| 619922 | Madd | MAP-kinase activating death domain | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity; INVOLVED IN negative regulation of growth hormone secretion; negative regulation of pancreatic amylase secretion; anterograde synaptic vesicle transport (ortholog); PARTICIPATES IN ceramide signaling pathway; tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH transient cerebral ischemia; autistic disorder (ortholog); DEEAH Syndrome (ortholog); FOUND IN synapse; synaptic vesicle; cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil | 3 | 97570141 | 97613688 | Rat | 135 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1578796 | Maddm1Mcwi | MAP-kinase activating death domain; mutation 1, Medical College of Wisconsin | mutation generated by ENU (N-ethyl-N-nitrourea); G120R mutation is generated | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 1311559 | Dennd3 | DENN domain containing 3 | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN endosome to lysosome transport (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH Hirschsprung's disease (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphen ol; 6-propyl-2-thiouracil | 7 | 107304860 | 107362573 | Rat | 106 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1307927 | Dennd1a | DENN domain containing 1A | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); phosphatidylinositol phosphate binding (ortholog); phosphatidylinositol-3-phosphate binding (ortholog); INVOLVED IN endocytic recycling (ortholog); endocytosis (ortholog); positive regulation of GTPase activity (o rtholog); FOUND IN clathrin-coated vesicle (ortholog); clathrin-coated vesicle membrane (ortholog); dendrite (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; bisphenol A | 3 | 41974502 | 42461816 | Rat | 111 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1308441 | Dennd1b | DENN domain containing 1B | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN endocytic recycling (ortholog); positive regulation of GTPase activity (ortholog); positive regulation of T-helper 2 cell cytokine production (ortholog); ASSOCIATED WIT H autistic disorder (ortholog); COVID-19 (ortholog); Crohn's disease (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; gentamycin | 13 | 53096717 | 53324372 | Rat | 119 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1590869 | Dennd1c | DENN domain containing 1C | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN endocytic recycling (inferred); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; FOUND IN clathrin-coated ves icle (inferred); cytoplasmic vesicle (inferred); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol | 9 | 1991035 | 2003330 | Rat | 71 | old_gene_name , ensembl_full_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1306142 | Dennd2a | DENN domain containing 2A | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN retrograde transport, endosome to Golgi (ortholog); FOUND IN actin cytoskeleton (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; bisphenol AF | 4 | 69199814 | 69299128 | Rat | 78 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1308197 | Dennd2c | DENN domain containing 2C | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; acetamide; acrylamide | 2 | 193310822 | 193378986 | Rat | 79 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1305120 | Dennd2d | DENN domain containing 2D | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 196661465 | 196680505 | Rat | 100 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1562639 | Dennd4a | DENN domain containing 4A | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; FOUND IN cytoplasm (inferred); cytosol (inferred); INTERACTS WITH 17beta -estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 8 | 74218131 | 74331543 | Rat | 97 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1560320 | Dennd4b | DENN domain containing 4B | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN regulation of Rab protein signal transduction (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; AS SOCIATED WITH Dwarfism (ortholog); Familial Prostate Cancer (ortholog); FOUND IN Golgi apparatus (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | 2 | 178018095 | 178034054 | Rat | 69 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1308489 | Dennd4c | DENN domain containing 4C | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN cellular response to insulin stimulus (ortholog); protein localization to plasma membrane (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathwa y; Rab family mediated signaling pathway; FOUND IN cytosol (ortholog); Golgi apparatus (ortholog); insulin-responsive compartment (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine | 5 | 106316942 | 106421484 | Rat | 89 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1306759 | Dennd5a | DENN domain containing 5A | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of neuron projection development; retrograde transport, endosome to Golgi (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 49 (ortholog); genetic disease (ortholog); FOUND IN Golgi apparatus (ortholog); retromer complex (ortholog); trans-Golgi network (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A | 1 | 173362959 | 173428973 | Rat | 109 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2318606 | Dennd5b | DENN domain containing 5B | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN positive regulation of triglyceride transport (ortholog); FOUND IN membrane (inferred); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine | 4 | 183688039 | 183821012 | Rat | 75 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1306064 | Dennd6a | DENN domain containing 6A | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN positive regulation of cell-cell adhesion mediated by cadherin (ortholog); FOUND IN cytoplasm (ortholog); recycling endosome (ortholog); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; amitrole | 16 | 1843803 | 1892165 | Rat | 63 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1308012 | Dennd6b | DENN domain containing 6B | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); FOUND IN recycling endosome (inferred); INTERACTS WITH (+)-schisandrin B; 4,4'-sulfonyldiphenol; amphetamine | 7 | 122139159 | 122154720 | Rat | 47 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |