ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity; calcium channel regulator activity (ortholog); cAMP binding (ortholog); INVOLVED IN cellular response to epinephrine stimulus (ortholog); cellular response to lipopolysaccharide (ortholog); cellular response to xenobiotic s
timulus (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; ASSOCIATED WITH Burns; acute myeloid leukemia (ortholog); alcohol dependence (ortholog); FOUND IN perinuclear region of cytoplasm; cell periphery (ortholog); centrosome (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol
These gene was generated using a pair of zinc finger nucleases targeting exon 1 of the rat PDE4B gene, and the 16-bp frameshift deletion (AGCGGCGTCGCTTCAC) in exon 1 was verified by genomic DNA sequencing.