Atg5 (autophagy related 5) - Rat Genome Database

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Gene: Atg5 (autophagy related 5) Rattus norvegicus
Analyze
Symbol: Atg5
Name: autophagy related 5
RGD ID: 1359580
Description: Predicted to contribute to Atg8-family ligase activity. Involved in several processes, including chaperone-mediated autophagy; positive regulation of stress granule assembly; and response to iron(II) ion. Located in axon. Part of protein-containing complex. Biomarker of ischemia. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (autophagy related 5); PARTICIPATES IN autophagy pathway; Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 3-methyladenine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: APG5 autophagy 5-like; ATG5 autophagy related 5 homolog; ATG5 autophagy related 5 homolog (S. cerevisiae); autophagy protein 5; LOC365601; similar to autophagy 5-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82049,380,835 - 49,471,826 (+)NCBIGRCr8
mRatBN7.22047,798,217 - 47,889,216 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2047,798,290 - 47,889,209 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2049,539,098 - 49,629,485 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02049,188,983 - 49,279,371 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02049,872,609 - 49,962,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02049,301,783 - 49,393,147 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2049,318,308 - 49,393,140 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02050,934,688 - 51,026,125 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42048,273,977 - 48,366,743 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12048,302,673 - 48,395,435 (+)NCBI
Celera2052,117,260 - 52,207,732 (-)NCBICelera
Cytogenetic Map20q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP,ISO)
4'-epidoxorubicin  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-amanitin  (EXP,ISO)
alpha-D-galactose  (EXP)
alpha-pinene  (ISO)
Alpinetin  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buprofezin  (ISO)
butachlor  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
candesartan  (EXP)
capsaicin  (ISO)
carbamazepine  (EXP)
carbon disulfide  (ISO)
carbon nanotube  (EXP,ISO)
carglumic acid  (ISO)
CGP 52608  (ISO)
chloroquine  (EXP,ISO)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
colistin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
curcumin  (ISO)
Curcumol  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
diphenhydramine  (ISO)
disodium selenite  (ISO)
Doramectin  (EXP,ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (ISO)
embelin  (ISO)
erastin  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ferric oxide  (ISO)
ferrostatin-1  (EXP)
fingolimod hydrochloride  (ISO)
flavokawain B  (ISO)
flutamide  (EXP)
folic acid  (ISO)
Fusaric acid  (ISO)
galactose  (EXP)
gefitinib  (ISO)
genistein  (ISO)
geraniol  (ISO)
glucose  (EXP)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glyphosate  (ISO)
gossypetin  (ISO)
hesperetin  (EXP)
hexadecanoic acid  (EXP,ISO)
HU-308  (ISO)
hyaluronic acid  (EXP)
hydroquinone  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
JTE-013  (EXP)
kainic acid  (EXP)
L-leucine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
levamisole  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP,ISO)
LY294002  (ISO)
lycopene  (ISO)
melatonin  (ISO)
menadione  (EXP,ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
microcystin-LR  (ISO)
mitoxantrone  (ISO)
MJN110  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
Nonidet P-40  (ISO)
obeticholic acid  (ISO)
oleanolic acid  (ISO)
oligopeptide  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
Paeonol  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
promethazine  (ISO)
propiconazole  (ISO)
pterostilbene  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
roxadustat  (EXP)
ruthenium red  (EXP)
Sanggenon C  (EXP)
SB 203580  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
swainsonine  (EXP,ISO)
T-2 toxin  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thiacloprid  (ISO)
thymoquinone  (ISO)
trans-piceid  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP,ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aggrephagy  (IEA,ISO)
antigen processing and presentation of endogenous antigen  (IEA,ISO)
apoptotic process  (ISO)
autophagosome assembly  (IEA,IMP,ISO)
autophagy  (IMP,ISO,ISS)
blood vessel remodeling  (IEA,ISO)
cardiac muscle cell apoptotic process  (IEA,ISO)
cellular response to nitrogen starvation  (IBA,IEA)
cellular response to nitrosative stress  (IEA,ISO)
cellular response to starvation  (ISO)
chaperone-mediated autophagy  (IMP)
chromatin organization  (IEA,ISO)
defense response to virus  (ISO)
establishment of localization in cell  (IEA,ISO)
heart contraction  (IEA,ISO)
innate immune response  (ISO)
macroautophagy  (ISO)
mitophagy  (IEA,ISO)
mucus secretion  (IEA,ISO)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of autophagic cell death  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of defense response to virus  (IEA,ISO)
negative regulation of innate immune response  (IEA,ISO)
negative regulation of phagocytosis  (IEA,ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of reactive oxygen species metabolic process  (IEA,ISO)
negative regulation of type I interferon production  (IEA,ISO)
negative stranded viral RNA replication  (IEA,ISO)
negative thymic T cell selection  (IEA,ISO)
nucleophagy  (IEA)
otolith development  (IEA,ISO)
piecemeal microautophagy of the nucleus  (IBA)
positive regulation of mucus secretion  (IEA,ISO)
positive regulation of stress granule assembly  (IMP)
positive regulation of viral translation  (IEA,ISO)
post-translational protein modification  (ISO)
protein ubiquitination  (IEA,ISO)
regulation of autophagosome maturation  (IEA,ISO)
regulation of cilium assembly  (IEA,ISO,ISS)
regulation of cytokine production involved in immune response  (IEA,ISO)
regulation of reactive oxygen species metabolic process  (ISO)
regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
response to fluoride  (IEP)
response to fungus  (IEA,ISO)
response to iron(II) ion  (IEP)
response to xenobiotic stimulus  (IEA,ISO)
vasodilation  (IEA,ISO)
ventricular cardiac muscle cell development  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Castillo K, etal., Autophagy. 2013 Sep;9(9):1308-20. doi: 10.4161/auto.25188. Epub 2013 Jun 6.
2. Induction of autophagic cell death in the rat brain caused by iron. Chen G, etal., Am J Med Sci. 2013 May;345(5):369-74. doi: 10.1097/MAJ.0b013e318271c031.
3. Cold ischemia-induced autophagy in rat lung tissue. Chen X, etal., Mol Med Rep. 2015 Apr;11(4):2513-9. doi: 10.3892/mmr.2014.2999. Epub 2014 Nov 26.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. Jiang M, etal., Am J Pathol. 2010 Mar;176(3):1181-92. doi: 10.2353/ajpath.2010.090594. Epub 2010 Jan 14.
7. Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Kochl R, etal., Traffic. 2006 Feb;7(2):129-45.
8. Changes in autophagy after traumatic brain injury. Liu CL, etal., J Cereb Blood Flow Metab. 2008 Apr;28(4):674-83. Epub 2007 Dec 5.
9. RNA interference may suppress stress granule formation by preventing argonaute 2 recruitment. Lou Q, etal., Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C81-C91. doi: 10.1152/ajpcell.00251.2018. Epub 2018 Nov 7.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Early and sustained activation of autophagy in degenerating axons after spinal cord injury. Ribas VT, etal., Brain Pathol. 2015 Mar;25(2):157-70. doi: 10.1111/bpa.12170. Epub 2014 Sep 12.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Sirtuin1 and autophagy protect cells from fluoride-induced cell stress. Suzuki M and Bartlett JD, Biochim Biophys Acta. 2014 Feb;1842(2):245-55. doi: 10.1016/j.bbadis.2013.11.023. Epub 2013 Dec 1.
17. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Ulbricht A, etal., Curr Biol. 2013 Mar 4;23(5):430-5. doi: 10.1016/j.cub.2013.01.064. Epub 2013 Feb 21.
18. Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. Weng LQ, etal., Acta Pharmacol Sin. 2014 Aug;35(8):1005-14. doi: 10.1038/aps.2014.45. Epub 2014 Jul 7.
19. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
Additional References at PubMed
PMID:11266458   PMID:15292400   PMID:17450150   PMID:19273585   PMID:19783847   PMID:20190558   PMID:20453062   PMID:20577052   PMID:22496425   PMID:22710871   PMID:22982048   PMID:23093945  
PMID:23382543   PMID:23446737   PMID:23455425   PMID:23704209   PMID:23863932   PMID:23878245   PMID:23918802   PMID:24035364   PMID:24089205   PMID:24089209   PMID:24185898   PMID:24550300  
PMID:24582693   PMID:26251076   PMID:26812546   PMID:28231469   PMID:28389568   PMID:29241069   PMID:29799519   PMID:30864677   PMID:33831322   PMID:34734681   PMID:34958937   PMID:35927903  


Genomics

Comparative Map Data
Atg5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82049,380,835 - 49,471,826 (+)NCBIGRCr8
mRatBN7.22047,798,217 - 47,889,216 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2047,798,290 - 47,889,209 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2049,539,098 - 49,629,485 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02049,188,983 - 49,279,371 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02049,872,609 - 49,962,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02049,301,783 - 49,393,147 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2049,318,308 - 49,393,140 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02050,934,688 - 51,026,125 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42048,273,977 - 48,366,743 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12048,302,673 - 48,395,435 (+)NCBI
Celera2052,117,260 - 52,207,732 (-)NCBICelera
Cytogenetic Map20q13NCBI
ATG5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386106,184,476 - 106,325,760 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6106,045,423 - 106,325,791 (-)EnsemblGRCh38hg38GRCh38
GRCh376106,632,351 - 106,773,635 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366106,739,045 - 106,880,388 (-)NCBINCBI36Build 36hg18NCBI36
Build 346106,739,044 - 106,880,359NCBI
Celera6107,253,905 - 107,395,251 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6104,079,375 - 104,220,613 (-)NCBIHuRef
CHM1_16106,894,763 - 107,036,172 (-)NCBICHM1_1
T2T-CHM13v2.06107,360,315 - 107,501,922 (-)NCBIT2T-CHM13v2.0
Atg5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391044,144,325 - 44,240,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1044,144,354 - 44,240,287 (+)EnsemblGRCm39 Ensembl
GRCm381044,268,322 - 44,364,299 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1044,268,358 - 44,364,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv371043,988,164 - 44,084,097 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361043,956,773 - 44,052,706 (+)NCBIMGSCv36mm8
Celera1045,141,131 - 45,237,099 (+)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1023.24NCBI
Atg5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541131,522,420 - 31,646,827 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541131,501,191 - 31,646,407 (-)NCBIChiLan1.0ChiLan1.0
ATG5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25126,183,703 - 126,346,578 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16124,071,501 - 124,233,849 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06103,997,824 - 104,140,931 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16107,871,201 - 108,027,064 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6107,871,208 - 108,013,807 (-)Ensemblpanpan1.1panPan2
ATG5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11263,565,859 - 63,692,383 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1263,567,568 - 63,683,485 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1263,353,188 - 63,480,151 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01264,411,072 - 64,538,081 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1264,410,753 - 64,538,102 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11263,770,621 - 63,897,766 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01263,612,694 - 63,739,640 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01263,886,649 - 64,013,653 (-)NCBIUU_Cfam_GSD_1.0
