negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); genetic disease (ortholog); purine nucleoside phosphorylase deficiency (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene