ENCODES a protein that exhibits amine binding; dopamine:sodium symporter activity; heterocyclic compound binding; INVOLVED IN dopamine transport; response to cAMP; response to ethanol; PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacody
namics pathway; ASSOCIATED WITH heroin dependence; high grade glioma; hyperprolactinemia; FOUND IN dopaminergic synapse; neuron projection; plasma membrane; INTERACTS WITH (S)-amphetamine; (S)-naringenin; (S)-nicotine
solute carrier family 6 member 3; ENU induced mutant 1, Span
This allele was identified in the N-ethyl-N-nitrosourea (ENU)-driven target-selected mutagenesis screen. A point mutation in the Slc6a3 (DAT) coding sequence (exon 3) with a T/G transversion at nucleotide position 471 was identified in a male rat. This nucleotid
e exchange leads to substitution of an asparagine amino acid residue by a lysine residue at position 157 (N157K) in the SLC6A3 (DAT) protein, which introduces new positive charge into the amino acid sequence.