Atg5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494698,484,245 - 98,610,566 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365642,758,598 - 2,885,420 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365642,759,085 - 2,885,394 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATG5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl172,270,799 - 72,520,396 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1172,343,950 - 72,520,402 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ATG5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11367,482,538 - 67,619,201 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1367,482,595 - 67,617,902 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604039,817,584 - 39,954,576 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atg5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478015,987,397 - 16,124,151 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478015,987,483 - 16,124,158 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atg5
751 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:467
Count of miRNA genes:245
Interacting mature miRNAs:284
Transcripts:ENSRNOT00000057078
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

Markers in Region
C88337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,888,971 - 47,889,178 (+)MAPPERmRatBN7.2
Rnor_6.02049,392,903 - 49,393,109NCBIRnor6.0
Rnor_5.02051,025,881 - 51,026,087UniSTSRnor5.0
RGSC_v3.42048,366,499 - 48,366,705UniSTSRGSC3.4
Celera2052,117,298 - 52,117,504UniSTS
Cytogenetic Map20q13UniSTS
AA859872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,888,177 - 47,888,370 (+)MAPPERmRatBN7.2
Rnor_6.02049,392,109 - 49,392,301NCBIRnor6.0
Rnor_5.02051,025,087 - 51,025,279UniSTSRnor5.0
RGSC_v3.42048,365,705 - 48,365,897UniSTSRGSC3.4
Celera2052,118,106 - 52,118,298UniSTS
RH 3.4 Map20497.9UniSTS
Cytogenetic Map20q13UniSTS
RH127825  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,888,177 - 47,888,368 (+)MAPPERmRatBN7.2
Rnor_6.02049,392,109 - 49,392,299NCBIRnor6.0
Rnor_5.02051,025,087 - 51,025,277UniSTSRnor5.0
RGSC_v3.42048,365,705 - 48,365,895UniSTSRGSC3.4
Celera2052,118,108 - 52,118,298UniSTS
RH 3.4 Map20497.91UniSTS
Cytogenetic Map20q13UniSTS
AW528235  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,816,613 - 47,816,767 (+)MAPPERmRatBN7.2
Rnor_6.02049,319,491 - 49,319,644NCBIRnor6.0
Rnor_5.02050,952,750 - 50,952,903UniSTSRnor5.0
RGSC_v3.42048,292,595 - 48,292,748UniSTSRGSC3.4
Celera2052,189,058 - 52,189,211UniSTS
RH 3.4 Map20497.3UniSTS
Cytogenetic Map20q13UniSTS
AI178683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,889,032 - 47,889,150 (+)MAPPERmRatBN7.2
Rnor_6.02049,392,964 - 49,393,081NCBIRnor6.0
Rnor_5.02051,025,942 - 51,026,059UniSTSRnor5.0
RGSC_v3.42048,366,560 - 48,366,677UniSTSRGSC3.4
Celera2052,117,326 - 52,117,443UniSTS
RH 3.4 Map20498.4UniSTS
Cytogenetic Map20q13UniSTS
AU049869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,878,216 - 47,878,400 (+)MAPPERmRatBN7.2
Rnor_6.02049,382,150 - 49,382,329NCBIRnor6.0
Celera2052,127,977 - 52,128,202UniSTS
Cytogenetic Map20q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 57 41 19 41 1 4 74 35 34 11 1
Low 8 7 7 7 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000057078   ⟹   ENSRNOP00000053910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2047,815,494 - 47,889,209 (+)Ensembl
Rnor_6.0 Ensembl2049,319,307 - 49,393,140 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080283   ⟹   ENSRNOP00000075339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2047,798,330 - 47,888,589 (+)Ensembl
Rnor_6.0 Ensembl2049,318,308 - 49,391,940 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101057   ⟹   ENSRNOP00000086278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2047,798,290 - 47,889,209 (+)Ensembl
RefSeq Acc Id: NM_001014250   ⟹   NP_001014272
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82049,380,835 - 49,471,826 (+)NCBI
