystallin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cryab PhenoGen
PIRSF Sm_HSP_B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ACRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SHSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010524 RatGTEx
  ENSRNOG00055029072 RatGTEx
  ENSRNOG00060014408 RatGTEx
  ENSRNOG00065017518 RatGTEx
Superfamily-SCOP HSP20-like chaperones UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6J4F4 ENTREZGENE, UniProtKB/TrEMBL
  A6J4F7_RAT UniProtKB/TrEMBL
  CRYAB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6LDR2 ENTREZGENE
UniProt Secondary Q6LDR2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Cryab  crystallin, alpha B    Crystallin, alpha polypeptide 2  Name updated 625702 APPROVED
2002-06-10 Cryab  Crystallin, alpha polypeptide 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization translocated to the N(2)-line area of myofibrillar I-bands of cardiomyocytes during ischemia 704398