ENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN tricarboxylic acid cycle (ortholog); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH Disease Progression (ortholog); fundus dystrophy (o
rtholog); optic atrophy (ortholog); FOUND IN isocitrate dehydrogenase complex (NAD+) (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A