mRatBN7.22047,798,217 - 47,889,216 (+)NCBI
Rnor_6.02049,301,783 - 49,393,147 (+)NCBI
Rnor_5.02050,934,688 - 51,026,125 (+)NCBI
RGSC_v3.42048,273,977 - 48,366,743 (+)RGD
Celera2052,117,260 - 52,207,732 (-)RGD
Sequence:
RefSeq Acc Id: NM_001399019   ⟹   NP_001385948
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82049,380,835 - 49,471,826 (+)NCBI
mRatBN7.22047,798,217 - 47,889,216 (+)NCBI
RefSeq Acc Id: NM_001399020   ⟹   NP_001385949
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82049,380,835 - 49,471,826 (+)NCBI
mRatBN7.22047,798,217 - 47,889,216 (+)NCBI
RefSeq Acc Id: NM_001399021   ⟹   NP_001385950
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82049,380,835 - 49,471,826 (+)NCBI
mRatBN7.22047,798,217 - 47,889,216 (+)NCBI
RefSeq Acc Id: NP_001014272   ⟸   NM_001014250
- Peptide Label: isoform 1
- UniProtKB: Q5XIS0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075339   ⟸   ENSRNOT00000080283
RefSeq Acc Id: ENSRNOP00000053910   ⟸   ENSRNOT00000057078
RefSeq Acc Id: ENSRNOP00000086278   ⟸   ENSRNOT00000101057
RefSeq Acc Id: NP_001385950   ⟸   NM_001399021
- Peptide Label: isoform 3
- UniProtKB: Q3MQ06 (UniProtKB/Swiss-Prot),   A6K6V9 (UniProtKB/TrEMBL),   A0A0G2KAB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385949   ⟸   NM_001399020
- Peptide Label: isoform 3
- UniProtKB: Q3MQ06 (UniProtKB/Swiss-Prot),   A6K6V9 (UniProtKB/TrEMBL),   A0A0G2KAB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385948   ⟸   NM_001399019
- Peptide Label: isoform 2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3MQ06-F1-model_v2 AlphaFold Q3MQ06 1-275 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359580 AgrOrtholog
BioCyc Gene G2FUF-3293 BioCyc
Ensembl Genes ENSRNOG00000000322 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055000734 UniProtKB/Swiss-Prot
  ENSRNOG00060006932 UniProtKB/Swiss-Prot
  ENSRNOG00065008666 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057078.5 UniProtKB/TrEMBL
  ENSRNOT00000080283 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000080283.2 UniProtKB/Swiss-Prot
  ENSRNOT00000101057 ENTREZGENE
  ENSRNOT00000101057.1 UniProtKB/TrEMBL
  ENSRNOT00055001267 UniProtKB/Swiss-Prot
  ENSRNOT00060011358 UniProtKB/Swiss-Prot
  ENSRNOT00065013759 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.246.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.20.620 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133143 IMAGE-MGC_LOAD
InterPro Atg5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATG5_HBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Atg5_HR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATG5_UblA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Atg5_UblA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATG5_UblB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:365601 UniProtKB/TrEMBL
MGC_CLONE MGC:94348 IMAGE-MGC_LOAD
NCBI Gene 365601 ENTREZGENE
PANTHER AUTOPHAGY PROTEIN 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13040 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam APG5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATG5_HBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATG5_UblA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atg5 PhenoGen
RatGTEx ENSRNOG00000000322 RatGTEx
  ENSRNOG00055000734 RatGTEx
  ENSRNOG00060006932 RatGTEx
  ENSRNOG00065008666 RatGTEx
UniProt A0A0G2KAB9 ENTREZGENE, UniProtKB/TrEMBL
  A6K6V9 ENTREZGENE, UniProtKB/TrEMBL
  ATG5_RAT UniProtKB/Swiss-Prot
  D3ZJZ1_RAT UniProtKB/TrEMBL
  Q3MQ06 ENTREZGENE
  Q5XIS0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-06-07 Atg5  autophagy related 5  Atg5  ATG5 autophagy related 5 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Atg5  ATG5 autophagy related 5 homolog (S. cerevisiae)  Atg5  autophagy related 5 homolog (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-03 Atg5  autophagy related 5 homolog (S. cerevisiae)   LOC365601  similar to autophagy 5-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED